Adsorbent Selection Guide Modality
Antibodies
Binding interaction
Usage
Adsorbent Recommendation
Affinity
Kappa & Lambda light chains, IgGs and fragments, Fab fragments, F(ab’)2, ScFv, domain antibodies, antibody-drug conjugates, bispecifics
Fabsorbent https://www.astreabioseparations.com/product/fabsorbent-f1p-hf/
AEX
Primary capture, host cell protein removal
HIC
Host cell DNA, aggregates
MMC (HIC & HB)
Plasmid
Host cell proteins, host cell DNA, aggregates
AEX
pDNA capture
HIC
Polishing (separation of supercoiled pDNA) Isoagglutinnin removal
Affinity
Plasma Derived Therapeutics
DEAE/Q PuraBead® https://www.astreabioseparations.com/product/iex/ Phenyl/Hexyl/Butyl/Octyl PuraBead® https://www.astreabioseparations.com/product/hic/ HCPure https://www.astreabioseparations.com/product/hcpure/ DEAE PuraBead® https://www.astreabioseparations.com/product/iex/ Hexyl PuraBead® https://www.astreabioseparations.com/product/hic/ ™
tps:/ www.astreabioseparBations.com/product/isoclear-b/ https:/ www.astreabioseparIsoclear ations.com/product/isocAlear-a/ & htIsoclear ™
™
Mimetic cBlue® SA HL https://www.astreabioseparations. om/product/mimetic-blue-sa-hl-p6xl/ Mimetic Blue® SA HF https://www.astreabioseparations. com/product/mimetic-blue-sa-p6-hf/ AlbuPure® https://www.astreabioseparations. com/product/albupure/ Mabsorbent® https://www.astreabioseparations. com/product/mabsorbent-a2p-hf-ll/
IVIG
IVIG
AEX
Primary capture blood clotting factors (requires affinity polish)
CEX
C1-esterase inhibitor protein capture
HIC
C1-esterase inhibitor protein polish
Q PuraBead® https://www.astreabioseparations.com/product/iex/ CM PuraBead® https://www.astreabioseparations.com/product/iex/ Phenyl/Hexyl/Butyl/Octyl PuraBead® https://www.astreabioseparations.com/product/hic/
Fc region
Mabsorbent® https://www.astreabioseparations. com/product/mabsorbent-a2p-hf-ll/
Kappa & Lambda light chains, IgGs and fragments, Fab fragments, F(ab’)2, ScFv, domain antibodies, antibody-drug conjugates, bispecifics
Fabsorbent™ https://www.astreabioseparations.com/product/fabsorbent-f1p-hf/
Botulinum toxin purification Insulin purification Alkaline phosphotase purification Phosphate binding protein purification (bind phosphate groups)
AEX
Primary capture, Host cell protein removal
HIC
Host cell DNA, aggregates
MMC (HIC & HB) Endotoxin Serine Protease Glycosolated Proteins
AAV
Plasma derived albumin capture (high selectivity) Albumin fusion protein
Affinity
Recombinant Proteins, Enzymes, Others
Recombinant albumin capture (high ligand density)
™
Host cell proteins, host cell DNA, aggregates Endotoxin from E. coli Serine protease capture Glycoprotein and glycosolated protein removal
CEX
AAV capture
MMC
HCP removal
AEX
Empty/Full separation
For more information please visit our website at www.astreabioseparations.com or contact us at sales@astrea-bio.com AlbuPure® is a registered trademark of Albumedix Ltd. All other trademarks, trade names, trade dress, product names and logos are the property of Astrea UK Services Limited. Copyright © 2023 Astrea Bioseparations Ltd. All rights reserved.
Matrix 215 https://www.astreabioseparations. com/product/matrix-215/ Insulin https://www.astreabioseparations. com/product/insulin-adsorbent/
Mimeticcom/product/mimetic-blue-sa-p6-hf/ Blue® AP https://www.astreabioseparations.
PE PuraBead® https://www.astreabioseparations. com/product/pe-purabead-1l/ DEAE/Q PuraBead® https://www.astreabioseparations.com/product/iex/ Phenyl/Hexyl/Butyl/Octyl PuraBead® https://www.astreabioseparations.com/product/hic/ HCPure https://www.astreabioseparations.com/product/hcpure/ EtoxiClear® https://www.astreabioseparations.com/product/etoxiclear/ ™
https://www.astreabip-Aminobenzamidine oseparations.com/product/p-aminobenzamidine-agarose-6xl/ Aminophenylboronate https://www.astreabioseparations. com/product/aminophenylboronate-p6xl/
SP PuraBead® https://www.astreabioseparations.com/product/hcpure/ HCPure https://www.astreabioseparations.com/product/hic/ Q PuraBead® https://www.astreabioseparations.com/product/iex/ ™