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A-level BIOLOGY Paper 1 Thursday 5 June 2025
Afternoon
Time allowed: 2 hours
Materials
For this paper you must have: • a ruler with millimetre measurements • a scientific calculator.
Instructions
• Use black ink or black ball-point pen. • Fill in the boxes at the top of this page. • Answer all questions. • You must answer the questions in the spaces provided. Do not write outside the box around each page or on blank pages. • If you need extra space for your answer(s), use the lined pages at the end of this book. Write the question number against your answer(s). • Show all your working. • Do all rough work in this book. Cross through any work you do not want to be marked.
Information
• The marks for the questions are shown in brackets. • The maximum mark for this paper is 91.
For Examiner’s Use Question 1 2 3 4 5 6 7 8 9 10
TOTAL
Mark
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2 Do not write outside the box
Answer all questions in the spaces provided. 0 1 . 1
The digestion and absorption of lipids involves: • emulsification by bile salts • micelles. Explain each of the following.
[4 marks]
The importance of emulsification in the digestion of lipids
The role of micelles in the absorption of lipids
0 1 . 2
Describe and explain the arrangement of phospholipid molecules in the cell-surface membrane. [2 marks]
6
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3 0 2 . 1
Describe how mRNA is obtained from pre-mRNA.
0 2 . 2
Describe how RNA polymerase joins RNA nucleotides.
Do not write outside the box
[1 mark]
[2 marks]
Question 2 continues on the next page
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4 0 2 . 3
Figure 1 shows the energy contained in molecules during an enzyme-controlled reaction. Figure 1
Which expression represents the activation energy (Ea) of this reaction? Tick () one box.
A–C D–C D–C B D
[1 mark]
Do not write outside the box
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5 0 2 . 4
Do not write outside the box
In 1914, a group of scientists investigated enzyme action. After studying their results, the scientists reached the following conclusions: An enzyme is a substance which causes a reaction to occur at “ordinary” temperatures by being present, but not by its ability to combine with another substance. An enzyme changes the rate of a reaction without itself being changed by that reaction. Our current understanding of enzyme action is based on the induced-fit model. Describe similarities and differences between the conclusions from 1914 and our current understanding of enzyme action. [4 marks] Similarities
Differences
8
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