Mupirax slides pdf

Mupirax Ointment | Mupirocin 2% • Each gram of Mupirax ointment contains 20 mg mupirocin.

Pharmacodynamics • Mupirax, mupirocin, is a topical antibacterial agent which inhibits bacterial protein synthesis & RNA synthesis by binding to isoleucyl transferRNA synthetase.

• It is mainly active against aerobic isolates of Staphylococcus aureus (including Methicillinresistant & B-Iactamase producing strains). S. epidermidis, S. saprophyticus & Streptococcus pyogenes are susceptible to mupirocin.

• It is also active against gram-negative organisms, such as Escherichia coli & Haemophilus influenzae. Mupirax shows no cross-resistance with other antibiotics.

Pharmacokintics • Mupirax has shown no measurable systemic absorption. • Its penetration into deeper epidermal & dermal layers of the skin is enhanced in traumatised skin & under occlusive dressings.

Indications •

Treatment of primary & secondary superficial skin infections.

• Treatment of various topical bacterial infections. such as impetigo, folliculitis & furunculosis caused

by S. aureus (including Methicillin-resistant Staphylococcus aureus (MRSA), beta-hemolytic streptococcus, S. pyogenes.

• Treatment of burn wound infections caused by MRSA infections.

• Treatment of infected wounds & lacerations.

Side effects • Mupirocin is usually well tolerated but local reactions such as burning, stinging, & itching may occur after its application to the skin.

Contraindications • Hypersensitivity reactions to Mupirax or other ointments containing polyethylene glycols. • Mupirax ointment formulation is not suitable for ophthalmic or intranasal use.

Precautions • When Mupirax ointment is used on the face, avoid contact with the eyes.

• Open wounds: Polyethylene glycol can be absorbed from open wounds & damaged skin & is excreted by the kidney. As with other polyethylene based ointments, it should be used with caution if absorption of large quantities of polyethylene glycol is possible. & especially if there is evidence of moderate or severe renal impairment.

• Pregnancy: It should be used during pregnancy only if clearly needed, as there are no adequate and well-controlled studies in pregnant women.

• Lactation: It is not known whether mupirocin is excreted in human milk. Because many drugs are excreted in human milk. caution should be exercised to a nursing woman.

Drug - drug interactions • The effect of the concurrent application of topical mupirocin ointment and other topical products has not been studied.

• Dosage & adminstration • Adults & children: Mupirax ointment should be applied to the affected area up to three times daily for up to 10 days.

• The area may be covered with a gauze dressing if desired.

Patient’s instractions • Use this medication only as directed by your doctor.

• It is for external use only.

• Avoid contact with the eyes.

• The medication should be stopped & your doctor contacted if irritation, severe itching, or rash occurs.

Presentation • Mupirax ointment is supplied in tubes of 10 g and 30 g each.

• Store at room temperarure.

• Keep out of reach of children.

Mupirax company • GLOBAL NAPI PHARMACEUTICALS • 2nd industrial Zone , 6th of October City· Egypt • www.globolnapi.com