OUR TECHNOLOGY
Early-stage process development requires rapid identification of both the optimal resin and process conditions to achieve desired purity, yield, and scalability. Screening tools enable fast, efficient evaluation of multiple adsorbents and parameters in parallel, accelerating timelines from research through to clinical production.
With over 30 years of expertise in chromatography chemistry, Astrea Bioseparations Ltd is a trusted partner to leading pharmaceutical companies worldwide, with our technology used in 21 FDA-regulated processes.
Astrea Bioseparations offers a comprehensive range of screening formats tailored to different stages of process development:
• 1 mL & 5 mL high-throughput columns: Ideal for method development and scale-up studies
• RoboColumns®: Automation-compatible, pre-packed mini-columns for parallel screening
• 96-well plates: High-throughput formats for rapid resin evaluation with minimal sample consumption
Screening tools can be employed across multiple phases:
• Early development: To compare different resins, ligands, and operating conditions in parallel
• Process optimization: To refine parameters such as binding capacity, elution conditions, and cleaning protocols
• Scale-up support: To validate findings in formats that closely mimic larger-scale column performance
High-throughput pre-packed columns
Available in 1 mL & 5 mL volumes, these columns provide a convenient, reproducible format for resin screening and method development.
Key features
• Pre-packed with a wide range of Astrea Bioseparations’ resins
• Robust polypropylene housings compatible with most chromatography systems
• Consistent packing quality and bed integrity across batches
Advantages
• Comparison of multiple resins under identical conditions
• Format supports transition to larger columns
• Reduced setup time and preparation effort
RoboColumns®
RoboColumns® are miniaturized, pre-packed columns designed specifically for use in automated liquid handling workstations.
Key features
• Small bed volumes optimized for high-throughput automation platforms
• Reliable, consistent packing and performance
• Wide selection of resins available for diverse applications
Advantages
• Compatible with automated screening systems for increased productivity
• Minimal sample and buffer consumption
• Enables parallel evaluation of multiple parameters
96-well plates
MiMode™ 96-well plates are designed for rapid screening of mixed-mode resins, offering unmatched flexibility and speed in early-stage process development.
Key features
• Pre-packed with MiMode™ mixed-mode resins
• Standard 96-well format, compatible with multichannel pipettes and automation
• Low bed volume, enabling efficient screening with small sample volumes
Advantages
• High-throughput parallel screening of multiple conditions and resins
• Fast identification of optimal binding and elution parameters
• Accelerates decision making and reduces development timelines
Commitment to quality
Astrea Bioseparations is honored to support the biopharmaceutical industry with products and services that help bring life-saving and improving medicines to market. Regardless of process scale, we are ready to build Purity by Design into each process to ensure quality and speed to market.
Technical support
Astrea Bioseparations provides expert technical support to help optimize purification strategies. Our chromatography specialists are available to assist with process development, troubleshooting, and scalability considerations.
Manufacture & supply
Adsorbent batches are manufactured in Astrea Bioseparations’ controlled environment facility, under a certified ISO 9001 quality system. We also offer a range of single-use, process-ready Evolve®D columns, pre-packed with your choice of resin for a convenient, ready-to-go manufacturing solution.
Order information
plate format
Pre-packed column formats
Regulatory support
Astrea Bioseparations can provide comprehensive regulatory support files for manufactured adsorbents and offers assistance with regulatory filings to support specific process requirements.
P6XL Column,
Blue® SA P6HF Column,
6724 Mimetic Blue® SA HL P6HF Column,
6725 Mimetic Blue® SA HL P6HF Column,
6733 Fabsorbent™ F1P HF Column,
Pre-packed column formats
Astrea Bioseparations also supplies larger volumes of bulk resins & pre-packed chromatography columns for cGMP development and manufacturing-scale processes. For more information on this or any other matters, please do not hesitate to contact
