What is J-147 powder?

1. What is J-147 powder?

J-147 powder cas: 1146963-51-0 is a potent neuroprotective phenyl hydrazide compound(EC50=60-115 nM) that protects against neurotoxicity in cortical neurons in vitro, it has significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF). it was discovered based upon efficacy in multiple cell culture models of age-associated pathologies rather than exclusively amyloid metabolism. It is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer’s disease (AD) transgenic mice. These effects are associated with an increase in brain derived neurotrophic factor levels, enhanced long-term potentiation, preservation of synaptic proteins, a reduction of markers for oxidative stress and inflammation, a reduction of amyloid plaques, and lower levels of soluble amyloid β.These pleiotrophic effects of a single molecule suggest that J-147 powder has potential for the treatment of AD

Enhanced neurogenic activity over J-147 powder cas: 1146963-51-0 in human neural precursor cells has its derivative called CAD-31. CAD-31 is enhancing the use of free fatty acids for energy production by shifting of the metabolic profile of fatty acids toward the production of ketone bodies, a potent source of energy in the brain when glucose levels are low.The target molecule is a protein called ATP synthase, which is found in the mitochondria.