The book is about the Italian school of architectural and urban design in relation to the phenomenon of urban regeneration, an focuses on the idea of the nature-city, which represents the most original contribution of our research. By reconstructing its educational path from the second half of Twentieth Century, it is developed the thesis aimed at proving how, in the design practice, a new criticality of the relationship with nature could help making clear the specificity of Italian “project culture�. The book, addressed to all the young architects interested in this role of criticality of nature-city, ends with an excursus on the design topics that build visions of nature-city.