AGEM Research Programs

Based on an inventory of the strengths of the research in gastroenterology, endocrinology and metabolism conducted at the Amsterdam UMC, the following four research programs have been specified. Our aim is to stimulate research in these 4 themes, and also multidisciplinary research that bridges them.

1. Re-generation and neoplasms of the digestive system

The groups embedded in the research program “Re-generation and neoplasms of the digestive system” focus on the postnatal development, repair and carcinogenesis of the digestive tract. The mechanisms regulating gut-development, post-surgical healing, and tumorigenesis, as well as the development of novel treatment strategies are important areas of study.

2. Digestive function and pathology

The research program “Digestive function and pathology” focusses on the function of the human digestive system in health and disease. The main research areas are: (patho)physiology of the digestive tract, including gastrointestinal motility, the role of the microbiome in digestive health and disease, the mechanism of action of therapies of diseases of the digestive system, nutrition, and the development of novel surgical and medical treatment strategies.

3. Endocrinology, metabolism and nutrition

In the research program “Endocrinology, metabolism and nutrition”, the effect of lifestyle, diet and malnutrition on metabolism and hormonal regulation plays a central role. The ultimate aim of this research program is to improve metabolic health of patients with metabolic and endocrine pathologies.

4. Inborn errors of metabolism

Within the research program of “Inborn errors of metabolism” the research groups investigate rare inborn errors of metabolism manifesting from the (pre)neonatal period into adulthood. To unravel the cause of a metabolic derangement in patients suspected of a genetic metabolic disorder and to develop and improve treatment for patients with a genetic metabolic disorder are the main areas of focus in this research program.