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Int J Obes 2013;37(1):135-139 Winkler JK, Schultz JH, Woehning A et al. Taq1A polymorphism in dopamine D2 receptor gene complicates weight maintenance in younger obese patients. Effectiveness of a low-calorie weight loss program in moderately and severely obese patients. Buchler, Beat P. Muller-Stich Excessive weight loss after sleeve gastrectomy: a systematic review Obes Surg. 2012 May;22(5):721-31 Impact: 3,7 Lars Fischer, Gabriella Ambrus, Tobias Gehrig, Hannes Kenngott, Kristianna Becker, Thomas Bruckner, Carsten N. Gebhardt C, Riehl A, Durchdewald M, Nemeth J, Furstenberger G, Muller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, Hess J, Angel P. Hammes H-P, Du X, Edelstein D, Taguchi T, Matsumara T, Ju Q, Lin H, Bierhaus A, Nawroth PP, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M: Benfotiamine blocks three major pathways of hyperglycemic damage and prevent experimental diabetic retinopathy. Folgende Studien wurden im Rahmen des Optifast-Programms am Uniklinikum Heidelberg bereits durchgefuhrt. Gender specific temporal and cross-sectional associations between BMI-class and symptoms of depression in the elderly. Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B. Gutt, Markus W. Buchler, Beat Muller-Stich Challenges and pitfalls of experimental bariatric procedures in rats Obesity Facts 2012;5(3):359-371 Impact: 1,2 Lars Fischer, Zeinab Elzein, Thomas Bruckner, Katharina Hunnemeyer, Gottfried Rudofsky, Matthias Reichenberger, Kai Schommer, Carsten N. A novel pathway for inflammatory cell recruitment. J. Exp. Med. 198, 1507-1515, 2003. Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab. 13:389-400, 2011. Kashif M, Hellwig A, Kolleker A, Shahzad K, Wang H, Lang S, Wolter J, Thati M, Vinnikov I, Bierhaus A, Nawroth PP, Isermann B. Friederich, H.C., Schild, S., Wild, B., deZwaan, M., Quenter, A., Herzog, W., Zipfel, S., 2007. Treatment outcome in obese people with subthreshold compared to full syndrome binge eating disorder. Obesity Facts 2013;6(5):469-480 Wallmeier D, Woehning A, Winkler JK et al. Wild B, Herzog W, Wesche D, Niehoff D, Muller B, Hain B. Buchler DiaSurg-Studien: Kann Diabetes mellitus Typ 2 chirurgisch therapiert werden. Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance. Schneider J, Schafer S, Lettgen B, Keiper T, Nawroth P.P, Dugi K. Siblings with hepatosplenomegaly and lipoprotein lipase deficiency. Kenngott, Anna-Laura Wekerle, Lars Fischer, Markus W. Set-shifting ability across the spectrum of eating disorders and in overweight and obesity: A systematic review and metaanalysis. Zhou Z, Immel D, Xi C-X, Bierhaus A, Feng X, Mei L, Nawroth PP, Stern D.M, Xiong W-Ch: Regulation of osteoclast function and bone mass by RAGE. J. Exp. Med. 203, 1067-1080, 2006. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc. Natl. Acad. Sci. USA 110:648-53, 2013. Chirurgische Allgemeine Zeitung 2013 Impact: 0,1 Beat P. Tolllike receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8:487-96, 2007. Isermann B, Vinnikov IA, Madhusudhan T, Herzog S, Kashif M, Blautzik J, Corat MA, Zeier M, Blessing E, Oh J, Gerlitz B, Berg DT, Grinnell BW, Chavakis T, Esmon CT, Weiler H, Bierhaus A, Nawroth PP. Wu M, Brockmeyer T, Hartmann M, Skunde M, Herzog W, Friederich HC. Liliensiek B, Weigand MA, Bierhaus A, Nicklas W, Kasper M, Hofer S, Plachky J, Grone H-J, Kurschus FC, Schmidt A.M, Yan SD, Martin E, Schleicher E, Stern DM, Hammerling G, Nawroth PP, Arnold B: Receptor for advanced glycation end products regulates sepsis but not the adaptive immune response. J. Clin. Invest. 113, 1641-1650, 2004. Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Chavakis T, Bierhaus A, Al-Fakhari N, Schneider D, Witte S, Linn T, Nagashima M, Morser J, Arnold B, Preissner K.T, Nawroth PP: The pattern recognition receptor RAGE is a counterreceptor for leukocyte integrins. Nutrition 2012;28(10):996-1001 Woehning A, Schultz JH, Roeder E et al.
Zhou Z, Immel D, Xi C-X, Bierhaus A, Feng X, Mei L, Nawroth PP, Stern D.M, Xiong W-Ch: Regulation of osteoclast function and bone mass by RAGE. J. Exp. Med. 203, 1067-1080, 2006. Folgende Studien wurden im Rahmen des Optifast-Programms am Uniklinikum Heidelberg bereits
durchgefuhrt. Friederich, H.C., Schild, S., Wild, B., deZwaan, M., Quenter, A., Herzog, W., Zipfel, S., 2007. Treatment outcome in obese people with subthreshold compared to full syndrome binge eating disorder. Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance. Nawroth P, Kasperk Ch: Concerted action of androgens and mechanical strain shifts bone metabolism from high turnover into an osteoanabolic mode. J. Exp. Med. 196, 13871392, 2002. Gender specific temporal and cross-sectional associations between BMI-class and symptoms of depression in the elderly. Buchler, Beat P. Muller-Stich Excessive weight loss after sleeve gastrectomy: a systematic review Obes Surg. 2012 May;22(5):721-31 Impact: 3,7 Lars Fischer, Gabriella Ambrus, Tobias Gehrig, Hannes Kenngott, Kristianna Becker, Thomas Bruckner, Carsten N. Nutrition 2012;28(10):996-1001 Woehning A, Schultz JH, Roeder E et al. Meissburger B, Ukropec J, Roeder E, Beaton N, Geiger M, Teupser D, Civan B, Langhans W, Nawroth PP, Gasperikova D, Rudofsky G, Wolfrum C. Cell 97:889-901, 1999. Nawroth P.P., Haring H.-U.: Thrombomodulin and coronary heart disease (commentary). Kenngott, Anna-Laura Wekerle, Lars Fischer, Markus W. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8:487-96, 2007. Isermann B, Vinnikov IA, Madhusudhan T, Herzog S, Kashif M, Blautzik J, Corat MA, Zeier M, Blessing E, Oh J, Gerlitz B, Berg DT, Grinnell BW, Chavakis T, Esmon CT, Weiler H, Bierhaus A, Nawroth PP. Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B. Rauschenberger K, Scholer K, Sass JO, Sauer S, Djuric Z, Rumig C, Wolf NI, Okun JG, Kolker S, Schwarz H, Fischer C, Grziwa B, Runz H, Numann A, Shafqat N, Kavanagh KL, Hammerling G, Wanders RJ, Shield JP, Wendel U, Stern D, Nawroth P, Hoffmann GF, Bartram CR, Arnold B, Bierhaus A, Oppermann U, Steinbeisser H, Zschocke J. Effectiveness of a low-calorie weight loss program in moderately and severely obese patients. Gebhardt C, Riehl A, Durchdewald M, Nemeth J, Furstenberger G, Muller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, Hess J, Angel P. Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab. 13:389-400, 2011. Kashif M, Hellwig A, Kolleker A, Shahzad K, Wang H, Lang S, Wolter J, Thati M, Vinnikov I, Bierhaus A, Nawroth PP, Isermann B. Psychodedukative Behandlung nach Adipositaschirurgie. Adipositas. 2010 2010;4(3):125-130. Schneider J, Schafer S, Lettgen B, Keiper T, Nawroth P.P, Dugi K. Siblings with hepatosplenomegaly and lipoprotein lipase deficiency. Taq1A polymorphism in dopamine D2 receptor gene complicates weight maintenance in younger obese patients. Wild B, Herzog W, Wesche D, Niehoff D, Muller B, Hain B. Orlova VV, Choi EY, Xie C, Chavakis E, Bierhaus A, Ihanus E, Ballantyne CM, Gahmberg CG, Bianchi ME, Nawroth PP, Chavakis T. Set-shifting ability across the spectrum of eating disorders and in overweight and obesity: A systematic review and metaanalysis. Gutt, Markus W. Buchler, Beat Muller-Stich Challenges and pitfalls of experimental bariatric procedures in rats Obesity Facts 2012;5(3):359-371 Impact: 1,2 Lars Fischer, Zeinab Elzein, Thomas Bruckner, Katharina Hunnemeyer, Gottfried Rudofsky, Matthias Reichenberger, Kai Schommer, Carsten N. Chirurgische Allgemeine Zeitung 2013 Impact: 0,1 Beat P. Chavakis T, Bierhaus A, AlFakhari N, Schneider D, Witte S, Linn T, Nagashima M, Morser J, Arnold B, Preissner K.T, Nawroth PP: The pattern recognition receptor RAGE is a counterreceptor for leukocyte integrins. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc. Natl. Acad. Sci. USA 110:648-53, 2013. A novel pathway for inflammatory cell recruitment. J. Exp. Med. 198, 1507-1515, 2003.
Folgende Studien wurden im Rahmen des Optifast-Programms am Uniklinikum Heidelberg bereits durchgefuhrt. Buchler DiaSurg-Studien: Kann Diabetes mellitus Typ 2 chirurgisch therapiert werden. Kenngott, Anna-Laura Wekerle, Lars Fischer, Markus W. Schneider J, Schafer S, Lettgen B, Keiper T, Nawroth P.P, Dugi K. Siblings with hepatosplenomegaly and lipoprotein lipase deficiency. Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B. Meissburger B, Ukropec J, Roeder E, Beaton N, Geiger M, Teupser D, Civan B, Langhans W, Nawroth PP, Gasperikova D, Rudofsky G, Wolfrum C. Obesity Facts 2013;6(5):469-480 Wallmeier D, Woehning A, Winkler JK et al. Wu M, Brockmeyer T, Hartmann M, Skunde M, Herzog W, Friederich HC. Liliensiek B, Weigand MA, Bierhaus A, Nicklas W, Kasper M, Hofer S, Plachky J, Grone H-J, Kurschus FC, Schmidt A.M, Yan SD, Martin E, Schleicher E, Stern DM, Hammerling G, Nawroth PP, Arnold B: Receptor for advanced glycation end products regulates sepsis but not the adaptive immune response. J. Clin. Invest. 113, 1641-1650, 2004. Buchler, Beat P. Muller-Stich Excessive weight loss after sleeve gastrectomy: a systematic review Obes Surg. 2012 May;22(5):72131 Impact: 3,7 Lars Fischer, Gabriella Ambrus, Tobias Gehrig, Hannes Kenngott, Kristianna Becker, Thomas Bruckner, Carsten N. Friederich, H.C., Schild, S., Wild, B., deZwaan, M., Quenter, A., Herzog, W., Zipfel, S., 2007. Treatment outcome in obese people with subthreshold compared to full syndrome binge eating disorder. Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab. 13:389-400, 2011. Kashif M, Hellwig A, Kolleker A, Shahzad K, Wang H, Lang S, Wolter J, Thati M, Vinnikov I, Bierhaus A, Nawroth PP, Isermann B. Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert P M, Petrov D, Ferstel R, Wendt Th, Rudofsky G, Joswig M, Morcos M, Schwaninger M, McEwing B, Kirschbaum C, Nawroth PP: A mechanism converting psychosocial stress into mononuclear cell activation. Proc. Natl. Acad. Sci. USA 100, 1920-1925, 2003. Gutt, Markus W. Buchler, Beat Muller-Stich Challenges and pitfalls of experimental bariatric procedures in rats Obesity Facts 2012;5(3):359-371 Impact: 1,2 Lars Fischer, Zeinab Elzein, Thomas Bruckner, Katharina Hunnemeyer, Gottfried Rudofsky, Matthias Reichenberger, Kai Schommer, Carsten N. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Effectiveness of a low-calorie weight loss program in moderately and severely obese patients. Set-shifting ability across the spectrum of eating disorders and in overweight and obesity: A systematic review and metaanalysis. Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance. Nawroth P, Kasperk Ch: Concerted action of androgens and mechanical strain shifts bone metabolism from high turnover into an osteoanabolic mode. J. Exp. Med. 196, 1387-1392, 2002. Hammes H-P, Du X, Edelstein D, Taguchi T, Matsumara T, Ju Q, Lin H, Bierhaus A, Nawroth PP, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M: Benfotiamine blocks three major pathways of hyperglycemic damage and prevent experimental diabetic retinopathy. Psychodedukative Behandlung nach Adipositaschirurgie. Adipositas. 2010 2010;4(3):125-130. The A-allele of the common FTO gene variant rs9939609 complicates weight maintenance in severe obese patients. Orlova VV, Choi EY, Xie C, Chavakis E, Bierhaus A, Ihanus E, Ballantyne CM, Gahmberg CG, Bianchi ME, Nawroth PP, Chavakis T. Tolllike receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8:487-96, 2007. Isermann B, Vinnikov IA, Madhusudhan T, Herzog S, Kashif M, Blautzik J, Corat MA, Zeier M, Blessing E, Oh J, Gerlitz B, Berg DT, Grinnell BW, Chavakis T, Esmon CT, Weiler H, Bierhaus A, Nawroth PP. Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Cell 97:889-901, 1999. Nawroth P.P., Haring H.-U.: Thrombomodulin and coronary heart disease (commentary). Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc. Natl. Acad. Sci. USA 110:648-53, 2013. Gebhardt C, Riehl A, Durchdewald M, Nemeth J, Furstenberger G, Muller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, Hess J, Angel P. A novel pathway for inflammatory cell recruitment. J. Exp. Med. 198, 1507-1515, 2003. Chirurgische Allgemeine Zeitung 2013 Impact: 0,1 Beat P.
