Suf f er i ngFr om
PARKI NSON DI SEASE Par ki nson' sdi seasei sapr ogr essi vebr ai ncondi t i ont hathasani mpactonbot ht he neur ol ogi calsyst em andt hebodi l ypar t st hatar eundert hecont r oloft hener vous syst em. Thebasalgangl i a,ar egi onoft hebr ai nt hatr egul at esmovement ,exper i encesner ve cel li mpai r mentand/ ordeat h,whi ch r esul t si nt he mostnot i ceabl e si gns and sympt omsofPar ki nson' sdi sease.
CAUSESOFPD Thesener vecel l s,orneur ons,nor mal l ygener at et hecr uci albr ai nneur ot r ansmi t t er dopami ne.Movementi ssuesl i nked t ot he condi t i on ar e br oughton bydecr eased dopami nepr oduct i onasar esul toft heneur ons' degener at i onordeat h.Sci ent i st sar e st i l lunsur e ofwhatcauses neur ons t o degener at e.The ner ve t er mi nal s cr eat e nor epi nephr i ne,t hepr i mar ychemi calmessengeroft hesympat het i cner voussyst em, whi chr egul at esnumer ousbodi l yact i vi t i essuchasbl oodpr essur e.
SYMPTOMSOFPD Each per son wi l lexper i ence t he si gns and sympt oms ofPar ki nson' s di sease di f f er ent l y .Ear l ysympt omscoul dbenegl i gi bl eandover l ooked.Evenaf t ersympt oms st ar tt oaf f ectt hel i mbsonbot hsi des,sympt omsf r equent l yst ar tononesi deoft he bodyandusual l ycont i nuet obesever et her e.Ri gi dmuscl es,t r emor s,poorpost ur e andbal ance,al ackofaut omat i cmot i ons,changesi nspeech,di f f i cul t i esswal l owi ng, emot i onaldi st ur bances,andot hersympt omsar epossi bl e.
ARETHEREANYTESTSTO DI AGNOSEPD? Ther e ar e cur r ent l y no bl ood orl abor at or yt est s avai l abl et oi dent i f y Par ki nson' s di seasei nnongenet i ccases.Doct or st ypi cal l ydoaneur ol ogi calexam andobt ai na pat i ent ' smedi calhi st or yt odet er m espi t et hef actt hatt her ei snocur ef orPar ki nson' s di sease,somesympt omscanf r equent l ybemanagedwi t hmedi cat i on,sur ger y ,and ot hert her apy .
HOW CANSTEM CEL LTHERAPYHEL P? Numer ous st udi es have descr i bed how mesenchymalst em cel l s obt ai ned f r om var i ous aut ol ogous sour ces as wel las al l ogenei c sour ces r epr esentexcel l ent candi dat es f ort her apeut i c appl i cat i ons due t ot hei rt r ansdi f f er ent i at i on capaci t y . Al t houghi tmaynotbepossi bl et oconver tal lst em cel l si nt odopami ner gi cneur onsat t hi st i me,some st udi eshave suggest ed t hatadmi ni st er i ng t hese cel l sal ong wi t h exosomesmayhaveaddi t i onal advant ages,suchasant i i nf l ammat or ypr oper t i esand neur opr ot ect i ve act i vi t yst i mul at ed byr esi dentst em cel l sasa r esul tofpar acr i ne ef f ect s.Wi t ht hehel poft heseencour agi ngst udi es,t hepr operquant i t yofst em cel l s i sgi venal ongwi t hexosomesf orsuccessf ulcl i ni calr esul t s.