OUR TECHNOLOGY
Early-stage process development requires rapid identification of both the optimal resin and process conditions to achieve desired purity, yield, and scalability. Screening tools enable fast, efficient evaluation of multiple adsorbents and parameters in parallel, accelerating timelines from research through to clinical production.
With over 30 years of expertise in chromatography chemistry, Astrea Bioseparations Ltd is a trusted partner to leading pharmaceutical companies worldwide, with our technology used in 21 FDA-regulated processes.
Astrea Bioseparations offers a comprehensive range of screening formats tailored to different stages of process development:
• 1 mL & 5 mL high-throughput columns: Ideal for method development and scale-up studies
• RoboColumns®: Automation-compatible, pre-packed mini-columns for parallel screening
• 96-well plates: High-throughput formats for rapid resin evaluation with minimal sample consumption
Screening tools can be employed across multiple phases:
• Early development: To compare different resins, ligands, and operating conditions in parallel
• Process optimization: To refine parameters such as binding capacity, elution conditions, and cleaning protocols
• Scale-up support: To validate findings in formats that closely mimic larger-scale column performance
High-throughput pre-packed columns
Available in 1 mL & 5 mL volumes, these columns provide a convenient, reproducible format for resin screening and method development.
Key features
• Pre-packed with a wide range of Astrea Bioseparations’ resins
• Robust polypropylene housings compatible with most chromatography systems
• Consistent packing quality and bed integrity across batches
Advantages
• Comparison of multiple resins under identical conditions
• Format supports transition to larger columns
• Reduced setup time and preparation effort
RoboColumns®
RoboColumns® are miniaturized, pre-packed columns designed specifically for use in automated liquid handling workstations.
Key features
• Small bed volumes optimized for high-throughput automation platforms
• Reliable, consistent packing and performance
• Wide selection of resins available for diverse applications
Advantages
• Compatible with automated screening systems for increased productivity
• Minimal sample and buffer consumption
• Enables parallel evaluation of multiple parameters
96-well plates
MiMode® 96-well plates are designed for rapid screening of mixed-mode resins, offering unmatched flexibility and speed in early-stage process development.
Key features
• Pre-packed with MiMode® mixed-mode resins
• Standard 96-well format, compatible with multichannel pipettes and automation
• Low bed volume, enabling efficient screening with small sample volumes
Advantages
• High-throughput parallel screening of multiple conditions and resins
• Fast identification of optimal binding and elution parameters
• Accelerates decision making and reduces development timelines
Commitment to quality
Astrea Bioseparations is honored to support the biopharmaceutical industry with products and services that help bring life-saving and improving medicines to market. Regardless of process scale, we are ready to build Purity by Design into each process to ensure quality and speed to market.
Technical support
Astrea Bioseparations provides expert technical support to help optimize purification strategies. Our chromatography specialists are available to assist with process development, troubleshooting, and scalability considerations.
Order information
96-well plate format
FG00692
FG00619
FG00620
FG00621
FG00689
FG00690
FG00691
Pre-packed column formats
MiMode PuraBead® HX1 Single-Resin Plate
plate
MiMode PuraBead® HX2 Single-Resin Plate 96-well plate
MiMode PuraBead® HL4 Single-Resin Plate 96-well plate
MiMode PuraBead® Mixed-H Multi-Resin Plate
MiMode PuraBead® AX1 Single-Resin Plate
MiMode PuraBead® CBX1 Single-Resin Plate
MiMode PuraBead® Mixed-C Multi-Resin Plate
plate
plate
plate
plate
6716
MiMode PuraBead® CBX1 Column,
6717 MiMode PuraBead® CBX1 Column,
6718 p-Aminobenzamidine A6XL Column, 1 x 1 mL
A6XL Column,
6720 MiMode PuraBead® CX1 Column, 1 x 1 mL
6724
6725
MiMode PuraBead® CX1 Column, 1 x 5 mL
Mimetic Blue® SA HL P6HF Column, 1 x 1 mL
Mimetic Blue® SA HL P6HF Column, 1 x 5 mL
mL 6726 AlbuPure® Column, 1 x
MiMode PuraBead® HL3 Column,
PuraBead® HX2 Column,
6733 MiMode PuraBead® HX2 Column, 1 x
6734 Butyl PuraBead® HF Column,
Butyl PuraBead® HF Column,
Hexyl PuraBead® HF Column,
Hexyl PuraBead® HF Column,
6738 PE PuraBead® 6HF Column, 1 x 1 mL
PE PuraBead® 6HF Column, 1 x 5 mL
Pre-packed column formats
6740
6741
6742
6743
6744
6745
6746
6747
6748
6749
6750
6751
Mimetic Blue® AP HL P6HF Column, 1 x 1 mL
Mimetic Blue® AP HL P6HF Column, 1 x 5 mL
Mimetic Blue® SA HL P6XL Column, 1 x 1 mL
Mimetic Blue® SA HL P6XL Column, 1 x 5 mL
Insulin Adsorbent Column, 1 x 1 mL
Insulin Adsorbent Column, 1 x 5 mL
EtoxiClear® Column, 1 x 1 mL
EtoxiClear® Column, 1 x 5 mL
MAbsorbent® A2P HF Column, 1 x 1 mL
MAbsorbent® A2P HF Column, 1 x 5 mL
MiMode PuraBead® HL4 Column, 1 x 1 mL
MiMode PuraBead® HL4 Column, 1 x 5 mL
6752 Q PuraBead® Edge Column, 1 x 1 mL
6753 Q PuraBead® Edge Column, 1 x 5 mL
6754 SP PuraBead® Edge, 1 x 1 mL
6755
FG00638
FG00639
FG00632
FG00633
FG00687
SP PuraBead® Edge, 1 x 5 mL
MiMode PuraBead® AX1
MiMode PuraBead® AX1
MiMode PuraBead® HX1
MiMode PuraBead® AX1
MiMode® CBX2
FG00688 MiMode® CBX2
FG00644
FG00645
FG00681
FG00682
RoboColumn® format
Code
4520-PC3416
MiMode PuraBead® CX1
MiMode PuraBead® CX1
MiMode PuraBead® CX2
MiMode PuraBead® CX2
x 5 mL
Butyl PuraBead® HF 200 μm RoboColumns® 200 μm RoboColumns®
4520-PC3455 Octyl PuraBead® HF 200 μm RoboColumns® 200 μm RoboColumns®
4520-PC3250 EtoxiClear® 200 μm RoboColumns® 200 μm RoboColumns®
4520-PC3160
Insulin Adsorbent 200 μm RoboColumns® 200 μm RoboColumns®
4520-PC0320 p-Aminobenzamidine A6XL 200 μm RoboColumns® 200 μm RoboColumns® 4520-PC9501
4520-PC3260
PE PuraBead® 6HF 200 μm RoboColumns® 200 μm RoboColumns®
MiMode PuraBead® HL4 200 μm RoboColumns® 200 μm RoboColumns® 4520-PC3450 CM PuraBead® HF 200 μm RoboColumns® 200 μm RoboColumns®
4520-PC3451
4520-PC3452
DEAE PuraBead® HF 200 μm RoboColumns® 200 μm RoboColumns®
Q PuraBead® HF 200 μm RoboColumns® 200 μm RoboColumns® 4520-PC3453
4520-PC3408
SP PuraBead® HF 200 μm RoboColumns® 200 μm RoboColumns®
Phenyl PuraBead® HF 200 μm RoboColumns® 200 μm RoboColumns® 4520-PC3426
MiMode PuraBead® HX1, 200 μm RoboColumns® 200 μm RoboColumns®
Astrea Bioseparations also supplies larger volumes of bulk resins & pre-packed chromatography columns for cGMP development and manufacturing-scale processes.
For more information on this or any other matters, please do not hesitate to contact us at sales@astrea-bio.com.
