OUR TECHNOLOGY
Astrea Bioseparations Ltd offers SNAP® and Evolve® columns to support a wide variety of chromatographic processes and biopharmaceutical applications. These columns provide cost-effective, high-performance, easy-to-use, and scalable technology. Our extensive packing service further enhances their suitability for seamless integration into diverse workflows. Designed for both speed and precision, we deliver fast turnaround times, personalized support, and the flexibility to pack nearly every resin, ensuring high-quality results every time.
Successful chromatographic separations in the downstream processing workflow rely on effective column packing. By ensuring uniform flow distribution, minimizing pressure drops, and maintaining consistent packing conditions, biopharmaceutical manufacturers can improve process efficiency and safeguard the integrity of their therapeutic products. As biopharmaceutical demand continues to rise, optimizing column packing processes will remain critical to the success and sustainability of operations in the competitive landscape.
The variability of chromatographic resin properties and the complex interplay of many packing parameters underscore why column packing is as much an art as it is a science. Being able to optimize packing for different resins, flow rates, and purification objectives requires not only technical expertise but also hands-on experience.
By outsourcing column packing to Astrea Bioseparations, biopharmaceutical companies benefit from timely delivery of prequalified, process-ready columns that are accompanied by all necessary documentation to integrate column quickly into downstream processing lines, saving valuable time and resources.
Benefits
• Rapid turnaround times; delivery approximately 21 days
• Reduced process downtime
• Cost effective compared to in-house packing
• Highly reproducible performance
• Column diameters from 10 mm to 600 mm
• Columns packed in ISO 7 cleanrooms
Flexible resin choices
• Packing service available for all Astrea Bioseparations resins
• Supports third-party resin suppliers
• Wide range of packable resin types
• Hardware offers resin recovery options
• Evaluation of used resin available
Global experts & support
• Expert column packing operations based in Europe (Isle of Man) and US (Canton, MA)
• Global team of Field Application Specialists (FAS)
• Documentation for seamless process integration
PRODUCT FORMATS
SNAP® columns: From R&D to clinical production
SNAP® columns are highly configurable, offering the versatility to evaluate an array of process variables and resin types during process development. In their process ready format, they provide a seamless transition from early-stage work to clinical manufacturing.
Our packing service can prepare SNAP® or process-ready SNAP® columns with your choice of resin, saving time and allowing teams to focus on exploring purification strategies before moving into a controlled, regulated
Designed for purpose
SNAP® columns:
• Flexible and scalable
• Available in diameters of 10,15, 25, 35, and 50 mm
• Column tube lengths from 125 mm to 1 M
• Material options available
• Process-ready option: Bioprocess-ready materials with supporting documentation
Packed for you
columns:
Wide range of resin types
Multiple bed heights available
Packed in ISO 7 cleanrooms
Performance Certificate of Conformity supplied
Bioburden statement provided on process-ready SNAP®
Height adjustment options (piston length): Short/Short, Short/Long, Long/Long
O-ring options: Viton, Kalrez (or equivalent)
Bed support materials: Polyethylene, stainless steel
Pressure rating (bar): 13–40 bar. Variable across size range and application
Operating temperature (°C): 4–40°C
PRODUCT FORMATS
Evolve® process columns: Scaling up for commercial production
Astrea Bioseparations’ Evolve® process columns provide scalable, high-quality solutions for diverse bioprocessing needs, from pilot- to large-scale manufacturing. Traditionally available in a self-pack format, they are now also available pre-packed.
Engineered for extended use, Evolve® process columns enable efficient resin removal to maximize cycle life, supporting long-term studies, and reduce costs, making them ideal for large-scale manufacturing applications.
Designed for purpose
Evolve® process columns:
• Available in 9 diameters with scalable performance
• Manufactured using bioprocess ready materials
• Include a non-metallic flow path compatible with high halide solutions and guanidine HCL
• Optimized inlet and outlet sizes to accommodate range of process flow rates and minimize pressure drop
Packed for you
Evolve® process columns:
• Wide range of resin types available to be packed
• Customer specified or Suitable Packing method used
• Certificate of Conformity supplied
• Bioburden statement
• RSF document available
