Abstracts

A summary of the latest clinical studies

Title: Use of Liquid Concentrated Growth Factor in the Management of Necrotic Tissue after Facial Vascular Complications Induced by Hyaluronic Acid Injection Authors: Wang X, et al. Published: A Compendium of Clinical Research and Practice, November 2022 Keywords: Complication Management, Facial Tissue Necrosis, HA Filler Abstract: HA fillers may induce facial vascular embolism, resulting in tissue ischemia and necrosis are severe iatrogenic complications. This single-centre case series studied the use of liquid CGF in managing facial tissue necrosis due to HA injections. All 12 patients with facial tissue necrosis (two mild, three moderate, seven severe) were previously treated with hyaluronidase injection in outside hospitals. They received a routine injection of hyaluronidase (dose of 400-1500 U) at the site of ischemia immediately after admission to the authors’ hospital, but CGF was also injected. CGF injection was repeated once weekly until wound healing. Efficacy was assessed at four weeks. No patient experienced wound expansion or aggravation or infection at the sites of necrosis. A complete healing rate of 91.67% was noted at the four-week follow-up. No scarring was evident in patients with mild to moderate necrosis. Those with moderate necrosis exhibited varied degrees of scarring after recovery, and scarring was evident in those with severe necrosis. No severe adverse effects occurred. CGF promoted the healing of ischemic and necrotic tissue wounds induced by facial vascular embolism following injection of HA fillers. CGF should be considered as a non-surgical treatment method for this complication.

Title: Multi-centre Pivotal Study Demonstrates Safety and Efficacy of a New Cellulite Procedure: Final Results at 12 Months Authors: Stevens W, et al. Published: Aesthetic Surgery Journal, November 2022 Keywords: Body, Cellulite, Device Abstract: A single-arm, multi-centre, open-label pivotal study, using CONtrolled Focal Fibrous Band Release Method to assess Targeted Verifiable Subcision (TVS) for the treatment of cellulite. Final, twelve month data describing durability of treatment effect and safety of using a single TVS procedure performed by the Avéli device (Revelle Aesthetics, Inc., Mountain View, CA) to treat cellulite on the buttock and thigh areas of adult females are presented here for the first time. Effectiveness was determined by three independent physicians using the Cellulite Severity Scale (CSS) and Global Aesthetic Improvement Scale to assess improvement of baseline photographs when compared to 3-, 6- and 12-months post-treatment photographs. Blinded participant-reported outcomes and safety evaluations were also performed at all post-procedure time points. Clinically significant improvement in primary endpoint CSS scores were sustained out to one year, improving by 1.50 (p< .0001) at three months, 1.54 points at six months and 1.48 points at 12 months. Adverse events were mild and mostly resolved by the 12 month visit. A single TVS treatment has durable efficacy and safety in reducing cellulite on the buttocks and thighs of women with moderate to severe cellulite out to 12 months post-treatment. Title: Condensing of Low-Density Fat by Mechanical Process Improves Fat Retention and Reduces Oil Cyst Formation in Breast Reconstruction Authors: Quan Y, et al. Published: Aesthetic Plastic Surgery, November 2022 Keywords: Breast Reconstruction, Breast Surgery, Plastic Surgery Abstract: Although autologous fat grafting is a useful adjunct for breast reconstruction, its indications remain limited as largevolume fat grafting results in high absorption and complication rates. Low-density fat includes small numbers of viable cells and considerable oil, resulting in nodules and oil cysts. This study evaluated the volumisation effect and complications with combined fat grafting of condense low-density fat and high-density fat. This retrospective, single-centre study included 25 patients who underwent combined grafting of condensed low-density fat and high-density fat (CLDF + HDF) and 20 patients who underwent conventional Coleman fat grafting for breast reconstruction from December 2017 to January 2022. Graft retention rate was higher in patients who underwent CLDF + HDF than Coleman fat grafting. One patient in the CLDF + HDF grafting group, compared with twelve in the Coleman fat grafting group, developed oil cysts exceeding 1cm. Patient satisfaction rate was higher in the CLDF + HDF grafting group. Mechanical processes can concentrate the cellular content of LDF and remove oil, condensing LDF to the level of HDF. Combined grafting of CLDF and HDF is effective for breast reconstruction, with a higher retention rate and a lower incidence of complications than Coleman fat grafting.

Title: Recent Advances in Herbal-Derived Products with Skin Anti-Ageing Properties and Cosmetic Applications Authors: Costa E, Magalhães W, di Stasi L Published: Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry, November 2022 Keywords: Anti-ageing, Herbal Formulations, Wellness Abstract: Although aesthetic benefits are a desirable effect of the treatment of skin ageing, it is also important in controlling several skin diseases, mainly in aged people. The development of new dermocosmetics has rapidly increased due to consumers’ demand for non-invasive products with low adverse effects. Natural compounds of plant origin and herbal-derived formulations have been popularised due to various safe active designed for treatment of skin ageing. Based on this, the aim of the review was to identify the recent advances in herbal-derived product research, including herbal formulations and isolated compounds with skin anti-ageing properties. The studies evaluated the biological effects of herbal-derived products in vitro, ex vivo and in vivo studies, highlighting the effects that were reported in clinical trials with available pharmacodynamics data that support their protective effects to treat, prevent or control human skin ageing. Thus, it was possible to identify that gallic and ferulic acids and herbal formulations containing Thymus vulgaris, Panax ginseng, Triticum aestivum or Andrographis paniculata are the most promising natural products for the development of new dermocosmetics with skin anti-ageing properties.