Aminophenylboronate
P6XL
www.astreabioseparations.com
2 | Aminophenylboronate P6XL
OUR TECHNOLOGY Aminophenylboronate affinity adsorbents are used for purification of a diverse range of macromolecules which possess 1,2- diols, 1,3-diols, 1,2-hydroxy acids and 1,2- hydroxylamine groups. These functionalities are present in glycoproteins, carbohydrates, nucleic acids (nucleosides, nucleotides and RNA’s), and polyphenols (catechols, flavonoids). Aminophenylboronate P6XL is an affinity adsorbent for the purification of glycoproteins, or the removal of glycoprotein and carbohydrate impurities from nonglycosylated molecules. The product can also be used for purification and removal of certain enzymes such as proteases and hydrolases where the boronic acid group has affinity for the active site.
Key Features • Affinity purification and removal of glycoproteins and glycans • High purity m-aminophenylboronic acid ligand • Ligand binds selectively to carbohydrate groups with cis- diols • High dynamic binding capacity • Robust, long life adsorbent • Sanitisable with NaOH allowing multiple cycles
Advantages • PuraBead® 6XL beads manufactured in house for security of supply and minimal lead times • Uniform particle size which enables easy packing and high flow rates at low back-pressure • Stable across the pH range 3 -13 • Highly reproducible batch-to-batch manufacture to ISO 9001 standard Aminophenylboronate P6XL is produced in a controlled environment to ISO 9001 quality standard and is designed for use in cGMP manufacturing of biological molecules and for incorporation into diagnostic assays.
• Supported with a comprehensive Regulatory Support File • Multiple end users in regulated processes
Adsorbent Uses • Capture/purification of glycoproteins • Removal of glycosylated/glycated impurities • Quantification of glycated proteins (e.g.HbA1c test for diabetes) • Purification of enzymes (e.g. serine proteases) where boronic acid is an active site inhibitor • Capture/purification of Monoclonal Antibodies
Aminophenylboronate P6XL | 3
PRODUCT FORMATS Bulk Manufacture & Supply Astrea Bioseparations can provide Aminophenylboronate P6XL in volumes sufficient to meet the requirements of the largest biomanufacturing processes. Single batches of up to 275 litres are produced in Astrea Bioseparations’ controlled environment manufacturing facility under an ISO 9001 quality system.
Pre-Packed Columns Code
Description
Pack Size
6616
Aminophenylboronate P6XL HT 1 mL Column Kit
4 x 1 mL columns
6617
Aminophenylboronate P6XL HT 5 mL Column Kit
4 x 5 mL columns
Ordering information For small orders up to 500 mL, please visit our webshop. We also offer a range of larger pack sizes for supply of bulk resins into cGMP development and manufacturing scale processes.
Adsorbent Gel Slurry Pack Size
Product Code
25 mL
3355-00025
100 mL
3355-00100
500 mL
3355-00500
1000 mL
3355-01000
Astrea Bioseparations also offers a range of pre-packed columns including 1 mL and 5 mL column kits and a range of other larger pre-packed column solutions.
Commitment to Quality
Technical Support
Astrea Bioseparations is honored to support the biopharmaceutical industry with products and services that help bring life-saving and improving medicines to market. Regardless of process scale, we are ready to build Purity by Design into each process to ensure quality and speed to market.
Astrea Bioseparations has comprehensive knowledge of the properties and applications of Aminophenylboronate P6XL adsorbent and we can provide full support for the development of new applications and their implementation for biopharmaceutical manufacture.
+44 (0) 1223 433 800 | astreabioseparations.com sales@astrea-bio.com | techsupport@astrea-bio.com | quality@astrea-bio.com Global bases in North America, Canada and Cambridge UK HQ: Horizon Park, Barton Road, Comberton, Cambridge, CB23 7AJ, UK
Aminophenylboronate P6XL - V1 This product is covered by or for use under one or more patents: www.astreabioseparations.com/patents All trademarks, trade names, trade dress, product names and logos appearing in this brochure are the property of Astrea UK Services Ltd. Copyright © 2022 Astrea Bioseparations Ltd. All rights reserved.