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The power of magnetic resonance: CHEM UK 2024
In this issue of Industrial Process News, we are delighted to showcase Bruker BioSpin as our Magnetic Resonance Solutions Company of the Month
Bruker provides industry-leading Magnetic Resonance-based solutions for organisations to deliver high-quality products and materials. Nuclear Magnetic Resonance (NMR) is a proven technique for chemical analysis from primary identification, quantification of substances to molecular structure elucidation.
Exhibiting at CHEM UK 2024 from the 15th-16th May at the NEC Birmingham, the expert team from Bruker will be showcasing benchtop devices to precisiondriven floor-standing instruments to attendees from laboratory, operational/production, quality/health & safety, to chemical sectors.
“We provide a solution portfolio for overarching value chain coverage from product innovation to manufacturing. Our robust NMR systems allow our partners to attain strategic technology deployment across all facilities, allowing the streamlined sharing of expertise, methods and data between different elements in the supply chain.” explained Dr Joerg Koehler, Senior Director for Cleantech, Industrial and Applied Markets at Bruker.
Big things come in small packages: high-performance NMR benchtop systemThe Fourier 80 from Bruker, for example is a compact benchtop system, allowing advanced analytical capabilities with simplicity at heart. It can be easily installed in the fume hood or on the bench seamlessly, without the need for additional infrastructure. This NMR instrument has been thoughtfully designed for intricate molecular analysis at the highest level, providing premium data quality and stability at 80MHz. The lineshape, resolution and sensitivity are incomparable, with an adjustable temperature for measured samples from 25°C to 60°C. The Fourier 80 is a next-generational benchtop spectrometer for routine laboratory usage in industrial manufacturing, research facilities and university settings.
The 80-MHz cryogen-free permanent magnet design features bring the following multiple benefits:
Direct seamless synthesis and process control on the bench
Sample automation with up to 120 positions
Automated data interpretation and report filing
Reduces errors for optimised efficiency
Pulsed field gradient
Full flexibility with use of TopSpin® software
GoScan software provides pre-defined, dedicated workflows
Push-button operation
“TopSpin® is our standard NMR software across a full range of workflows, from spectrometer control to the processing and analysis of multifaceted NMR spectra.”
“The Fourier 80 is perfect for applications such as: structure verification, process and product optimisation and control, forensics and narcotics profiling, through to the specific authenticity and quality analysis of olive oil or the quantification of ethanol content in hand sanitisers,” continued Joerg.
Transforming Chemical Analysis for the Industry: Avance Chemical Profiling Bruker has recently launched a new mixture analysis software product for its market-leading floor-standing NMR spectrometer series. The Avance Chemical Profiling Solution seamlessly integrates into the industry-standard NMR instrument control software TopSpin. It allows for intuitive workflow creation from sample handling, data acquisition, and processing, to interpretation, and report filing. Expert-created methods can be made available to spectroscopic non-experts by the push of a button. The new software significantly increases sample throughput and operator-independent result comparability. It supports R&D specialists in lab-scale synthesis optimization, in pilot up-scaling, and the whole organization in volume manufacturing.
The new software for floor-standing NMR Avance spectrometers directly links to the existing Fourier 80 Mixture profiling. This fully automated end-to-end solution is also a market-driven solution for analytical needs such as final product quality control or synthesis control in the manufacturing process. It is perfect for determining what constituents are in a mixture and to what degree, with a report stating all results. Both hardware instrument lines with cutting edge endto-end automation software from sample to report feature perfect use-case coverage whilst optimizing deployment capabilities.
This is a NMR gamechanger.
The new profiling software solutions on floor-standing and benchtop NMR systems negate the need for expert data interpretation. The software does all the hard work, capturing the required information, leaving the operator to merely load the samples into the autosampler and start the flow.
Distributed Lab Topology: Solution deployment enabled by softwareOne of the biggest headaches in the plant industrial extraction process for example, is the guaranteed raw material consistency, across all batches, which can vary according to harvesting and plant growing and processing conditions. A state-of-the art NMR method ensures consistency across defined parameters through automated spectra comparisons across batches quickly and efficiently. Furthermore, the systems store all models giving quick results for future comparisons across batches.
By implementing integrated NMR solutions, highinvestment instruments can focus on sophisticated tasks, reducing time-to-result and optimizing testing frequencies in high-throughput environments. Harmonized methods across the value chain enhance the benefits. Validating new testing methods, streamlining audit trails, and analytical case escalation all benefit significantly from using one core technology.
“This intuitive end-to-end solution doesn’t need specialist NMR knowledge or trained operators. Our long-standing reputation in the market and innovations has allowed us to partner with industrial key-players in their field, with academic innovators, to even forensics and police work.”
“We are open to working with new applications and have the proven capability to meet market-needs across the board.”
A long history of partnership with new marketsIt is this openness and curiosity to new markets that has made Bruker a formidable player in the industry. Established by Prof. Gunther Laukien: Professor for Experimental Physics back in 1960, the company started out as Bruker Physik-AG and developed the first high-resolution systems for analytical chemistry usage in the USA. Even at this early stage, Bruker understood the importance of NMR and the intrinsic need for an impulse spectrometers and produced laboratory magnets and power supplies.
By 1968, systems were delivered to Yale University and the first US office was opened in the state of New York. The Global Bruker Group carried out further expansion through the USSR, Australia, China and Europe throughout the late 1960’s and 1970’s. Synonymous with innovation, over the last sixty-four years, Bruker has developed the world’s first FT-NMR spectrometer system, leading optics division and pre-clinical systems, ion mobility spectrometry, materials research and quality-control instruments for elemental and crystalline structure investigations, superconducting wire products and devices and magnetic resonance division.
Bruker operates under four divisions: Bruker BioSpin Group, Bruker CALID Group, Bruker Scientific Instruments (BSI) NANO Segment and Bruker Energy & Supercon Technologies.
Nuclear Magnetic Resonance: A powerful technology for proven benefits Bruker BioSpin Group is chiefly responsible for designing, manufacturing and distributing instruments based on magnetic resonance technology, such as the nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectrometers. This is further enhanced by single and multiple modality preclinical imaging systems using magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), computed tomography (CT), and magnetic particle imaging (MPI) technologies. Specific applications include: structural proteomics, drug discovery, pharmaceutical and biotechnology research and production, and the food and materials science fields.
Bruker has been laser focused on designing a benchtop NMR system that replicates the industry standards of the renowned floor-standing instruments. Synonymous with reproducibility, system stability and quality, Bruker has developed benchtop systems with the following proven features: magnet stability, result reproducibility, magnet uniformity and use-friendly, intuitive operating.
There are a few lingering myths surrounding NMR technology, such as the usage of radio waves both for the excitation of a sample and the reception of signal. Bruker is all about myth-busting and maintains that NMR spectroscopy is a prized analytical tool across multiple applications. To reiterate, here are the proven benefits of using NMR:
NMR is inherently quantitative featuring standard-setting instrument-to-instrument result comparability
Non-destructive analysis allows for further usage of the sample in orthogonal methods
Provides highly detailed and accurate data (on the molecular structure of a sample)
Extracts rich data from intact molecules (without compromising the integrity or sample quality)
Rapid and simplified data acquisition (simply: high quality data with less resources)
Pulsed Field Gradients (PFG) on benchtop solutions can record changes in NMR signals and subsequently measure the diffusion coefficients of sample components.
Cost-effective and easy to use
The versatile nature of NMR technology provides a high number of multiple substances and material analysis from just a single-run. Furthermore, the benchtop instruments are ideal for manufacturing environments, with the NMR analysis ideal for production, process and final production control.
“Our intuitive NMR solutions require no third-party software and offer IP-secure data integrity. We now have subsidiaries across 90 countries and welcome new partners to visit our sites, such as Coventry in the West Midlands, to begin a conversation, following detailed consultation.”
“If you’re looking to increase efficiency in new product roll-out and scale-up, we can help with the optimised volume production of a new product.”
“With sustainability now a key concern for many organisations, NMR technology brings many benefits such as precision analysis meeting quality benchmarks more quickly and reducing waste and energy simultaneously.”
This steadfast commitment to premium scientific instruments and analytical and diagnostic solutions for the expert application of scientific living organisms and substances research has earnt Bruker global industrial recognition.
Today, with an eye on cutting-edge instrumentation, Bruker manufactures its range using nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), spectrometers and preclinical imaging systems, to help scientists uncover startling discoveries at molecular, cellular and microscopic levels. Across life science molecular research, allied and pharma sectors, microscopy, nanoanalysis, through to cell biology, clinical phenomics, proteomics and clinical microbiology, Bruker is helping leading the way in pioneering research. In 2022, the FY revenue was more than $2.5 billion and the corresponding R&D investment was over 9% of revenue.
From humble beginnings in Karlsruhe, this German powerhouse has taken the industry by storm and now heads up more than 8,500 employees across 90 global locations, with 14 manufacturing sites and over 4,000 patents pending or granted. With a market-driven approach, Bruker has maintained its pole position as one of the world’s leading analytical instrumentation companies.
“Our magnetic resonance-based analytical solutions are widely used in polymer R&D, production and quality-control for example. We offer solutions across diverse instrument platforms, focused on standardisation of methods. Leveraging applications of the same technology can produce comparable outcomes and drastically reduce the timescale for new polymer innovations to enter the market.”
“Through meticulous in-house R&D, we have discovered that our NMR spectroscopy offers next-level estimated molecular weight of unknown substances. This is a robust method for reliable measurement of unidentified compounds in mixtures, allowing cost-effective and precise methodology for laboratories around the world.”
As a fact Bruker Corporation (NASDAQ: BRKR) has been selected as the Instrument Business Outlook (IBO) ‘Company of the Year’ for 2023. IBO cited Bruker’s double-digit organic revenue growth in 2023 in all major regions, and in all business groups, demonstrating a transformed portfolio and operational strength.
Meet Bruker at CHEM UK 2024 from the 15th-16th May at the NEC Birmingham (Stand F72): https://www.bruker.com/en.html
