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SPECIAL presented by

ropean Biotechn gy gy Biotechnology News Science & Industry Science&Industry

The official Biotechnology and Life Sciences Guide to 1_Achema_Special_Titel.indd 1

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[tank truck] [tank truck] NEXT GENERATION BIOFUELS NEXT GENERATION BIOFUELS

As a worldwide leading company in catalysts and adsorbents technologies, we also provide innovative technologies and processes for the production of next generation biofuels and bio-based chemicals. Süd-Chemie offers innovative system solutions including As a worldwide leadingdown company in catalysts and adsorbents technologies, alsohand. provide catalysis, biocatalysis, stream processing and process technology out we of one innovative technologies and processes for the production of next generation biofuels The sunliquid®chemicals. process forSüd-Chemie the production of cellulosic from straw and and bio-based offers innovativebioethanol system solutions including other lignocellulosic residues is one of our contributions to climate friendly solutions catalysis, biocatalysis, down stream processing and process technology out of one hand. in CleanTech – energy efficient, environmentally friendly, resource efficient and no The sunliquidto® food process for the production of cellulosic bioethanol from straw and competition or feed. other lignocellulosic residues is one of our contributions to climate friendly solutions Süd-Chemie forefficient, innovation and tradition –friendly, for moreresource than 150efficient years and no in CleanTechstands – energy environmentally competition to food or feed. Süd-Chemie stands for innovation and tradition – for more than 150 years

SUD-CHEMIE AG Corporate Strategic Research and Development SUD-CHEMIE AG Staffelseestraße 6 Corporate 81477Strategic Munich Research Phone:and +49Development 89 710661-0 Staffelseestraße 6 Fax: +49 89 710661-122 81477 Munich sunliquid@sud-chemie.com Phone: +49 89 710661-0 www.sunliquid.com Fax: +49 89 710661-122 www.sud-chemie.com sunliquid@sud-chemie.com www.sunliquid.com www.sud-chemie.com

* sunliquid is a registered trademark in Europe

* sunliquid is a registered trademark in Europe

SCCL-Anz Sunliquid A4 E RZ.indd 1 Unbenannt-18 1 2-3_Achema_Special_einleitung_bk.indd 2

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13:12 :57 Uhr

Photo: DECHEMA

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ContEnts Intro Chemistry, pharma and biotech hand in hand

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PrevIew 4

Biobasedworld at ACHeMA

foCAl PoInts ACHEMA

Chemistry, pharma and biotech hand in hand Started as early as 1920 ACHEMA is today the leading international trade fair for the chemical industry including a large number of related sectors. This year's event will take place from 18-22 June. The doors of the fairgrounds in Frankfurt/ Main will be open from 9am to 6pm. With 4,000 exhibitors and more than 180,000 participants from all over the world, ACHEMA provides a unique platform for an intensive dialogue between suppliers and buyers, and the identification of synergies. With BiobasedWorld, ACHEMA introduces a special focus on biotechnology and enviromental protection (see pp. 4-5). With good reason: In recent years the knowledge-based bioeconomy transformed from a lofty idea to an irreversible process. The organizers will offer in total 140,000 m² exhibition space and 900 lectures in the accompanying congress, which is expected to attract 27,000 participants. Visitors interested in biotechnology and life science might get lost easily at ACHEMA, where highlights of biotechnology and enviromental protection will be spread across the fair. This official Biotechnology and Life Science Guide to BiobasedWorld at ACHEMA 2012 will lead you to find your mustattends. As a centrepiece it delivers six pre-arranged routes that will bring visitors interested in Biotechnology and Life Sciences directly to exhibitors with strong ties to these sectors. The titles of the prepared walks are (see pp. 6-10): – Bioengineering and Process Technology – Instrumentation, Control and Automation Techniques

– Laboratory and Analytical Techniques – Pharmaceutical, Packaging and Storage Techniques – Pumps, Compressors, Valves and Fittings – Research and Innovation. BiobasedWorld at ACHEMA is the venue where bioeconomy becomes visible. The vibrant community driving these progresses is constantly changing. But, the congresses, lectures and other events at ACHEMA BioBasedWorld will make it easy to track the emerging new technologies, innovative ideas and rising key players. This sector event allows the participants to meet key players from the bio-based value chain and to discuss new technologies, processes, latest developments and ideas at one time and in one place. Obviously, the biotechnology finds its way into more and more industry sectors and value chains: The chemical and pharma industries are getting ready to produce platform chemicals such as glycerin or dicarbon acids for biofuels and bioplastics from agricultural feedstock. In this autumn, a large algae production plant went into operation in China. The algae are fed with scrubbed flue gas, absorb the carbon dioxide and metabolise it into valueadded substances like fat or carbohydrates. Several Airlines launched first commercial flights using bio-kerosine in the past. Interested? Screen this official guide to BiobasedWorld at ACHEMA and find out how the industrial future will look like. B

walk 1: Bioengineering and Process technology

6

walk 2: Instrumentation, Control and Automation techniques

8

walk 3: laboratory and Analytical techniques

8

walk 4: Pharmaceutical, Packaging and storage techniques

8

walk 5: Pumps, Compressors, valves and fittings

10

walk 6: research and Innovation

10

BIoeConoMY 12

where do we stand?

PersPeCtIves Interview: Marcel wubbolts, DsM

IMPrInt This is an ACHEMA special jointly presented by the magazines European Biotechnology News and |transkript, published by BIOCOM AG in cooperation with DECHEMA Ausstellungs-GmbH and DECHEMA Gesellschaft für Chemische Technik und Biotechnologie e.V. BIOCOM AG, Luetzowstr. 33–36, 10785 Berlin, Tel.: +49-30-2649210, Fax: +49-30 -264921-11, E-Mail: service@eurobiotechnews.eu; w w w.eurobiotechnews.eu, w w w.transkript.de. Publisher: Andreas Mietzsch, Editorial Team: Thomas Gabrielczyk, Dr. Patrick Dieckhoff, Dr. Bernd Kaltwasser, Andreas Macht, Steffen Seitz; Advertising: Oliver Schnell, +49-30-2649-2145, Advertising USA: Avani Media, Inc., Leslie Hallanan, Tel.: +1-415-331-2150, Fax: +1-415-289-0402, E-Mail: leslie@avanimedia.com; Distribution: Angelika Werner, +49-30-2649-2140; Printed at: Druckhaus Humburg, Bremen; Graphic Design: Oliver-Sven Reblin. As regards contents: individually named articles are published within the sole responsibility of their respective authors. All material published is protected by copyright. No article or part thereof may be reproduced in any way or processed, copied and proliferated by electronic means without the prior written consent of the publisher. Cover Photo: © DECHEMA Frankfurt/Main ® BIOCOM is a registered trademark of BIOCOM AG, Berlin, Germany.

ACHEMA 2012

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PrEvIEw

munity, representatives of NGOs and of industries along the biomass value chain.

BiobasedWorld – future opportunities

BiobasedWorld as an integral part of ACHEMA

Dr. Kathrin Rübberdt, Head of Biotechnology at DECHEMA e.V., Frankfurt

What is the BiobasedWorld at ACHEMA? Is it the c. 800 exhibitors that can be easily allocated to the life sciences and biotech industry, not even mentioning all the companies who present apparatus, processes and concepts for everything from biomass processing to cell culture and from pharmaceutical production to lab technology? Is it the more than 200 lectures in the congress or the broad range of special and guest events addressing the bio-community? It’s all of this and more. Photo: BMBF

How deeply the BiobasedWorld is rooted within ACHEMA becomes apparent when looking at exhibitors’ offerings: The laboratory and analytics group has always been a centre of attraction for the biotechnology and life sciences community. But the BiobasedWorld reaches beyond: Exhibitors in the pumps and compressors group present equipment that is designed to fulfill the specific needs of biomass processing, from the handling of biomass whose properties may change between batches to ethanol-resistant seals. In mechanical and thermal processing, visitors find equipment for any kind or imaginable bioprocess, be it microscale or large volume. A lot of innovations for the monitoring of bioprocesses and pharmaceutical production can be found in the measurement, control and automation hall. And producers of biopharmaceuticals can get information on the latest in filling and packaging technology in Hall 3. The congress features more than 200 presentations in five parallel sessions running all week in Halls 4 and 9 that specifically address life sciences and bioprocess issues. This does not even include questions of more general interest such as laboratory and analytical techniques or mixing and separations that are also covered in the congress.

Promoting a dialogue between politics, science and industry

Also the German Ministry of research participates at ACHEMA and shows its "Biotechnikum" truck where visitors can do research themselves.

Biotechnology, biomass processing and life sciences have always been an important part of ACHEMA. BiobasedWorld at ACHEMA is a new virtual platform that shines a bright spotlight on what the process industry is already doing in this area and which solutions are available to anyone who is interested in using biomass or bioprocesses. The reasoning behind the concept of BiobasedWorld that covers all aspects of biotechnology from cell culture and pharmaceutical production to biomass processing and industrial biotechnology is that chemistry, process engineering and biotechnology are increasingly working hand in hand on the route towards a bio-based economy. Pharmaceutical produc4

tion, life sciences or food processing have always been bio-based or bio-related. With the foreseeable shift away from fossil resources due to economic and ecologic reasons, the chemical industry of the future will also rely heavily on renewable resources and biorefineries where the handling of bio-products and bio-processes plays a decisive role. To bring these ideas to life, engineers, chemists and biotechnologists need to cooperate closely and to learn from each other. Thus, the BiobasedWorld is intended to intensify the dialogue between these communities. Moreover, it brings together stakeholders beyond the core ACHEMA community, including politicians from federal ministries and the European Com-

The opening day of ACHEMA will accentuate the importance of bioeconomy. Clemens Neumann, BMELV, Martina Fleckenstein, WWF Deutschland, Lutz Guderjahn, CropEnergies AG, Joachim von Braun, University of Bonn and Holger Zinke, BRAIN AG, will discuss what it takes to make the bioeconomy become reality. Subsequently, the Roadmap Biorefineries will be presented. This roadmap has been developed as part of the Action plan of the Federal Government for the use or renewable resources („Aktionsplan der Bundesregierung zur stofflichen Nutzung nachwachsender Rohstoffe“) in cooperation of the Federal Ministries of Education and Research, Food, Agriculture and Consumer Protection, Economics and Technology and Environment, Nature Conservation and Nuclear Safety. 30 renowned experts from science and industry have worked on the roadmap that presents

SPECIAL

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Timetable of the BiobasedWorld conference Hall 4.0 Europa 1

Hall 4.C Consens

A 18.06.

Hall 4.C Entente

Hall 4.C Alliance

Hall 9.1 Logos/Genius

Hall 9.1 Esprit

Hall 9.2 Dialog

Experiences in Advanced Pharmaceutical Technology

Pharmaceutical Production

Bioprocesses

Bioprocesses

Biorefineries and processing of renewables

Pharmaceutical Production

Bionik im Betrieb

Bioprocesses

Biorefineries and processing of renewables

Pharmaceutical Production

Raw Materials for biotechnology: Synthesis gas, lignocellulose

A 19.06.

A 20.06.

Single-UseTechnologies

A 21.06.

Food biotechnology

A 22.06.

an overview of currently available technologies as well as the fields where further research and development efforts are necessary. The two-day conference European Bioeconomy: From knowledge via demonstration to products and markets on 20-21 June with high-ranking speakers from European and national institutions and from industry brings together all stakeholders of the bioeconomy. The event covers the complete value chain – from the regulative setting at the EU level via the availability of feedstock and the required logistic integration of agri- and silviculture with the chemical industry, the holistic processing approach in biorefineries up to the conditions for a successful market-entrance of technologies and products.

Not a vision, but reality A “View on Biobased Economy” is presented in the Galleria between Halls 8 and 9. Current and future products of a bio-based economy are presented in this area. Participants who are not familiar with biotechnological methods might want to have a look at the Biotechnikum Truck in the outdoor area where they can get information on biotechnology and do some research themselves. At the Technology Transfer Day on June 21st, researchers and developers present their closeto-market findings to technology scouts and business developers. For SMEs who want to bring their own ideas to market, the EU Project BIOCHEM organises an Accelerator Forum on 20-21 June; here the tools that have been developed in the course of the project are presented, en-

Biorefineries and processing of renewables

Bioprocesses

Pharmaceutical Production

Development and application of novel biocatalysts

Biorefineries and processing of renewables

Bioprocesses

Pharmaceutical Production

Development and application of novel biocatalysts

New products through Biotechnology

trepreneurial teaching classes give practical information on how to enter the market, and at the Venture Capital Day there is the opportunity to get information on funding and meet potential investors. A number of guest and special events feature different regional approaches to the bio-economy: Events like “Bioeconomy in Eastern Europe”, “Industrial Biotechnology: Innovation made in Switzerland” or “German Bioindustry 2012” present different approaches and will provide an opportunity for international networking.

How to find your way For the BiobasedWorld at ACHEMA, the same holds true as for ACHEMA as a whole: It is colorful, inspiring, multifaceted - and sometimes overwhelming. ACHEMA online (www.achema.de) and the special BiobasedWorld website www. achema.de/biobasedworld provide orientation. the exhibitors’ database has information on products, innovations and company news and offers extensive search functions. The congress planner helps you to compile your individual schedule. The ACHEMA app! brings this wealth of information to participants’ pockets. And ACHEMA Partnering allows for the targeted search of interesting contacts weeks before ACHEMA and enables the scheduling of meetings during the event. Just register and provide your profile, search for your fields of interest or receive meeting requests from other participants. The journey to the BiobasedWorld is an expedition – not into the unknown, but into the present and the future of our world. B

BiobasedWorld – International Events Mon., 18.6.12: Bioeconomy in Eastern Europe Hall 4.0, Europa 2 Tue., 19.6.12: Industrial Biotechnology in Switzerland Hall 9.2, Discussion Corner Tue., 19.6.12: Axelera and Trimatec – Dynamic French Clusters Hall 4.C, Entente Tue., 19.6.12: European Bioeconomy Hall 4.0, Europa 2 Wed., 20.6.12: German Bioindustry 2021 leading to Bioeconomy Hall 9.1, Esprit Wed., 20.6.12: European Bioeconomy Hall 4.0, Europa 2 Wed., 20. - Fri. 22.6.12: Development and application of novel biocatalysts Hall 9.1, Esprit BiobasedWorld – From Science to Market 20./21.6.12: BIOCHEM Accelerator Forum Hall 9.2, Motiv 21.6.12: Technology Transfer Day Hall 9.1, Logos/Genius

ACHEMA 2012

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14.05.2012 17:19:32 Uhr


IKA-Werke GmbH & Co. KG

DASGIP GmbH

Stand: B7, Hall 4.1

5

Automatik Plastic Machinery GmbH

Stand: L15, Hall 4.2

6

IKA® is the leading company for laboratory and analytical technology. Our innovative high quality products provide best solutions for mixing, dispersing, distilling and heating applications.

DASGIP – We know bioprocessing. As the industry leader for benchtop bioprocessing solutions, we have defined the state of the art in Parallel Bioreactor Systems and innovative bioprocess information management. www.ika.com www.dasgip.com

Stand: C33, Hall 5.0

Pierre GUERIN – Biolafitte, an expert for sterile and biological forms in the GMP environment, brings you innovative and adapted solutions to your fermentation and cell cultivation process.

Stand: F44, Hall 4.0

Stand: A68, Hall 6.1

18 17

9.2

13

16

Bioquell are very excited to launch a groundbreaking new system in sterility testing. Bringing together two of the most trusted names in life sciences. HPV bio-decontamination from Bioquell, and sterility test systems from Millipore. www.bioquell.com

12

14 11

3

10 9

11.1 11.Via

8.0

11.0 4.2 10

4.1

2

Energy efficiency and more specifically waste heat recovery is one of Alfa Laval’s focus areas. Alfa Laval applies its unique range of heat exchangers to help plants increase profits from waste heat Hall4/D4 www.alfalaval.com/achema

19

4.0

4

3

GE Healthcare

www.gelifesciences.com

3.1

Entrance Portalhaus

1

GE Healthcare Life Sciences offers the expertise and tools spanning applications from basic research of proteins and cells to large-scale purification of biopharmaceuticals.

6

Walk 1 Cargo Centre Bioengineering and Process Technology

Inv Sys

Stan

Inven matio system and co and in

Dependance

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LEWA system custo ments tems HPLC

Gal.0

Alfa Laval

Stand: D19, Outdoor Area

Stan

Entrance Torhaus

Gal.1

9.T

9.0

GEA Wiegand offers evaporation, distillation, membrane filtration and fermentation plants, jet pumps and vacuum systems for the processing of biobased substances of the chemical and food industry. www.gea-wiegand.com

Stand: D4, Hall 4.0

8

15

9.1

GEA Process Engineering

LEW

Entrance Galleria

4

www.pierreguerin.com

7

Innovative solution provider for pump, pelletizing and filtration systems. We deliver high-quality components and complete systems. Our pelletizing systems are customized for each specific requirement. www.maag.com

Pierre Guérin SAS Stand: J43, Hall 4.0

Bioquell UK Ltd.

14.05.2012 17:21:09 Uhr


nch a sterilwo of ences. oquell, lipore. ll.com

LEWA GmbH

Uhde High Pressure Technologies

Stand: C62, Hall 8.0

9

LEWA is a manufacturer of pumps and systems. We provide process solutions, customized to meet customer requirements: Hygienic metering pumps, systems for hygienic processes, LPLC and HPLC systems. www.lewa.com

M+W Process Industries GmbH

Stand: H47, Hall 8.0

10

Stand: B3, Hall 9.1

Xylem water solutions Herford GmbH 11

True to the new motto “Engineered Solutions in High Pressure” Uhde High Pressure Technologies GmbH, Hagen will give an overview of its business activities at the ACHEMA 2012.

M+W Process Industries GmbH is a global engineering and construction company delivering complete process and facilities solutions for the biotechnological, pharmaceutical, chemical, medical devices, consumer care, and food industries. www.uhde-hpt.com www.pi.mwgroup.net

Stand: C25, Hall 9.1

12

Over 250,000 installed WEDECO systems for UV disinfection and ozone oxidation ensure a healthy and sustainable water quality in numerous private, municipal and industrial areas of application worldwide. www.wedeco.com

Bilfinger Berger Ind. Services Stand: E52, Hall 9.1

DECHEMA

The new bioreactor featuring userfriendly E/I&C, automation and special software, meets all requirements for optimum production operations. The customer selects his specific configuration from a range of options available. www.BIS.bilfinger.com

CMF Congress Center Messe Frankfurt

ance haus

6.1

Process Systems Enterprise

5.1

8

Stand: C9, Hall 9.2

5.0

7

Forum

6

Entrance LEA

Festhalle

Beta Renewables

1

5

14

Convert batch to continuous, extract more knowledge from data, scale-up with confidence, increase throughput and reduce cost with PSE's gSOLIDS and gCRYSTAL for solids and crystallisation processes. www.psenterprise.com/gsolids.html

6.0

Stand: E38, Hall 9.2

2

1

Enzymicals AG

Stand: A3, Hall 11.0

19

Invensys is a leading provider of automation and information technologies, systems, software solutions, services and consulting to global manufacturing and infrastructure industries.

Stand: C62, Hall 9.2

BlueSens gas sensor GmbH 18

Stand: C62, Hall 9.2

15

Beta Renewables licenses PROESA 2ndgeneration biomass technology. Enables cost-competitive cellulosic ethanol and biochemicals using non-food biomass. Building world’s first commercial-scale cellulosic ethanol plant, in production 2012. www.betarenewables.com

Entrance CITY

4.C

Invensys Systems

13

Süd-Chemie AG 17

Stand: D38, Hall 9.2

16

Our focus is the development and pro- BlueSens offers unique gas analysers for Süd-Chemie is a specialty chemicals

Entrance duction of enzymes as well as the bio- bioprocesses (e.g. O2/CO2, Ethanol, H2) company with a focus on industrial Hall 3 synthesis of fine chemicals. We for the pharmaceutical, chemical and bi- biotechnology. The company develcatalytic

deliver concept-to-completion solutions otechnical industry - from the laboratory ops energy-efficient processes for the to create and develop high performance scale to the industrial application. manufacture of biomass-based chemiprotein based products and processes. cals and fuels. www.iom.invensys.com www.bluesens.com www.enzymicals.com www.sud-chemie.com ACHEMA 2012

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7

14.05.2012 17:21:24 Uhr


Pierre Guérin SAS

Dornier-LTF GmbH

Stand: J43, Hall 4.0

1

Pierre GUERIN – Biolafitte is a world leader in design and provision of turnkey biopharmaceutical manufacturing equipment, integrated with control & automation solutions from best globalstandard providers. www.pierreguerin.com

Invensys Systems

Stand: K60, Hall 4.2

2

Dornier-LTF is a joint-venture of two high-tech companies. This union guarantees the best value in sophisticated laboratory technology and affordable high precision liquid handling robots. www.dornier-ltf.com

MICHELL Instruments GmbH

Stand: A3, Hall 11.0

3

We Sof Sys

Stand: E2, Hall 11.1

4

Invensys is a leading provider of automation and information technologies, systems, software solutions, services and consulting to global manufacturing and infrastructure industries.

Michell Instruments, your specialist for Moisture, Humidity and Oxygen. Manufacturing, Sales and Service for sensors, field transmitters, instrumentation solutions and calibration equipment for process. www.iom.invensys.com www.michell.de

Entrance Galleria

9.2 9.1

9.T

Entrance Torhaus

Gal.1 Gal.0

9.0

11.1 5

11.Via

8.0

11.0 4.2 4

10

2 3

4.1

4.0

3

Entrance Portalhaus

2

1

3.1

Dependance Cargo Centre

8

SPECIAL

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14.05.2012 17:21:40 Uhr

Stan

Werum ufact tion S Its Ma PAS-X comp


Werum Software & Systems AG

Wilhelm Werner GmbH

Stand: A73, Hall 11.1

5

ist for Manr senmentaequip-

Werum is the leading supplier of Manufacturing IT/Manufacturing Execution Systems for the pharma industry. Its Manufacturing IT Business Platform PAS-X enables integrated GMP/FDAcompliant IT solutions. hell.de www.PAS-X.com

Stand: J23, Hall 4.1

Wyatt Technology Europe GmbH 1

Stand: N29, Hall 4.1

Werner provides solutions for pure and ultra pure water for every customer request. Smallest systems for lab analytics up to pharmaceutical and process water plants for 20 cubicmeter/hour.

Greiner Bio-One GmbH 2

Wyatt Technology, leading supplier of advanced instruments for macromolecular characterization, presents new developments: Möbius for zeta potential, Eclipse DUALTEC for AF4 and HF5 and the SOLARIS UV sterilizer. www.werner-gmbh.com www.wyatt.eu

Stand: B67, Hall 4.1

3

Greiner Bio-One is specialised in the development and production of plastic laboratory products such as microplates for high-throughput screening, labware for cell and tissue culture or innovative biochips. www.gbo.com/bioscience

Eppendorf AG

Stand: G7, Hall 4.2

DECHEMA

Eppendorf is a life science company that develops, produces, and distributes systems for use in laboratories worldwide. The company has subsidiaries in 23 countries and is represented in all other markets by distributors. www.eppendorf.com

CMF Congress Center Messe Frankfurt

ance haus

6.1 5

Okawara MFG CO. Ltd.

5.1 2

Stand: C74, Hall 6.1

1

5.0

4

Forum

Entrance LEA

6.0

4

Manufacturer for Thin-film Evaporator, Hybrid Drying System available for any types of hot air dryers, and Filter Vacuum Dryer. www.okawara-mfg.com

Festhalle

Automatik Plastics Machinery GmbH

1

1

Stand: C33, Hall 5.0

 Entrance CITY

4.C

Walk 2 Instrumentation, Control and Automation Techniques

Entrance Hall 3

Walk 3 Laboratory and Analytical Techniques Walk 4 Pharmaceutical, Packaging and Storage Techniques

1

Our Pharmaceutical Pelletizer SPHERO®THA is a world novelty that completes the hot melt extrusion process with a pelletizing system that supplies uniform pellets with perfect free-flow behavior. www.maag.com

Belimed Deutschland GmbH Stand: B40, Hall 6.1

2

Equipment and complete systems for cleaning, disinfection and sterilization in the medical area, in pharmaceutical industry und laboratories. www.belimed.com ACHEMA 2012

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5

9

14.05.2012 17:21:52 Uhr


Pierre Guérin SAS Stand: J43, Hall 4.0

Institut für Mikrotechnik Mainz GmbH 1

BMBF BMELV "View on Biobased Economy"

Stand: B54, Hall 4.1

2

Pierre GUERIN – Biolafitte designs and builds world class GMP biomanufacturing equipment that brings highest quality, process security and performance gains.

IMM is your R&D partner for analytics. We are developing chemical and (bio) chemical-analytical systems based on customer specific requirements. This includes online process monitoring and control. www.pierreguerin.de www.imm-mainz.de

Stand: A1, Galleria Level 1

"View on Biobased Economy"

Stand: A1, Galleria Level 1

4

In a special exhibition, the BioIndustry 2021 clusters feature examples of products and processes from the biobased economy of the future. www.bioindustry2021.eu

Entrance Galleria

1

Technology leader in the development and manufacture of gear pumps and complete system solutions to convey high-viscosity products e.g. polymers and chemicals, meeting the requirements of industrial users. www.maag.com

3

The two German Federal Ministries, together with the Agency for Renewable Resources and Project Management Jülich, provide information on biobased economy strategies and present examples of currently funded projects. www.bmbf.de www.bmelv.de

Maag Pump Systems AG Stand: C38, Hall 8.0

BioIndustrie 2021 Clusters

11 7

9.2

8

9

6

9.1

10

12 5

Entrance Torhaus

Gal.1 9.T

4

3

Gal.0

9.0

1

11.1 11.Via

8.0

11.0 4.2 10

2

4.1

4.0

Entrance Portalhaus

1

3.1

Dependance Cargo Centre

10

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14.05.2012 17:22:21 Uhr

Xyl Solu ford

Stan

Over tems f idatio ble w munic cation


d Economy"

Bilfinger Berger Ind. Service

Xylem Water Solutions Herford GmbH Stand: C25, Hall 9.1

5

dustry Over 250,000 installed WEDECO sysprod- tems for UV disinfection and ozone oxbased idation ensure a healthy and sustainable water quality in numerous private, municipal and industrial areas of application worldwide. 021.eu www.wedeco.com

VBU

Stand: E52, Hall 9.1

6

The biogas upgrading unit for the production of biomethane is a forward-looking solution for storing biogas that is not immediately needed for electricity production. Variably scalable, operation in partial load ranges, costs below € 0.01/kWh. www.BIS.bilfinger.com

c-LEcta

Stand: C62, Hall 9.2

7

VBU is an association of companies and institutions active in the fields of biotechnology, pharmaceutical research and diagnostics. VBU is the active interface between companies and scientific research institutions. www.v-b-u.org

Stand: C62, Hall 9.2

8

c-LEcta develops efficient industrial bioprocesses. Screening biodiversity and protein engineering deliver optimized enzymes and strains for biocatalysis and metabolic engineering to make valuable chemicals. www.c-LEcta.com

ORGANOBALANCE GmbH Stand: C62, Hall 9.2

DECHEMA

ORGANOBALANCE develops microbial production strains – based on Saccharomyces yeast – for bulk and fine chemicals. The company works in co-developments with partners and grants licenses for own products. www.organobalance.com

CMF Congress Center Messe Frankfurt

ance haus

6.1

Süd-Chemie AG

5.1

Stand: D38, Hall 9.2

Entrance LEA

5.0

6.0

Forum

Festhalle

Süd-Chemie is a specialty chemicals company with a focus on industrial biotechnology. The company develops energy-efficient processes for the manufacture of biomass-based chemicals and fuels. www.sud-chemie.com

Stand: E38, Hall 9.2

 Entrance CITY

4.C

Walk 5 Pumps, Compressors, Valves and Fittings

Walk 6 Research and Innovation

11

Beta Renewables licenses PROESA 2ndgeneration biomass technology. Enables cost-competitive cellulosic ethanol and biochemicals using non-food biomass. Building world’s first commercial-scale cellulosic ethanol plant, in production 2012. www.betarenewables.com

Process Systems Enterprise Stand: C9, Hall 9.2

12

Extract more knowledge from lab/plant data, design information rich experiments, facilitate design, scale-up and operation of crystallisation and solids process with PSE’s gSOLIDS and gCRYSTAL. www.psenterprise.com/gcrystal.html ACHEMA 2012

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Beta Renewables

1

Entrance Hall 3

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BIOECONOMY

Where do we stand? What is the truth about the “bio-based economy”? How close are developments for the renewable energy, food, animal feed, fine & bulk chemical, textile, printing, machinery manufacturing and IT industries to market introduction? From 18 June to 22, BioBasedWorld at ACHEMA 2012 will attract technology, process and product developers along with Business Development and Senior Executives from around the world. Biotechnology and renewables can already deliver solutions to meet the challenges of tomorrow.

Most people will have seen the Schizophyllum commune (commonly known as the split gill fungus) at some point. Colonies form on dead trees and wounded bark. It has been known since the early 1990’s that the fungus protects itself against decay by coating its surface with hydrophobins. These proteins, which are about 100 to 150 amino acids long, are hydrophobic and readily soluble in fat. Closer scientific scrutiny has shown that hydrophobins have the opposite property as well: As is the case with soap, hydrophobins are amphiphilic. This multi-functionality can be exploited to create customer valueadd for many products. However, that has not been easy. 1 mg of the hydrophobins is distributed over an area covering one square meter on the surface of the fungus. “Far too little ever to be of any use to humans,” explained Claus Bollschweiler, a developer at BASF Performance Chemicals and Biologicals. “Biotechnology and genetic engineering provide the only path for producing such a naturally rare but highly efficient protein on a large scale so that it can be used to develop innovative products.” Genetic engineering techniques and fermentation have only recently made it feasible to produce hydrophobins by the ton. Functional coatings on construction materials are the initial applications including water-repellent insulating foam and silicon sealant which can be painted over. The silicon will only absorb paint once the surface has been treated with the fungus protein.

by linking them to keratin-binding natural or synthetic polypeptides. These hydrophobins might also help achieve functional improvements in pharmaceuticals, textiles and aquaculture feed. Hydrophobins are expected to play a significant role in the chemical production of thermoplastic particles where static charge on polystyrene foam continues to cause problems.

The customer counts The current approach is to prevent the problem by coating the particles, but the particles tend to stick together when conventional techniques are used, which impairs pourability. There is virtually no limit to the possible applications for these and other natural substances (e.g. succinic acid and microbial fuel cells) produced with the aid of biotechnology. The same applies to many other precursors and intermediates which the biotech industry is currently introducing. However, in the final analysis, the applications are customer driv-

en. Developers that produce biotech products on an industrial scale must establish contact with the companies (in many cases SMEs) which are able to use them for their special applications. Even the secretions of the split gill have to find partners that have an indepth understanding of their products, niche markets and end users but are not sufficiently aware of the business opportunities which new developments in biotechnology can offer away from the media paths. Forced to deal with commodity market volatility, nonpayment risks, financial crises, new trade barriers in agricultural and food markets and regulatory conflicts relating to genetically modified plants, companies are noticeably reluctant to abandon so far reliable sources of raw materials, replace equipment that works reliably, modify production processes to handle new materials or build new systems from scratch based on new technologies. Investment – yes, technology revolution – no; me-too products – no, something new – yes, say the decisionmakers. As a result, the preference is for components, modules, process solutions and systems which are able to accommodate different raw materials to produce the same end product and which are suitable for small test series. The expectations of what biotechnology should deliver are high: – Zero waste, utilization of byproducts – Ability to process heterogeneous raw materials and input chemicals to produce the same end products – Changeover during production of multiple products without interruption – Utilization of existing infrastructure Up to this point, there have been few biotech solutions outside of the pharmaceutical indus-

From cosmetics to textiles

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Photo: Fotolia

The application spectrum for new product development is as broad as it is open. The fungus proteins could potentially be used in cosmetics for skin rehydration or in fur coloring products for pedigree dogs and cats. This would be done

Straw – a renewable resource for the bioeconomy

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try, which have been affordable and have met expectations on a large scale. That is due to the nature of the technology: The products are generally precursors and intermediates made of biological material which is subject to variation. They are seldom of the “off-the-shelf” variety, and it takes additional expertise to produce a saleable (end) product. In addition, biotech process systems are also not plug & play at this stage. Customer-specific modifications are always necessary, and customers must have the confidence that after-sales service will provide dependable support and will not increase prices after the fact.

By-product management Rapid advances are also being made in the development of separators which facilitate the lucrative (and climate friendly) utilization of byproducts. In the autumn, a large algae production plant went into operation in China. Scrubbed flue gas from a coal-fired power station is fed to the algae. The algae plant is capable of capturing up to 2,500 kg of CO2 per day in the form of biomass. The algae absorb the carbon dioxide and metabolize it into substances such as fat and carbohydrates. Special separators harvest the algae and concentrate the biomass. The process generates additional value-add from gas emissions through the sale of valuable protein to the animal feed industry. In this instance and in many others, the combination of mechanical engineering, electronics, IT and biotechnology makes it possible to optimize existing production processes and generate profitable by-products.

Renewable resources The plant engineering industry is also exploiting new opportunities. So far, output cost optimization and modernization of old production assets play a bigger role than the construction of new biorefineries. Bioethanol and vegetable oil added to fossil fuel are only the beginning in the petrochemical industry. They are mostly still made from agricultural crops. There is a public consensus however that competition with food production must be avoided. Next-generation biofuels will be made from wood, straw, food residue and plant or animal industrial waste rather than food products. A number of pilot plants are already in operation. The chemical industry is also getting ready to produce platform chemicals such as glycerin or starch from agricultural feedstock. To do that, it will need components, equipment and process systems that offer pro-

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duction flexibility and are designed to adapt to varying types of feedstock without putting overall operations at risk. Reducing the logistics costs (which can be considerable) is another deliverable for plant engineering. Oil and biomass will be used to fire power stations in either parallel or alternating mode. Supplemental combustion or gasification of vegetable oil or ethanol at the site of an existing oil refinery or power station is an approach which is still in its infancy. The Brazilian petrochemical producer Braskem is showing the way. Parallel production of up to 200,000 MT of ethylene and polyethylene resin from cane sugar ethanol started up in the autumn of 2010. The produc-tion line was built right next to an existing petrochemical plant, and it uses the plant’s polymerization infrastructure.

European Biotechnology Net work

Cost disadvantage Organic hydrocarbons are still cheaper on the world market than bio-based materials. However, the price differential compared to renewables is narrowing. What we are looking at for the foreseeable future is not the replacement of oil but instead the alternating use of heterogeneous resources. Alfred Oberholz, former head of R&D at Evonik Degussa, once said: “Biomass-based raw materials will continue to compete with petrochemical feedstock. At the end of the day, C atoms will have the same market value regardless of whether they are derived from biomass or petrochemical feedstock.”

Cross-sectional industry The deck is being reshuffled, cutting across existing supply chains and national and industry boundaries. In a world of globalised economic relationships, we will be seeing the inexorable advance of biotech methodologies and process techniques which are costefficient and create products that offer greater value-add. Of course the market does not simply soak up innovation. Technology suppliers should not assume that what they have to offer is self-explanatory. They have to work to acquire and retain customers. Potential customers on the other hand who expect the sales force to show up at the door with innovation in hand have already lost the battle. Both sides, technology suppliers and customers, need a dedicated platform where they can get together and hold face-to-face discussions. BioBased-World at ACHEMA 2012 is one of the few forums worldwide which provides access to such a large cross-section of the industry. B

Join the European Biotechnology Network! The European Biotechnology Network is dedicated to facilitating co-operation between professionals in biotechnology and the life sciences all over Europe. The network is run by the European Biotechnology Foundation, a non-profit organisation based in Brussels. Do you want to know more about the advantages of a (free) membership? Just have a look at our website: www.european-biotechnology.net

European Biotechnology Foundation Rue d‘Egmont 15 B-1000 Bruxelles, Belgique Tel: +32 2 50 08 531 Fax +32 2 64 92 989 info@european-biotechnology.org www.european-biotechnology.net

14.05.2012 17:23:18 Uhr


IntErvIEw

wubboLtS:

Biotech is the enabler for the bio-economy Bioeconomy development is currently boosted by numerous national funding initiatives across Europe and in the US. Briefly before the start of ACHEMA, the world leading congress-fair for bioprocessing, bioengineering and biotechnology, DSM's CTO Marcel Wubbolts provided insight into the latest developments that are pushing this dynamic field forwards. Photo: DSM

ing to more consumption and a bigger claim on the world’s resources. With fossil resources becoming scarce and having an adverse effect on climate, there is a need to find renewable solutions that will enable the world to move beyond the fossil age and return to Living off the Land again. Biotechnology is the enabler in the transformation to such a bio-based economy.

ACHEMA|Life Sciences|Guide

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Which fields in the chemical industry will be impacted most by biotechnology? wubboLtS:

Marcel Wubbolts is currently Chief Technology Officer at DSM, based in Urmond (NL). Following a career in academia with over 80 publications and patents, he joined DSM (Geleen, NL) as a senior scientist and became Manager R&D and Managing Director of DSM Biotech GmbH in Jülich (Germany). After positions as Competence Manager Biocatalysis & Biotransformations with DSM Pharmaceutical Products in Geleen and as Program Director at the DSM Innovation Center in Delft he was appointed VP Research & Technology in 2011 and has held his current position since last October.

ACHEMA|Life Sciences|Guide

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Dr Wubbolts, bioeconomy is high on the agenda of this year’s ACHEMA in Frankfurt. What are the current drivers in bioprocessing, chemical engineering and biotechnology? wubboLtS:

!

The global population is expected to grow from 7 billion now to 9 billion by 2050. In addition it is ageing, urbanising and becoming wealthier, lead14

!

Many fields in the sector have already been transformed by biotechnology, such as food, materials and building blocks. For example, for DSM, biotechnology is the key technology in the production of advanced biofuels or cellulosic bioethanol. Biotechnology is also the basics for the production of biochemical building blocks. DSM and Roquette are currently building a commercial scale bio-based succinic acid plant in Italy. DSM is also producing bio-based materials clean/green materials, which means they are made from sustainable, renewable raw material, for coatings, automotive and electronics. And we use biotechnology in our processes to make ingredients for food and medicine. With biotechnology currently accounting for approximately 20% of DSM’s turnover, our company is at the forefront of innovation in creating a bio-based economy that will increasingly take over from our current fossil based society.

ACHEMA|Life Sciences|Guide

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Are there specific technological advances coming from biotechnology that will drive industrial transformation in the future?

!

Yes, the industrial transformation will be driven by different advances coming from biotechnology; synthetic biology, microreactors the size of a shoe box or smaller, advanced scaling up of processes, advanced technologies that are able to convert any bio source into product and advanced manufacturing using nature’s toolbox.

ACHEMA|Life Sciences|Guide

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DSM has moved several sector headquarters to Asia. How are European biotech and engineering firms positioned in the competition with Asian companies? wubboLtS:

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DSM is a global company with operations and R&D across the globe. We hire the best research, development and business people and resources available in the global market to fill our innovation pipeline and turn our R&D into business. DSM uses open innovation and partnership models to speed up innovative solutions.

ACHEMA|Life Sciences|Guide

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The US government has adopted a blueprint on bioeconomy at the end of April. How do you appraise those plans compared to the efforts of European countries? wubboLtS:

!

Strong, longer term incentives are necessary for countries to go forward. This drives innovation, creates jobs and prosperity. In January 2012, the European Commission took further steps to improve its long term strategy towards a bio-based economy. These are good steps, but more needs to be done to move Europe from R&D and pilot scale production to a full scale production capacity.

ACHEMA|Life Sciences|Guide

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What kind of political support for bioeconomy would you demand from the EU? wubboLtS:

!

The bio-economy is the way forward to prosperity for all regions in the EU, creating new and retaining millions of existing jobs, breathing new life into the whole economy. To get there, the European Union needs to strongly endorse the development of the bio economy with focus on up scaling and bringing pilot scale to large commercial scale production. To do that it needs to provide significant, long term incentives and as such, create a framework for the bio-economy to develop in a sustainable way. B

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|transkript Spezial 06/2012 - Achema 2012  

Wie sehr die Biotechnologie die Chemieindustrie mittlerweile für sich eingenommen hat, zeigen die vielen Schwerpunktveranstaltungen der Bio...

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