Pre-packed columns: An extension of your downstream manufacturing capability Astrea Bioseparations, Horizon Park, Barton Road, Comberton, Cambridge, CB23 7AJ, UK
Introducing Evolve®D: Faster access to pre-packed bioprocessing columns
As biologics manufacturing scales, the cost and complexity of downstream processing continue to increase. With downstream processing accounting for 50–80% of biologics manufacturing costs¹, and with commercial biologics facilities incurring operating costs that can exceed US $100,000 per day2, manufacturers need faster access to process-ready chromatography columns that accelerate GMP readiness, reduce operational burden and support demanding project timelines. Evolve®D combines robust engineering, specialist packing expertise and regulatory-ready documentation to accelerate manufacturing readiness while reducing operational burden, from process development through commercial manufacture.
70 mm 100 mm 140 mm (0.2-0.8 L) (0.4-1.5 L) (0.7-3.1 L)
200 mm (1.5-6.5 L)
250 mm (2.5-19.6 L)
300 mm (3.5-28.3 L)
350 mm (4.8-38.5 L)
450 mm (8.0-63.6 L)
Larger scale formats coming soon
600 mm (14.1-113.1 L)
Move faster at process scale, with pre-packed columns from 70 – 600 mm, providing a consistent platform for downstream manufacturing 1
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Designed for performance
Packed by experts
Evolve®D has been engineered to reduce operational burden while delivering reliable performance. Purpose-designed for GMP operations, it combines robust engineering with practical features that simplify implementation and support confident scale-up. • Single-use convenience with the stability and handling confidence required for manufacturingscale operations • Removable upper endplate enables 99% resin recovery, minimizing media loss and process waste • A non-metallic flow path provides compatibility with demanding process chemistries • Engineered to support future scale-up toward larger-diameter chromatography systems
Fast turnaround
Third-party media packing
ISO 7 cleanroom packing
Global packing and distribution
Responsive manufacturing that keeps your project moving
Experienced in 45+ commercial chromatography media, including Protein A and CHT
Multiple packing suites certified for Process-Ready use
Packing operations in Europe and North America for global shipment
Astrea Bioseparations combines three decades of chromatography expertise with dedicated ISO 7 cleanroom packing facilities across the UK & USA to deliver fast-turn around processready columns qualified for immediate installation. Our packing specialists work closely with customers to develop robust packing methodologies across a broad range of chromatography media, helping reduce implementation risk and accelerate manufacturing readiness.
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Qualified for confidence
Every pre-packed Evolve®D column is supplied with the documentation required to simplify implementation within regulated environments. Performance qualification, bioburden assessment, material compliance and Regulatory Support Files provide confidence throughout process validation and manufacturing. Transportation robustness has also been demonstrated through ISTA transportation testing, confirming packed-bed integrity following simulated global shipping conditions.
Built for today’s manufacturing. Engineering for tomorrow
• Packed-bed efficiency (HETP) • Peak symmetry (Asymmetry) • Pressure-flow verification • Bioburden assessment • Certificate of Analysis • Regulatory Support File
RoboColumns®
DEVELOPMENT
Evolve®S
CLINICAL
Evolve®D
COMMERCIAL
• ISTA transportation validation Evolve®D provides a consistent platform supporting confident process scale-up from process development through to commercial-scale manufacturing. References
¹ Almeida, B.P. et al. (2023). Frontiers in Bioengineering and Biotechnology, 11:1037436 2
etrides D, Carmichael D, Siletti C, Koulouris A. Biopharmaceutical Process Optimization with Simulation and Scheduling Tools. P Bioengineering. 2014;1(4):154–187.
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Built on a scalable architecture, the platform has been engineered to support future largerdiameter manufacturing formats currently in development.