EB_Winter_2024 Leseprobe

Interview

ISSN 2364-2351 | A 60711 |

Life Sciences and Industry Magazine Winter Edition 2024 | Volume 23 | 20 €

Thomas Lingelbach, CEO of French Valneva SE, on the vaccine maker’s latest approval and his strategy.

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The proteins strike back

Antibodies & more

BIO-Europe

Climate Financing

BioFairs Compass

The latest news and deals from Europe’s biggest partnering event

COP diplomats fail once again to cut the Gordian Knot of CO2

Attractive Life Sciences events in the first half of next year

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INTRO

European Biotechnology | Winter Edition | Vol. 23 | 2024

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The golden age of engineered therapeutic antibodies Therapeutic antibodies today represent a cornerstone of the treatment of various diseases including cancer, infectious, autoimmune, cardiovascular, haematological, metabolic, neurologic and ocular diseases, and make up a major proportion of blockbuster drugs with global sales of more than US$230bn in 2023.

Since the first approval of monoclonal antibodies more than 25 years ago, the field has seen the emergence of engineered antibodies, e.g.

Fc-engineered antibodies, antibody drug conjugates (ADCs) and bispecific antibodies (bsAbs). Notably, as of today, 13 ADCs and 17 bsAbs have been approved by health authorities and already account for more than US$10bn and US$8bn in global sales, respectively.

DR CHRISTIAN KLEIN, CXO in residence and drug hunter at the earlystage VC specialist Curie.Bio, has 22 years of industry experience in the field of therapeutic antibodies, co-authored 220 publications and is co-inventor of 240 patent families.

The biochemist joined Roche pRED in 2002 and co-led teams pioneering the development of CrossMabs, 2+1 TCBs, 4-1BB/CD28 costimulators and PD1-cis immunocytokines.

He contributed to 32 clinical NMEs for Roche of which four are approved and to numerous collaborations with biotech companies.

It is important to note that bsAbs are increasingly being applied for the treatment of diseases beyond oncology. Based on the recent therapeutic progress, ADCs and bsAbs represent the fastest growing class of therapeutic antibodies in (pre-)clinical development and have been a major driver of deal-making in the biopharmaceutical industry in the past years. Interestingly, the first bispecific antibodies approved, catumxomab and blinatumomab, were originally developed by academic start-ups in Munich, Germany.

ADCs and bsAbs continue to be an attractive area of research for innovative biotech companies due to the availability of technologies allowing a comparably rapid identification and optimisation of development candidates, the progress made with the manufacturing of complex molecules, and the generally favourable clinical development success rates for therapeutic antibodies.

Picture: © Curie.Bio

BsAbs are particularly attractive from a conceptual point of view, as they allow the mediation of completely novel mechanisms of action for the therapy of various diseases that cannot be achieved with conventional monospecific antibodies. This includes, for example, the recruitment and engagement of immune cell subsets for tumour cell killing, e.g., with T-cell engagers, mimicking of blood coagulation factors, dual-targeted bispecific ADCs with selectivity for defined cancer types, cis-targeting of T-cell subsets with dual checkpoint inhibitors or cytokines, degradation of cell surface proteins, transport of antibodies across the blood-brain-barrier, triggering of cytokine receptors with cytokine mimetics or activation mechanisms that can switch bsAbs on/off in the tumour microenvironment to prevent undesired peripheral toxicities, and many more.

It is amazing to see how researchers after 50 years of antibody engineering continue to come up with novel and ingenious solutions to tackle therapeutic challenges and to observe how novel methods like single-cell sequencing, proteomics, cryo-EM, machine learning and artificial intelligence help to further accelerate therapeutic innovation. Given all this progress and the diversity of ideas pursued in biotech companies and biopharmaceutical industry, I firmly believe that the golden age of engineered antibodies and their use for synthetic L biology is only about to start. Their potential is beyond our imagination.

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CONTENTS

European Biotechnology | Winter Edition | Vol. 23 | 2024

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COVER STORY

INSIGHT EUROPE

REGIONAL NEWS

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Country alliance calls for launch of a European protein strategy

58 Northern Europe: Sweden, Denmark, Norway and Finland

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Climate and biodiversity paralysis in Baku and Cali

11 Commission seeks industry input over Novo/Calalent acquisition

ECONOMY 20 Interview: Thomas Lingelbach, CEO, Valneva SE 22 Analyst commentary 23 European Biotech Stocks

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A Golden Age for protein engineering Monoclonal antibodies laid the foundation for precision medicine, and still dominate the US$417bn biologics market. However, after decades of development, new treatments are now hitting the market. Among them: improved versions of artificial bispecific antibodies, antibody-drug conjugates and other engineered proteins used in immunoreceptor-based therapies such as CAR-T and TCR-T cell therapies. We took a deep dive into what bioengineers were talking about at the most recent iteration of the PEGS Europe summit.

60 Western Europe: France, Belgium, The Netherlands, Luxembourg and the UK 62 Central Europe: Germany, Switzerland and Austria 64 Southern Europe: Italy, Spain and Slovenia 66 Eastern Europe: Poland and Hungary

SCIENCE & TECHNOLOGY

26 Novartis writes down MorphoSys deal

67 Researchers discover fat memory

27 Radiopharma acquisitions

68 Biotechnological climate rescue

28 30 years of BIO-Europe

70 New data on NK cell engager

32 Update on clinical trials

71 Turning macrophages from bad to good; Testing gene function

35 Unified Patent Court: quo vadis?

72 Nobel Prize award ceremony 37 In focus: Protein engineering 38 Interview: Nina Kreymborg, SVP/CSO Partner Team, Curie.bio 39 Getting to the next stage in ADC development 41 Precision oncology 42 Pharma industry at CPHI 48 Italy’s genius move to captial

74 One in a billion: Basel Institute of Immune Engineering

PICK & MIX 56 Biopeople 75 News from associations 79 New products 80 Company index 81 Events 82 Encore

IMPRINT European Biotechnology (ISSN 2364-2351) is published quarterly by: BIOCOM Interrelations GmbH, Jacobsenweg 61, D-13509 Berlin, Germany, Tel.: +49-30-264921-0, Fax: +49-30-264921-11, Email: service@european-biotechnology.com, Internet: www.european-biotechnology.com; Publisher: Andreas Mietzsch; Editorial Team: Thomas Gabrielczyk (Editor in Chief), Derrick Williams (Co-editor), Dr. Georg Kääb, Uta Mommert, Maren Kühr, Dr. Christian Kähler; Anette Mertens; Advertising: Oliver Schnell, +49-30-264921-45, Christian Böhm, +49-30-264921-49, Andreas Macht, +49-30-26492154; Distribution: Nancy Weinert +49-30-264921-40; Graphic Design: Michaela Reblin; Production: Martina Willnow; Printed at: Königsdruck, Berlin; European Biotechnology Life Sciences & Industry Magazine is only regularly available through subscription with a BIOCOM CARD. Annual subscription BIOCOM CARD Europe: €80 for private individuals (students €40) incl. VAT, €120 plus VAT for corporates. Prices includes postage & packaging. Ordered subscriptions can be cancelled within two weeks directly at BIOCOM AG. The subscription is initially valid for one calendar year and is automatically renewed every year after. The subscription can be cancelled at any time and is valid until the end of that calendar month. Failures of delivery, which BIOCOM AG is not responsible for, do not entitle the subscriber to delivery or reimbursement of pre-paid fees. Seat of court is Berlin, Germany. As regards contents: individually named articles are published within the sole responsibility of their respective authors. All material published is protected by copyright. No article or part thereof may be reproduced in any way or processed, copied, and proliferated by electronic means without the prior written consent of the publisher. Cover Photo: © Mirror-images stock.adobe.com; ® BIOCOM is a registered trademark of BIOCOM AG, Berlin, Germany.

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CONTENTS

European Biotechnology | Winter Edition | Vol. 23 | 2024

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CLIMATE CHANGE

BIO-EUROPE

EDITORIAL

No will to zero

Stress test for Council Germany, Denmark and 19 supporting states have called on the EU Commission to adopt a protein strategy that prominently includes cultured protein for food and feed, but Hungary is likely to contest the idea. It holds the EU Council presidency and leads a blocking minority calling for rules on banning and approving laboratory foods similar to those in place for medicines.

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Spotlight Scandinavia

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In the latest BIO-Europe in Stockholm, representatives from Sweden, Denmark, Norway and Lithuania grabbed the chance to step out of the shadows. The positive messaging came through loud and clear, along with a load of impressive data about the power of the region’s innovation motor.

Pictures: Freepik - Consilium (left above); Informa /EBD Group (middle); BIOCOM AG (right)

SPECIAL

The fight against climate change and species extinction is a popular topic among politicians. It is becoming increasingly difficult to deny the consequences of global inaction, and looking the other way no longer helps. A lot of money was promised in Montreal back in 2022. At the UN COP15 Biodiversity Conference, negotiators agreed to set up a provisional fund to help heal environmental damage by protecting 30% of land and marine areas and pushing back invasive species. To date, only 2% of the promised cash has been raised. At the follow-up conference in Cali (COP16), further negotiations on the US$200bn biodiversity fund by 2030 agreed in Montreal failed.

At the same time, climate diplomats at COP29 in Baku argued about the financing of climate protection funds (p.

8). Estimates say around US$2,400bn is needed per year to limit global warming to 2°C by 2100. The countries of the Global South, which are responsible for just 5% of greenhouse gas emissions (CHG), called for US$1,300bn. But wealthy nations only countered with an offer of US$300bn. Since the Paris Agreement, CHG emissions have risen by 9% instead of falling by 67.5% as agreed.

Collective action – like that sometimes seen during the pandemic – is critical.

Now that the potential of biotechnology in medicine has grown clear, the biologisation of industry is next. It’s the only way for us all to win in the end.

Biofairs Compass 44 BIO-Europe Spring 2025, Milan, Italy 46 GMP Pharma Conference, Wiesbaden, Germany

Thomas Gabrielczyk Editor-in-Chief

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PROTEIN ENGINEERING

European Biotechnology | Winter Edition | Vol. 23 | 2024

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Pictures: © xxx

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PROTEIN ENGINEERING

European Biotechnology | Winter Edition | Vol. 23 | 2024

New proteins on the block Monoclonal antibodies still dominate the US$417bn biologics market.

After decades of development, however, improved antibodies and protein formats with better target selectivity and safety profiles are now hitting markets and pipelines. A range of bi­specific antibodies and antibody-drug conjugates – along with CAR-Ts, TCR-RTs and NK cell-based immunoreceptor constructs – were in focus at the PEGS Europe Summit.

PEGS EUROPE 2024

Pictures: © AddMeshCube - stock.adobe.com; Mabswitch

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ince the first antibody drug (muromonab-CD3) was approved back in 1986, monoclonal antibodies (mAbs) have emerged as the dominant class in the global US$417bn market for biologics. At the end of 2023, sales stood at more than US$230bn. However, as tumours – in addition to auto­ immune diseases still one the most important application fields of mAbs – are moving targets, newly engineered antibody and engineered protein formats that unite complementary cell-killing mechanisms in a single molecule have been developed, approved and are increasingly leaving clinical pipelines for the market.

They include refined bispecific antibodies, antibody drug conjugates (ADCs) and targeted radio­pharmaceuticals, as well as immune-receptor-based cell therapies such as CAR-T and TCR-T cell therapies.

Every year at the PEGS Europe Summit, the CSOs of bio/pharma companies provide a detailed overview of newly developed therapeutic modalities, and thus an outlook for the future. This year in Barcelona, the 16th summit helped clarify why the approval of bispecific antibody formats has increased dramatically (13 out of 18 approvals in the past three years) and why improved ADCs, CAR-Ts, TCR-Ts and new modalities are entering the market.

The freshly engineered formats promise to reduce current problems of bispecif-

ic antibody and T-cell therapies such as cyto­kine release syndrome (CRS), neurotoxicity, and on-target/off-tumour toxicity.

In addition, targeting two targets simultaneously increases selectivity, and allows

YEMI ONAKUNLE Founding Director and CEO, Mabswitch Inc., Los Angeles, USA

?

How can toxicities and T-cell exhaustion that occur in all T-cell-based therapies be avoided?

!

Mabswitch’s remote-controlled anti­bodies offer a novel approach to enhance the efficacy of antibodyredirected therapies – such as CAR-T cells, T-cell engagers, and ADCs – for treating devastating diseases like cancer, autoimmune disorders and chronic infectious diseases, all while minimising side effects.

drug developers to combine complementary cancer-killing mechanisms that could reduce resistance to cancer therapies and improve efficacy.

“Based on recent therapeutic progress, ADCs and bispecific antibodies (bsAbs) represent the fastest-growing class of thera­ peutic antibodies in development and have been a major driver of deal­making in the biopharmaceutical industry in the past years,” emphasised Dr Christian Klein at the PEGS summit, which took place from 5-7 November. The patent champion (240!) in protein engineering, who moved to early-stage investor Curie.Bio in the summer after 22 years at Roche pRED (see p. 3, p. 38) started with a brief summary of the 14 bispecifics (and 17 – still mono­ specific – ADCs on the market) approved until December 2023. But he quickly turned to what’s new, interesting and probably a business case. And there is a lot of ground to cover, as around 50% of bispecific antibodies are already in late phase testing (Phase II or III, see Fig. 1, p. 14).

New age for bispecifics According to Klein, T-cell engagers (TCEs), together with cancer immunotherapies, now account for almost 80% of the bispecific antibodies clinically developed to fight cancer. They are also increasingly used in indications beyond haematological

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RUBRIK

European Biotechnology | Winter Edition | Vol. 23 | 2024

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Things got busy around the cubicles for partnering at BIO-Europe 24.

Pictures: © xxx

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ECONOMY

European Biotechnology | Winter Edition | Vol. 23 | 2024

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Scandinavia’s gangbuster biotech It was the 30 th anniversary for the largest pharmaceutical sector partnering event on the European continent, and this year’s programme saw a colourful mix of veterans, first-timers and absolute newcomers. The Nordic countries and host Sweden in particular made quite a splash.

BIO-EUROPE

Picture: © EBD Group, Ludwig Schedl

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hat began three decades ago as the mother of all partnering events has turned both participants and organisers into professionals and veterans. BIO-Europe is all about the repetition of participation and routine reunions for relationships that may have been established years ago. It’s about the friendly handshake hinting that unfortunately you have to leave immediately for the next meeting, or really lingering over small talk. Maybe followed by a lunch appointment at a less draughty location in the exhibition hall in Stockholm or elsewhere in the city, because there are so many interesting topics to discuss. Those and many other ways of approaching people in the industry are all part of the job.

MC Services – a communications agency and long-time partner in crime with the organisers – collected examples of necessary, cultivated small talk into a little booklet called “The Stockholm Pocket Phrase Book”, with the standard introductory chit-chat in Swedish. It also revealed that about five questions are sufficient to sail through the event without peril. The first should be:

What’s new in your drug pipeline?

Veteran observer Mike Ward, a true trendsetter who was himself celebrating 40 years in the communications indus-

try, echoed the ‘Groundhog Day’ feeling that the event at times inspires: a kind of ‘been there, done that, got the t-shirt’ attitude. Like Donald Trump’s re-election after four years out of office, which dominated discussions on the second day of the fair, but also the industry’s ritualised annual meeting to find partners in general. Repetition is a constant companion at BioEurope, and no one is particularly bothered by it, regardless of where the event’s entourage sets up camp. This time it took place in Stockholm, outside the German-speaking core of Europe. The choice was a nod to Nordic dynamism, which has given the world league of large pharmaceutical players a new North Star with Copenhagen-based pharma heavyweight Novo Nordisk.

Sweden and Denmark can also be mentioned in one breath and considered together, as industry savants in Copenhagen refer to the Øresund region as Medicon Valley, which includes nearby Lund (Sweden) across a watery border.

While the Danes make waves around the world and have a giant pharmaceutical tanker at anchor with Novo, Sweden likes to present more as a hotbed of innovation benefiting both neighbouring countries and Europe as a whole. Both regularly top the innovation and patent league tables in the life sciences, especially in relation to their populations. But even without that kind of caveat, Sweden

is second only to Switzerland in global innovation rankings. In early October and then again at their presentation in December, the country radiates scientific excellence with the Nobel Prizes, still viewed as the top global award for the international research elite.

Considered a partnership?

At this year’s showcase event, Sweden didn’t just want to bask in the glow of other successes, it also wanted to highlight its own strengths. With around 4,000 life sciences companies in a country of around 10.5 million, there is plenty to brag about. By comparison, Austria – which has a similar population – is home to just over 1,000 life sciences companies (biotech, pharma and medtech).

In Sweden, medical technology is the largest sector within the life sciences in terms of number of companies, while lab technology and diagnostics are the smallest sectors. Swedish companies though are often active in several different industries. For example, there is a large overlap between laboratory equipment and diagnostics and medical technology. The Swedish innovation agency Vinnova tried to illustrate these overlaps in a very unique 3D graphic.

In 2022, the Swedish life sciences sector employed around 52,400 people in ›› Read the full story in the printed issue.

3,838 companies.

These companies gen-

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COMPANY INDEX

European Biotechnology | Winter Edition | Vol. 23 | 2024

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10x Genomics (USA) . . . . . . . . . . . . . . . . 36 A a:head (AT) . . . . . . . . . . . . . . . . . . . . . . . . 63 Accord Healthcare AB (SE) . . . . . . . . . . . . 59 AC Immune SA (CH) . . . . . . . . . . . . . . . . . 23 Adaptimmune Ltd (GB) . . . . . . . . . . . . . . . 34 AgomAb Therapeutics N.V. (BE) . . . . . . . . 61 Akeso Biopharma Co. Ltd. (CN) . . . . . 14, 15 Algeta ASA (N) . . . . . . . . . . . . . . . . . . . . . 27 Alzinova AB (SE) . . . . . . . . . . . . . . . . . . . . 23 Amgen Inc. (USA) . . . . . . . . . . . . . . . . . . . 14 Ansell Alpha Tec (DE) . . . . . . . . . . . . . . . . 79 Araris Biotech AG (CH) . . . . . . . . . . . . . . . 18 Asabys Partners (ES) . . . . . . . . . . . . . . . . . 65 Ascendis Pharma A/S . . . . . . . . . . . . . . . . 58 Astellas Pharma (JP) . . . . . . . . . . . . . . . . . 61 AstraZeneca (GB/SE) . . . . . . . . 14, 27, 34, 56 ATB Therapeutics BV (BE) . . . . . . . . . . . . . 18 Atlas Venture (USA) . . . . . . . . . . . . . . . . . 27 Autolus Therapeutics Ltd. (GB) . . . . . . . . . 22 Avantium Life Sciences BV (NL) . . . . . . . . 61 AvioadoBio Ltd. (GB) . . . . . . . . . . . . . . . . 61 Axol Bioscience Ltd . . . . . . . . . . . . . . . . . 61 B Bayer AG (DE) . . . . . . . . . . . . . . . . . . 27, 29 Beckman Coulter Life Sciences (USA) . . . . 56 BerGenBio AS (N) . . . . . . . . . . . . . . . . . . . 58 Berlin Partner f. Wirtschaft und Tech (DE) . 55 BioArctic Neuroscience AB (SE) . . . . . 14, 54 BIOCOM (DE) . . . . . . . . . . . . 49, 57, 73, 79 Biogen Idec (USA) . . . . . . . . . . . . . . . . . . 54 Biomunex SA (F) . . . . . . . . . . . . . . . . . . . . 15 BioNTech SE (DE) . . . . . . . . . . . . . 15, 22, 82 Biotheus Inc. (CN) . . . . . . . . . . . . . . . . . . 15 Boehmert & Boehmert (DE) . . . . . . . . . . . 35 Boehringer Ingelheim (DE) . . . . . . . . . 22, 55 Bormioli Pharma (IT) . . . . . . . . . . . . . . . . 65 Brenus Pharma SA (F) . . . . . . . . . . . . . . . . 60 Bristol-Myers Squibb (USA) . . . . . 18, 27, 62 C Calluna Pharma SA (NO) . . . . . . . . . . . . . 56 Cancer Research UK . . . . . . . . . . . . . . . . . 60 Caszyme LLC (LT) . . . . . . . . . . . . . . . . . . . 65 Catalent (USA) . . . . . . . . . . . . . . . . . . . . . 11 CDP Venture Capital . . . . . . . . . . . . . . . . . 64 Celonic AG (CH) . . . . . . . . . . . . . . . . . . . 82 Centessa Pharmaceuticals Ltd (GB) . . . . . . 32 Chiesi Farmaceutici S.p.A. (IT) . . . . . . 29, 65 Chiron B.V. (NL) . . . . . . . . . . . . . . . . . . . . 20 CN Bio (GB) . . . . . . . . . . . . . . . . . . . . . . . 79 Concept Heidelberg / GMP PharmaCongress 2025 (DE) . . . . . . . 47 Constellation Pharmaceuticals (USA) . . . . 26 Crossfire Oncology BV . . . . . . . . . . . . . . . 16 Curie.Bio . . . . . . . . . . . . . . . . . . . . . . . . . 13 D Daiichi Sankyo (JP) . . . . . . . . . . . . . . . 34, 62 Danaher Group (USA) . . . . . . . . . . . . . . . 56 DASGIP GmbH an Eppendorf Company DE) . . . . . . . . . . . . . . . . . . . . . . 19 DeepTrack Capital ( . . . . . . . . . . . . . . . . . 27 DiogenX SA (F) . . . . . . . . . . . . . . . . . . . . . 56 E EBD Group (USA) . . . . . . . . . . . . . . . . . . . 45 Eisai Co. Ltd. (JP) . . . . . . . . . . . . . . . . . . . 54 Eli Lilly & Co Ltd (USA) . . . . . . . . . . . 27, 33

Elicit Plant (F) . . . . . . . . . . . . . . . . . . . . . . 82 Endocyte Inc. (USA) . . . . . . . . . . . . . . . . . 27 Eni srl (IT) . . . . . . . . . . . . . . . . . . . . . . . . . 65 Enifer Biotech (FI) . . . . . . . . . . . . . . . . . . . 59 Enilive (IT) . . . . . . . . . . . . . . . . . . . . . . . . 65 Epigenomics AG (DE) . . . . . . . . . . . . . . . . 23 European Biotechnology Network (BE) . .CP3 Evotec AG (DE) . . . . . . . . . . . . . . . . . . 55, 62 F FGK Clinical Research GmbH (DE) . . . . . . 39 Forbion Capital Partners (NL) . . . . . . . 27, 60 Fosun Pharma (CN). . . . . . . . . . . . . . . . . . 18 Fusion Pharmaceuticals (CDN) . . . . . . . . . 27 G Galapagos NV (BE) . . . . . . . . . . . . . . . . . . 34 Genespire srl (IT) . . . . . . . . . . . . . . . . . . . 64 Google Inc. (USA) . . . . . . . . . . . . . . . . . . 73 H Halix B.V. (NL) . . . . . . . . . . . . . . . . . . . . . 56 Halozyme Therapeutics Inc. (USA) . . . . . . 62 Hamlet BioPharma AB (SE) . . . . . . . . . . . . 59 Hangzhou Jiuyuan Gene Engineering (CN) 11 Harbinger Health Inc. (USA) . . . . . . . . . . . 60 I IBA Lifesciences GmbH (DE) . . . . . . . . . . . 7 Iksuda Therapeutics Ltd. . . . . . . . . . . . . . . 16 Immatics NV (DE) . . . . . . . . . . . . . . . . 32, 63 Indaco SGR . . . . . . . . . . . . . . . . . . . . . . . 64 Indivumed GmbH (DE) . . . . . . . . . . . . . . . 41 Informa Markets B.V. | CPHI (GB) . . . . . . . 42 Innate Pharma SAS (F) . . . . . . . . . . . . 15, 70 Integra Therapeutics (ES) . . . . . . . . . . . . . . 65 Invus S.A.S. (F) . . . . . . . . . . . . . . . . . . . . . 61 Ipsen S.A. (F) . . . . . . . . . . . . . . . . . . . . . . 29 J Janssen-Cilag International NV (BE) . . . . . 34 Jazz Pharmaceuticals plc (IRL) . . . . . . . . . 14 Johnson & Johnson (USA) . . . . . . . . . . 26, 29 Just Biologics (USA) . . . . . . . . . . . . . . . . . 62 K Kancera AB (SE) . . . . . . . . . . . . . . . . . . . . 58 KKR & Co. L.P. (USA) . . . . . . . . . . . . . . . . 65 L L'Oréal (F) . . . . . . . . . . . . . . . . . . . . . . . . 69 Labena d.o.o. (SL) . . . . . . . . . . . . . . . . . . . 64 LaNova Medicines (CN) . . . . . . . . . . . . . . 15 Lanzatech Inc. (USA) . . . . . . . . . . . . . . . . 69 Lek Pharmaceuticals dd (SL) . . . . . . . . . . . 64 LimmaTech Biologics AG (CH) . . . . . . . . . 34 Lindis Biotech GmbH (DE) . . . . . . . . . . . . 14 M Mabswitch Inc. (USA) . . . . . . . . . . . . . 13, 15 Madrigal Pharmaceuticals Inc. (USA) . . . . 33 Mariana Oncology (USA) . . . . . . . . . . . . . 27 Medicxi Ventures (CH/GB) . . . . . . . . . . . . 32 Merck Sharp & Dohme Ltd (USA) . . . . . . . 15 Merus BV (NL) . . . . . . . . . . . . . . . . . . . . . 24 Molecular Partners AG (CH) . . . . . . . . . . . 18 Monte Rosa Therapeutics (USA) . . . . . . . . 63 MoonLake Immunoltherapeutics AG (CH) 32 MorphoSys AG (DE) . . . . . . . . . . . . . . 26, 27 Mosaic Therapeutics (GB) . . . . . . . . . . . . . 56 MSD Sharp & Dohme GmbH (USA) . . . . . 58

Mylan Pharmaceuticals (NL) . . . . . . . . . . . 11 N Nabriva Therapeutics plc (IRL) . . . . . . . . . 24 Nanostring Technologies Inc (USA) . . . . . . 36 Novartis AG (CH) . . . . . . . 20, 26, 27, 29, 63 Novartis Pharmaceutical Production (SL) . 64 Novo Nordisk A/S (DK) . . . 11, 33, 51, 58, 62 NürnbergMesse GmbH | POWTECH 2025 (DE) . . . . . . . . . . . . . .CP2 Nxera Pharma Co. Ltd (JP) . . . . . . . . . . . . 32 O Onego Bio Ltd. (FI) . . . . . . . . . . . . . . . . . . 59 P Pfizer (USA) . . . . . . . . . . . . . . . . . . . . . . . 20 Pharmahungary Group . . . . . . . . . . . . . . . 66 PharmaMar SA (ES) . . . . . . . . . . . . . . . . . . 24 Pharmanovia (GB) . . . . . . . . . . . . . . . . . . 14 Phenocell SAS (F) . . . . . . . . . . . . . . . . . . . 61 PlasmidFactory GmbH & Co.KG (DE) . 53, 54 Point Biopharma Inc. (USA) . . . . . . . . . . . 27 PolTREG SA (PL) . . . . . . . . . . . . . . . . . . . . 66 PPF Group (NL) . . . . . . . . . . . . . . . . . . . . 32 Q Quantro Therapeutics (AT) . . . . . . . . . . . . 55 R RA Capital Management (USA) . . . . . . . . . 27 RayzeBio Inc. (USA) . . . . . . . . . . . . . . . . . 27 Regeneron Pharmaceuticals Inc. (USA) . . . 14 Rentschler Biopharma SE (DE) . . . . . . . . . 17 Resalis Therapeutics srl. (IT) . . . . . . . . 33, 64 Richter Biologics (DE) . . . . . . . . . . . . . . .CP4 Roche AG (CH) . . . . . . . . . . . . . . . . . . 14, 34 S Sandoz AG (CH) . . . . . . . . . . . . . . . . . . . . 64 Sanofi SA (F) . . . . . . . . . . . . . . . . . 33, 61, 64 Seamless Therapeutics (DE). . . . . . . . . . . . 54 Sino Biological Europe GmbH (DE) . . . . . . 9 SixPeaks Bio AG (CH) . . . . . . . . . . . . . . . . 14 Sofinnova Partners (F) . . . . . . . . . . . . . . . . 64 Somagenetix AG (CH) . . . . . . . . . . . . . . . . 63 Sophia Genetics SA (CH) . . . . . . . . . . . . . 25 Sosei Group (JP) . . . . . . . . . . . . . . . . . . . . 32 Sotio a.s. (CZ) . . . . . . . . . . . . . . . . . . . . . . 32 Stayble Therapeutics AB (SE) . . . . . . . . . . . 25 Summit Therapeutics plc (IRL). . . . . . . 14, 15 SystImmune Co. Ltd. (CN) . . . . . . . . . . . . 18 T Trion Pharma GmbH (DE). . . . . . . . . . . . . 14 U UAB BiotechPharma (LT) . . . . . . . . . . . . . 31 UCB Pharma SA (BE) . . . . . . . . . . . . . . . . 60 V Valneva SE (F) . . . . . . . . . . . . . . . . . . . 20, 34 Vetter Pharma InternationalGmbH (DE) . . 33 X Xbrane Biopharmaceuticals AB (SE) . . . . . 59 XGEN Venture (IT) . . . . . . . . . . . . . . . . . . 64 Z Zealand Pharmaceuticals A/S (DK) . . . . . . 22 Zymeworks Inc. (CDN) . . . . . . . . . . . . 14, 16

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