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Mobile Pilot Unit for Membrane Filtration A trial, prototyping and development platform for automated hygienic liquid filtration processes in the food and beverage industries.

Food & Beverage Industry

Technology that delivers

PILOT UNIT IN THE CONTEXT OF INDUSTRY

High precision environement for large scale innovations. The Pilot Process Unit uses modules and technologies that are standardly used in the food and beverage industries. As a research and development platform, it guarantees the results of the process and output, which can be repeated and up-scaled to any production level. The Pilot Membrane Unit is an advanced and mobile platform offering a safe environment for product prototyping, product development, process development, and process testing. The unit is modularly built and flexible as it enables a wide range of configurations that are common in the food and beverage industries. It is compatibile with all relevant industrial module producers. And it is reliable by ensuring the predictable up-scaling of the proffered configuration. The unit gives process developers the freedom to maximize the benefits of processes that are based on membrane filtration. It was designed to be ultimative tool to develop and make new products.

The unit uses standard industrial modules, industrial-sized spiral wound and ceramic membrane modules, and equipment for heating and cooling according to the desired specification. Samples can be taken at any stage of the process. The unit is designed as a small-scale production system and is fully compatible with industrial standards, technologies, and processes. Throughout any given trial, the process conditions (for example, the flow rate, pressure or temperature) are monitored and documented. Achieved end-results are independently proven to be reproducible with optimal precision and give solid foundations for safely up-scaling to any planned production level.

MODULES AND FEATURES

Configure, measure, reconfigure. Repeat until the results are perfect. The Pilot Process Unit provides industrial stakeholders with tangible benefits during research, development and up-scaling operations for all known filtering processes. Its simple yet effective design focuses on the modularity of a unit, the measurability of each and every dimension within the process, and on the reliability of the results. The unit contains all instruments and software required to reduce the risk of an up-scale failure. Due to the unit’s innovative design, fewer sources are needed for successful development – even compared to other pilot systems.

The unit is designed with a high level of hygienic design and is compatible with the level used in dairy production systems. As a result, the unit design complies with all major recommendations (like 3A Sanitary Standards or EHEDG).

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Electrical control panel with energy consumption meter Permeate flowmeter Retentate flowmeter Operating panel for controlling and monitoring operation of the unit Pump for circulating the product Pressure sensor Swing bend panel Heat exchanger Elements for automatic temperature control during cooling and heating High pressure pump Housing for industry-sized filter cartridge type “spiral wound” Housing for the filter cartridge type “ceramic” Temperature sensor A set of sampling valves

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Additional units: CIP Dosing Station for cleaning concentrates in protective housing boxes which enable safe storage of sensitive parts in between the use and transportation of modules

CIP Dosing Station

BENEFITS

Made to bring a difference to your process The Pilot Process Unit provides industry players with tangible benefits during research, development and up-scaling operations. As a powerful testing tool, it gives an opportunity for business growth by optimizing products and processes. The flexibility that comes with the unit’s modular design means the needs of process owners are met more precisely, more cost effectively and within shorter time frames. It elevates the organization’s competence to successfully predict needs, specifications and results while developing its production facilities. In doing so, the unit shortens the time needed to kick-start new production lines, makes installation phases more controllable and ultimately shortens the time to market. The overall effect is a significant reduction of losses in all relevant areas. The unit’s set-up is universally applicable over the whole spectrum of food and beverage processes that use membrane filtering. With it, one can produce any given product by using various liquid media. It can be used as a small-scale production facility, as a mobile production and prototyping unit, or for producing a small-scale model which can be flexibly up-scaled to the optimal production level. The ordered modules and their technology can be flexibly changed, as can all the parameters during different production process stages. The unit is

effectively controlled and monitored through simple and clear command and display sections. Since cleaning is the key challenge in the filtering process, the unit offers all key features that enable the optimal cleaning procedure to be developed. It makes cleaning trials with various qualities of water and different cleaning concentrates possible. The pilot unit’s design is a reflection of the excellent plant knowledge of an experienced process engineering team. It contains all sensors, pumps, piping elements and control equipment to successfully run microfiltration, ultrafiltration, nano filtration and reverse osmosis without restriction. In every project, Brinox brings in the experience and expertise from successful food and beverage production sites across Europe, including Russia. As a specialist in automated hygienic processing systems for all types of liquids, the company holds all the distinguished references and valuable resources required in the concept, installation, trial, and production phases. 11

Overview of Applicable Processes Cereal and bakery ¬ Gelatin concentration ¬ Membrane enzyme reactors for corn starch production

Meat, fish and poultry ¬ Whole-egg concentration ¬ Egg-white concentration ¬ Agar and agarose concentration

Dairy products ¬ Cheese milk standardization ¬ Cheese brine treatment ¬ Microfiltration of milk – ESL (extended shelf life) ¬ Concentration of milk prior to cheese making ¬ Separation of whey proteins from whey ¬ Demineralization of whey products

Fruit and vegetables ¬ Concentration of tomato juice ¬ Refining of coffee extract ¬ Apple and citrus pectin concentration

Sugars and other sweets ¬ Demineralization of sugar juice prior to refining

¬ Sugar beet clarification ¬ Clarification of dextrose syrup ¬ Demineralization of high-fructose corn syrup

Fats and oils ¬ Manufacture of biofuels ¬ Separation and purification of fatty acids ¬ Degumming of crude palm oil by membrane filtration

Non-alcoholic beverages / alcoholic beverages ¬ Concentration of fruit juices ¬ Apple juice clarification ¬ Citrus juice purification ¬ Preclarification of grape juice ¬ Clarification of beer after fermentation ¬ Beer de-alcoholisation

Other products ¬ ¬ ¬ ¬ ¬ ¬

Concentration of enzymes Purification of enzymes Standardization of enzyme-solutions Purification of amino acids Concentration of amino acids Fractionation of amino acids

Partner Profile “BRINOX is a partner that brings in almost 40 years of experience. Its excellent reputation in the biopharmaceutical, bipharmaceutical, and food industries is a guarantee of its flawless process systems.” BRINOX is an innovative European company specializing in fast, efficient, cost-competitive, and personalized process systems. BRINOX is on the way to becoming Europe’s first-choice partner for customized process solutions. The company focuses on developing, producing, and installing solutions that optimally address the complex challenges of automated processes.

With its headquarters in Slovenia, partners in Europe and Russia and over 350 highly skilled employees, the company has adopted a system of ambitious corporate values based on the customer-centered approach.

Regulatory compliance

Engineering

Client support in the field of regulatory compliance, generating customized plans for increasing productivity in line with cGMP requirements

A precise definition of the functionality of process systems, of the links between them and development of the process flow chart (P&ID diagram). Designing of every process component, anticipating any possible process problems and ensuring high levels of efficiency and productivity.

R&D A rigorous approach, advanced tools and collaboration with leading experts and institutions

Conceptual design Development of the optimal solution that is cost-effective, high-performing, and GMP compliant

Testing Having our own testing facilities and strict test plans allow extensive FAT prior to delivery and successful SAT.

Assembly On-site assembly is provided globally, regardless of the manufacturer’s location, ensuring proper installation and guaranteeing problem-free functioning.

Automation

Manufacturing A high level of flexibility and adaptability to ever changing demands, guaranteeing the highest possible quality control and respecting budget and time constraints

Quality control and validation

Monitoring quality within the manufacturing system, monitoring and addressing any errors or disruptions. Assistance during validation procedures, including complete documentation support.

Maintenance Intervention, repair, and assembly. Spare parts for all equipment installed, engineer-supported interventions, online support and preventive check-ups.

Comprehensive automation solutions are based on the ISA S88.01 standard, 21CFR part 11 guidelines, PLC-SCADA open solutions, and GAMP 5 guidelines 13

Brinox d.o.o. Sora 21 SI-1215 Medvode, Slovenija T: +386 1 361 97 30 info@brinox.eu www.brinox.eu

Brinox Deutschland GmbH Maria-und-Georg-Dietrich Str. 2 77652 Offenburg Deutschland T: +49 (0) 781 970 678 10 info@brinox.de

Brinox Innovations AG Poststrasse 14 CH-6300 Zug Switzerland T: +41 41 727 81 50 info@brinox-innovations.ch

ООО «БРИНОКС РУС» Кутузовский пр-т 9/2, офис 98, 121248 Москва Российская Федерация T: +7 499 243 71 55 russia.office@brinox.eu