Test Bank For Cellular and Molecular Immunology, 10th Edition by Abul K. Abbas, Andrew H. Lichtman,

Test Bank For Cellular and Molecular Immunology, 10th Edition by Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai Chapter 1-21 Chapter 1: Properties and Overview of Immune Responses Multiple Choice The principal function of the immune system is: A. Defense against cancer B. Repair of injured tissues C. Defense against microbial infections D. Prevention of inflammatory diseases E. Protection against environmental toxins ANS: C. The immune system has evolved in the setting of selective pressures imposed by microbial infections. Although immune responses to cancer may occur, the concept that ―immunosurveillance‖ against cancer is a principal function of the immune system is controversial. Repair of injured tissues may be a secondary consequence of the immune responses and inflammation. Although the immune system has regulatory features that are needed to prevent excessive inflammation, prevention of inflammatory diseases is not a primary function. The immune system can protect against microbial toxins, but it generally does not offer protection against toxins of nonbiologic origin. 2. Which of the following infectious diseases was prevented by the first successful vaccination? A. Polio B. Tuberculosis C. Smallpox D. Tetanus E. Rubella ANS: C. In 1798, Edward Jenner reported the first intentional successful vaccination, which was against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, smallpox was reported to be eradicated worldwide by a vaccination program. Effective vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th century and are widely used. There is no effective vaccine against Mycobacterium tuberculosis. 3. Which of the following is a unique property of the adaptive immune system? A. Highly diverse repertoire of specificities for antigens B. Self-nonself discrimination C. Recognition of microbial structures by both cell-associated and soluble receptors D. Protection against viral infections E. Responses that have the same kinetics and magnitude on repeated exposure to the same microbe

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ANS: A. Highly diverse repertoires of specificities for antigens are found only in T and B lymphocytes, which are the central cellular components of the adaptive immune system. Both the innate and the adaptive immune systems use cell-associated and soluble receptors to recognize microbes, display some degree of self-nonself discrimination, and protect against viruses. On repeated exposure to the same microbe, the adaptive immune response becomes more rapid and of greater magnitude; this is the manifestation of memory. 4. Antibodies and T lymphocytes are the respective mediators of which two types of immunity? A. Innate and adaptive B. Passive and active C. Specific and nonspecific D. Humoral and cell-mediated E. Adult and neonatal ANS: D. Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes produce antibodies, which are the recognition and effector molecules of humoral immune responses to extracellular pathogens. T cells recognize and promote eradication of intracellular pathogens in cell-mediated immunity. Passive and active immunity both can be mediated by either B or T lymphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocytes participate in adult adaptive immunity but are still developing in the neonatal period. 5. A. B. C. D. E.

The two major functional classes of effector T lymphocytes are: Helper T lymphocytes and cytotoxic T lymphocytes Natural killer cells and cytotoxic T lymphocytes Memory T cells and effector T cells Helper cells and antigen-presenting cells Cytotoxic T lymphocytes and target cells

ANS: A. T cells can be classified into effector subsets that perform different effector functions. Most effector T cells are either helper T lymphocytes, which enhance the responses of other immune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, which directly kill infected cells. Natural killer cells are not T lymphocytes. Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. 6. A. B. C. D. E.

Which of the following cell types is required for all adaptive humoral immune responses? Natural killer cells Dendritic cells Cytolytic T lymphocytes B lymphocytes Helper T lymphocytes

ANS: D. Humoral immune responses are antibody-mediated immune responses, and all antibodies are made by B lymphocytes and no other cell type.

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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition Test Bank Chapter 2: Cells and Tissues of the Immune System Matching Questions 1-5 Match each of the descriptions in questions 1-5 with the appropriate name (A-M) of an anatomic feature of lymphoid tissues. A. Periarteriolar lymphoid sheath B. Thymic medulla C. Thymic cortex D. Parafollicular cortex of lymph node E. Hematopoietic bone marrow F. Afferent lymphatic G. Efferent lymphatic H. Marginal zone I. Red pulp of spleen J. White pulp of spleen K. Epidermis L. Dermis M. Peyer’s patch 1.

Location of most T lymphocytes in the spleen

ANS: A. The periarteriolar lymphoid sheath surrounds the central arteries in the spleen and is the T cell zone in this organ. 2.

Vessels that drain lymph away from a lymph node

ANS: G. Efferent lymphatic vessels drain lymph away from lymph nodes; afferent vessels drain lymph into lymph nodes. 3.

Site of least mature T cell precursors in the thymus

ANS: C. Bone marrow–derived T cell precursors first enter the thymic cortex and migrate into the medulla as they become more mature. 4.

Location of Langerhans cells

ANS: K. Langerhans cells are dendritic cells in the epidermis of the skin that develop from fetal macrophages.

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5.

Lymphoid aggregate of the mucosal immune system

ANS: M. Peyer’s patches are B cell–rich lymphoid aggregates located in the submucosa of the small intestine. Multiple Choice 6. A. B. C. D. E.

Which of the following is the generative (primary) lymphoid organ for T lymphocytes? Bone marrow Spleen Lymph node Thymus Tonsil

ANS: D. Generative (primary) lymphoid organs are the organs where lymphocytes first express antigen receptors and attain functional maturity. Although T cell precursors arise in the bone marrow, these precursors migrate to the thymus, where maturation takes place. In contrast, B cells mature in the bone marrow. Spleen, lymph node, and tonsil are secondary lymphoid organs populated by mature B and T cells. 7. Which of the following statements about tissue-resident macrophages is correct? A. They are all derived from blood monocytes that enter tissues during infections B. Many of these cells first populate tissues during fetal development C. They differentiate from different kinds of epithelial cells in each tissue D. They constantly recirculate between different tissues E. They are professional antigen-presenting cells that activate naive T cells that migrate into tissues ANS: B. Many tissue-resident macrophages are derived from fetal yolk sac and fetal liver precursors and establish residence in the different tissues during fetal development. Other tissueresident macrophages are derived from bone marrow–derived blood monocytes that enter tissues under normal conditions or during infections. Epithelial cells do not differentiate into macrophages. Once in the tissue, tissue-resident macrophages cells do not leave to recirculate. Naive T cells do not usually enter non-lymphoid tissues, and tissue-resident macrophages have no role in presenting antigen to naive T cells. 8. Which type of leukocyte is the most abundant in the blood of a healthy adult? A. Monocytes B. B lymphocytes C. T lymphocytes D. Polymorphonuclear leukocytes E. Basophils

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ANS: D. Polymorphonuclear leukocytes (or neutrophils) are the most abundant blood leukocyte (~ 4,000/mm3), about twice the number of B and T lymphocytes combined. 9. Which of the following is a feature of fibroblastic reticular cells (FRCs)? A. They line the lumens of lymphatics entering lymph nodes B. They are derived from hematopoietic precursors C. They play a critical role in establishing where lymphocytes are located in lymph nodes D. They secrete cytokines that stimulate T cell proliferation E. They are phagocytic cells of innate immunity that kill microbes ANS: C. FRCs are mesenchymal-derived (not haematopoietically-derived) cells with properties of muscle and fibroblast (myofibroblasts) that drive formation of secondary lymphoid organs during embryonic development and contribute to the anatomic segregation and movement of lymphocytes and dendritic cells in secondary lymphoid organs. They are not phagocytic, have no direct antimicrobial effector functions, do not secrete IL-2 or other T cell growth factors, and do not line lumens of lymphatics. 10. Which type of cell is most important in capturing protein antigens of microbes that enter through epithelial barriers and presenting them to naive T cells in secondary lymphoid organs? A. Classical dendritic cells B. Plasmacytoid dendritic cells C. Plasma cells D. Macrophages E. Follicular dendritic cells ANS: A. Classical (or conventional) dendritic cells (DCs) are the main cell type that brings microbial antigens from infected tissues into draining lymph nodes and presents peptides derived from these antigens to naive T cells that circulate though the lymph nodes. Plasmacytoid DCs secrete type 1 interferons in response to viral infection. Plasma cells are antibody-secreting cells derived from B cells and do not present antigen to T cells. Macrophages can present antigen to effector T cells, but they are not efficient activators of naive T cells. Follicular dendritic cells display antigens to B cells on lymphoid follicles.

Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition Test Bank Chapter 3: Leukocyte Circulation and Migration Into Tissues Multiple Choice 1. In naive T cell recirculation, entry of the cells into lymph nodes occurs through which specialized vessel? A. Efferent lymphatic B. Thoracic duct

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Test Bank For Cellular and Molecular Immunology, 10th Edition by Abul K. Abbas, Andrew H. Lichtman,

Published on Feb 27, 2026

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Enhance student learning and exam preparation with the Test Bank for Cellular and Molecular Immunology, 10th Edition by Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai (Chapters 1–21). This comprehensive test bank includes multiple-choice, true/false, short answer, and case-based questions covering essential topics such as innate and adaptive immunity, immune cell signaling, antigen recognition, cytokines, immunological disorders, vaccines, and immune response regulation. Designed for instructors and students alike, it enables effective assessment and reinforces practical application of immunology concepts in clinical, research, and academic settings. Perfect for medical, nursing, and biomedical science programs, this test bank strengthens critical thinking, analytical skills, and problem-solving abilities, making it an indispensable tool for teaching and evaluating foundational and advanced immunology knowledge.