Test Bank For Larsen's Human Embryology, 6th Edition Authors Gary C. Schoenwolf & Steven B. Bleyl & Philip R. Brauer & Philippa H. Francis-West Chapter 1-20
Chapter 1: Gametogenesis, Fertilization, and First Week MULTIPLE CHOICE 1. A child with a large sacrococcygeal teratoma is delivered by cesarean section. The teratoma likely arose from which type of cells? A. Neuroectodermal stem cells B. Neural crest cells C. Primitive streak cells D. Primordial germ cells E. Secondary oocyte cells ANS: D 2. A baby is diagnosed with Down syndrome shortly after birth. Which of the following events occurred abnormally during prenatal development? A. Anaphase of mitosis B. Metaphase of mitosis C. Telophase of mitosis D. Anaphase of meiosis E. Metaphase of spermatogenesis ANS: D 3. The birth control pill acts by blocking which process? A. Fertilization B. Ovulation C. Cleavage D. Capacitation E. Implantation ANS: B 4. RU-486 is an effective abortifacient. It acts by which mechanism? A. Blocking oogenesis B. Causing menstruation C. Blocking ovulation D. Causing polyspermy E. Blocking capacitation ANS: B
Copyright © 2022 Elsevier, Inc. All rights reserved.
Test Bank
1-2
5. A 36-year-old woman is unable to conceive a child because both her oviducts were severely scarred by pelvic inflammatory disease resulting from gonorrhea. Which type of assisted reproductive technology could be used to help her conceive? A. Gamete intrafallopian transfer (GIFT) B. Zygote intrafallopian transfer (ZIFT) C. In vitro fertilization (IVF) and embryo transfer ANS: C 6. A researcher knocks out expression of the POU domain transcription factor Oct4 in the early epiblast of a mouse embryo. Which cell type would you expect to be affected? A. Neural crest cells B. Neural plate cells C. Mesodermal cells D. Primordial germ cells E. Endodermal cells ANS: D 7. Formation of haploid spermatozoa occurs during which developmental event? A. Spermiation B. Capacitation C. Spermatogenesis D. Spermiogenesis E. Fertilization ANS: C 8. Increase in the levels of which hormone prevents menstruation during a cycle in which fertilization occurs? A. LH B. FSH C. GnRH D. hCG E. Estrogen ANS: D 9. A newborn girl is suspected of having Turner syndrome. Which diagnostic procedure would be used to determine if this is indeed the case? A. Karotyping B. Spectral karotyping (SKY) C. Comparative genomic hybridization (CGH) D. Fluorescent in situ hybridization (FISH) ANS: A
Copyright © 2022 Elsevier, Inc. All rights reserved.
Test Bank 1-3 10. A researcher establishes mouse spermatozoa lacking one of the following two sperm-specific proteins: Izumo and CD9. Which developmental events will be perturbed in the absence of either of these proteins? A. Spermatogenesis B. Capacitation C. Binding of spermatozoa to the zona pellucida D. Fusion of the egg and spermatozoa membranes E. Spermiogenesis ANS: D
Schoenwolf: Larsen's Human Embryology, 6th Edition Chapter 2: Second Week: Becoming Bilaminar and Fully Implanting Test Bank
MULTIPLE CHOICE
1. A young child is diagnosed with Angelman syndrome, a syndrome in which a deletion occurs in a portion of the long arm of chromosome 15. Both Angelman syndrome and another syndrome involve the same deletion, but the two syndromes differ depending on whether the defect was inherited from the mother or father. What is the related syndrome? A. Prader-Willi syndrome B. Down syndrome C. Treacher Collins syndrome D. Branchio-oto-renal syndrome E. CHARGE syndrome ANS: A 2. A researcher inactivates the Sox17 gene in an animal model. As a result of this, one of the primary germ layers fails to form. What germ layer is most likely to be affected? A. Ectoderm B. Somatic mesoderm C. Splanchnic mesoderm D. Extraembryonic mesoderm E. Endoderm ANS: E 3. The early conceptus can spontaneously abort if it doesn’t implant into the uterine wall and develop a uteroplacental circulation. Which vessels of the embryo directly contribute to this essential circulation?
Copyright © 2022 Elsevier, Inc. All rights reserved.
Test Bank A. Dorsal aortae B. Precardinal veins C. Vitelline arteries and veins D. Allantoic arteries and veins E. Postcardinal veins
1-4
ANS: D 4. A 45-year-old woman who tests positive on a home pregnancy test is later diagnosed with a complete hydatidiform mole. What is unusual about the chromosomes of complete moles? A. All chromosomes are derived from the mother. B. All chromosomes are derived from the father. C. Roughly two-thirds of the chromosomes are derived from the mother. D. 23 chromosomes are present. E. 69 chromosomes are present. ANS: B 5. X inactivation is an example of which process? A. Imprinting B. Meiosis C. Mitosis D. Dosage compensation E. Oogenesis ANS: D
Schoenwolf: Larsen's Human Embryology, 6th Edition Chapter 3: Third Week: Becoming Trilaminar and Establishing Body Axes Test Bank
MULTIPLE CHOICE
1. A researcher inactivates Lefty1, a gene expressed in the anterior visceral endoderm of the mouse. What effect would inactivation of this gene have on the gastrula-stage embryo? A. The epiblast becomes abnormally thickened throughout its cranial-caudal extent. B. The primitive streak fails to form. C. The endoderm fails to form. D. The neural plate fails to form. E. Extra primitive streaks form. ANS: E
Copyright © 2022 Elsevier, Inc. All rights reserved.
Test Bank 1-5 2. A boy is admitted to the hospital for an emergency appendectomy. During surgery it is noted that the inflamed appendix is located on the left side, rather than the right side, and that the patient has situs inversus viscerum totalis. Mutations in which gene are known to cause this condition in animal models? A. Pitx2 B. Bmp4 C. Hoxd13 D. Chordin E. Tbx3 ANS: A 3. A man with recurrent respiratory infections and infertility is diagnosed with Kartagener syndrome. Mutations in the gene encoding which protein cause this syndrome? A. Dynein B. Surfactant C. FGF8 D. BMP2 E. Insulin ANS: A 4. Rieger syndrome, which affects development of both the teeth and eyes, results from haploinsufficiency in which gene in humans? A. NODAL B. PITX2 C. SHH D. LEFTY1 E. FGF8 ANS: B 5. Patterning of the mesoderm involves so-called dorsalizing and ventralizing factors. Inactivation of which protein(s) in the early embryo would be expected to result in dorsalized mesoderm? A. Chordin B. Noggin C. Follistatin D. Fgfs E. Wnts ANS: E 6. A researcher knocks out the Tbx6 gene in a mouse. Which tissue will not form in the early embryo? A. Neural plate B. Notochord C. Lateral plate mesoderm
Copyright © 2022 Elsevier, Inc. All rights reserved.