Abstracts

A summary of the latest clinical studies

Title: A Study of Combined Microfocused Ultrasound and Hyaluronic Acid Dermal Filler in the Treatment of Enlarged Facial Pores in Asians Authors: Vachiramon V, et al. Published: Journal of Cosmetic Dermatology, November 2021 Keywords: Energy-based device, ultrasound, dermal fillers, rejuvenation Abstract: Microfocused ultrasound with visualization (MFU-V) and low-degree crosslinked hyaluronic acid filler (L-HA) injection has recently become a popular procedure for skin rejuvenation. The effectiveness of the combined MFU-V and L-HA injection in the treatment of enlarged pores has not been evaluated. The objective was to compare the efficacy of MFU-V monotherapy (single technique) and MFU-V combined with L-HA injection (combined technique) for the treatment of enlarged facial pores in Asians through a randomized, single-blinded, split-face study on 46 participants with enlarged facial pores. Each side of the face was randomly assigned to treatment with one session of single technique or combined technique and pore volume was measured by an Antera 3D system. Assessment was evaluated by one-blinded physician using a pore grading score (0-4). Patients rated the improvement in terms of satisfaction using the visual analog scale (VAS, 0-10). Mean pore volume of both sides declined with statistical significance at every visit compared to baseline, with the lowest mean at 4 months post-treatment. The combined technique showed a lower mean pore volume than single technique throughout the follow-ups and there was no significant difference between the two techniques. The patient satisfaction score showed a similar trend to the mean pore volume, with a statistically significant difference at 4- and 6-months post-treatment.

Title: Effects of Topical Retinoids on Acne and Post-inflammatory Hyperpigmentation in Patients with Skin of Color: A Clinical Review and Implications for Practice Authors: Callender V.D, et al. Published: The American Journal of Clinical Dermatology, November 2021 Keywords: Skin of colour, acne, retinoids, hyperpigmentation Abstract: Acne is a common cause for post-inflammatory hyperpigmentation (PIH), particularly in patients with skin of color (SOC), and PIH is often more distressing to patients than the acne itself. Topical retinoids are approved for the treatment of acne and for pigmentation disorders such as melasma or mottled hyperpigmentation associated with photodamage; moreover, they have been shown to reduce hyperpigmentation in patients with SOC. Therefore, treatment with topical retinoids should be started as early as possible unless contraindicated. Use of novel formulations or application of commonly recommended moisturizers may help reduce irritation. Combining retinoids with other topical agents and procedures such as superficial chemical peels can help to improve hyperpigmentation. Primary acne lesions are likely to improve weeks before PIH resolves and helping patients manage their expectations may reduce frustration. Providing clinicians and researchers with more education about the presentation and management of dermatologic conditions in patients with SOC is also recommended. Title: The Potential of Platelet-Rich Plasma Injections and Stem Cell Therapy for Penile Rejuvenation Authors: Israeli J.M, et al. Published: International Journal of Impotence Research, November 2021 Keywords: Impotence, PRP, stem cell therapy, penile rejuvenation Abstract: Penile concerns include erectile dysfunction (ED) and Peyronie disease (PD). Restorative therapies including Stem Cell Therapy (SCT) and Platelet Rich Plasma (PRP) injections are proposed to treat these concerns. SCT encompasses the harvesting and injection of mesenchymal stem cells or stromal vascular fractions from various tissue sources. PRP is derived autologously from a patient’s plasma and is then injected into the penile tissue. These therapies repair damaged penile tissue and promote both new cellular and vascular growth, as demonstrated in basic science studies. Human trials on SCT and PRP for both ED and PD and have yielded promising results with few side effects. While encouraging, small cohort size and lack of blinding or placebo control limit these studies’ external validity. Recently, the first double-blinded randomized controlled trial on PRP for ED was published, providing significant evidence of efficacy. With the rapid commercial availability of SCT and PRP for ED and PD, it is imperative to perform more randomized and placebo-controlled trials with standardized procedures and preparations to evaluate efficacy and safety. This narrative review will summarize the available literature on these penile restorative therapies to date.

Title: A Critical Review of Complications in Non-Surgical Rhinoplasty and Their Management Authors: Babu S.H, et al. Published: Journal of Cosmetic Dermatology, November 2021 Keywords: Non-surgical rhinoplasty, complications, hyaluronic acid, vascular occlusion Abstract: In recent years, there has been a rise in non-surgical rhinoplasty (NSR) due to its minimally invasive approach. As with all procedures, NSR can result in complications. Although rare, the consequences of complications can result in a devastating outcome and therefore an evidence-based approach to enable the recognition and management of NSR complications is required. This paper aims to review and appraise current literature to determine the evidence base for complications experienced with NSR including their causes and management. A systematic review was conducted using a PRISMA methodology. The PubMed and WebofScience databases were queried. Papers relating to the three most used filler materials; hyaluronic acid (HA), calcium hydroxyapatite and collagen were collated. 490 studies were identified in the initial literature search and after applying an inclusion and exclusion criteria, 12 papers were included. The results showed a paucity of high-level evidence which may indicate underreporting of NSR complications. Although treatment is not always effective, early recognition and treatment favors better outcomes with the potential for complete resolution in some cases. Immediate availability of hyaluronidase is important when undertaking NSR with HA as this review showed early use was critical in the management of serious complications such as vascular occlusion.

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