14th Guide to German Biotech Companies: Blick ins Buch

24th Guide to German Biotech Companies 2023

24 Guide to German Biotech Companies th

2023

In cooperation with: BIO Deutschland – German Biotech Industry Organisation ISBN 978-3-92838-85-1

European Biotechnology Network

Content

Editorial . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

3

The German Biotech Sector 2022 . .

7

Prefaces of Biotech Associations Oliver Schacht, PhD, BIO Deutschland – German Biotech Industry Organisation . . . . . . . .

European Biotechnology Network AISBL . . . . . . .

Profiles of German Biotech Companies . . . . . . . .

4HF Biotec GmbH . . . . . . . . . . . . . . . . . . . . . . . . . acromion GmbH . . . . . . . . . . . . . . . . . . . . . . . . . .

Aeterna Zentaris GmbH . . . . . . . . . . . . . . . . . . . . .

Affimed GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . .

AGC Biologics . . . . . . . . . . . . . . . . . . . . . . . . . . . .

AiCuris Anti-infective Cures AG . . . . . . . . . . . . . . .

AvenCell Europe GmbH. . . . . . . . . . . . . . . . . . . . .

Axolabs GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . .

BAG Health Care GmbH . . . . . . . . . . . . . . . . . . . .

Biaffin GmbH & Co KG . . . . . . . . . . . . . . . . . . . . .

BioCopy GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . .

BioEcho Life Sciences GmbH . . . . . . . . . . . . . . . .

BioGenes GmbH . . . . . . . . . . . . . . . . . . . . . . . . . .

Biotype GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Boehringer Ingelheim Biopharmaceuticals GmbH BRAIN Biotech AG. . . . . . . . . . . . . . . . . . . . . . . . .

Cardior Pharmaceuticals GmbH . . . . . . . . . . . . . .

CeGaT GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Cellex Cell Professionals . . . . . . . . . . . . . . . . . . . .

ClinAssess GmbH . . . . . . . . . . . . . . . . . . . . . . . . .

Coherent Shared Services B.V. . . . . . . . . . . . . . . .

Coriolis Pharma Research GmbH . . . . . . . . . . . . .

CureVac AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . eleva GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Eppendorf SE . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Eurofins BioPharma Product Testing Munich GmbH EVONIK . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Fassisi, Gesellschaft für Veterinärdiagnostik . . . . und Umweltanalysen mbH FGK Clinical Research GmbH . . . . . . . . . . . . . . . .

Formycon AG . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Fraunhofer ITEM . . . . . . . . . . . . . . . . . . . . . . . . . .

GALAB Laboratories GmbH . . . . . . . . . . . . . . . . .

Gilson International BV Deutschland . . . . . . . . . . .

18 21

22 24 26 28 30 32 34 36 38 40 42 44 46 48 50 52 54 56 58 60 62 64 66 68 70 72 74 76 78 80 82 84 86 88

glyXera GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90 GOENOMICS GmbH . . . . . . . . . . . . . . . . . . . . . . . 92 Heidelberg Pharma AG . . . . . . . . . . . . . . . . . . . . . 94 IBA Life sciences GmbH . . . . . . . . . . . . . . . . . . . . 96 ibidi GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98 IDT Biologika GmbH . . . . . . . . . . . . . . . . . . . . . . . 100 Immunic AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102 INCYTON GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . 104 Indivumed GmbH . . . . . . . . . . . . . . . . . . . . . . . . . 106 InfanDx AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108 INHECO GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . 110 invIOs GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 112 InVivo BioTech Services GmbH . . . . . . . . . . . . . . . 114 iOmx Therapeutics AG . . . . . . . . . . . . . . . . . . . . . 116 ITM Isotope Technologies Munich SE . . . . . . . . . . 118 KyooBe Tech GmbH . . . . . . . . . . . . . . . . . . . . . . . 120 LAMPseq Diagnostics GmbH . . . . . . . . . . . . . . . . 122 leon-nanodrugs GmbH . . . . . . . . . . . . . . . . . . . . . 124 Leukocare AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126 MetrioPharm Deutschland GmbH . . . . . . . . . . . . . 128 Mettler-Toledo GmbH . . . . . . . . . . . . . . . . . . . . . . 130 Microcoat Biotechnologie GmbH . . . . . . . . . . . . . 132 Microsynth Seqlab GmbH . . . . . . . . . . . . . . . . . . . 134 Molecular Health GmbH . . . . . . . . . . . . . . . . . . . . 136 Molzym GmbH & Co.KG . . . . . . . . . . . . . . . . . . . . 138 MorphoSys AG . . . . . . . . . . . . . . . . . . . . . . . . . . . 140 Navigo Proteins GmbH . . . . . . . . . . . . . . . . . . . . . 142 Neovii Biotech GmbH . . . . . . . . . . . . . . . . . . . . . . 144 New England Biolabs GmbH . . . . . . . . . . . . . . . . . 146 Nordmark Pharma GmbH . . . . . . . . . . . . . . . . . . . 148 Nova Biomedical GmbH . . . . . . . . . . . . . . . . . . . . 150 Novaliq GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . . 152 Optimapharm Deutschland GmbH . . . . . . . . . . . . 154 Pantherna Therapeutics GmbH . . . . . . . . . . . . . . . 156 PeproTech GmbH . . . . . . . . . . . . . . . . . . . . . . . . . 158 Pharmaplan GmbH . . . . . . . . . . . . . . . . . . . . . . . . 160 Phyton Biotech GmbH. . . . . . . . . . . . . . . . . . . . . . 162 PlasmidFactory GmbH & Co. KG . . . . . . . . . . . . . 164 PRAMOMOLECULAR GmbH . . . . . . . . . . . . . . . . 166 Premier Research . . . . . . . . . . . . . . . . . . . . . . . . . 168 ProBioGen AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170 Profil Institut für Stoffwechselforschung GmbH . . 172 PROGEN Biotechnik GmbH . . . . . . . . . . . . . . . . . 174 ProJect Pharmaceutics GmbH . . . . . . . . . . . . . . . 176 ProtaGene GmbH . . . . . . . . . . . . . . . . . . . . . . . . . 178 PSL Peptide Specialty Laboratories GmbH . . . . . 180 Rentschler Biopharma SE . . . . . . . . . . . . . . . . . . . 182 Resolve BioSciences GmbH . . . . . . . . . . . . . . . . . 184

Richter-Helm BioLogics GmbH & Co. KG . . . . . . . 186 RNATICS GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . 188 Roche Diagnostics GmbH . . . . . . . . . . . . . . . . . . . 190 Sanofi-Aventis Deutschland GmbH . . . . . . . . . . . . 192 Sartorius CellGenix GmbH . . . . . . . . . . . . . . . . . . 194 ScheBo® · Biotech AG . . . . . . . . . . . . . . . . . . . . . . 196 SciRhom GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . 198 Secarna Pharmaceuticals GmbH & Co. KG . . . . . 200 SERVA Electrophoresis GmbH . . . . . . . . . . . . . . . 202 SGS Analytics Germany GmbH . . . . . . . . . . . . . . . 204 Singleron Biotechnologies GmbH . . . . . . . . . . . . . 206 Sino Biological Europe GmbH . . . . . . . . . . . . . . . . 208 Sirius Fine Chemicals SiChem GmbH . . . . . . . . . . 210 SynapCon© GmbH. . . . . . . . . . . . . . . . . . . . . . . . . 212 Synovo GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 Tentamus Pharma & Med Deutschland GmbH . . . 216 TETEC AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 218 Thermo Fisher Scientific . . . . . . . . . . . . . . . . . . . . 220 Tosoh Bioscience GmbH . . . . . . . . . . . . . . . . . . . . 222 TRIGA-S Scientific Solutions . . . . . . . . . . . . . . . . . 224 Valicare GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . . 226 VERAXA Biotech GmbH . . . . . . . . . . . . . . . . . . . . 228 Vetter Pharma International GmbH . . . . . . . . . . . . 230 Viscofan BioEngineering . . . . . . . . . . . . . . . . . . . . 232 Vivoryon Therapeutics N.V. . . . . . . . . . . . . . . . . . . 234 YMC Europe GmbH . . . . . . . . . . . . . . . . . . . . . . . . 236 YUMAB GmbH . . . . . . . . . . . . . . . . . . . . . . . . . . . 238 Zymo Research Europe GmbH . . . . . . . . . . . . . . . 240

Meissner Bolte Patentanwälte Rechtsanwälte . . . 274 Partnerschaft mbB Technologiepark Heidelberg GmbH . . . . . . . . . . . 276 Technologiepark Weinberg Campus . . . . . . . . . . . 278 TVM Life Science Management GmbH . . . . . . . . . 280 V.O. Patents & Trademarks . . . . . . . . . . . . . . . . . . 282 Wirtschaftsförderung Sachsen GmbH. . . . . . . . . . 284 Woll Maschinenbau GmbH . . . . . . . . . . . . . . . . . . 286 Wuesthoff & Wuesthoff Patentanwälte PartG mbB 288

German Biotech Companies . . . . . . . . . 290 Advertisements BIOCOM AG . . . . . . . . . . . . . . . . . . . . . . . . . 6, 22, 242 European Biotechnology Network . . . . . . . . . . . . . 16 eurobiotechjobs. . . . . . . . . . . . . . . . . . . . . . . . . . . 20

Profiles of Service Providers . . . . . . . . . 242 AGCT Consulting GmbH i. G. . . . . . . . . . . . . . . . . 244 anteris medical GmbH . . . . . . . . . . . . . . . . . . . . . . 246 Applied Critical Fluids GmbH . . . . . . . . . . . . . . . . 248 BIO.NRW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 BioM Biotech Cluster Development GmbH . . . . . . 252 BIOPRO Baden-Württemberg GmbH . . . . . . . . . . 254 btS e.V . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 256 Covington & Burling LLP . . . . . . . . . . . . . . . . . . . . 258 Evosciences Leasing GmbH . . . . . . . . . . . . . . . . . 260 HealthCapital Berlin-Brandenburg . . . . . . . . . . . . 262 HOX Life Science GmbH . . . . . . . . . . . . . . . . . . . . 264 IMG - Investitions- und Marketinggesellschaft . . . 266 Sachsen-Anhalt mbH IZB - Fördergesellschaft IZB mbH . . . . . . . . . . . . . 268 Life Science Nord Management GmbH . . . . . . . . . 270 LUMIS International GmbH . . . . . . . . . . . . . . . . . . 272 24 TH GUIDE TO GERMAN BIOTECH COMPANIES 2023

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Turnover at an all-time high

generate sales of €24.2bn. Excluding BioNTech sales, this still amounted to €5.2bn (+18%; 2020: €4.4bn excluding BioNTech). However, non-specific biotech services (€1.85bn; +32%) and companies focusing on industrial biotechnology (€399 m, 11%) also recorded a significant increase in sales.

Compared to 2020, the sales of the 753 dedicated biotech companies have virtually exploded in 2021, reaching the incredible sum of €26.5bn - admittedly, the enormous growth rate of almost 400% is primarily attributable to BioNTech’s vaccine sales. But even if the sales of the Mainz-based company are excluded, the result is a remarkable sum of €7.5bn. This represents growth of more than 20% compared to 2020 (€6.2bn excluding BioNTech revenue) - an increase unmatched in the years before the pandemic.

This shows that many German biotech companies have now reached a high level of maturity, which has been reflected accordingly.

By the end of 2021, a total of 753 German biotech companies were counted (2020: 736). Half (52%) focus their activities on the healthcare sector, either developing new therapeutics, diagnostics or vaccines or working on technology platforms relevant for this. About a third (30%) of the companies provide biotechnological services and just over 10% are involved in industrial biotechnology. Only a small proportion (2%) of German biotech companies are active in agricultural biotechnology and 5% focus on bioinformatics.

As in 2020, the immense growth is attributable in particular to sales generated with vaccines as well as diagnostics. The healthcare sector alone was able to

Fig. 1: Turnover and R&D expenditure of dedicated biotech companies in EUR million 7.500 7.000

Turnover

6.500

R&D Expenditure

6.000 5.500 5.000 4.500 4.000 3.500 3.000 2.500

2,011

2,191 +9%

−0.3%

1,049

1,061

2,184

+8.7%

2,374

2,619

+10.9%

2,903

-1.4%

+10.5%

2.000 1.500 1.000 500

+8%

+1.1%

2007

2008

1,046 −1.4%

1,015

975

−3%

−4%

2010

2011

937 −4%

0 2008

2012

−3.7%

Once again high spending on research and development

26,485

Also in 2021, successes in developing new vaccines and diagnostics to combat the COVID 19 pandemic had a major impact on research and development (R&D) spending. After surpassing the two billion mark for the first time in 2020, research spending in 2021 was already reaching for the three billion mark €2.83bn was invested in R&D, an increase of 32.4% compared to 2020.

+295%

BioNTech invested just under one billion in research and development in 2021. But even here, if you exclude the research expenditures of the Mainz-based company, there is still a very significant increase of 26% compared to 2020. €1.88bn would then be compared with €1.49bn.

7,508*

6,709

*excluding sales of BioNTech SE

+20.6% +48.7% 6,230*

4,510 4,105

2,864

3,031 +5.9%

3,284 +8.0%

+9.9%

3,545 +15.8% 2,830

+8.3% 2,140

2013

1,195

1,117

1,104

1,038

954

899

+32%

+6.2%

+8.8%

+6.3%

+1.2%

+7%

+26% 1,884* +79.1% 1,495*

2014

2015

2016

2017

2018

2020

2021

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Name › BRAIN Biotech AG Address/P.O. Box › Darmstädter Str. 34–36 Postal Code/City › 64673 Zwingenberg State › Hesse Telephone › +49-6251-9331-0 Fax › +49-6251-9331-11 Email › public@brain-biotech.com Website › www.brain-biotech.com Social Media › L I Number of Employees › ~ 320 (BRAIN Group) Founded (year) › 1993 Type of Laboratory › S1, S2, L1, L2 Areas of Activity › Discovery, development and optimization of enzymes, microbial strains and natural bioactive substances for applications in the food, diagnostics, pharma and chemical industry as well as for environmental issues. l Enzymes from discovery to production for diverse industrial applications l Microorganisms as producer strains, for precious metal extraction, for waste stream transformation, as probiotics and much more l Bioactive substances, e.g. as ingredients for food, animal feed, skin care External › Collaborations with global players as Collaborations well as with renowned universities.

Request for › Looking for partners to develop Further Collaborations novel applications in industrial biotech, agriculture, diagnostics and therapeutics leveraging our independent CRISPR/Cas genome editing platform

Creating a #BiobasedFuture We are one of Europe’s leading companies in the field of industrial (white) biotechnology. We identify previously untapped efficient enzymes, microbial producer organisms, and natural substances from biological systems for industrial applications. We optimize production strains and enable efficient bioprocesses.

Our innovative solutions are successfully applied in the feed, food, diagnostics, pharma, and chemical industries, many of them serving to make products and processes more sustainable.

Products and solutions Within the BRAIN Group we use synergies for R&D as well as for specialized production of functional biomass, enzymes, or bioactives. We offer products and solutions from small-scale to large-scale approaches. › Enzymes: Discovery, analysis, optimization, sampling, formulation, and production in a variety of hosts. › Microorganisms: Identification; strain development (non-GMO and GMO); supply of functional biomass to optimize industrial production processes. › Bioactives and performance biologicals: Discovery (high-throughput isolation; extraction and purification of natural products from variable biological resources); structure elucidation and characterization; activity- and sequence-based screenings incl. biochemical and human cell-based assays; production.

R&D Services Genome Editing tools and services We use a proprietary CRISPR/Cas genome editing platform with a toolbox of several nucleases to perform custom genome editing services (“We CRISPR for you”) in a variety of applications. These genome editing tools have been identified and developed in-house, and are independent of common nucleases like e.g. Cas9 or Cas12a. We also provide and license these tools to our partners.

BRAIN

Enzymes optimization and search for new Enzymes If a particular enzyme product is not found in the BRAIN Group’s enzyme portfolio, our metagenome libraries are the basis for our sequence- or activity-based search for new enzyme product candidates. We further optimize enzymes already used by our customers so that complex process and application requirements can be met even better.

Process development and optimiziation We develop bioprocesses at lab-scale and to scale-up (200L) for process validation and sample generation.

Our engineers within the BRAIN Group are experts for the tech and process transfer to enable a production at an industrial scale (up to 10,000L).

Applied technologies › Protein engineering › Eucaryotic cell expertise › Natural compound libraries › Genome editing / independent BRAIN Cas nucleases › BRAIN BioArchive with access to nature‘s biodiversity › Metagenome technologies › Next generation sequencing › Precision fermentation & bio-processing › Applied bioinformatics › 3D modelling › Analytics

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