Abstracts

A summary of the latest clinical studies

Title: The Role of Hyaluronidase for the Skin Necrosis Caused by Hyaluronic Acid Injection-Induced Embolism Authors: Li J, Xu Y, Wang Y et al. Published: Aesthetic Plastic Surgery, May 2019 Keywords: Complication, Hyaluronidase, Skin necrosis Abstract: This paper investigates the effects of hyaluronidase injection timing on the treatment of skin necrosis. In an in vitro experiment, the carbazole method was used to determine the degradation time of hyaluronic acid gels in a large volume of hyaluronidase. In vivo experimental rabbit ear models were developed to simulate the skin necrosis caused by hyaluronic acid and the test animals distributed into five groups. Except one control group, the other four groups were injected with a large volume of hyaluronidase as treatment at 2h, 4h, 8h and 16h, respectively, after models were built. The necrosis degree of models was analyzed with necrotic area and histologic examination on the postoperative 7th day. Besides, temperatures of rabbit ears were observed to demonstrate the healing process of flap models. The average necrotic area of flaps in the 2-h and 4-h injection groups showed a significant difference compared with that of the control group (p<0.05; p<0.05). The histologic examination showed that there were HA embolisms, vascular thrombolytic recanalization and arteriovenous thromboses in the survival area. In addition, the mean temperatures of the rabbit ear flaps fluctuated over time and showed clear differences between distal and proximal parts. The area of flap necrosis positively correlates with injection timing of the large volume of hyaluronidase. More importantly, when injection timing is within 4h, treatment effectiveness will be significantly improved.

Title: Amniotic fluid-derived mesenchymal stem cell products combined withmicroneedlingfor acne scars Authors: El-Domyati M, Moftah NH, Nasif GA et al. Published: Journal of Cosmetic Dermatology, June 2019 Keywords: Acne scars, Microneedling, Growth factors Abstract: Postacne scars are still a challenge in its management. Microneedling is a popular minimally invasive technique in treatment of such scars. However, the addition of topical stem cell products after microneedling is considered a new treatment regimen for these scars. To compare efficacy of amniotic fluidderived mesenchymal stem cell-conditioned media (AF-MSCCM) and microneedling vs microneedling alone in management of atrophic acne scars. Ten cases with atrophic postacne scars received five sessions of microneedling, with 2-week interval on both sides of the face. Then, AF-MSC-CM was topically applied to right side of the face after microneedling. Clinical examination with histopathological and computerized histometric analysis was done 1month after the sessions. There was significant increase in the improvement percentage of acne scars on right side (dermaroller and AF-MSC-CM) vs left side of face (dermaroller; P<0.001). Histologically, improvement of character of collagen and elastic fibers was noticed, especially on right side. Meanwhile, significant increase in epidermal thickness on both sides of face was detected. Title: A Cross-cultural exploration on the psychological aspects of skin color aesthetics: implications for sun-related behavior Authors: Chen HY, Robinson JK, Jablonski NG Published: Translational Behavioral Medicine, May 2019 Keywords: Body image, Skin colour, Cross-cultural psychology Abstract: This study explores how sociocultural contexts shape attitudes toward skin color and sun-related behaviors in three groups of genetically Chinese women, located on a spectrum from predominantly Chinese culture to predominantly Euro-American culture. Using ethnographic and qualitative comparative approaches, interviews were conducted with (a) 15 Chinese women (Mage = 25; SD = 2.73) who grew up in mainland China until at least age 18 years and then moved to the United States, (b) 15 second-generation Chinese Americans (Mage = 20; SD = 1.16) raised in the United States by Chinese parents, and (c) 18 Chinese adoptees (Mage = 21; SD = 1.13) raised in the United States by Euro-American parents. Overall, Chinese women leaned toward Chinese culture, preferred lighter skin, and engaged in more sun-protection practices. Chinese adoptees leaned toward Euro-American culture, preferred tanned skin and sun-seeking behaviors, and experienced more sunburns. Chinese Americans had mixed results, exemplifying a double-bind in adherence to either Euro-American or Chinese cultural values. Findings elucidate the connections between sun-related behaviors and sociocultural backgrounds, especially how embracing Euro-American culture might increase sun exposure and sunburn tendency. Since sun exposure contributes to health outcomes (e.g., skin cancer, vitamin D status, and bone density), these findings have significant implications for public health prevention efforts.

Title: Topical skin therapies in subjects undergoing full facial rejuvenation Authors: Dayan SH, Bacos JT, Ho TT et al. Published: Journal of Cosmetic Dermatology, June 2019 Keywords: L-ascorbic acid, Trichloroacetic acid, Growth factor Abstract: The aim of this study was to characterize the effect of skincare products in subjects undergoing full facial rejuvenation with abobotulinumtoxinA and hyaluronic acid in improving facial skin appearance, patient satisfaction, and projected first impressions. Twenty subjects were recruited and divided into two treatment groups. Subjects in Group A followed a standard skin care regimen, whereas subjects in Group B received a more robust skin care regimen including chemical peels and antioxidant formulations. All subjects underwent facial rejuvenation treatments with hyaluronic acid at Visit 2 and with abobotulinumtoxinA at Visit 7. Patient aesthetic improvement, satisfaction, self-esteem, and first impression were evaluated via the Fitzpatrick Wrinkle Assessment Scale, Global Aesthetic Improvement Scale, Skin Quality Assessment, Heatherton & Polivy State Self-Esteem Scale, Subject Satisfaction Scale, and the First Impressions Questionnaire. Both treatment groups experienced significant improvements in the Skin Quality Assessment, Fitzpatrick Wrinkle Assessment Scale, Heatherton and Polivy State Self-Esteem Scale, and First Impressions Questionnaire. Larger studies are needed to determine the most efficacious combination of topical skin therapies with facial rejuvenation therapy.