2021 AALAS National Meeting Final Program by aalasoffice

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CONTENTS

WELCOME

PROGRAM COMMITTEE

Program Chair’s Message President’s Message Committee Meeting and Events Exhibitor Advisory Council Chair’s Message

4 4 6 11

EXHIBITORS & SPONSORS Exhibitors & Sponsors

EDUCATION PROGRAM & MEETING SCHEDULE Program Overview 16 Opening General Session and General Membership Meeting 20 Sunday 22 Monday 28 Tuesday 40 Wednesday 52 Thursday 65 Facilitators 70 Posters 71 District Meeting 77 Foundation Events 78 Exhibitor by Category 79 Exhibitor Profiles 84 Platform Session Abstracts 107

Chair: Rachel R Rubino Vice Chair: Temeri Wilder-Kofie Seminars Chair: Kristin D Evans Vice Chair: Sean C Adams Special Topic Lectures Chair: Karen L Lencioni Vice Chair: Crystal Howard Johnson Panel Discussions Chair: Jennifer S Wood Vice Chair: Sarah Hansen Workshops Chair: Natasha J Melfi Vice Chair: Fakhrid-deen S. Muhammad Facilitators Chair: Heather E Marshall Vice Chair: Verda A Davis Local Arrangements Chair: Julie V Vineyard BOT Liaison, President, ex oficio: Doug Taylor Abstract Review Subcommittee Chair: Tanya L Herzog Platform Session: Maggie Struck Behnke Poster Session: Karuna Patil, James B Finlay, Lauren Habenicht, Sharoll L’Italien, Adam Murphy, Karen Strait, Kristin Weisbrod, Wanda West

EXHIBITOR ADVISORY COUNCIL Chair: Eugene Marino Vice Chair: Perry Spires Warren Ball, Karen Froberg Fejko, William McDonald, Donna Monroe, Rachel Rubino, Joseph Guider Past President: Tracy Parker BOT Liaison: Teresa Woodger

EXECUTIVE DIRECTOR

VIRTUAL MEETING INFO

Ann Turner

Sessions that will be livestreamed for the virtual meeting will be indicated with a microphone icon. Livestreamed content is subject to change. Please check the virtual meeting platform for the latest updates.

ADVERTISER INDEX A-Tune Software Inc 76 Allentown 1, 41 Ancare 51 Animal Specialties and Pro 54 Bio-Serv 35 Cleanspace Technology 38 ClearH2O 19, 31 DiaSys Diagnostic Systems 63 E-Z Systems 69 Envigo 33 Explora BioLabs 23 Fidelis Pharmaceuticals 42/43 Gruenberg TPS 53 Hilltop Lab Animals Inc 83 Kent Scientific Corp 3, 47 Lomir Biomedical Inc 5

Marshall BioResources 55 Medline Industries Inc 57 Mispro Biotech Services BC Northeastern Products Corporation 25 NuAire Inc 68 Plas-Labs Inc 9 PMI LabDiet IFC, 61 Priority One Services Inc 37 Quip Laboratories Inc 39 Robinson Services Incorporated IBC Siemens Industry Inc 67 Sol Del Mar Inc 50 Transnetyx Inc 21 VetEquip Inc 48 Vivarium Operational Excellence Network 64

A A LAS 7 2 ND NATIO NAL MEETI N G

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KANSAS CITY, MISSOURI

EXCITING PROGRAM PLANNED FOR ONSITE AND VIRTUAL ATTENDEES! On behalf of the National Meeting Program Committee (NMPC), I would like to welcome you to Kansas City, Missouri, for our 72nd AALAS National Meeting. We have put together a stimulating and exciting program that we hope you can enjoy and benefit from, whether you made the trip to Kansas City or are attending virtually. As we are just emerging from our pandemic bubbles, this meeting presents a great opportunity to learn from and reconnect with our colleagues. I would like to thank the NMPC, and the Local Arrangements Committee for their time and effort during a difficult year, in putting together a terrific program. I would also like to extend a huge thank you to the AALAS staff for showing tremendous flexibility and innovation in enabling virtual content for this conference but also rolling out the “Ask Me Anything” sessions and vendor “Demo Days” this past year. Finally, a well-deserved thank you to those that submitted topic ideas and abstracts. We had so many great submissions this year. This is a testament to the resolve and commitment of the members of our community to share knowledge and research during a very difficult year. Please enjoy the meeting content that this group has worked hard to put together for you!

Rachel Rubino, DVM 2021 Program Committee Chair

IT IS TIME TO GATHER AGAIN! Dear AALAS Nation, It is with indescribable joy that I welcome you to the 72nd Annual AALAS National Meeting in Kansas City! As you all know, we could not hold the 2020 AALAS National Meeting in person for obvious reasons. Although the virtual meeting was a success, we must admit it was not anything like coming together. So, this year, as we prepare to meet IN PERSON IN KANSAS CITY, one thing occurs to me; that we are meeting is perhaps more important than the meeting itself. Trust me when I say that Dr. Rachel Rubino and her program committee have assembled a stellar program, a product of the excellent content submitted by our membership. You will want to soak in all you can. But, this year, more than any other in recent memory, we need to be together. The long-awaited time to gather with your friends and colleagues once again has come.

Doug Taylor, DVM 2021 AALAS President

A A LAS 7 2 ND NATIO NAL MEETI N G

COMMITTEES & EVENTS

SATURDAY, OCTOBER 16 Exhibit Hall Exhibitor Set-Up 10:00 AM-6:00 PM, CC, Exhibit Hall D First Aid 7:30 AM-6:00 PM, CC, Bridge walkway between Hall D & 3501 Meeting Rooms Mothers Room 2:00 PM-6:00 PM, CC, Lobby 2300 (under escalators to exhibit hall) Registration 2:00 PM-6:00 PM, CC, Lobby 2300

COMMITTEE MEETINGS 2021 AALAS Board of Trustees Annual Business Meeting 2:00 PM-6:00 PM, Loews, Mermaid A AALAS Executive Committee Meeting (2021/2022 Members) 9:00 AM-1:00 PM, Loews, Mermaid B AALAS Executive Committee Meeting (2021/2022 Members) 9:00 AM-11:00 AM, Loews, Muse B

AFFILIATE EVENTS Allied Trade Association (ATA) Board Meeting 3:00 PM-5:00 PM, CC, 2207 LAMA Board Meeting 11:00 AM-5:00 PM, Loews, Leadership

Emergent Leadership Forum Luncheon (Invitation only; RSVP required) 12:00 PM-1:00 PM, Loews, Neptune Ballroom C Facilitators Meeting 3:00 PM-3:30 PM, CC, 2202 Facility Directors-Yale University 8:30 AM-1:00 PM, Loews, Neptune Ballroom E National Meeting Orientation (first time attendees, new members, international attendees) 2:00 PM-3:00 PM, CC, 2504A Technical Trade Presentations - Track I - Innovative Solutions in Animal Welfare 1:00 PM-4:00 PM, CC, 2503A Technical Trade Presentations - Track II - Is Your Facility State-ofthe-Art? 1:00 PM-4:00 PM, CC, 2505A Tecniplast Welcome Breakfast 9:00 AM-1:00 PM, CC, 2215C

COMMITTEE MEETINGS AALAS Foundation Board of Directors 1:00 PM-4:00 PM, Loews, Muse B Educational Resources Committee 10:00 AM-12:00 PM, CC, 2207 Nominations Committee 10:00 AM-11:30 AM, CC, 2209 Scientific Advisory Committee 3:30 PM-4:30 PM, CC, 2207 Program Committee Walk Thru 4:00 PM-5:00 PM, CC, meet at Registration

AFFILIATE EVENTS ACLAM Board of Directors 7:30 AM-4:00 PM, Loews, Mermaid A ACLAM Exam Committee 1:00 PM-3:00 PM, Loews, Muse A

Mothers Room 7:30 AM-7:00 PM, CC, Lobby 2300 (under escalators to exhibit hall)

ACLAM Foundation Committee 11:00 AM-1:00 PM, Loews, Northland

Poster Sessions set-up by presenting author 2:00 PM-5:00 PM, CC, Inside Exhibit Hall

ACLAM GRAC 2:00 PM-5:00 PM, Loews, Northland

Registration 7:30 AM-7:00 PM, CC, Lobby 2300

ACLAM Publications Committee 9:00 AM-12:00 PM, Loews, Muse A

Speaker Ready Room 12:00 PM-5:00 PM, CC, 2214

ACLAM Training Program Directors 2:00 PM-4:00 PM, Loews, Bacchus

SPECIAL EVENTS

Allied Trade Association (ATA) Membership Meeting/Breakfast (Invitation only; RSVP required) 8:30 AM-10:30 AM, CC, 3501 E

Opening General Session / General Membership Meeting 5:00 PM-6:00 PM, CC, Grand Ballroom Welcome Reception 6:00 PM-7:30 PM, Loews, TBD

ASLAP Board of Directors Meeting 12:00 PM-3:00 PM, Loews, Mermaid B

MEETINGS & EVENTS

ASLAP General Membership Meeting 4:00 PM-5:00 PM, CC, 2205

AALAS Foundation Silent Auction & "Swing into Science" Contest 9:00 AM-5:00 PM, Virtual Only, Virtual Only

Association of Gnotobiotics Meeting 3:30 PM-5:00 PM, CC, 2203

District 8 Council 2:00 PM-5:00 PM, CC, 2210

Camp ACLAM 8:00 AM-4:00 PM, Loews, Pomona

Emergent Leadership Forum (Invitation only; RSVP required) 7:30 AM-4:30 PM, Loews, Neptune Ballroom B

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MONDAY, OCTOBER 18

ACLAM Forum Program Committee 10:00 AM-12:00 PM, Loews, Muse B

Career Center 8:00 AM-5:00 PM, CC, 2211

ACLAM IT Management Committee 8:00 AM-12:00 PM, Loews, Northland

Exhibit Hall 8:30 AM-5:00 PM, CC, Exhibit Hall D Exhibit Hall (opening ceremony w/ribbon cutting 8:30 a.m.) 8:30 AM-5:00 PM, CC, Exhibit Hall D Entrance First Aid 7:30 AM-6:15 PM, CC, Bridge walkway between Hall D & 3501 Meeting Rooms Mothers Room 7:30 AM-5:00 PM, CC, Lobby 2300 (under escalators to exhibit hall) Poster Sessions 8:30 AM-5:00 PM, CC, Inside Exhibit Hall Poster Sessions set-up by presenting author 7:30 AM-8:30 AM, CC, Inside Exhibit Hall Registration 7:30 AM-5:00 PM, CC, Lobby 2300 Speaker Ready Room 7:30 AM-4:00 PM, CC, 2214

MEETINGS & EVENTS AALAS Foundation Silent Auction & "Swing into Science" Contest 8:00 AM-5:00 PM, Virtual Only, Virtual Only District 1 Membership Meeting 5:15 PM-6:15 PM, CC, 2504A District 2 Membership Meeting 5:15 PM-6:15 PM, CC, 2202 District 3 Membership Meeting 5:15 PM-6:15 PM, CC, 2205 District 4 Membership Meeting 5:15 PM-6:15 PM, CC, 2203 District 5 Membership Meeting 5:15 PM-6:15 PM, CC, 2204 District 6 Membership Meeting 5:15 PM-6:15 PM, CC, 2503A District 7 Membership Meeting 5:15 PM-6:15 PM, CC, 3501G District 8 Membership Meeting 5:15 PM-6:15 PM, CC, 3501A Government Relations Network Meeting 3:00 PM-4:00 PM, CC, 2209 Technician Lunch & Learn Sponsored in part by PMI Lab Diet 12:30 PM-2:00 PM, CC, 3501 E

COMMITTEE MEETINGS Certification & Registry Board 2:00 PM-4:00 PM, CC, 2208

ACLAM Mentoring Committee 3:00 PM-5:00 PM, Loews, Northland ACLAM Outreach Committee 3:00 PM-5:00 PM, Loews, Muse A ACLAM TBD 3:00 PM-5:00 PM, Loews, Muse B ACLAM Training Program Oversight Committee 3:00 PM-5:00 PM, Loews, Leadership Americans for Medical Progress (AMP) Meet Up 10:00 AM-11:00 AM, CC, 2208 ASLAP Animal Welfare Committee 4:00 PM-5:00 PM, Loews, Neptune B ASLAP LARC Meeting 5:00 PM-6:00 PM, Loews, Mermaid B ASLAP Networking 12:00 PM-2:00 PM, CC, 2215B ACLAM Meeting 2:00 PM-4:00 PM, Loews, Neptune Ballroom C LAWTE General Membership Meeting 3:00 PM-5:00 PM, CC, 2204

TUESDAY, OCTOBER 19 Career Center 8:00 AM-5:00 PM, CC, 2211 Exhibit Hall 9:00 AM-5:00 PM, CC, Exhibit Hall D First Aid 7:30 AM-5:00 PM, CC, Bridge walkway between Hall D & 3501 Meeting Rooms Mothers Room 7:30 AM-5:00 PM, CC, Lobby 2300 (under escalators to exhibit hall) Poster Sessions 9:00 AM-5:00 PM, CC, Inside Exhibit Hall Registration 7:30 AM-5:00 PM, CC, Lobby 2300 Speaker Ready Room 7:30 AM-4:00 PM, CC, 2214

MEETINGS & EVENTS AALAS Foundation Silent Auction & "Swing into Science" Contest 8:00 AM-5:00 PM, Virtual Only, Virtual Only Branch Leadership Meeting 4:00 PM-5:00 PM, CC, 2205

Editorial Staff Meeting 3:00 PM-5:00 PM, CC, 2207

ILAR Town Hall: Introduction of the Standing Committee on Care and Use of Animals in Research - sponsored by AALAS 2:00 PM-3:30 PM, CC, 2501B

AFFILIATE EVENTS

Lab Animal Breeders Meeting 8:00 AM-9:00 AM, Loews, Muse A

ACLAM COC Committee 8:00 AM-10:30 AM, Loews, Muse A ACLAM Committee Chair Orientation Meeting 10:00 AM-12:00 PM, Loews, Sea Horse

COMMITTEES & EVENTS

AAL AS 72 N D N AT I ON AL MEETI N G

Past President's Luncheon 12:00 PM-2:00 PM, Loews, Sea Horse

COMMITTEES & EVENTS 8

Poster Sessions Reception w/poster award winners announced at 2:30pm 2:00 PM-4:00 PM, CC, Inside Exhibit Hall VAVMO & VMU Supervisors Business Meeting/Luncheon 12:00 PM-2:00 PM, Loews, Neptune Ballroom B

COMMITTEE MEETINGS Abstract Review Subcommittee 12:00 PM-1:30 PM, CC, 2208 Editorial Review Board Meeting 7:30 AM-8:30 AM, CC, 2207 Government Relations Committee 10:00 AM-11:00 AM, CC, 2209 ILAM Committee 2:00 PM-5:00 PM, CC, 2208 LAS Pro Editorial Advisory Board 3:00 PM-5:00 PM, CC, 2207

AFFILIATE EVENTS ACLAM General Business Meeting 5:00 PM-7:00 PM, Loews, Neptune Ballroom E ACLAM New Diplomate Orientation 9:00 AM-11:00 AM, Loews, Neptune Ballroom D

WEDNESDAY, OCTOBER 20 Career Center 8:00 AM-5:00 PM, CC, 2211

MEETINGS & EVENTS AALAS Affiliates Roundtable Conference Breakfast (Invitation only; RSVP required) 7:30 AM-9:30 AM, Loews, Sea Horse AALAS Foundation Live Auction (Virtual Only) & Appreciation Reception sponsored by Charles River 6:30 PM-8:30 PM, Loews, TBD AALAS Foundation Silent Auction 8:00 AM-11:00 AM, Virtual Only, Virtual Only AALAS Foundation Silent Auction (Auction ends at 1pm) 8:00 AM-1:00 PM, Virtual Only, Virtual Only President's Reception (Invitation only; RSPV required) 5:30 PM-6:30 PM, Loews, City Beautiful Ballroom E RBL/NBL Animal Care Meeting 4:00 PM-6:00 PM, CC, 2208

COMMITTEE MEETINGS Exhibitor Advisory Council 3:30 PM-5:00 PM, CC, 2209

AFFILIATE EVENTS ACLAM TBD 1:30 PM-4:00 PM, Loews, Muse B ACLAM/ASLAP Program Committee 8:00 AM-12:00 PM, Loews, Muse B ASLAP Foundation Meeting 12:00 PM-2:00 PM, Loews, Mermaid A

Exhibit Hall 9:00 AM-1:00 PM, CC, Exhibit Hall D

THURSDAY, OCTOBER 21

Exhibit Hall Exhibitor Dismantle 1:00 PM-10:00 PM, CC, Exhibit Hall D

Career Center 8:00 AM-2:00 PM, CC, 2211

First Aid 7:30 AM-10:00 PM, CC, Bridge walkway between Hall D & 3501 Meeting Rooms

First Aid 7:30 AM-5:00 PM, CC, Bridge walkway between Hall D & 3501 Meeting Rooms

Mothers Room 7:30 AM-5:00 PM, CC, Lobby 2300 (under escalators to exhibit hall)

Mothers Room 7:30 AM-2:00 PM, CC, Lobby 2300 (under escalators to exhibit hall)

Poster Sessions 9:00 AM-1:00 PM, CC, Inside Exhibit Hall

Registration 7:30 AM-12:00 PM, CC, Lobby 2300

Poster Sessions - dismantle 1:00 PM-3:00 PM, CC, Inside Exhibit Hall

Speaker Ready Room 7:30 AM-1:00 PM, CC, 2214

Registration 7:30 AM-5:00 PM, CC, Lobby 2300

COMMITTEE MEETINGS

Speaker Ready Room 7:30 AM-4:00 PM, CC, 2214

2021/2022 AALAS Program Committee 2:15 PM-5:00 PM, Loews, Neptune Ballroom D

A A LAS 7 2 ND NATIO NAL MEETI N G

OPER

VIV

A A LAS 7 2 ND NATIO NAL MEETI N G

1010

PROGRAM SPONSORS IU

“I’m going to Kansas City, Kansas City, here I come!” The spirit expressed in this classic rock ’n roll song pretty much speaks for all of us who are planning the trip this year to the 72nd AALAS National Meeting. As the Chair of the Exhibitor Advisory Council and from all of us at AALAS, we are glad to extend a warm welcome. Without any further discussion about the challenging business and social climates we’ve all experienced over the past many months, we look ahead with excitement to our in-person annual meeting, the largest gathering of professionals concerned with the use of laboratory animals and commercial partners that support the lab animal science community. As in years past, thanks go to those who work behind the scenes of this important gathering who have been busy throughout the interim making sure this year’s meeting reflects the best of those of us who will meet to teach, learn and share our expertise and experiences with the lab animal community. Attendees will be encouraged to take full advantage of the event by attending the many informative talks and presentations curated by the respective AALAS councils, view the hundreds of posters, and by joining the workshops led by the leading professionals in their fields. Check these pages to plan your schedule. In our role to serve both commercial and professional partners, AALAS is once again proud to present two tracks of Technical Trade Presentations on Sunday, October 17: “Innovative Solutions in Animal Welfare” and “Is Your Facility State-ofthe-Art” This valuable forum is where exhibitor members will highlight products and services that provide innovations and benefits to the workplace environments and challenges regularly faced by new and veteran attendees. Be sure to review the topics covered and make your plans early to attend these informative presentations. Especially this year, many attendees are looking forward to visiting their friends, colleagues, and suppliers to learn about new products and solutions. For two and a half days, the exhibit hall at Kansas City will the ideal venue for this important networking and is sure to have something for all. There are a number of new exhibitors joining for the first time in addition to the mainstay commercial partners we have come to rely on to exhibit their latest advancements under one roof. You won’t want to miss the Ribbon Cutting Ceremony at 8:30 a.m. in the main exhibit hall. On behalf of the EAC Council, AALAS, and all of our 1,300 plus commercial members of the lab animal science community, welcome to Kansas City and the 72nd AALAS National Meeting! “Kansas City, here we come!”

Eugene Marino III Chair, Exhibitor Advisory Council

PROGRAM SPONSORS

WELCOME TO KANSAS CITY AND THE 72ND AALAS NATIONAL MEETING!

DON’T MISS THE AALAS NATIONAL MEETING EXHIBIT HALL! Approximately 180 companies and organizations will exhibit at the AALAS National Meeting in 2021. Exhibitors interact with people from the academic community, research institutions, government organizations, and commercial companies. Visit the Exhibitors section of nationalmeeting.aalas.org for a prospectus, a list of previous exhibitors, sponsorship opportunities, and other information.

RIBBON CUTTING CEREMONY COMMERCIAL COMPANY BOOTHS AFFILIATE BOOTHS

Monday, October 18, 8:30 a.m.

Visit with our affiliate members and check out their public outreach and educational materials.

CHARGING STATIONS

Located in the Exhibit Hall and the Registration Lobby (sponsored by TBD)

Learn about the latest products and services offered by vendors in the field.

REFRESHMENT BREAKS

Monday: 8:30 a.m. – 10:30 a.m. (sponsored by NEPCO) 1:00 p.m. – 3:00 p.m. (sponsored by Bio-Serv) Tuesday: 9:00 a.m. – 11:00 a.m. 1:00 p.m. – 3:00 p.m. (sponsored by Bio-Serv) Wednesday: 9:00 a.m. – 11:00 a.m.

POSTER SESSIONS

Come view this year’s poster sessions, and don’t miss the Poster Reception on Tuesday from 2:00 p.m. – 4:00 p.m. Meet the authors, enjoy some refreshments, and see who won this year’s Poster Awards.

(Located in the Exhibit Hall Lounge)

EXHIBIT HALL HOURS

Monday, October 18: 8:30 a.m. – 5:00 p.m. Tuesday, October 19: 9:00 a.m. – 5:00 p.m. Wednesday, October 20: 9:00 a.m. – 1:00 p.m.

Denotes an AALAS Premium Commercial Member

EXHIBITORS & SPONSORS

Access Technologies Advanced Ovine Solutions

Allentown

Silver Level Sponsor Notebook Sponsor Alpha Genesis Inc.

Alternative Design Manufacturing & Supply Inc Bronze Level Sponsor ALZET® Osmotic Pumps/DURECT Corp. American Protective Products LLC Ancare Corp. Andersen Sterilizers Animal Care Systems, Inc Animal Identification & Marking Systems, Inc. Animal Welfare Institute Aquaneering Inc. Arcoplast, Inc. Art’s Way Scientific

A-Tune Software Inc

Silver Level Sponsor Avante Scientific Avid Identification Systems Avidity Science LLC Baker BASi Research Products Beta Star Life Science Equipment BetterBuilt bioBUBBLE, Inc. BioInfoRx, Inc.

Bio-Serv

Refreshment Break Sponsor Gold Level Sponsor Biotrans LLC BioVolume Bootie Butler | TEAM Technologies BSI - Brain & Software International Braintree Scientific, Inc. Britz & Co. Carter 2 Systems, Inc. Cayuse Charles River Clark & Enersen

Cleanspace Respirators Virtual Meeting Platform Silver Level Sponsor

ClearH2O

Gold Level Sponsor ClorDiSys Solutions, Inc Colonial Medical Supply Co., Inc. CURIS System Danio Lab/SoBoDash

DiaSys Diagnostic Systems, USA, LLC NM Aisle Signs in Exhibit Hall Silver Level Sponsor Drexel University- MLAS Dustcontrol, Inc. Eastern Virginia Medical School EBV/Expo Bioterios Ecolab Elm Hill Labs

Envigo

Virtual Meeting Platform Silver Level Sponsor Esco Technologies, Inc

Explora BioLabs

NM Ink Pens Silver Level Sponsor E-Z Systems/Euthanex Corp. FiberCore, LLC

Fidelis Pharmaceuticals

Wifi Sponsor President’s Level Sponsor Fine Science Tools GemPharmatech GenoTyping Center of America

Getinge

Bronze Level Sponsor Girton Manufacturing Co Inc Gruenberg - TPS Heartland Vivarium

Hilltop Lab Animals, Inc

Bronze Level Sponsor Notebook Sponsor

1212

A A LAS 7 2 ND NATIO NAL MEETI N G

HotDog Patient Warming IDEXX BioAnalytics iMedRIS Data Corporation InfoEd Global Innovive Instech Laboratories, Inc. InterMetro Intuitive Biosciences IPS-Integrated Project Services, LLC Iwaki Aquatic JANVIER LABS Jurox Inc KARL STORZ Veterinary Endoscopy America Inc.

Kent Scientific Corporation

Virtual Meeting Platform Silver Level Sponsor Lab Products Inc Lab Supply Inc. LABEX of MA Lane Industries Co., LLC Lenderking Caging Products LGL Animal Care Products, Inc. Life Science Products, Inc. Lighthouse Life Science Partners, LLC Lithgow Laboratory Services

Lomir Biomedical Inc

President’s Level Sponsor MAI Animal Health Marshall BioResources

Medline Industries, Inc.

Virtual Meeting Platform Silver Level Sponsor MedTech International Group

Mispro Biotech Services Tote Bag Sponsor NM Aisle Signs in Exhibit Hall Gold Level Sponsor Mosaic Vivarium Mouse Specifics, Inc. New England Ovis

NuAire

Silver Level Sponsor Oak Hill Genetics, LLC Pharmacal Research Laboratories, Inc.

Transnetyx President’s Level Sponsor

PMI LabDiet

Turner Scientific Tuttnauer USA Unified Information Devices Verona Safety Supply

Technician Lunch & Learn Sponsor Neck Cord Sponsor President’s Level Sponsor Virtual Meeting Platform Precigen Exemplar PreLabs Premier BioSource (formerly S&S Farms) Progressive Recovery, Inc.

Quip Laboratories

Hand Sanitizer Station Sponsor Gold Level Sponsor Rad Source Technologies RapID Lab Red Plank Software Research Diets, Inc. Res-Tek, Inc. RICA Surgical Products, Inc. Ridglan Animal Care Systems Ridglan Farms Robinson Services Incorporated Rochester Midland Corporation RockStep Solutions RSM-Equipment SAI Infusion Technologies SARSTEDT Scientific Plastics Company, Inc. Shepherd Specialty Papers Shoe Cover Magic Sika Resinous Floor & Wall Systems Sinclair Bio Resources, LLC

Smartlabs

VetEquip, Inc

Tote Bag Sponsor Silver Level Sponsor Visron Design, Inc. VRL Laboratory WF Fisher & Son Wedgewood Pharmacy Worldwide Primates, Inc. XpressBio Xybion Zeigler Bros., Inc Zoologix

NON-EXHIBITING SPONSORS

Animal Specialties and Provisions LLC Tote Bag Sponsor Silver Level Sponsor

Bristol-Myers Squibb President’s Level Sponsor

Merck Gold Level Sponsor

Northeastern Products Corporation (NEPCO) Refreshment Break Sponsor Silver Level Sponsor

Silver Level Sponsor

Pfizer Global Research & Development

SMC-Roe SoftMouse.NET Sound Imaging (Antech) Spire Integrated Solutions SteraMist by TOMI Sterile Science STERIS Life Sciences Stoelting Co Studylog Animal Study Workflow Software Suburban Surgical Co Systems Engineering (SE Lab Group) Tecniplast The Andersons Lab Bedding Products Thoren Caging Systems Inc

AREA Program Sponsor

Priority One Services Inc Silver Level Sponsor

Siemens Industry Inc Virtual Meeting Platform Silver Level Sponsor

AFFILIATE EXHIBITORS AAALAC International American College of Lab Animal Medicine (ACLAM)

American Society of Laboratory Animal Practitioners (ASLAP) Association of Primate Veterinarians (APV) CALAS/ACSAL (Canadian Association of Laboratory Animal Science) Foundation for Biomedical Research (FBR) Institute for Laboratory Animal Research (ILAR) International Council for Laboratory Animal Science (ICLAS) International Society for Transgenic Technologies (ISTT) Laboratory Animal Management Association (LAMA) Laboratory Animal Welfare Training Exchange (LAWTE) National Association for Biomedical Research (NABR) North American 3Rs Collaborative (NA3RsC) Scientists Center for Animal Welfare (SCAW) Society for Laboratory Animal Veterinary Technicians (SLAVT) Thai Association for Laboratory Animal Science (TALAS)

Vivarium Operational Excellence Network Inc. Tote Bag Sponsor Silver Level Sponsor

TECH FUN FAIR PARTICIPANTS AAALAC International Americans for Medical Progress Animal Care Systems, Inc Animal Welfare Institute Aquaneering Inc. a-tune software, Inc. BASi Research Products Beta Star Life Science Equipment BioInfoRx, Inc. Bio-Serv ClearH2O ClorDiSys Solutions, Inc Danio Lab/SoBoLifeScience DiaSys Diagnostic Systems, USA, LLC Drexel University- MLAS Ecolab Elm Hill Labs Envigo Explora BioLabs Fidelis Pharmaceuticals Fine Science Tools Foundation for Biomedical Research GemPharmatech GenoTyping Center of America

EXHIBITORS & SPONSORS

P. J. Murphy Forest Products Corp. PLAS-LABS

EXHIBITORS & SPONSORS 1414

Getinge HotDog Patient Warming IDEXX BioAnalytics Kent Scientific Corporation LabDiet LABEX of MA Laboratory Animal Management Association Lomir Biomedical Inc Marshall BioResources Mouse Specifics North American 3Rs Collaborative (NA3RsC) NuAire Oak Hill Genetics, LLC Progressive Recovery, Inc. Quip Laboratories Res-Tek, Inc. SAI Infusion Technologies SARSTEDT Scientists Center for Animal Welfare Shepherd Specialty Papers Sinclair Bio Resources, LLC SoftMouse.NET SteraMist by TOMI Sterile Science Studylog Animal Study Workflow Software Tecniplast Transnetyx Unified Information Devices Vivarium Operational Excellence Network Inc. XpressBio

2021 AALAS FOUNDATION AUCTION DONORS Corporate Auction Donors AbbVie Abbvie ACT Ancare Animal Specialties & Provisions Arizona State University - Dept. of Animal Care & Technologies AstraZeneca Bristol-Myers Squibb Carter 2 Systems Drexel University - MLAS GenoTyping Center of America Getinge LABEX of MA Marshall BioResources Oregon National Primate Research Center Quip Laboratories Quip Laboratories Sanitation Strategies Terrestrial Animal Care Services / University of Oregon University of Maryland/College Park

University of South Alabama University of Texas Health Science Center at Houston (UT Health) University of TN Health Science Center University of TN Health Science Center East Campus Wake Forest School of Medicine Yerkes Field Stationi / Animal Care Yerkes Field Station / Vet Staff

Branch Auction Donors Kansas City Branch Louisiana Branch New England Branch New Jersey Branch Research Triangle Branch Sacramento Valley Branch Southeastern Branch Texas Branch Washington Branch

Individual Auction Donors Juliet Bade Curtis Black Laura Breidenbach Madeline Burke Vicki Campbell Silvia Cortez Juliane Daggett-Vondras Brian Ebert Amanda Evans Sarah Gilliam Donna Goldsteen Audrey Harris Lindsay Holmes Julie Kent Nicole La Mattina Valeri Lansford Morag Mackay Kristin Matthews Colleen McCoy Brittney McDonald Tracy Parker Amy Pierce Molly Romick Pat Sikes Emily Slocum Rachelle Stammen Erin Straley Terri Swanson Amy Weger Heather Zimmerman

A A LAS 7 2 ND NATIO NAL MEETI N G

2021

AALAS AWARD WINNERS William J. White, VMD, MS, DACLAM, DECLAM Consultant

Nathan R. Brewer Lifetime Achievement Award

Dr. White is currently a consultant in lab animal medicine and biosecurity and was the Corporate Vice President at Charles River where he headed global biosecurity and professional services activities. He serves on the International Air Transport Association’s (IATA) Live Animals and Perishables Board’s animal care team. Prior to joining Charles River, he was on the Comparative Medicine faculty at the Milton S. Hershey Medical Center where he conducted basic research in numerous areas including the effects of environment on laboratory animals. He was a member of the 1996 Guide committee and was president of ACLAM and IACLAM.

Betty R. Theriault, DVM, DACLAM

Director, Gnotobiotic Research Animal Facility Professor, Department of Surgery Clinical Veterinarian, Animal Resources Center The University of Chicago

Pravin N. Bhatt Scientific Investigator Award

Neil S. Lipman, VMD

Executive Director and Professor Memorial Sloan Kettering Cancer Center Weill Cornell Medicine

Charles River Prize

Neil Lipman is the Executive Director, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine (WCM); Professor of Veterinary Medicine in Pathology and Laboratory Medicine, WCM; and, Laboratory Member, Sloan-Kettering Institute, MSK. A graduate of the University of Pennsylvania’s School of Veterinary Medicine, Dr. Lipman completed postdoctoral training at MIT. An ACLAM Diplomate, he has held professional and faculty appointments at MIT, Brown University, Tufts University, and the University of Chicago, served as an AAALAC ad hoc Consultant and on the committee to update the Guide (8th Edition), and has been actively engaged in research, vivarium design and operations, and training of laboratory animal specialists throughout his career.

Dondrae Coble, DVM, DACLAM, CertAqV Director and Attending Veterinarian Abigail Wexner Research Institute at Nationwide Children’s Hospital

George R. Collins Education and Training Award

Dr. Coble graduated from Tuskegee University School of Veterinary Medicine prior to completing a rotating small animal medicine and surgery internship. He worked as an emergency veterinarian before pursuing residency training at Emory University and Yerkes National Primate Research Center. He became a Diplomate in the American College of Laboratory Animal Medicine and began employment at The Ohio State University with a dual appointment in University Laboratory Animal Resources and the Department of Veterinary Preventive Medicine. He is currently the Director of the Animal Resources Core and Attending Veterinarian of the Abigail Wexner Research Institute at Nationwide Children’s Hospital.

Thomas Meier, DVM, MBA, DACLAM Chair, Department of Comparative Medicine Mayo Clinic

Joseph J. Garvey Management Award

Dr. Meier is the Chair of the Department of Comparative Medicine and the Attending Veterinarian for Mayo Clinic. He completed his veterinary training at the University of Minnesota. He is a diplomat of the American College of Laboratory Animal Medicine and an Assistant Professor of Comparative Medicine in the Mayo Clinic College of Medicine. His professional responsibilities include membership on the Institutional Animal Care and Use Committee for Mayo Clinic as well as leading Mayo’s animal husbandry/veterinary care department. Dr. Meier’s passions centers around leveraging technology to improve processes, outcomes, and safety in the animal care program.

Robin M. Miller, AAS, RLATG Senior Laboratory Technician WuXi AppTec

Technician of the Year Award

Robin Miller is a Senior Laboratory Technician at WuXi AppTec. Robin has 30 years of experience in the research industry, including former employment at Medtronic. She has provided service in both the animal husbandry and research areas. She has been heavily involved in the local branch of Minnesota AALAS, including positions as president and secretary. She has served on various committees at the local and national levels. Robin’s passion for research and unending devotion to animal welfare and care can be observed in her drive to educate and promote learning opportunities at WuXi AppTec and her involvement with AALAS.

For livestream session information please review the education section of this program on pages 22-68.

PROGRAM OVERVIEW

SUNDAY

Why You Need a Real-time Data Solution in 2021: Gennifer Caesar. Room: 2503A. 2:40 PM–3:00 PM (TTP)

Pilot Survey Results on Diversity and Inclusion within AALAS: Janet Lynn Steele. Room: 2504A. 12:30 PM–2:00 PM (P)

Afternoon Track I – Innovative Solutions in Animal Welfare

Taking the Guesswork Our of Cleaning and Disinfection: Morgan Holmes. Room: 2503A. 3:00 PM–3:20 PM (TTP)

The Veterinary Consortium for Research Animal Care and Welfare and Stakeholders Discuss Progress and Areas of Interest for the Guide Revision: John J Hasenau. Room: 2503A. 12:30 PM–2:00 PM (P)

OCTOBER 17

Feed Safety in the 21st Century: An Overview of Feed Safety Programs Used in Laboratory Animal Feed Production: Laura N Tracey. Room: 2505A. 1:00 PM–1:20 PM (TTP) Solutions to Improve Animal Study Reproducibility: Brad Nemer. Room: 2505A. 1:20 PM–1:40 PM (TTP) A Novel System for Continuous, Undisturbed, and Remote Monitoring of Digital Biomarkers Temperature and Activity - in Group-housed Mice: Jose R Gadea. Room: 2505A. 1:40 PM–2:00 PM (TTP) Reducing Stress in Animals and Researchers: Integrating Catheter Access Buttons into an Automated Blood Collection System: Candace A Rohde-Johnson. Room: 2505A. 2:00 PM–2:20 PM (TTP) New Developments in Percutaneous Catheter Access Buttons for Small and Large Animal Research: Merryl Cramer. Room: 2505A. 2:20 PM–2:40 PM (TTP) Achieving Greater Repeatability in the Measurement and Analysis of Subcutaneous Tumors by Using a 3D and Thermal Imaging Platform: Jason Steed. Room: 2505A. 2:40 PM–3:00 PM (TTP) Working With Isoflurane Anesthesia: Is It Safe for Me and My Animals?: Eugene Marino. Room: 2505A. 3:00 PM–3:20 PM (TTP) The Value of Documenting Your Animal Care and Husbandry Data with an Integrated Management Software: Eric Y Rieux. Room: 2505A. 3:20 PM–3:40 PM (TTP) What’s in a Cage Card? Maximizing Productivity With Coded Cage Cards: Anne M Gath. Room: 2505A. 3:40 PM–4:00 PM (TTP) Cannibalism and Other Challenges in Rodent Breeding Colonies: Tips and Solutions to Improve Performance: TBD. Room: 2505A. 4:00 PM–4:20 PM (TTP)

Track II – Is Your Facility State-of-Art? Program Planning for Animal Facility Construction and Renovation: Andrew G Stepp. Room: 2503A. 1:00 PM–1:20 PM (TTP) From Isolators to Vivariums: Cutting Edge HHP Decontamination Technology for Various Spaces in Laboratory Animal Facilities: Frances M Grinstead. Room: 2503A. 1:20 PM–1:40 PM (TTP) Designing a UV-C Disinfection Pass-through Room: Emily Lorcheim. Room: 2503A. 1:40 PM–2:00 PM (TTP) New Generation Dry Heat Sterilizers: Robert C Davis. Room: 2503A. 2:00 PM–2:20 PM (TTP) Integrating Your Animal Welfare Program: Lindsay Andrews. Room: 2503A. 2:20 PM–2:40 PM (TTP)

Importance of Continuous Monitoring of Extrinsic Environmental Conditions in the Research Lab Animal Environment: Jeremy G Turner. Room: 2503A. 3:20 PM–3:40 PM (TTP) Disaster Planning? Automation Has You Covered: Andrew Arvanites. Room: 2503A. 3:40 PM–4:00 PM (TTP)

MONDAY OCTOBER 18 Morning

W-01 A Guide to Implementing Evidenced-based Medicine in Laboratory Animal Medicine: Zachary T Freeman. Room: 2202. 8:00 AM–12:00 PM (W) W-02A Microsurgery Skills Training Using Surgical Loupes (A): Robert F Hoyt. Room: 2201. 8:00 AM–12:00 PM W) Mammals and Microbial Communities: What We’ve Learned from Animal Models: Robert P Marini. Room: 2501B. 8:00 AM–10:15 AM (S) Research Animal Transportation: How Do I Get My Animals from Here to There?: Karen L. Rogers. Room: 2501C. 8:00 AM–10:15 AM (S) Switching to Environmental Health Monitoring for Rodents: How, Why, and Will It Cost More?: Megan R LaFollette. Room: 2501A. 8:00 AM–10:15 AM (S) Husbandry/Management. Room: 2505A. 8:00 AM–10:15 AM (PS) Pathology Quiz Bowl: Marcia L Hart. Room: 3501A. 8:30 AM–10:00 AM (P) 2021 Update Regarding Changes at ILAR: Robert C Dysko. Room: 3501A. 11:00 AM–12:00 PM (STL) Charles C Hunter Lecture: Aerobic Capacity, Energy Metabolism, and Risk for Metabolic Disease: John P Thyfault. Room: 2501B. 11:00 AM–12:00 PM (STL) From Rabbits to Rodents: Current and Practical Analgesic Techniques for Laboratory Animals: Rebecca A Johnson. Room: 2501A. 11:00 AM–12:00 PM (STL) History of Animal Research in Pandemic Responses: Jacqueline K Brockhurst. Room: 2501C. 11:00 AM–12:00 PM (STL)

MONDAY Afternoon Animal Research: Time to Talk!: Kirk Leech. Room: 3501G. 12:30 PM–2:00 PM (P) Mouse Anesthesia Is Really an Art More than Science: Cholawat Pacharinsak. Room: 3501H. 12:30 PM–2:00 PM (P)

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W-02B Microsurgery Skills Training Using Surgical Loupes (B): Robert F Hoyt. Room: 2201. 1:00 PM–5:00 PM (W) W-03 Teaching Monkeys to Cooperate with Restraint: Using Positive Reinforcement Training and Temperament Testing Methods: Jaine E Perlman. Room: 2202. 1:00 PM–5:00 PM (W) What’s Your Diagnosis?. Room: 2505A. 2:15 PM–5:15 PM (PS) COVID-19 Animal Models: Of Mice, Other Species, and Men: Jason S Villano. Room: 2501B. 2:45 PM–5:00 PM (S) Ongoing Changes within Animal Research Oversight Environment: B Taylor Bennett. Room: 2501A. 2:45 PM–5:00 PM (S) Optimization of Husbandry and Study Outcomes during a Pandemic Using Automated Housing Systems: John J Hasenau. Room: 2501C. 2:45 PM–5:00 PM (S) Updates on Emerging Infectious Agents: Neil S Lipman. Room: 3501A. 2:45 PM–5:00 PM (S)

TUESDAY OCTOBER 19 Morning

W-03 cont Teaching Monkeys to Cooperate with Restraint: Using Positive Reinforcement Training and Temperament Testing Methods Continue: Jaine E Perlman. Room: 2202. 8:00 AM–12:00 PM (W) W-04 Would You Like to Improve Your Suturing and Rodent Surgery Aseptic Technique?: Marcel I Perret-Gentil. Room: 2204. 8:00 AM–12:00 PM (W) ASAP: Assessment and Surveillance of Adverse Phenotypes in Genetically Engineered Models (GEMs): Jeffrey J Lohmiller. Room: 2501B. 8:00 AM–10:15 AM (S) Cultivating a Culture of Employee Recognition: Denise M Molk. Room: 2501C. 8:00 AM–10:15 AM (S) Digging Deep: The Science and Care of Naked Mole Rats: Vera Gorbunova. Room: 2501A. 8:00 AM–10:15 AM (S) Insights, Challenges, and Outcomes When Producing, Maintaining, and Evaluating Severely Immunodeficient Mouse Models: Robert S Livingston. Room: 3501A. 8:00 AM–10:15 AM (S) Laboratory Investigations 1. Room: 2505. 8:00 AM–10:30 AM (PS) Charles River Ethics and Animal Welfare Lecture: Optimizing the Care Pathway: A Global Approach to Perioperative Care: Daniel SJ Pang. Room: 2501B. 11:00 AM–12:00 PM (STL)

Compassion Fatigue and Job Burnout in the Animal Research Field: Heather N Hersh. Room: 2501A. 11:00 AM–12:00 PM (STL)

Gnotobiotic Rodent Facility Management: Novel and Traditional: Alexander RodriguezPalacios. Room: 2501C. 8:00 AM–10:15 AM (S)

Once in a Century Event: Lessons Learned from the 2021 Texas Snowstorms: Stacy L Pritt. Room: 2501A. 2:45 PM–5:00 PM (S)

Naturally Occurring Large Animal Models of Neurodegenerative Diseases and Gene Therapy: George J DeMarco. Room: 3501A. 11:00 AM–12:00 PM (STL)

Problem Solving 101: Breaking Roadblocks to Success for Miniature Swine Users: Derek Brocksmith. Room: 2501A. 8:00 AM–10:15 AM (S)

Practical Application of the 3Rs: Megan R LaFollette. Room: 3501A. 2:45 PM–5:00 PM (S)

Wallace P. Rowe Lecture: The Microbiome and Animal Models of Disease, Progressing Beyond Correlations: Betty R Theriault. Room: 2501C. 11:00 AM–12:00 PM (STL)

TUESDAY Afternoon Advancing the IACUC Mission through Metrics: Stacy L Pritt. Room: 2504A. 12:30 PM–2:00 PM (P) Promoting Animal Welfare through Improvements in Nonhuman Primate Housing Designs: Part II: John J Hasenau. Room: 3501G. 12:30 PM–2:00 PM (P) The New 3Rs: Reduce, Reuse, and Recycle— Going Green in the Vivarium: Jeffrey D Wyatt. Room: 3501H. 12:30 PM–2:00 PM (P) U.S. Openness Initiative: Where Are We and Where Do We Go from Here?: Paula A Clifford. Room: 2503A. 12:30 PM–2:00 PM (P) W-05 Anesthetic Monitoring 101: Cholawat Pacharinsak. Room: 2203. 1:00 PM–5:00 PM (W) W-06 Animal Facility, Design, Processes, Decisions, and Technology: Mark A Corey. Room: 2202. 1:00 PM–5:00 PM (W) Resident Laboratory Investigations 1. Room: 2505A. 2:15 PM–5:00 PM (PS) COVID-19 and One Health in Zoos: Keeping Animals, Staff, and the Public Healthy during a Pandemic: Kirk Suedmeyer. Room: 3501A. 2:45 PM–5:00 PM (S) Shake It, You Won’t Break It! Rodent Health Monitoring Using Media Agitated with Soiled Bedding: Robert S Livingston. Room: 2501A. 2:45 PM–5:00 PM (S) When All Your Plans Go Up in Smoke: The 2020 Oregon Wildfires: Jennifer L Sargent. Room: 2501C. 2:45 PM–5:00 PM (S)

WEDNESDAY OCTOBER 20 Morning

W-07 Developing a Sustainable Program to Promote Compassion Resiliency and Prevent Fatigue: Sally Thompson-Iritani. Room: 2205. 8:00 AM–12:00 PM (W) W-08 Publish with LAS Pro: Elizabeth Rozanski. Room: 2204. 8:00 AM–12:00 PM (W) Coronaviruses: Troubling Crown of the Animal Kingdom: Nancy Hitt. Room: 2501B. 8:00 AM–10:15 AM (S)

The Extrinsic Factors in Facilities: Hidden Impacts on Animals and Science: Jeremy G Turner. Room: 3501A. 8:00 AM–10:15 AM (S) Clinical. Room: 2502A 8:00 AM–10:45 AM (PS) Resident Laboratory Investigations 2. Room: 2505A. 8:00 AM–10:45 AM (PS) Indexing a Drug for Minor Species: The Injectable Anesthetic Alfaxalone as a Case Example: Kirby Pasloske. Room: 3501A. 11:00 AM–12:00 PM (STL) Nathan E Brewer Lecture: Assumptions and Certainty: William J White. Room: 2501B. 11:00 AM–12:00 PM (STL) Perspective on the Future of Animal Research: Edwin S Kreitlein. Room: 2501C. 11:00 AM–12:00 PM (STL) Responsibility of the IACUC for Ensuring Reproducibility, Scientific Rigor, and Transparency: Lauren M Danridge. Room: 2501A. 11:00 AM–12:00 PM (STL)

WEDNESDAY Afternoon

Stressed and Burned Out? Learn How to Create a Wellness Program by Laboratory Animal Technicians for Laboratory Animal Professionals: Raphael A Malbrue. Room: 2501B. 2:45 PM–5:00 PM (S)

THURSDAY OCTOBER 21 Morning

W-11 Developing a Cost Accounting System for Your Animal Facility: David G Baker. Room: 2202. 8:00 AM–12:00 PM (W) Electronic Medical Records and Advance Data Reporting for Laboratory Animal Medicine: Zachary T Freeman. Room: 2501B. 8:00 AM–10:15 AM (S) Refining Mouse Handling: Why and How to Use Non-aversive Handling to Picking Up Mice: Megan R LaFollette. Room: 2501C. 8:00 AM–10:15 AM (S) Laboratory Investigations 3: Room: 2505A. 8:00 AM–10:45 AM (PS) The Biggest Threat to the Future of Biomedical Research: Cindy A Buckmaster. Room: 2501A. 11:00 AM–12:00 PM (STL)

A Candid Conversation about Racial Justice in Laboratory Animal Science: Sharron M Kirchain. Room: 2503A. 12:30 PM–2:00 PM (P)

The National Bio and Agro-Defense Facility: Maximum Biocontainment in Manhattan, KS: Ken R Burton. Room: 2501B. 11:00 AM–12:00 PM (STL)

Efficient Management of Controlled Substances in the Lab Animal Research Facility Using Paper and Automated Systems: Matthew Ruiter. Room: 2504A. 12:30 PM–2:00 PM (P)

What Operational Excellence Looks Like in a High Stakes Environment: Sharron M Kirchain. Room: 2501C. 11:00 AM–12:00 PM (STL)

Not All Individually Ventilated Caging Systems Are Created Equal: Scott E Perkins. Room: 3501H. 12:30 PM–2:00 PM (P) Working with Emotional Labor: An Interactive Discussion: Annabella J Williams. Room: 3501G. 12:30 PM–2:00 PM (P) W-09 Impacting the Outcome: Novel Leadership/Management Approaches Using Core Values for Today’s Vivaria: Clifford R Roberts. Room: 2205. 1:00 PM–5:00 PM (W) W-10 Occupational Health and Safety Considerations in Animal Research: Learning through Interactive Case Studies: Lesley A Colby. Room: 2204. 1:00 PM–5:00 PM (W) Animal Welfare. Room 2505A. 2:15–5:00 PM (PS) Laboratory Investigations 2. Room: 2502A. 2:15 PM–5:00 PM (PS)

PROGRAM OVERVIEW

For livestream session information please review the education section of this program on pages 22-68.

THURSDAY Afternoon Document Mindfulness: Best Practices for Creating Clearer, Better Animal Health Documents to Maximize Welfare and Minimize Misuse: Paula A Clifford. Room: 2503A. 12:30 PM–2:00 PM (P) Challenging the Status Quo for Nonhuman Primate Enrichment: Dawn M Abney. Room: 3501H. 12:30 PM–2:00 PM (P) CUSP: An Institutional Level Approach to Addressing Administrative Burden: Scott D Bury. Room: 3501G. 12:30 PM–2:00 PM (P) Installing Robotics in an Established Facility? How to Roll with the Punches and Come Out with the Improvements you Intended: Scott L Benzler. Room: 2504A. 12:30 PM–2:00 PM (P)

Bench to Bedside: Optimizing the Translational Relevance of Preclinical Animal Modeling: William P Feeney. Room: 2501C. 2:45 PM–5:00 PM (S)

Animal Welfare, Regulatory Compliance, and Public Education

Biomedical Research, Medicine, and Methodology

Facility Design, Management

Livestream

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A A LAS 7 2 ND NATIO NAL MEETI N G

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OPENING GENERAL SESSION/ GENERAL MEMBERSHIP MEETING Kansas City Convention Center | Sunday, October 17, 2021 5:00-6:00 PM | Kansas City Convention Center, Grand Ballroom • Welcome from AALAS President, Doug Taylor • AALAS Awards presentations • Recognition of guests and Board of Trustees members • Gavel ceremony introducing the new president

• Introduction of new trustees • Incoming president, Marc Hulin’s address • Welcome Reception from 6:00-7:30 PM, Loews Hotel, City Beautiful Ballroom B

Welcome Reception, Loews Hotel, Location to Be Determined, Sunday, October 17, 2021 District membership meetings will be held on Monday, October 18 at 5:15 PM. See the mobile app for room numbers.

WIN $200 Drawings will be held during the General Membership Meeting. Must be present to win. Badges must be printed by 5:00 p.m. on Sunday to be entered into the drawing.

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SUNDAY AFTERNOON

SUNDAY, OCTOBER 17 Career Center 8:00 AM-5:00 PM, CC, 2211 Exhibit Hall Exhibitor Set-Up 7:30 AM-7:00 PM, CC, Exhibit Hall D First Aid 7:30 AM-8:00 PM, CC, Bridge walkway between Hall D & 3501 Meeting Rooms Mothers Room 7:30 AM-7:00 PM, CC, Lobby 2300 (under escelators to exhibit hall) Poster Sessions set-up by presenting author 2:00 PM-5:00 PM, CC, Inside Exhibit Hall Registration 7:30 AM-7:00 PM, CC, Lobby 2300 Speaker Ready Room 12:00 PM-5:00 PM, CC, 2214

SPECIAL EVENTS

Opening General Session / General Membership Meeting 5:00 PM-6:00 PM, CC, Grand Ballroom Welcome Reception 6:00 PM-7:30 PM, Loews, TBD

MEETINGS & EVENTS

AALAS Foundation Silent Auction & “Swing into Science” Contest 9:00 AM-5:00 PM, Virtual Only, Virtual Only District 8 Council 2:00 PM-5:00 PM, CC, 2210 Emergent Leadership Forum (Invitation only; RSVP required) 7:30 AM-4:30 PM, Loews, Neptune Ballroom B Emergent Leadership Forum Luncheon (Invitation only; RSVP required) 12:00 PM-1:00 PM, Loews, Neptune Ballroom C Facilitators Meeting 3:00 PM-3:30 PM, CC, 2202 Facility Directors-Yale University 8:30 AM-1:00 PM, Loews, Neptune Ballroom E National Meeting Orientation (first time attendees, new members, international attendees) 2:00 PM-3:00 PM, CC, 2504A Technical Trade Presentations - Track I - Innovative Solutions in Animal Welfare 1:00 PM-4:00 PM, CC, 2503A Technical Trade Presentations - Track II - Is Your Facility State-of-theArt? 1:00 PM-4:00 PM, CC, 2505A Tecniplast Welcome Breakfast 9:00 AM-1:00 PM, CC, 2215C

COMMITTEE MEETINGS

AALAS Foundation Board of Directors 1:00 PM-4:00 PM, Loews, Muse B Educational Resources Committee 10:00 AM-12:00 PM, CC, 2207 Nominations Committee 10:00 AM-11:30 AM, CC, 2209 Scientific Advisory Committee 3:30 PM-4:30 PM, CC, 2207 Program Committee Walk Thru 4:00 PM-5:00 PM, CC, meet at Registration

AFFILIATE EVENTS

ACLAM Board of Directors 7:30 AM-4:00 PM, Loews, Mermaid A

ACLAM Exam Committee 1:00 PM-3:00 PM, Loews, Muse A

TECHNICAL TRADE PRESENTATIONS TRACK I – INNOVATIVE SOLUTIONS IN ANIMAL WELFARE Feed Safety in the 21st Century: An Overview of Feed Safety Programs Used in Laboratory Animal Feed Production 1:00 PM - 1:20 PM/ Room: 2505A Speaker/Moderator: Laura N Tracey

Safe manufacturing practices are of the utmost importance to laboratory animal feed manufacturers, from choosing and receiving ingredients to packaging finished products and preparing for shipment to facilities. This talk will briefly summarize the different programs followed to ensure only the highest quality of feed is provided. It will include information about corporate guided systems as well as scrutinous external, third-party certification programs implemented. Of particular focus will be Food Safety System Certification 22000 (FSSC 22000), an elite third-party certification held by a select few feed manufacturers globally. Information provided will inform attendees, including facility managers, veterinarians, and researchers, of important feed safety measures they should expect from their feed manufacturing company to ensure their most important assets, the animals and research, are never compromised. This Technical Trade Presentation is sponsored in part by PMI Nutrition International (LabDiet).

Solutions to Improve Animal Study Reproducibility 1:20 PM - 1:40 PM/ Room: 2505A Speaker: Brad Nemer Moderator: Nathan Fahrenthold

A 2012 study published by Amgen researchers found that 90% of the in vivo oncology studies were not reproducible. Historically, 95% of post-phase III oncology clinical trial therapies failed to receive regulatory approval due to a lack of demonstrated efficacy, not toxicity. The lack of reproducible data underscores the need to examine current animal study conduct processes for potential improvement areas. In today’s competitive climate, researchers must identify poor animal study reproducibility causes and implement meaningful and effective solutions. Recently, questions and debates concerning the validity of preclinical science data have resulted in multiple published reviews. Cost-effective technology exists to mitigate this crisis of animal study irreproducibility. Studylog’s presentation covers the factors contributing to poor animal study reproducibility and publicly available and online resources and practically applicable concepts, such as the ARRIVE guidelines, PHISPS protocols, and the N3R Design Assistant. Attendees receive first-hand experiences with various animal study conduct approaches and commercially available animal study workflow software applications, along with a summary of each tool’s direct and indirect impacts on the causes of animal study irreproducibility. Attendees will explore the Studylog Animal Study Workflow Software in the context of solving problems, improving animal study reproducibility, and faithfully preserving detailed study results for future access. Researchers will leave the presentation with an understanding of the factors contributing to animal study reproducibility failures and the application of the latest public, online tools to mitigate reproducibility issues. Scientists attending this presentation will experience what animal study workflow software is like and how it can help solve many

A A LAS 7 2 ND NATIO NAL MEETI N G

study reproducibility concerns while easily standardizing processes of detailed study design planning and study conduct. This Technical Trade Presentation is sponsored in part by Studylog Systems, Inc.

A Novel System for Continuous, Undisturbed, and Remote Monitoring of Digital Biomarkers Temperature and Activity - in Group-housed Mice 1:40 PM - 2:00 PM/ Room: 2505A Speaker: Jose Gadea Moderator: Matthew Ruiter

Animal temperature, activity, and behavior are essential parameters to assess in biomedical research when evaluating the efficacy of pharmacological agents and for monitoring animal welfare. Current systems designed for evaluating activity and behavior in mice usually involve removing the animals from their home-cage and placing them into novel environments. Here they undergo a series of tests, which are often conducted for short periods of time, under social isolation and during their sleep phase. Furthermore, common methods for recording animal temperature require the use of intrusive devices (i.e., rectal probes) that require frequent animal handling, which also alter animal behavior. These methodologies often introduce unwanted levels of animal stress, which can interfere with study outcomes. Therefore, there is a need for a system that allows for automated monitoring of individual mice housed within their social environment to remove researcher bias and animal disruption during experimentation. The UID Mouse Matrix was developed to address the chal-

OCTOBER 17, 2 0 2 1

lenges researchers currently face when evaluating temperature and activity in socially housed and undisturbed mice. This presentation will describe a novel RFID-enabled system that allows continuous and remote monitoring of digital biomarkers, such as locomotor activity and temperature, for one or multiple mice in their home-cage environment. Participants will learn how this system can be used to automatically monitor key digital biomarkers from group-housed mice and collect data in real-time (24/7), even in the dark phase when animals are most active, and evaluation would not be feasible with current methods. In addition to removing experimenter bias, the system has the potential to improve study outcomes by enabling frequent and accurate measurement of progressive behavioral and physiological changes in the same animal. The target audience includes research directors, lab facility managers, animal care program directors and supervisors, veterinarians, IACUC members, research personnel, and lab animal technicians. This Technical Trade Presentation is sponsored in part by UID Identification Solutions.

Reducing Stress in Animals and Researchers: Integrating Catheter Access Buttons into an Automated Blood Collection System 2:00 PM - 2:20 PM/ Room: 2505A Speaker: Candace A Rohde-Johnson Moderator: Shelly Carballo

Catheter access ports and buttons have become the preferred way to access catheters in rodents as well as some larger species. The

SUNDAY AFTERNOON

SUN DAY

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Animal Welfare, Regulatory Compliance, and Public Education

Biomedical Research, Medicine, and Methodology

Facility Design, Management

Livestream

SUNDAY AFTERNOON

ACLAM Foundation Committee 11:00 AM-1:00 PM, Loews, Northland ACLAM GRAC 2:00 PM-5:00 PM, Loews, Northland ACLAM Publications Committee 9:00 AM-12:00 PM, Loews, Muse A ACLAM Training Program Directors 2:00 PM-4:00 PM, Loews, Bacchus Allied Trade Association (ATA) Membership Meeting/Breakfast (Invitation only; RSVP required) 8:30 AM-10:30 AM, CC, 3501 E ASLAP Board of Directors Meeting 12:00 PM-3:00 PM, Loews, Mermaid B ASLAP General Membership Meeting 4:00 PM-5:00 PM, CC, 2205 Association of Gnotobiotics Meeting 3:30 PM-5:00 PM, CC, 2203 Camp ACLAM 8:00 AM-4:00 PM, Loews, Pomona

acceptance of this technology is due to several factors, including improved animal welfare, prolonged catheter patency, and ease of use for researchers. However, there are some limitations to the technology, such as restrictions to the study design due to a dependence on liquid swivels, and the fact that incorporating buttons into the protocol still requires humans to be present to collect samples. A commercially available automated sampling system that addresses these issues already exists. By combining the two technologies, it is possible to create a flexible study that takes advantage of both the buttons/ports and the low-stress sampling system. In this system, movement responsive caging takes the place of a liquid swivel. The animal tether can be easily changed to accommodate the button, a collar, or a harness all while increasing the number of fluid lines that can be connected. In addition, the system makes it possible to collect programmed blood samples anytime of the day or night. This means that researchers do not have to handle the animal or even be present during the collection periods, resulting in increased laboratory efficiency, better study data from low-stress animals, and the ability to run studies while staying socially distanced. Recent updates to the automated sampling system make it easier than ever to integrate with the port and button technology. This Technical Trade Presentation is sponsored in part by BASi Research Products.

New Developments in Percutaneous Catheter Access Buttons for Small and Large Animal Research 2:20 PM - 2:40 PM/ Room: 2505A Speaker: Merryl Cramer Moderator: Kelly Gregrow

In recent years, buttons have become a preferred method to access catheters for infusion and sampling in rodents. Buttons consist of a rigid housing protecting the externalization site of the catheter anchored by a fiber ingrowth disk. Access is gained by piercing a self-sealing silicone septum minimizing animal interference while creating clean, easy access to the intended site. The use of buttons with protective metal caps in rats and mice has improved animal welfare by permitting group housing and, in many cases, has extended catheter

patency. In large animal models, the more common approach is to use a Vascular Access Port (VAP) or an externalized catheter. The externalized catheter can be difficult to keep protected and clean, especially for long-term studies. VAPs require the use of a non-coring needle to pierce the skin at each access. Using a needle increases the risk of needle-stick incidents and can increase the likelihood that the animal will become sensitized or “needle-shy.” New catheter access button technology makes it possible to easily access the catheter without the risk of catheter disconnects or needle-stick accidents. New technology has been developed using this platform, improving animal welfare while making studies safer for both animals and researchers alike. In this presentation, we will share the updated technology, discuss the benefits and limitations of using this updated technology in both large and small animals, and share details on integrating these new products into a variety of research protocols. This session will be most beneficial for researchers performing awake animal studies, which require dosing and sampling, focusing on large animal species. The data will also be relevant to any animal researchers who are struggling with catheter patency issues. This Technical Trade Presentation is sponsored in part by SAI Infusion Technologies.

Achieving Greater Repeatability in the Measurement and Analysis of Subcutaneous Tumors by Using a 3D and Thermal Imaging Platform 2:40 PM - 3:00 PM/ Room: 2505A Speaker: Jason Steed Moderator: Karl Turley

We will discuss that using a 3D and thermal scanning system improves study reproducibility, through greater data traceability, reduced operator variability, and greater measurement accuracy. This Technical Trade Presentation is sponsored in part by Fuel3D BioVolume.

Working With Isoflurane Anesthesia: Is It Safe for Me and My Animals? 3:00 PM - 3:20 PM/ Room: 2505A Speaker: Eugene Marino Moderator: Perry L Spires

Isoflurane was developed as a safer alternative to the use of flammable ethers for anesthesia in the early days of surgery and was approved for medical use in the United States in 1979. Since then, it has become the ubiquitous agent for inhalant anesthesia in veterinary and laboratory research surgeries. But what about the safety of isoflurane not just for the animal subjects, but those who work around it on a regular basis and experience waste anesthesia gas exposure? What are the hazards and short and long-term effects to both personnel and animals from exposure? A quick look at available data and even the lab animal resource protocols of research centers show there is not even a consistent description of its isoflurane, much less empirical evidence of its risks. While we do have recommended maximum exposure limits from NIOSH, what exactly do, and don’t we know about safely working in an environment where isoflurane is in regular use? Our talk will outline what known and suspected risks are faced, what measures we can take to protect ourselves, and what methods and equipment are appropriate and safest to use. This presentation will be of interest to all laboratory and animal welfare personnel who perform surgeries or do other research work that requires the use of isoflurane anesthesia. This Technical Trade Presentation is sponsored in part by Kent Scientific Corporation.

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The Value of Documenting Your Animal Care and Husbandry Data with an Integrated Management Software 3:20 PM - 3:40 PM/ Room: 2505A Speaker: Eric Y Rieux Moderator: Mathew D Sanderson

When is the last time cages were changed? When is room ABC123 due for cleaning? How many cases of diarrhea has this NHP had in the last 2 years? Did we change diets on those dogs last week? How many matings did we start this week? How many mice are remaining on Dr. Jane’s protocol? How many males weighing between 2.8Kg and 3.3Kg and have not been in a study for 2 weeks are available right now? Are my rats recovering well from the surgical preparation? Where was that group of animals housed, and with which other animals were they in contact? Why did my control group unexpectedly react, was anything else going on in the vivarium? How many questions of this type do you get or ask yourself? How quickly can you answer so the best-informed decisions are made? This presentation will focus on the value and power of seemingly simple vivarium data that can easily be collected, stored, and mined as lab animal technicians go about their daily tasks. In this presentation, you will learn how collecting data while being animal-side is getting ever easier thanks to automation and connectivity of devices and software; how reporting and extracting meaningful data lead to increased animal welfare, better science, and more effective management decisions. The target audience for this presentation includes technicians, veterinary care staff, facility managers, and researchers.

OCTOBER 17, 2 0 2 1

What's in a Cage Card? Maximizing Productivity with Coded Cage Cards 3:40 PM - 4:00 PM/ Room: 2505A Speaker: Anne M Gath Moderator: Amanda M Coldwell, Jennifer L Hoard

This talk will discuss the advantages of coded cage cards for managing animal colony data. A robust colony management system can allow facility staff and researchers to access a wealth of information connected to a cage card. A cage card can be connected to protocol, breeding history, animal history, cage locations and history, billing, medical records, and much more. Learn how you can save time on cage counts and easily manage protocol counts and monthly billing with automated, real-time information connected directly to your cage cards. Allowing permission-based access to research staff also reduces the time spent on updating cage and animal information, managing cage counts, and tracking protocols. This Technical Trade Presentation is sponsored in part by BioInfoRx, Inc.

Cannibalism and Other Challenges in Rodent Breeding Colonies: Tips and Solutions to Improve Performance 4:00 PM - 4:20 PM/ Room: 2505A Speaker: Jay Palmer Moderator: William T Thomas

In laboratory rodent breeding colonies, pup mortality is one of This Technical Trade Presentation is sponsored in part by Brain & the most important challenges reported. The loss of pups due to ai16293037319_NEPCO_inhousead.pdf 1 8/18/2021 11:22:12 AM Software International (BSI). cannibalism is a common issue—so common, in fact, that it is often

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Animal Welfare, Regulatory Compliance, and Public Education

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overlooked or accepted as normal. However, it is indicative of reduced wellbeing and is an underestimated welfare issue in laboratory mouse breeding. Successful breeding is a critical part of providing animals for research, and cannibalism should be considered a serious problem in the lab animal vivarium. Indeed, reduced breeding performance leads to increased costs due to increased technician time and cage numbers. Cannibalism and pup mortality can even cause the complete loss of precious transgenic lines. This inefficient production violates the principles of the 3Rs, which define the refinement of research to enhance the welfare of animals and improve the quality of science. In this presentation, directed towards animal caretakers, students, postdocs, investigators, and veterinarians of all levels, we will review the causes and consequences of cannibalism and pup mortality and outline environmental and nutritional solutions to maximize the breeding performance of your rodent colonies. Our presenter has over 10 years of experience working with mice during her PhD and Post-doc. She coordinated contract mouse breeding services for researchers as a Breeding Project Manager at The Jackson Laboratory and is the author of many blog articles on breeding support. This Technical Trade Presentation is sponsored in part by ClearH2O.

TECHNICAL TRADE PRESENTATIONS TRACK II – IS YOUR FACILITY STATE-OF-THEART? Program Planning for Animal Facility Construction and Renovation 1:00 PM - 1:20 PM/ Room: 2503A Speaker: Andrew G Stepp, Shawn Diederich Moderator: Andrew G Stepp

Clark & Enersen is a national architecture and engineering firm that will present the basic concepts behind programming and space planning involved in the early design stages for new construction or renovation of animal holding and research facilities. Participants will learn about the following issues. What information should be included in a building program for the purpose of early space planning and cost estimating? What is the difference between net and gross square footage and what is an appropriate target net to gross ratio for planning purposes? How is the program plan used in the formulation of cost estimates? Who should be included in the programming process? What are the next steps once a program plan has been established? This Technical Trade Presentation is sponsored in part by Clark & Enersen.

From Isolators to Vivariums: Cutting Edge HHP Decontamination Technology for Various Spaces in Laboratory Animal Facilities 1:20 PM - 1:40 PM/ Room: 2503A Speaker: Frances M Grinstead Moderator: Bridget Collins

Traditional methods of hydrogen peroxide decontamination involve operational cycles of up to 2000 parts per million and are large and bulky, challenging safety and storage space within laboratory environments. In addition, decontamination of various laboratory spaces, such as isolators, filter housings, vivariums, or necropsy suites, typically requires multiple devices and technologies. This presentation explores modular hybrid hydrogen peroxide technology as an alternative decontamination model, featuring one versatile system

that will provide efficacious and safer results in each of the spaces. To investigate this system’s perceived challenges and successes, we will examine studies performed by Kansas State University, MD Anderson, Princeton University, the University of Chicago, and Texas A&M within their laboratories, necropsy suites, and biological safety cabinets germ-free isolators, filters, and filter housings. The audience will learn about hybrid hydrogen peroxide technology. They will see how a scalable system has proven efficacious in multiple closed-system environments. And they will discover how its operational cycles of less than 200 ppm lower risk. This presentation is ideal for facility directors, veterinarians, and researchers in charge of maintaining the integrity of the research environment. This Technical Trade Presentation is sponsored in part by CURIS System.

Room

Designing a UV-C Disinfection Pass-through

1:40 PM - 2:00 PM/ Room: 2503A Speaker: Emily Lorcheim Moderator: Kevin Lorcheim

This presentation is designed to discuss how laboratories can easily transform a space into a disinfection room. This capability allows for the transfer of items from a non-clean room setting and into a clean-room, disinfect incoming pallets, equipment, supplies, feed, and bedding bags, or simply disinfect communal spaces after use. Topics discussed will include the science and technology of ultraviolet light disinfection, pros, and cons to the method of disinfection, and applications. Details will include how to determine the necessary quantity, type, and placement of UV-C devices and options for installation and safety measures. The addition of a UV-C disinfection devices mounted on walls or ceilings can reduce organism colony counts significantly in a laboratory setting due to the elimination of human error and the overall effectiveness of the technology in a well-designed setting. The benefit of creating a disinfection room with the sole purpose of disinfecting incoming or used items is that possible external contaminants can be eliminated before entering a facility or even a different section of a facility. The application is easy to implement, is not a high capital expenditure, and creates a disinfection method that is very efficient in terms of both time and efficacy. This Technical Trade Presentation is sponsored in part by ClorDiSys Solutions, Inc.

New Generation Dry Heat Sterilizers

2:00 PM - 2:20 PM/ Room: 2503A Speaker/Moderator: Robert C Davis

Over the last few years, Gruenberg Steri-Dry has discretely released several new generations of dry heat sterilizers to the market for sterilizing caging, IVC racks, and enrichment. We are excited to tell you about four general areas of next generation products, including next generation small and medium dry heat sterilizers which only require electricity to operate; a new generation of flexible use dry heat sterilizers that scale as your facility grows; generation IV large dry heat sterilizers with enhanced monitoring and control and flexible configurations to meet any throughput; and BSL3 dry heat sterilizers. During the presentation, we will discuss examples of each of these four-product area and some of the available options such as VHP/ gaseous integration, bioseals, product and personnel safety features and warranties. Other topics will include dry heat sterilization efficacy against known pathogens and parasites, cycle times, validation, project cost savings and long-term reliability. Things have changed. Please join us for an updated look into this truly unique and highly effective technology. This Technical Trade Presentation is sponsored in part by TPS/ Gruenberg Steri-Dry.

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Integrating Your Animal Welfare Program

OCTOBER 17, 2 0 2 1

Importance of Continuous Monitoring of Extrinsic Environmental Conditions in the Research Lab Animal Environment

2:20 PM - 2:40 PM/ Room: 2503A Speaker: Lindsay Andrews Moderator: Perry L Spires

"My facility operates on one system, and my IACUC runs on another program, the IBC on another, and the disconnection is a nightmare.” If this sounds familiar, then this session may help. Learn how to eliminate time-intensive tasks that can lead to data inaccuracy in billing and cost tracking. Explore how to connect and integrate key processes and systems with tools to save both the IT and research teams headaches and money. Create a central hub that brings visibility to all areas of the animal research facility. In this session, learn what it takes to integrate all aspects of an animal welfare program, including between the IACUC and the facility. Understand how having a central hub that everyone can access increases accuracy, visibility, and transparency. This Technical Trade Presentation is sponsored in part by Cayuse.

Why You Need a Real-time Data Solution in 2021

2:40 PM - 3:00 PM/ Room: 2503A Speaker: Gennifer Caesar Moderator: Perry L Spires

In the age of accelerating amounts of information and data, having the ability to access this data in real-time is becoming a necessity to meet the needs of growing research operations. Unfortunately with antiquated systems, by the time you discover the information you are looking for, it is likely to have been modified many times over. This creates a challenge for institutions to be able to address issues expediently, make fast operational changes, and provide accurate research data. We will demonstrate 4 key ways that using a real-time data solution will not only address this increasing need but also benefit all groups in the laboratory animal research industry including but not limited to management teams, researchers, animal caretakers and veterinary staff. This Technical Trade Presentation is sponsored in part by Virtual Chemistry, Inc.

Taking the Guesswork Our of Cleaning and Disinfection 3:00 PM - 3:20 PM/ Room: 2503A Speaker: Morgan A Holmes Moderator: Perry L Spires

Description: Cleaning and disinfection is the first line of defense in protecting lab animal facilities against the threat of infection. Improper use of disinfectants can result in disease outbreaks in both animals as well as in staff, which can have devastating consequences on the progress of research. Selecting the right disinfectant and pairing it with appropriate application equipment and validation method can help ensure that your protocols are successful in preventing the spread of infection. What participants will learn: Participants will learn how to select a disinfectant that meets the needs of their facility, and that allows them to achieve compliance with their protocols. They will also be introduced to application tools such as mixing stations, test strips and foamers that can help ensure that the disinfectant is used effectively. Finally, common disinfectant validation methods will be discussed, along with key considerations for each one.

3:20 PM - 3:40 PM/ Room: 2503A Speaker: Jeremy G Turner Moderator: Eugene Marino

This presentation will use case studies to highlight the utility of continuous monitoring of environmental variables in the laboratory research animal facility. It will demonstrate how continuous monitoring of the key extrinsic factors of light, noise, vibration, temperature, and humidity can provide important information on a range of issues in the animal facility, such as the dynamic status of mechanical/ventilation equipment inside the cages and at the room level, impacts of normal husbandry practices, as well as impacts of construction. This Technical Trade Presentation is sponsored in part by Turner Scientific.

Disaster Planning? Automation Has You Covered

3:40 PM - 4:00 PM/ Room: 2503A Speaker: Andrew Arvanites, Andrew J Popadich Moderator: Lance Squires

The COVID-19 outbreak and subsequent lockdown had an immediate impact on vivarium operations. Facility managers’ priority was ensuring a safe and secure work environment for their staff. Next, they had to adjust essential lab functions, workflows, and operations. During this process, the managers’ two main challenges were running operations with limited staff and having a communication system in place for coordination and daily reporting. This presentation will share case studies showing how technology and automation benefited research protocols, facility operations, and daily reporting amid the pandemic. At the same time, it will examine tangible benefits and proven ways to manage facilities during an emergency for an extended period. It will introduce solutions for standardization of operations, including tools to prioritize functions and protocols, assist with daily health checks, conduct remote animal and animal room monitoring, program animal feeding and diet delivery, and assist with daily tasks in washing operations.

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This Technical Trade Presentation is sponsored in part by Tecniplast.

Surgical Instrument Alloys & Materials, Proper Care & Maintenance 4:00 PM - 4:20 PM/ Room: 2503A Speaker: Christina Callanta, Patrick Imhoff Moderator: Marc Shroers

Presentation of the different surgical instrument alloys and materials. Proper care and maintenance procedures recommended for longevity of instrumentation. This Technical Trade Presentation is sponsored in part by Fine Science Tools.

This Technical Trade Presentation is sponsored in part by Lighthouse Life Sciences.

Animal Welfare, Regulatory Compliance, and Public Education

Biomedical Research, Medicine, and Methodology

Facility Design, Management

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MONDAY MORNING

MONDAY, OCTOBER 18 Career Center 8:00 AM-5:00 PM, CC, 2211 Exhibit Hall 8:30 AM-5:00 PM, CC, Exhibit Hall D Exhibit Hall (opening ceremony w/ribbon cutting 8:30 a.m.) 8:30 AM-5:00 PM, CC, Exhibit Hall D Entrance First Aid 7:30 AM-6:15 PM, CC, Bridge walkway between Hall D & 3501 Meeting Rooms Mothers Room 7:30 AM-5:00 PM, CC, Lobby 2300 (under escalators to exhibit hall) Poster Sessions 8:30 AM-5:00 PM, CC, Inside Exhibit Hall Poster Sessions set-up by presenting author 7:30 AM-8:30 AM, CC, Inside Exhibit Hall Registration 7:30 AM-5:00 PM, CC, Lobby 2300 Speaker Ready Room 7:30 AM-4:00 PM, CC, 2214

MEETINGS & EVENTS AALAS Foundation Silent Auction & “Swing into Science” Contest 8:00 AM-5:00 PM, Virtual Only, Virtual Only District 1 Membership Meeting 5:15 PM-6:15 PM, CC, 2504A District 2 Membership Meeting 5:15 PM-6:15 PM, CC, 2202 District 3 Membership Meeting 5:15 PM-6:15 PM, CC, 2205 District 4 Membership Meeting 5:15 PM-6:15 PM, CC, 2203 District 5 Membership Meeting 5:15 PM-6:15 PM, CC, 2204 District 6 Membership Meeting 5:15 PM-6:15 PM, CC, 2503A District 7 Membership Meeting 5:15 PM-6:15 PM, CC, 3501G District 8 Membership Meeting 5:15 PM-6:15 PM, CC, 3501A Government Relations Network Meeting 3:00 PM-4:00 PM, CC, 2209 Technician Lunch & Learn Sponsored in part by PMI Lab Diet 12:30 PM-2:00 PM, CC, 3501 E

COMMITTEE MEETINGS Certification & Registry Board 2:00 PM-4:00 PM, CC, 2208 Editorial Staff Meeting 3:00 PM-5:00 PM, CC, 2207

AFFILIATE EVENTS ACLAM COC Committee 8:00 AM-10:30 AM, Loews, Muse A ACLAM Committee Chair Orientation Meeting 10:00 AM-12:00 PM, Loews, Sea Horse ACLAM Forum Program Committee 10:00 AM-12:00 PM, Loews, Muse B ACLAM IT Management Committee 8:00 AM-12:00 PM, Loews, Northland ACLAM Mentoring Committee 3:00 PM-5:00 PM, Loews, Northland ACLAM Outreach Committee 3:00 PM-5:00 PM, Loews, Muse A

WORKSHOPS W-01 A Guide to Implementing Evidenced-based Medicine in Laboratory Animal Medicine 8:00 AM - 12:00 PM/ Room: 2202 Leaders/Faculty: Zachary T Freeman, Portia S Allen, Joseph A Hampel Facilitator: Pradeep K Dumpala Workshop Fee: $150 Workshop Limit: 50

Laboratory animal medicine programs are faced with an ever increasing need to use evidenced-based decision making to guide everyday practices and clinical medicine. Evidenced-based medicine relies on a scientific approach to answer questions of interest with a particular emphasis on historical and generated data. Electronic capture systems that record data, such as census and medical record systems, are becoming more common in LAM and have increased the amount of data. Using these increasingly large datasets, often called big data, to guide decision making present significant challenges in understanding how to best answer programmatic questions. In this workshop, we will discuss best practices of approaching and using big data in laboratory animal medicine to guide both clinical and programmatic decisions. We will address how many of the challenges associated with big data including data collection and management, question generation, and analysis impact the decision process. We will combine literature review, lectures, and group-based discussion of real-world big data in LAM cases to discuss approaches to address these challenges. The aim of this workshop is to facilitate guided discussion and expose participants to practical ways to integrate evidenced based medicine in LAM programs. This workshop is intended for those involved in programmatic leadership and clinical medicine with interest in using evidenced based medicine in the overall decision-making process.

W-02A Microsurgery Skills Training Using Surgical Loupes 8:00 AM - 12:00 PM/ Room: 2201 Leader: Robert F Hoyt Jr Faculty: Robert F Hoyt Jr, Tanya L Herzog Facilitator: Margaret A Hull Workshop Fee: $250 Workshop Limit: 20

Performing surgical procedures with the aid of magnification has gained widespread use in human medicine over the past 30 years. Using surgical loupes, surgeons can now perform procedures on very small structures that were considered impossible a few decades ago. Within the past 25 years, the use of magnification to perform microsurgical techniques has also quickly spread to other health care disciplines, including dental specialties and dermatology, to increase surgical precision, such that it is now considered the standard of care to use them. The use of microsurgery and its value to biomedical research has, unfortunately, only just begun to be realized. Because of their small body structures, laboratory animals such as rats and mice, have generally not been considered as animal models for many types of surgical procedures routinely performed in biomedical research. Investigators have rather elected to utilize larger species such as dogs, pigs, sheep, rabbits, or nonhuman primates for such modeling because both surgical support equipment is more readily available, and the surgical techniques are more familiar to the support personnel. The recent shift to using genetically engineered rodents, especially mice, has now resulted in increased researcher desires to utilize these animals in more sophisticated modeling procedures, especially surgery. Rather than being limited to only simple procedures such as IM, IP, or IV injections, researchers using microsurgery can now perform complex surgical procedures on many rodent organ systems, such as the heart, lungs, and the gastrointestinal tract. This workshop will

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introduce the basic techniques, equipment, and general applications of microsurgery using surgical loupes. Hands-on training will be conducted in 2 phases: teaching students to develop technical skills by performing exercises using surgical loupes and applying these skills to perform simple surgical procedures using rodent and organ surrogates. The target audience are Veterinarians, Technicians and Investigators interested in gaining skills in microsurgery using surgical loupes. This Workshop is sponsored in part by Q-Optics Surgical Loupes, Supramid Suture, RICA Surgical Products, SurgiReal Products, Inc.

Exhibit Hall Refreshment Break! 8:30 a.m.– 10:30 a.m. Sponsored by NEPCO

SEMINARS Mammals and Microbial Communities: What We've Learned from Animal Models 8:00 AM - 10:15 AM/ Room: 2501B Leaders: Robert P Marini, Richard J Hurley Moderator: Richard J Hurley Facilitator: Lisa A Quinn

This seminar pays tribute to Dr. James G. Fox on his retirement after more than 45 years dedicated to comparative medicine by focusing on animal models used in microbial and microbiome research led by Dr. Fox and/or his trainees. Presentations are designed for scientists using animal models to study the microbiome and/or infectious diseases and for clinical laboratory animal veterinarians responsible for maintaining healthy research animals. The session opens with a historical review of animal models in infectious disease research. When the natural gastric microflora was “rediscovered” in the early 90s, several animal models became important in determining the contribution of these organisms to gastritis, ulcer disease, and cancer in both man and animals. Many of the early studies were performed by investigators in the Division of Comparative Medicine at MIT, working in conjunction with an international team of collaborators. This session will cover the history of those studies and their contributions to the early understanding of helicobacter-induced disease. The audience will then learn how investigations of natural infections and diseases in laboratory animals lead to experimental animal model generation guiding our understanding of disease pathogenesis and providing a window into the microbiome. The final presentations introduce how animal models inform research on the importance of the microbiome in human health and disease. The audience will learn how the gastrointestinal tract microbiota stimulates tissue specific host immune and neuroendocrine responses in multidirectional gut-brain-immune axes that contribute to sustained good health, and how the tractable nature and wide array of genetic engineering opportunities make the microbiome an attractive target for diverse biomedical applications to improve human health. Finally, the audience will learn how much of the research into the human microbiome has been guided by using animal models, and the challenges involved in using animal models due not only to differences in the host anatomy and physiology but also differences in the “anatomy” and physiology of the indigenous microbiota.

Animal Welfare, Regulatory Compliance, and Public Education

OCTOBER 18 , 2 0 2 1

Speakers/Topics: 8:00

Robert P Marini Welcome and Introductions & Richard J Hurley