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CONTENTS A A L A S 7 0 th N AT I O N A L M E E T I N G

PROGRAM COMMITTEE Chair: Trinka W Adamson Vice Chair: Chris A Manuel

WELCOME Program Chair’s Message President’s Message

Meeting/Registration Information

Exhibitor Advisory Council Chair’s Message

12–16

EDUCATION PROGRAM & MEETING SCHEDULE Program Overview

Sunday

Monday

Tuesday

Wednesday Thursday

MEETING NEWS & EVENTS Registration & Travel Info Technician Events

Snowboard Freestyle Throwdown Public Outreach

Branch & District Information Hotel Map

Workshops Chair: Sean C Adams Vice Chair: Rachel R Rubino Facilitators Chair: Misty J Williams-Fritze Vice Chair: Glicerio A Ignacio

Opening General Session and General Membership Meeting

Special Topic Lectures Chair: Jennifer S Wood Vice Chair: Jennifer L Asher Panel Discussions Chair: Kristin D Evans Vice Chair: Temeri Wilder-Kofie

EXHIBITORS & SPONSORS Exhibitors & Sponsors

Seminars Chair: Natasha J Melfi Vice Chair: Sarah Hansen

58 58 60 62

Local Arrangements Chair: Jori K Leszczynski BOT Liaison, President, ex oficio Morag Mackay Abstract Review Subcommittee Chair: Karen Lencioni Platform Session: Kari L Koszdin Poster Session: Tanya L Herzog, Maggie Behnke, James B Finlay, Eric Georgelos, Lauren Habenicht, Sharoll L’Italien, Karen Strait, Dana E Weir, Wanda West

EXHIBITOR ADVISORY COUNCIL Chair: John A Park, Jr Vice Chair: Joseph P Guider Warren Ball, Donald Basil, Paulina Michaud, Todd Poley, Trinka Adamson, Carrie Schultz Past President: Jennifer C Smith BOT Liaison: Teresa Woodger

EXECUTIVE DIRECTOR Ann Turner

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4 A A L A S 7 0 th N AT I O N A L M E E T I N G

PLEASE JOIN US IN THE MILE HIGH CITY! On behalf of the National Meeting Program Committee (NMPC), I would like to extend the warmest of welcomes to all who plan to attend the 70st AALAS National Meeting in Denver, CO! The spotlight forum of the 2019 National Meeting is, “One Health: Connections Between Animal, Human, and Environmental Health,” which will highlight how laboratory animal medicine and laboratory animal professionals integrate into this multidisciplinary effort to achieve optimal health for people, animals, and the world. The program this year includes many fascinating One Health topics as well as many other exciting, educational, and relevant submissions, which are sure to give all AALAS members numerous Seminars, Special Topic Lectures, and Panel Discussions of interest to choose from throughout the week. Don’t miss the Opening General Session on Sunday with keynote speaker, Dr. Guy Palmer. Dr. Palmer is the founding director of the Washington State University Paul G. Allen School for Global Animal Health and leads efforts to fight zoonotic and vector-borne infectious diseases in sub-Saharan Africa and Central and South America. His personal experience using the One Health concept to fight some of our world’s most persistent health problems will inspire everyone to contribute to the One Health movement in their own way. I would like to thank the NMPC, the AALAS staff, and the Local Arrangements Committee (led this year by Jori Leszczynski) for all their time and effort making this meeting one to remember. This amazing group of people spent countless hours to ensure a successful meeting on all fronts, and we can’t thank them enough. And thank you to all who submitted topic ideas and abstracts. Your willingness to share your knowledge and exciting research is what makes each meeting a unique and worthwhile educational experience for all AALAS members. Hope to see you all soon in lovely Denver!

Trinka Adamson 2019 Program Committee Chair

WONDERFUL OPPORTUNITIES IN DENVER! I hope everyone is excited to attend this year’s 70th AALAS meeting in Denver, Colorado! Don’t miss the opportunity to attend the largest laboratory animal science meeting available to us. There is something for everyone, including workshops, special topic lectures, panel discussions, and so many more educational opportunities. Don’t forget to make time to visit with our corporate partners in the Exhibit Hall. Be sure to attend the Opening General Session, where we will be introduced to a spectacular keynote speaker, Dr. Guy Palmer, who will focus on One Health. After the Opening General Session, stop by the Welcome Reception for some fun, food, and games. The Mile High City is where sophistication meets outdoor adventure. World-class cultural attractions, booming craft breweries, fun dining, and a great music scene, all are available for your enjoyment. Education, networking with colleagues and friends, and simply enjoying the wonderful opportunities provided will make this a meeting to remember. This is your meeting! Start making your plans today to join us for an event you will not want to miss.

Morag Mackay 2019 AALAS President

GENERAL MEETING INFORMATION 5 GETTING READY FOR DENVER

ONLINE REGISTRATION: Pre-registration fees are $340 for AALAS national members and $435 for nonmembers. Also, look for our new “best value” registration package, which allows you to purchase a meeting registration plus session recordings at a discounted rate—$439 members / $565 nonmembers. Note: You must be a current member at the time you register in order to get the membership discount. Pre-registration pricing is available until August 1. Advance registration pricing begins August 2-September 23. Onsite registration pricing only after September 23. Access the online registration portal here: https://www.aalas.org/national-meeting/general-information/registration

WORKSHOP REGISTRATION Descriptions for the 2019 workshops are available throughout this program or here: https://www.aalas.org/national-meeting/general-information/registration. Workshops may be purchased online during the registration process.

BADGE PICK-UP AND ONSITE REGISTRATION Saturday, October 12, 2 – 6 p.m. Sunday, October 13, 7:30 a.m. – 7 p.m. Monday–Wednesday, October 14 – October 16, 7:30 a.m.– 5 p.m. Thursday, October 17, 7:30 a.m. – noon

PRESENTER AND FACILITATOR INFORMATION Looking for speaker tips, session instructions, and facilitator/moderator guidelines, and more? Visit here: https://www.aalas.org/national-meeting/submission/presenter-information The National Meeting always needs facilitators. Access the facilitator sign-up form on the above website page. Help us make this the best meeting yet by being a volunteer!

COMMITTEE MEETINGS AND EVENTS A complete list of committee meetings and events will be added to www.aalas.org in July and loaded into the mobile app, which is set to launch in September 2019.

EXHIBIT HALL SET-UP AND EXHIBIT HALL HOURS Exhibit Hall set up will take place Saturday, October 12, 10:00 a.m.–6:00 p.m. through Sunday, October 13, 7:30 a.m.–7:00 p.m. The Exhibit Hall Ribbon Cutting will take place on Monday, October 14 at 8:30 a.m. Exhbit Hall hours are: Monday, October 14: 8:30 a.m.–5:00 p.m. Tuesday, October 15: 9:00 a.m.–5:00 p.m. Wednesday, October 16: 9:00 a.m.–1:00 p.m. The Exhbit Hall dismantling will take place Wednesday, October 16 from 1:00 p.m. to 10:00 p.m.

A A L A S 7 0 th N AT I O N A L M E E T I N G

Looking for quick info on Denver and the AALAS National Meeting? Here are some tips and links to help you plan for Mile High City. Remember, the most current information will be loaded on the AALAS website, www.aalas.org/national-meeting, and in the mobile app once it is launched in September.

PROGRAM OVERVIEW SUNDAY

OCTOBER 13 A A L A S 7 0 th N AT I O N A L M E E T I N G

Afternoon

TRACK I - Capitalizing Data Technology \ Facilitating Better Management and Better Research with Digital Enterprise Colony Management Solutions: Anne M Gath. Room: 205. 1:00 PM–1:20 PM (TTP)

Bedding: A Controllable Environmental Factor: Rene Ketelsen. Room: 203. 2:00 PM–2:20 PM (TTP)

g A Versatile Caging System to Collect

g Charles C Hunter Lecture: Bison, Brucel-

n Designed to Be Different: Liz Kramer.

DEA Rules and Regulations: Daniel McCormick. Room: Mile High Ballroom 4A. 11:00 AM–12:00 PM (STL)

Room: 203. 2:40 PM–3:00 PM (TTP)

\ Can Cleaners and Disinfectants Affect

cy and Productivity in the Digital Lab: Jay Campbell. Room: 205. 1:20 PM–1:40 PM (TTP)

ATP Readings?: Tim Hidell. Room: 203. 3:20 PM–3:40 PM (TTP)

\ Answering the Call of Wastewater Re-

\ Unlock Operating Efficiency with Better

quirements in Laboratory Animal Care Cage Washing Products: Amy S Ingraham. Room: 203. 3:00 PM–3:20 PM (TTP)

g Improving Animal Model Research by Making Data Fly In-Formation: Charles Donnelly. Room: 205. 2:00 PM–2:20 PM (TTP) Improved Study Workflows and Animal Welfare through the Use of Digital Biomarkers: Laura Schaevitz. Room: 205. 2:20 PM–2:40 PM (TTP)

\ Adding Dough to the Raisins Makes a Cake—Connecting Best of Breed Technologies to Increase Efficiency and Reduce Risks: Andreas Staubi. Room: 205. 2:40 PM–3:00 PM (TTP)

\ IVC Rack Monitoring and Control—New Technology Advancements: Rick Deitrich. Room: 205. 3:00 PM–3:20 PM (TTP)

\ Documenting and Tracking Processes in Animal Isolators and Cleanrooms: How to Overcome Obstacles: Stephan Eduard Edgar Hammelbacher. Room: 205. 3:20 PM–3:40 PM (TTP)

\ Managing Your Breeding Core Like a Business: Laura Gee. Room: 205. 3:40 PM–4:00 PM (TTP) Controlling Your Controlled Substances—Using RFID to Monitor, Track, and Report on Controlled Drugs: Matt Ruiter. Room: 205. 4:00 PM–4:20 PM (TTP)

TRACK II – Optimizing Operations g Rodent Surgical Monitoring and Anesthetized Imaging: Brianna Noel Sellers. Room: 203. 1:00 PM–1:20 PM (TTP) Are Your Animals Dying During Surgery?: Dave FitzMiller. Room: 203. 1:20 PM–1:40 PM (TTP) Improving Pain Management and Medication Delivery Techniques for Better Laboratory Animal Welfare and Research Outcomes: Morgane Stum. Room: 203. 1:40 PM–2:00 PM (TTP)

Ebola Response: Brianna L Skinner. Room: Mile High Ballroom 2A. 11:00 AM–12:00 PM (STL)

Simultaneous Fluid and Electrical Samples from Freely Moving, Low-stress Rodents: Candace Rohde-Johnson. Room: 203. 2:20 PM–2:40 PM (TTP)

\ The Missing Link to Improving Efficien-

Cage Change Processes and Digital Technology: Jon Ledford. Room: 205. 1:40 PM–2:00 PM (TTP)

n ACLAM Diplomates in the West African

\ Improving Safety and Reducing Costs in Automated Vivarium Doors: William R. Britz. Room: 203. 3:40 PM–4:00 PM (TTP)

\ The Science and Safety behind the White Suits: Alexander Bradley. Room: 203. 4:00 PM–4:20 PM (TTP)

MONDAY

OCTOBER 14 Morning

g W-01A Microsurgery Skills Training Using Surgical Loupes Robert F. Hoyt. Room: 301. 8:00 AM–12:00 PM (W)

g W-02 Perioperative Anesthetic Monitor-

losis, and Baby-making: Jennifer Barfield. Room: Mile High Ballroom 1A. 11:00 AM–12:00 PM (STL)

\ Does Relative Humidity Affect Reproducibility of Research?: Preben Leonhardt. Room: Mile High Ballroom 3A. 11:00 AM–12:00 PM (STL)

MONDAY Afternoon

21st Century Cures Act: Where Are We Now?: Aubrey Schoenleben. Room: 401. 12:30 PM–2:00 PM (P) Adding Your Voice to Social Media: Five Steps to Navigate This Important Outreach Too: Crister DelaCruz. Room: 403. 12:30 PM–2:00 PM (P)

n Animal Nursing Challenges in the Research Setting: Communicating, Collaborating, and Coordinating to Achieve Optimal Health Outcomes for All: Ann L. Murray. Room: 501. 12:30 PM–2:00 PM (P)

\ Groundhog Day: Learning from Lead-

ing: Cholawat Pacharinsak. Room: 302. 8:00 AM–12:00 PM (W)

ership Failures—What Not to Do: Gerard Cronin. Room: 503. 12:30 PM–2:00 PM (P)

\ W-03 Successful Operation of a Gnoto-

\ W-05 Animal Facility, Design, Process-

biotics Facility: Alton G Swennes. Room: 304. 8:00 AM–12:00 PM (W)

\ W-04 What Generational Gap? Effec-

es, Decisions, and Technology: Mark A Corey. Room: 302. 1:00 PM–5:00 PM (W)

tively Working and Leading across Generational Culture Differences: Jamie Mueller. Room: 303. 8:00 AM–12:00 PM (W)

\ W-06 Leading the Self and Others with

\ A Practical Guide to Change Manage-

g W-01B Microsurgery Skills Training

ment in the Laboratory Animal Science Environment: Lois A. Zitzow. Room: Mile High Ballroom 1A. 8:00 AM–10:15 AM (S)

Emotional Intelligence: Jamie Mueller. Room: 303. 1:00 PM–5:00 PM (W) Using Surgical Loupes: Robert F. Hoyt. Room: 301. 1:00 PM–5:00 PM (W)

Changing Times in the Animal Research Oversight Environment: B Taylor Bennett. Room: Mile High Ballroom 2A. 8:00 AM–10:15 AM (S)

W-07 Teaching Monkeys to Cooperate with Restraint: Using Positive Reinforcement Training and Temperament Testing Methods: Jaine E Perlman. Room: 607. 1:00 PM–5:00 PM (8-hour workshop continued Tuesday 8:00 AM)

n One Health: From Research to Applica-

\ W-08 Vivarium Ergonomics: Establishing

tion: Sue VandeWoude. Room: Mile High Ballroom 4A. 8:00 AM–10:15 AM (S)

g Pathology Quiz Bowl: Craig L Franklin. Room: Mile High Ballroom 3A. 8:30 AM–10:00 AM (P)

and Effective, Sustainable Program: Terry Snyder. Room: 304. 1:00 PM–5:00 PM (W)

n Fish Health Monitoring: Facilitating for One Health: Katy Murray. Room: Mile High Ballroom 2A. 2:45 PM–5:00 PM (S)

Animal Welfare, Regulatory Compliance, and Public Education g Biomedical Research, Medicine, and Methodology \Facility Design, Management, and Operation n One Health

PROGRAM OVERVIEW n One Health: Roots to Flowers: James

g Rodent Infectious Agents: The New Unknown, the Impact of Metagenomics: Neil Lipman. Room: Mile High Ballroom 4A. 2:45 PM–5:00 PM (S)

\ Valuing Emotional Labor in Animal Facilities: Kathryn Bayne. Room: Mile High Ballroom 3A. 2:45 PM–5:00 PM (S)

TUESDAY

OCTOBER 15 Morning

\ W-09 Impacting the Outcome: Novel Leadership/Management Approaches for Today’s Vivaria: Clifford R Roberts. Room: 303. 8:00 AM–12:00 PM (W) W-07 Teaching Monkeys to Cooperate with Restraint: Using Positive Reinforcement Training and Temperament Testing Methods: Jaine E Perlman. Room: 607. 8:00 AM–12:00 PM

\ Building Your Leadership Brand: Stacy Pritt. Room: Mile High Ballroom 2A. 8:00 AM–10:15 AM (S)

g I’m New to Gnotobiotics and Germ-free, How Do I Get Started?: Brian Bilecki. Room: Mile High Ballroom 3A. 8:00 AM–10:15 AM (S)

n One Health: Animals Connection to People: Lon V Kendall. Room: Mile High Ballroom 1A. 8:00 AM–10:15 AM (S)

g Reproducibility in Animal Research: Natalie A Bratcher. Room: Mile High Ballroom 4A. 8:00 AM–10:15 AM (S)

n A One Health Success Story in Borneo Advanced by Laboratory Animal Veterinarians and Physicians: Jeff D Wyatt. Room: Mile High Ballroom 1A. 11:00 AM–12:00 PM (STL) Charles River Ethics and Animal Welfare Lecture: More than 3Rs: The 3Vs and the Ethics and Science of Valid and Reproducible Animal Research: Hanno Wurbel. Room: Mile High Ballroom 4A. 11:00 AM–12:00 PM (STL) Public Outreach: Where We Are and Where Should We Be Going?: Allyson J Bennett. Room: Mile High Ballroom 2A. 11:00 AM–12:00 PM. (STL)

TUESDAY

g W-12 Introduction to Flexible GI Endos-

Afternoon

copy in Laboratory Animals: Kelly Rice. Room: 607. 8:00 AM–12:00 PM (W)

\ Ergonomic Training for the Animal Care

\ W-13 LAS Pro Article Writing Boot

Technician: Terry Snyder. Room: 401. 12:30 PM–2:00 PM. (P) Opioid Crisis: Exploring Effective Means to Support Investigators With Controlled Substances for Research Activities: Karen Lieber. Room: 403. 12:30 PM–2:00 PM (P) Transparency Initiatives that Could Be Implemented in the U.S. to Increase Public Acceptance of Animal Research: Paula A Clifford. Room: 501. 12:30 PM–2:00 PM (P)

\ Work Satisfaction: Recharge Your Career: Misty L Touchette. Room: 503. 12:30 PM–2:00 PM (P) W-10 CMAR Preparatory Class for the Animal Resources (AR) Exam: Diana P Baumann. Room: 302. 1:00 PM–5:00 PM (8-hour workshop continued Wednesday 8:00 AM) (W)

g W-11 Improving Your Suturing and Rodent Surgery Aseptic Technique?: Marcel I Perret-Gentil. Room: 304. 1:00 PM–5:00 PM (W)

g Intensive Care Swine Models: Meghan S Vermillion. Room: Mile High Ballroom 2A. 2:45 PM–5:00 PM. (S)

n One Health and Animal Research: A Crosslink to Promote Human, Animal, and Environmental Health: Jason Villano. Room: Mile High Ballroom 3A. 2:45 PM–5:00 PM (S)

\ Smart Approaches in Animal Facility Management: John J Hasenau. Room: Mile High Ballroom 4A. 2:45 PM–5:00 PM (S) The Changing Landscape of Animal Rights: Activism in the United States and Europe and How Institutions Should Respond: Jim Newman and Kirk Leech. Room: Mile High Ballroom 1A. 2:45 PM–5:00 PM (S)

WEDNESDAY OCTOBER 16 Morning

W-10 CMAR Preparatory Class for the Animal Resources (AR) Exam: Diana P Baumann. Room: 302. 8:00 AM–12:00 PM (8-hour workshop continued from Tuesday 1:00 PM) (W)

Camp: Liz Rozanski. Room: 304. 8:00 AM–12:00 PM (W) W-14 Legislative Advocacy: Watering the Grassroots: Anita T Richert. Room: 303. 8:00 AM–12:00 PM (W)

\ A Comprehensive Approach to Maximizing Facility Biosecurity and Animal Welfare across Geographically Diverse Locations: Peggy J Danneman. Room: Mile High Ballroom 1A. 8:00 AM–10:15 AM (S)

g Murine Chapparvovirus aka Mouse Kidney Parvovirus: A Novel Virus Identified Using Metagenomics: Neil Lipman. Room: Mile High Ballroom 2A. 8:00 AM–10:15 AM (S) Who’s Driving the 3Rs/Welfare Science and Does It Matter?: Natalie A Bratcher. Room: Mile High Ballroom 4A. 8:00 AM–10:15 AM (S)

g Zebrafish Husbandry and Veterinary Care: One Health Based on Many Small Fish: Monte Matthews. Room: Mile High Ballroom 3A. 8:00 AM–10:15 AM (S) Animal Ethics, Animal Ideology, and the Defense of Animal Research: Why Appealing to Science and the Benefits of Research Have Not Been Working: Jerrold Tannenbaum. Room: Mile High Ballroom 1A. 11:00 AM–12:00 PM (STL)

g Nathan E Brewer Lecture: TBN. Room: Mile High Ballroom 2A. 11:00 AM–12:00 PM (STL)

n The Pediatric Neurocysticereosis Crisis in Rural Sichaun: Time for a One Health Approach to Tibetan-Bacon-Makin’: Stephen A Felt. Room: Mile High Ballroom 4A. 11:00 AM–12:00 PM (STL)

n Zoognosis: Understanding The Knowledge We Share: Claire A Simeone. Room: Mile High Ballroom 3A. 11:00 AM–12:00 PM (STL)

WEDNESDAY Afternoon

\ A First Responders Worst Nightmare: Your Vivarium: Tasha M Thomas. Room: 401. 12:30 PM–2:00 PM (P)

g A Future with Marmosets: Understanding the Numbers: Patricia V Turner. Room: 403. 12:30 PM–2:00 PM (P)

g Wallace P Rowe Lecture: TBN. Room: Mile High Ballroom 3A. 11:00 AM–12:00 PM (STL) Animal Welfare, Regulatory Compliance, and Public Education g Biomedical Research, Medicine, and Methodology \Facility Design, Management, and Operation n One Health

A A L A S 7 0 th N AT I O N A L M E E T I N G

Owiny. Room: Mile High Ballroom 1A. 2:45 PM–5:00 PM (S)

PROGRAM OVERVIEW A A L A S 7 0 th N AT I O N A L M E E T I N G

Change Is Coming: Updates to the AVMA Panel on Euthanasia: Natalie A Bratcher. Room: 501. 12:30 PM–2:00 PM (P) The IACUC Role in Veterinary Clinical Trials: Lon V Kendall. Room: 503. 12:30 PM–2:00 PM (P)

n W-15 An Interactive Comprehensive Decontamination Experience: From Analysis to Understanding to Application: Frances M Grinstead. Room: 302. 1:00 PM–5:00 PM (W)

g W-16 Gnotobioic Isolators 101: David Holland. Room: 301. 1:00 PM–5:00 PM (W) W-17 IACUC Challenges: Real-Life Case Studies and Issues: Marcy A Brown. Room: 304. 1:00 PM–5:00 PM (W)

\ W-18 Technician to Supervisor, Management 101: Stephen T Baker. Room: 303. 1:00 PM–5:00 PM (W)

\ W-19 Working with Difficult Personalities: How to Survive and Thrive: Laura A Conour. Room: 612. 1:00 PM–5:00 PM (W)

g Are Your NSG Mice Feeling NSG (Not So Great)? Disease Conditions in Humanized Mouse Models: Robert S Livingston. Room: Mile High Ballroom 2A. 2:45 PM–5:00 PM (S) European-standard Housing and Procedures: Practicalities, Benefits for Animal Welfare, and Quality of Scientific Data: Helen Prior. Room: Mile High Ballroom 3A. 2:45 PM–5:00 PM (S)

g Extrinsic Factors that May Impact Animal Models and Study Reproducibility: Neil Lipman. Room: Mile High Ballroom 4A. 2:45 PM–5:00 PM (S)

n One Health Approach for the Animal

n A One Health Experiment: Laborato-

Caregiver: Occupational Health, Human-Animal Bond, and Compassion Fatigue: Sally Thompson-Iritani. Room: Mile High Ballroom 1A. 2:45 PM–5:00 PM (S)

ry-reared Lake Sturgeon as Sentinels of Ecosystem Health: Jeff D Wyatt. Room: Mile High Ballroom 1A. 11:00 AM–12:00 PM (STL)

THURSDAY OCTOBER 17 Morning

g W-20 Interviewing 101 for Veterinarians: Carissa Jones. Room: 302. 8:00 AM–12:00 PM (W)

g W-21 Introduction to Acupuncture in Laboratory Animal Medicine: Harvey Ramirez. Room: 303. 8:00 AM–12:00 PM (W)

\ W-22 Mentoring 101: How to Support, Coach, and Motivate New Hire Animal Husbandry Technicians to Reach Their Full Potential: Sarah Dollie Jordan. Room: 304. 8:00 AM–12:00 PM (W)

n Building the Perfect Beast: Refinements in Preclinical Models of Sepsis: Tanya Herzog. Room: Mile High Ballroom 2A. 8:00 AM–10:15 AM (S) Cephalopods in the Laboratory: An Overview of a Growing Class of Laboratory Animal: Joshua R Barber. Room: Mile High Ballroom 4A. 8:00 AM–10:15 AM (S)

g Enhancing Research Reproducibility: Considering Extrinsic Factors: Cory F Brayton. Room: Mile High Ballroom 3A. 8:00 AM–10:15 AM (S)

Cleaning and Disinfection as Key Elements of Your Biosecurity Program: Theory and Practice: Jose Ramirez. Room: Mile High Ballroom 2A. 11:00 AM–12:00 PM (STL)

g Evaluating Cannabis Products for Clinical Applications: Casara Andre. Room: Mile High Ballroom 4A. 11:00 AM–12:00 PM (STL)

\ Sustainable Concepts in Unique Vivaria: Kay Townsend. Room: Mile High Ballroom 3A. 11:00 AM–12:00 PM (STL)

THURSDAY Afternoon

\ Care and Husbandry for Immunodeficient Rodents and How It Can Affect Your Research: Jamie Naden. Room: 403. 12:30 PM–2:00 PM (P) Full House: Managing Breeding Mouse Cage Density: Elizabeth Dodemaide. Room: 501. 12:30 PM–2:00 PM (P)

n Harm/Benefit and Bioethics in Animal Research in the Era of One Health: Lida Anestidou. Room: 401. 12:30 PM–2:00 PM (P) Veterinary Verification and Consultation: Where Are We Now?: Jessica D Ayers. Room: 503. 12:30 PM–2:00 PM (P)

Animal Welfare, Regulatory Compliance, and Public Education g Biomedical Research, Medicine, and Methodology \Facility Design, Management, and Operation n One Health

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Visit us at Booth# 707

OPENING GENERAL SESSION/ GENERAL MEMBERSHIP MEETING Colorado Convention Center | Sunday, October 13, 2019 5:00-6:30 PM | Bellco Theatre • • • • •

Welcome from AALAS President, Morag Mackay AALAS Awards presentations Recognition of guests and Board of Trustees members Branch Challenge Award presentation Gavel ceremony introducing the new president

• • •

Introduction of new trustees Incoming president, Tracy Parker’s address Welcome Reception from 6:30-8:00 PM, Lobby D outside of Bellco Theatre

Welcome Reception, Lobby D outside the Bellco Theatre Sunday, October 13, 2019 District membership meetings will be held on Monday, October 14 at 5:15 PM. See the mobile app for room numbers.

WIN $200

Drawings will be held during the General Membership Meeting. Must be present to win. Badges must be printed by 5:00 p.m. on Sunday to be entered into the drawing.

DR. GUY PALMER, KEYNOTE SPEAKER Guy Palmer DVM, PhD holds the Jan and Jack Creighton Endowed Chair at WSU where he is Regents Professor of Pathology & Infectious Diseases. The founding director of WSUâ€™s Paul G. Allen School for Global Animal Health, he currently leads university-wide efforts as Senior Director of Global Health. A board-certified pathologist, Dr. Palmer leads global health programs in Africa and Central America as well as directing the Robert R. Fast Infectious Diseases Research Laboratory. He directed the NIH Training Program in Infectious Diseases from 2003-2018 and currently holds a NIH MERIT award for research on pathogen emergence. He holds a joint appointment at the Nelson Mandela African Institution of Science and Technology and directs the Bill & Melinda Gates Foundation supported Integrated PhD Program between WSU and the Nelson Mandela African Institution of Science and Technology. Dr. Palmer developed an interest in infectious diseases as an undergraduate in biology while working in a laboratory responsible for diagnosis of rabies. He followed his interest through veterinary school, pathology residency, and a PhD in infectious diseases. As a post-doctoral fellow, he had the opportunity to see first-hand the high burden of zoonotic and vector-borne infectious diseases in sub-Saharan Africa and, later, in Central and South America. The three pillars of his career are: i) the importance of basic research to uncover new methods for disease prevention; ii) the need for interdisciplinary approaches to effect change in public health and human opportunity; and iii) that the greatest impact is through training of future scientists, both in the U.S. and globally, to provide evidence-based solutions in health.

PROGRAM SPONSORS

A A L A S 7 0 th N AT I O N A L M E E T I N G

CHALMERS MEDICAL GROUP PRIMUS/SCIENTEK/ CSI-JEWETT

daniolab

WELCOME TO DENVER AND THE 70TH AALAS NATIONAL MEETING! One of Denver’s best kept secrets, in addition to its 300 plus days of sunshine each year, is the amazing Colorado Convention Center (CCC). Denver’s CCC is consistently ranked as one of the top 10 convention destinations in the nation and it sits within walking distance of over 200 restaurants, many award-winning.

John Park, LATG Chair, 2019 Exhibitor Advisory Council

The AALAS National Meeting is the largest gathering in the world of professionals concerned with the production, care, and use of laboratory animals. It is also the largest gathering of commercial partners that support the laboratory animal science community. In addition to the Exhibit Hall, we will again kick off this year’s program on Sunday afternoon with a dual track session of our Technical Trade Presentations. Track 1 will feature talks focused on the emerging field of data technology in lab animal science and Track 2 will center around optimizing facility operations. Please join us Monday at 8:30 a.m. for the Ribbon Cutting Ceremony to kick-off another exciting and productive AALAS National Meeting Exhibit Hall. The Program Committee has worked hard to provide dedicated exhibit hall time, so please plan to take full advantage of this. On behalf of the Exhibitor Advisory Council, our more than 1,300 commercial members, and the Blue Bear, we look forward to seeing you in the Mile High City!

John Park, LATG Chair, 2019 Exhibitor Advisory Council

DON’T MISS THE AALAS NATIONAL MEETING EXHIBIT HALL!

Approximately 300 companies (more than 650 booths) exhibit at the AALAS National Meeting. Exhibitors interact with people from the academic community, research institutions, government organizations, and commercial companies. Visit the Exhibitors section of nationalmeeting.aalas.org for a prospectus, a list of previous exhibitors, sponsorship opportunities, and other information.

RIBBON CUTTING CEREMONY COMMERCIAL COMPANY BOOTHS

Monday, October 14, 8:30 a.m. Learn about the latest products and services offered by vendors in the field.

AFFILIATE BOOTHS

Visit with our affiliate members and check out their public outreach and educational materials.

CHARGING STATIONS

Located in the Exhibit Hall and the Registration Lobby

(sponsored by Alfa Wassermann, a-tune Software, IDEXX, and Oak Hill Genetics)

REFRESHMENT BREAKS (Located in the Exhibit Hall Lounge)

Monday:

8:30 a.m.–10:30 a.m. sponsored by NEPCO 2:00 p.m.–4:00 p.m. sponsorsed by Getinge

Tuesday:

9:00 a.m.–11:00 a.m. sponsored by Priority One 2:00 p.m.–4:00 p.m. sponsored by BioServ

Wednesday:

9:00 a.m.–11:00 a.m. sponsored by The Jackson Lab

POSTER SESSIONS

Come view this year’s poster sessions, and don’t miss the Poster Reception on Tuesday from 2:00 p.m.–4:00 p.m. Meet the authors, enjoy some refreshments, and see who won this year’s Poster Awards.

EXHIBIT HALL HOURS Monday, October 14: 8:30 a.m.–5:00 p.m. Tuesday, October 15: 9:00 a.m.–5:00 p.m. Wednesday, October 16: 9:00 a.m.–1:00 p.m.

EXHIBITORS & SPONSORS

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AABC Testing & Certification Access Technologies Agilent Air Science USA, LLC

Alfa Wassermann Diagnostic Technologies LLC Mobile Device Charging Station Sponsor

Allentown Inc

Gold Level Sponsor Notebook Sponsor Tote Bag Sponsor Alpha Genesis Inc

Alternative Design Manufacturing & Supply Bronze Level Sponsor

ALZET® Osmotic Pumps/DURECT Corp

Ancare Corp

Bronze Level Sponsor Animal Care Systems Animal Care Training Services (ACTS) Animal Identification & Marking Systems Inc Animal Resource Management Inc Animal Welfare Institute APC Filtration Inc Aquaneering Inc Arcoplast Art’s Way Scientific Inc

a-tune Software Inc

Mobile Device Charging Station Sponsor AVID Identification Systems Inc

Avidity Science, LLC Gold Level Sponsor

BASF Corporation BASi Beta Star Life Science Equipment BetterBuilt BH Inc dba/Britz & Company bioBUBBLE Inc Biofresh Lab BioInfoRx, Inc. BioMedic Data Systems Inc Bioquell Inc

Bio-Serv

Charles River

President’s Level Sponsor CITI Program, a division of BRANY Class Biologically Clean Ltd Cleanspace Technology

ClearH2O Inc

Gold Level Sponsor ClorDiSys Solutions Inc Colonial Medical Supply Co Inc Consolidated Sterilizer Systems

Continental Equipment Company Inc Bronze Level Sponsor

Covetrus CRC Press/Taylor & Francis Group CURIS® System

Danio Lab

Bronze Level Sponsor DarvallVet - a division of Advanced Anaesthesia Specialists Datesand Ltd DRE Scientific, A Division of DRE Veterinary Drexel University Dudick Inc Dupont Personal Protection Dustcontrol Inc Dycem Corp. Eastern Virginia Medical School Elm Hill Labs Envigo Esco Technologies Inc ETC Sterilization Systems Exemplar Genetics E-Z Systems / Euthanex Corp FEFA

FiberCore LLC

Bronze Level Sponsor

Fidelis Pharmaceuticals President’s Level Sponsor Fine Science Tools Fuel3D-BioVolume

Galilei Software Gmbh Bronze Level Sponsor

Gold Level Sponsor Notebook Sponsor Refreshment Break Sponsor

GenoTyping Center of America George Tiemann & Co.

Bluemed BMT USA LLC Braintree Scientific Inc BSI Software BZ Sales & Support LLC Carter 2 Systems Inc Cayuse

Gold Level Sponsor Refreshment Break Sponsor

Chalmers Medical Group Bronze Level Sponsor

Getinge

Girton Manufacturing Co Inc Gruenberg TPS

Hilltop Lab Animals Inc Bronze Level Sponsor Notebook Sponsor

EXHIBITORS & SPONSORS NKP Isotec Systems NorayBio Software North American 3rs Collaborative (na3rsc)

IDEXX BioAnalytics

NuAire

iMedRIS Data Corporation

Oak Hill Genetics

Mobile App Sponsor Mobile Device Charging Station Sponsor Silver Level Sponsor

InfoEd Global

Bronze Level Sponsor Innovive Inc Instech Laboratories Inc iVention, LCC IWAKI Aquatic JRS / SAFE Complete Care Competence Karl Storz

Kent Scientific Corporation Mobile App Sponsor Silver Level Sponsor

Key Resin/Flowcrete Key Solutions Inc Lab Animal Lab Products Inc Lab Supply Inc LABeX of MA LabSource Inc LBS (Serving Biotechnology) Ltd Lenderking Caging Products LGL Animal Care Products Inc Life Science Products Lighthouse Life Sciences (Proudly Representing Peroxigard) Lithgow Laboratory Services Locus Technology Inc

Lomir Biomedical Inc President’s Level Sponsor

Lynx Products Group LLC MAI ANimal Health/Vetcorder Marshall BioResources Masimo Matachana Group MAXAIR-Systems

Medline Industries Gold Level Sponsor Mobile App Sponsor

MILA International, Inc. Mispro Biotech Services Inc Mopec Mosaic Vivarium (Virtual Chemistry, Inc.) MP Biomedicals, LLC MWI Animal Health NC3Rs

NEPCO

Refreshment Break Sponsor Silver Level Sponsor New England Ovis Newco Distributors Inc

Gold Level Sponsor Mobile App Sponsor Technician Lunch & Learn Sponsor Mobile Device Charging Station Sponsor Orient Bioresource Center, Inc Otto Environmental LLC Otto Trading Inc Patterson Scientific Pharmacal Research Labs Inc PJ Murphy Forest Products Corp Plas-Labs Inc

PMI LabDiet

Mobile App Sponsor Neck Cord Sponsor Notebook Sponsor President’s Level Sponsor Technician Lunch & Learn Sponsor Powers Scientific, Inc.

PreLabs

Silver Level Sponsor Tote Bag Sponsor Primate Products Inc

Priority One Services Inc Gold Level Sponsor Refreshment Break Sponsor

PVS Process Equipment, Inc. Quip Laboratories Inc Rad Source Technologies, Inc RapID Lab, Inc Rees Scientific Research Diets Inc Res-Tek RICA Surgical Products Inc Ridglan Animal Care Systems Ridglan Farms Rochester Midland Corporation Rockstep Solutions RWD Life Science Inc S&S Farms Sable Systems International Inc SAI Infusion Technologies Sanitation Strategies LLC SCANBUR Scintica Instrumentation Scivena Scientific Shepherd Specialty Papers Shoe Cover Magic Shoe Inn LLC Siemens Sika Industrial Flooring Sinclair BioResources LLC SMC-Roe SoBran Inc Softmouse.Net

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Horizon Discovery Hot Dog Patient Warming Huron Consulting Group

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EXHIBITORS & SPONSORS SOMARK Innovations SOMNI Scientific Sound Spray Master Technologies SR Veterinary Technologies ssniff Spezialdiaten GmbH Starr Life Sciences Corp Steelco USA Inc Sterilizing Systems STERIS Corporation Stoelting Co Stonhard Strahman Valves Inc Studylog Systems Inc Suburban Surgical Co Inc SwifTAG Systems Systems Engineering Taconic Biosciences Tandem Products/Tenderfoot Flooring TBJ Inc

Tecniplast

3Rs Lounge Sponsor Gold Level Sponsor The Andersons Lab Bedding Products

The Jackson Laboratory Gold Level Sponsor Mobile App Sponsor Refreshment Break Sponsor

Thoren Caging Systems Inc TMH Medizinhandel GmbH & Co. KG TOMI l SteraMist TOPAZ Technologies Total MRO

Translite, LLC

Bronze Level Sponsor

Transnetyx Inc

President’s Level Sponsor Mobile App Sponsor NM Leadership Academy Sponsor Turner Scientific Tuttnauer USA UID Identification Devices UNO Roestvaststaal B.V. Valumax International Verona Safety Supply Inc

VetEquip Inc

Gold Level Sponsor Tote Bag Sponsor Vetland Medical Sales & Services ViraTek Inc Visron Design Inc Vium Inc. VRL W F Fisher & Sons Inc World Courier Inc Worldwide Primates Inc XpressBio

Zeigler Bros Inc

Bronze Level Sponsor Zoologix

NONEXHIBITING SPONSORS Bristol-Myers Squibb-Princeton President’s Level Sponsor

Pfizer

AREA Program Sponsor

Sanofi-Aventis

Silver Level Sponsor

Altasciences

Silver Level Sponsor

Animal Specialties and Provisions Gold Level Sponsor Mobile App Sponsor Tote Bag Sponsor

AFFILIATES AAALAC International American College of Laboratory Animal Medicine (ACLAM) American Society of Laboratory Animal Practitioners (ASLAP) Americans for Medical Progress (AMP) Animal Transportation Association (ATA) Association for Gnotobiotics, Inc. Association of Primate Veterinarians (APV) Foundation for Biomedical Research (FBR) Institute for Laboratory Animal Research (ILAR) Institute of Animal Technology (IAT) International Council for Laboratory Animal Science (ICLAS) International Society for Transgenic Technologies (ISTT) Laboratory Animal Management Association (LAMA) Laboratory Animal Welfare Training (LAWTE) National Association for Biomedical Research (NABR) Public Responsibility in Medicine and Research (PRIM&R) Scientists Center for Animal Welfare (SCAW) Society for Laboratory Animal Veterinary Technicians (SLAVT) Thailand Association for Laboratory Animal Science (TALAS) Zebrafish Husbandry Association

Guard Your Research with PeroxiGard™ PeroxiGard™ is a 1-STEP CLEANER AND DISINFECTANT that protects your animals, people, facility and research. EFFECTIVE against key pathogens of concern in 1 min SAFE for your animals, you and your equipment SIMPLE to use, saving time and money Supported by 30+ peer reviewed studies! Attend special presentation by Dr. José A. Ramirez, MS, PhD

CLEANING & DISINFECTION AS KEY ELEMENTS OF YOUR BIOSECURITY PROGRAM: THEORY & PRACTICE October 17th, 11am

Visit us at AALAS, Booth 361 Peroxigard proudly represented by Lighthouse Life Sciences

SUNDAY AFTERNOON

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TECHNICAL TRADE PRESENTATIONS TRACK I - CAPITALIZING DATA TECHNOLOGY \ Facilitating Better Management and Better Research with Digital Enterprise Colony Management Solutions

1:00 PM - 1:20 PM/Room: 205 Speaker: Anne Gath and Derrick Cheng Moderator: Amanda Coldwell This talk will cover the advantages of moving to an enterprise solution for managing animal colony data. Although many animal resource centers are already using a digital solution for colony management, researchers may not have access or use their own solution for managing their animals. With an enterprise solution, researchers can digitally access real-time cage and animal information and submit a variety of electronic service requests. Using different access levels designated by the facility manager, many tasks can be completed within research labs while interfaced with the main animal facility. An interactive model streamlines many processes and saves precious time and resources for both researchers and facility staff. Researchers, technicians, veterinarians, and facility staff can improve processes and communication with interactive modules such as billing, medical records, cage census, and more. An enterprise solution improves communication, generates accurate data, and reduces the cost of labor and supplies, thus generating more revenue for animal resource centers. This Technical Trade Presentation is sponsored in part by BioInfoRx, Inc.

\ The Missing Link to Improving Efficiency and Productivity in the Digital Lab

1:20 PM - 1:40 PM/Room: 205 Speaker: Jay Campbell, Paul Donohoe Moderator: Eric Arlund The research industry is facing a growing problem—lack of trust within data. Across all phases of research and development, data is at increasing risk of human error, often lacks contextual insight, and can be lost through archaic collection methods. In this presentation, the speakers share an innovative strategy to tackle this challenge with insights on how companies are succeeding in this battle. Key takeaways include understanding why digitalization is at the heart of the smart lab, how to move beyond archaic data collection to gather smart and contextual information; and a case study on how RFID tagging can lead to superior data quality and connectivity. This Technical Trade Presentation is sponsored in part by Somark Innovations.

\ Unlock Operating Efficiency with Better Cage Change Processes and Digital Technology

1:40 PM - 2:00 PM/Room: 205 Speaker: Jon Ledford Moderator: Pat Guider Versatile and adaptable individual ventilated Caging (IVC) offerings and digital technology advances are set to streamline cage-changing processes and pave the way for improved animal facility operation at multiple levels. Jon Ledford illustrates how data-driven cage-change intervals and individual cage-change methods (partially/just the bottoms, or integrally/full cage) can streamline SOPs and processes. He will examine the pros and cons of different solutions and how intracage monitoring technologies will take efficiency

to the next level. He will extrapolate streamlined process data to illustrate the full impact on improved space utilization, reduced risk of cross-contamination, and more. This Technical Trade Presentation is sponsored in part by Tecniplast.

g Improving Animal Model Research by Making Data Fly In-Formation

2:00 PM - 2:20 PM/Room: 205 Speaker: Chuck Donnelly Moderator: Julie Morrison Data scientists often spend up to 80% of their time wrangling data. While the data generated from one study could often be reused and lead to new discoveries, they are often not findable. In spite of their value, data are often stored in share folders or dis-integrated databases where they are siloed and lie fallow because they are nearly impossible to search and reuse. Fractured data environments also inhibit analytical strategies, decrease security, and ultimately place a drag on ROI. Like the jets flying In-Formation, the power and value of scientific data is enhanced when data fly in formation. The speaker will challenge the status quo and ask the audience to imagine a research lab where precision informatics tools are deployed to manage laboratory operations and data from the animal room to the scientist’s desktop. The speaker will discuss how the cloud and the edge, with IoT, artificial intelligence, and machine learning, are transforming research, enabling science, accelerating discovery, and improving ROI. With emerging technologies, researchers can regain control of their data, obtain new insights from existing data, and improve lab operational efficiencies, and ultimately accelerate discovery. The speaker will present some of the ideas and technologies available and we caution about some potential pitfalls to watch out for to help you improve your animal lab research as you embark on your journey toward digital transformation. This Technical Trade Presentation is sponsored in part by RockStep Solutions.

Improved Study Workflows and Animal Welfare through the Use of Digital Biomarkers

2:20 PM - 2:40 PM/Room: 205 Speaker: Laura Schaevitz Moderator: Pat Guider Sensor technology is increasingly being used inside the vivarium to allow monitoring of the facility and environment, but also enabling noninvasive continuous collection of behavioral and physiological biomarker data from the animals themselves. Combining digital biomarkers with rapid advances in real-time machine learning and predictive analysis of preclinical big data, enables new study workflows that both improve scientific study outcomes and animal welfare. This session will examine a number of topics, including how digital data can be used to create specifications around normal animals prior to study start, improve randomization, design adaptive studies to reduce animal numbers, and creation of algorithms to alert on unhealthy animals to reduce dead animals. This Technical Trade Presentation is sponsored in part by Vium Inc.

\ Adding Dough to the Raisins Makes a Cake— Connecting Best of Breed Technologies to Increase Efficiency and Reduce Risks

2:40 PM - 3:00 PM/Room: 205 Speaker: Andreas Staubi Moderator: J Patrick Guider Jr Organizations can pick their “technology raisins” from a wide range of products for all areas of their operations to increase efficiency, reduce costs and risks, and increase data integrity. Additionally, many technologies exist for environmental monitoring, tracking

Animal Welfare, Regulatory Compliance, and Public Education g Biomedical Research, Medicine, and Methodology \Facility Design, Management, and Operation n One Health

SUNDAY AFTERNOON

\ IVC Rack Monitoring and Control—New Technology Advancements

3:00 PM - 3:20 PM/Room: 205 Speaker: Rick Deitrich Moderator: Pat Guider Since the introduction of rodent individually vented cage (IVC) systems in 1979, we continue to see innovations with respect to enrichment, plastic materials, modular design, and cage configurations, just to name a few. Key components of these IVC racks are the air supply and exhaust equipment that support these systems. This presentation will focus on the integration of rack monitoring and control systems. The new wireless sensor technologies provide 24-hour monitoring and data logging of air flow, pressures, air change rates, temperature, and humidity. Mobile apps provide remote access and status of the system, including text notifications and alarms. Secondly, we will discuss new advanced blower control systems that maintain proper airflow and cage air exchange rates. This Technical Trade Presentation is sponsored in part by Thoren Caging Systems.

\ Documenting and Tracking Processes in Animal Isolators and Cleanrooms: How to Overcome Obstacles

3:20 PM - 3:40 PM/Room: 205 Speaker: Stephan Hammelbacher Moderator: Pat Guider Clinical research organizations help scientists to augment animal models in isolators. Researchers are increasingly working with gnotobiotic animals in isolators. The documentation of breeding processes, for example, in isolators supported by software is made more difficult by the fact that the hands in the isolators are tied by the glove ports and must be removed from the gloves for documentation. Likewise, it is difficult to perform intermediate recordings in isolators that can be reused outside the isolators. This presentation will show ways and means of performing process documentation in isolators without any active electronic components in the isolators, while leaving the hands in the gloves.

Productivity progress is significant as a result of such measures and leads to significantly better data quality. The presentation is aimed at managers of large CROs using isolators, facility managers, researchers, supervisors, and animal technicians. This Technical Trade Presentation is sponsored in part by Galilei Software GmbH.

\ Managing Your Breeding Core Like a Business

3:40 PM - 4:00 PM/Room: 205 Speaker: Laura Gee Moderator: Kelly Rodriques A breeding core provides reproductive services to the research community to reduce over-breeding, excessive per diem fees, and associated laboratory personnel costs. Breeding cores may struggle to find a balance between these services and the human, technical, and financial resources needed to perform them. Responsible operation of a breeding core requires the ability to think like a business manager and a scientist at the same time. With fundamental business strategies, the right communication, and tracking tools along with a best-practice mindset, breeding cores can optimize processes, provide measurable insights into core functions, and increase awareness and trust among the research community. Attendees will learn about the tools available to implement business strategies and improve overall breeding core function, communication, and return on services provided. The target audience may include, but is not limited to facility, veterinary, breeding core, colony managers, operations personnel/management, and IACUC members. This Technical Trade Presentation is sponsored in part by SoftMouse.NET.

Controlling Your Controlled Substances—Using RFID to Monitor, Track, and Report on Controlled Drugs

4:00 PM - 4:20 PM/Room: 205 Speaker: Matthew Ruiter Moderator: Pat Guider With government regulation expanding, there is a growing need to accurately account for all controlled substances within laboratories. Recording drug inventory, user, and disposition data is a labor-intensive practice filled with errors and miscalculations. UID addresses these concerns by combining state of the art software with RFID technology to provide 100% accountability for all cabinet access, user, drug volume, disposition, use and full active inventory detail. This presentation will address how the daily challenges that are present with typical manual data entry systems are prevented by using RFID technology and enhanced software control processes to record and manage data automatically all while reducing costs and time. This Technical Trade Presentation is sponsored in part by UID Identification Solutions (UID).

Animal Welfare, Regulatory Compliance, and Public Education g Biomedical Research, Medicine, and Methodology \Facility Design, Management, and Operation n One Health

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cages, managing inventories, identifying animals, replacing cage cards, and managing training and financial data. This presentation provides insight into how organizations can greatly benefit from using the best fit-for-purpose technologies in a connected, integrated way. We’ll demonstrate this approach using the example of tick@ lab, a-tune’s compliance and lab animal research software suite that inter-operates with other laboratory animal science vendors. We will explain the prerequisites and requirements for creating an integrated technology landscape—forming the perfect cake from your technology raisins. This Technical Trade Presentation is sponsored in part by A-Tune Software, Inc.

SUNDAY AFTERNOON

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TECHNICAL TRADE PRESENTATIONS TRACK II – OPTIMIZING OPERATIONS g Rodent Surgical Monitoring and Anesthetized Imaging

1:00 PM - 1:20 PM/Room: 203 Speaker: Brianna Sellers Moderator: John Park This presentation highlights the importance of rodent surgical monitoring and describes different rodent anesthesia options, specifically focusing on options available during rodent surgical model procedures and subsequent imaging follow-up. Topics discussed include inhalation versus injectable anesthesia, the physiological side effects of anesthesia, the necessity of supporting core body temperature, and performing monitoring during surgical procedures and rodent imaging. Further, this presentation details the increasing Institutional Animal Care and Use Committee (IACUC) requirements as well as the use of monitoring devices and anesthesia systems to adapt to these increased requirements. This Technical Trade Presentation is sponsored in part by Scintica Instrumentation Inc.

various combinations of water, nutrients, minerals, and electrolytes to aid in consumption and recovery. These flavor-enhanced gels are pure and ready-to-use for mixing in the target medication. They are then placed into the recovering animal’s cage in place of the water supply or as supplemental to its normal food source for easy administration of medication. The highly palatable gels promote consumption among recovering rodents, delivering medication in a convenient way without animal handling. Research results demonstrate that effective dosage can be achieved by oral consumption of medicated gels to achieve sustained blood levels of analgesics, antibiotics, and anthelmintics. This Technical Trade Presentation is sponsored in part by ClearH2O.

Bedding: A Controllable Environmental Factor

1:20 PM - 1:40 PM/Room: 203 Speaker: Dave FitzMiller Moderator: John Park While the reasons for losing animals during and after surgery are numerous, many are easily identified and preventable. Why is warming important? What vital signs should I monitor? How does postsurgical care impact survival rates? This presentation will answer these questions and provide animal surgeons and caregivers insights into the best methods for surgical and recovery care to ensure successful survival outcomes. This Technical Trade Presentation is sponsored in part by Kent Scientific Corp.

2:00 PM - 2:20 PM/Room: 203 Speaker: René Ketelsen Moderator: Bob Bentzinger The potential impact that air, water, diet, caging systems, husbandry practices, and the animals themselves can have on the outcome of research data has been reviewed and guidelines established. Many husbandry standards have developed from accepted practices rather than from systematic data collection. Federal policies and accrediting agencies are increasingly requiring data to support performance-based standards or procedures. To date, there are no standards for laboratory animal bedding. According to the Guide, laboratory animal bedding is a controllable environmental factor. The influence it can have over experimental data is often overlooked. Minimizing environmental causes of physiological alterations in research animal populations has long been the focus of laboratory animal science. Laboratory animal science professionals, in consultation with the research staff, should select the most appropriate bedding which will not compromise the research data. This presentation will review the source, production, and the potential for microbial contaminants, phytoestrogens, mycotoxins, and endotoxins of the most commonly used bedding materials to confound research results. This Technical Trade Presentation is sponsored in part by Shepherd Specialty Papers.

Improving Pain Management and Medication Delivery Techniques for Better Laboratory Animal Welfare and Research Outcomes

g A Versatile Caging System to Collect Simultaneous Fluid and Electrical Samples from Freely Moving, Low-stress Rodents

Are Your Animals Dying During Surgery?

1:40 PM - 2:00 PM/Room: 203 Speaker: Morgane Stum Moderator: Jay Palmer It is the ethical obligation of animal care professionals to reduce or eliminate pain and improve medication delivery in research animals while minimizing any interference to achieve research objectives. Managing pain through the application of analgesics and other therapeutics to reduce conditional distress are essential husbandry practices to support animal welfare. For laboratory animal veterinarians, lab technicians, and principal investigators, injections, oral suspensions, and medicated feed are the most common methods of medication delivery to manage compromised research animals experiencing varying degrees of distress. Unfortunately, the added stress from the handling and restraint to provide injections, the dosage inaccuracy of nonwater soluble suspensions, and low palatability of medicated feed for the compromised rodent contradicts best practices of animal health and welfare and can impede recovery. In addition, the traditional practice of injection or water bottle delivery can be labor-inefficient, requiring only qualified staff for administration of injection or extra time for staff to shake water bottles daily for resuspension of the therapeutic. ClearH2O’s medication delivery gel products, MediGel®, MediDrop®, DietGel®, and LabGel® are nutritionally fortified dietary supplements containing

2:20 PM - 2:40 PM/Room: 203 Speaker: Candace Rohde-Johnson Moderator: Shelly Carballo Awake animal studies are a preferred way to collect data, but typical caging systems are limited in the type and variety of samples that can be collected. When using a liquid swivel-based system, the study is constrained by the number of fluid lines available, and when using a commutator there are limits to both the number of lines and the quality of the signal. In addition, these two technologies typically aren’t compatible, meaning that you cannot easily have a wired connection and a fluid connection side by side in the same animal. This creates restrictions on study designs and often results in the use of additional animals to gather all of the necessary data. There is a commercially available caging system that circumvents these issues. This caging system reacts to the movement of the animal, turning only when needed to keep connected lines from tangling. This system makes it possible to connect a fluid line and electrical line side by side, or to connect multiple fluid lines (such as bile collection, bile salts infusion, dosing line, and blood collection line) in a single animal and can increase study throughput while reducing animal numbers. Additionally, rats and mice can be dosed and sampled from outside of the cage to reduce stress and minimize interaction with the subject. A final benefit of the system is that activity data can be easily collected to learn

Animal Welfare, Regulatory Compliance, and Public Education g Biomedical Research, Medicine, and Methodology \Facility Design, Management, and Operation n One Health

SUNDAY AFTERNOON

n Designed to Be Different

2:40 PM - 3:00 PM/Room: 203 Speaker: Liz Kramer Moderator: John Park Ventilated rodent cages come in a variety of flavors, differing in air flow schemas, filter placement, blower control methods, and the convenience of disposables. What most ventilated caging has in common is the use of high velocity air passed over the bedding in order to rid the cage of contaminants. There is a new caging system that is designed to be different. It allows air to pass through the bedding rather than over it. The design affords the user a different experience including extended cage change, lower carbon footprint, labor efficiencies, and cleaner environment for the animal inhabitants. If the airflow can keep the bedding dry, ammonia generation will be low. The lower the ammonia, theoretically the longer the cage change interval. However, nobody changes cages based on performance data. Additionally, measuring ammonia is not a straightforward process. This talk will help to demystify some of the common challenges in measuring ammonia. The rationale for placement of the sensor, the different types of sensors, duration of the sensor exposure, and sample collection frequency will be discussed. Simple tricks for creating a sampling port will also be presented. The methods presented here were gathered during independent evaluations. The cost of research is rising, and translatability is being scrutinized. Can we afford to simply maintain the status quo or is it time to consider something different? This Technical Trade Presentation is sponsored in part by Lenderking Caging Products.

\ Answering the Call of Wastewater Requirements in Laboratory Animal Care Cage Washing Products

3:00 PM - 3:20 PM/Room: 203 Speaker: Amy Ingraham Moderator: Warren E Ball The laboratory animal science facility benefits from the use of mechanical cage washers and chemical agents chosen to clean high numbers of cages in a short period of time. Facilities request cleaning products that are more efficient in aiding the removal of gross soils and very importantly, that remain stable in high-wash temperatures. These products are normally on the alkaline side of the pH spectrum, and some may require the use of a neutralizer prior to being released to a common drain. Additionally, these products may benefit from including phosphates, caustics, or sodium hypochlorite. In very hard water areas or when working with certain species, there is a definite need for acidic compounds to remove urine scale. Working within state and local effluent regulations and acknowledging our own advancements in cleaning technology, we will discuss a new direction to produce products that offer exceptional cleaning for rodent and rabbit soils, without the use of caustic ingredients, chlorine, or phosphates. This has produced a product for us that is performing in hard water

conditions, while not requiring neutralization prior to discharge to effluent waste water. Meeting the expectations of regulatory requests, while providing a proficient cleaning product is sometimes like accomplishing “pure freaking magic.” This Technical Trade Presentation is sponsored in part by Pharmacal Research Laboratories.

\ Can Cleaners and Disinfectants Affect ATP Readings?

3:20 PM - 3:40 PM/Room: 203 Speaker: Nick Hidell Moderator: Tim Hidell Adenosine Triphosphate (ATP) monitoring systems, such as the AccuPoint™ Advanced system, are popular as an efficient, accurate, and economical method of surface cleaning validation. However, recently we have heard claims that certain types of cleaners/ disinfectants may interfere with readings from ATP testing, causing inaccurate readings and rendering the testing unreliable. ATP is a protein that is present in all organic matter. Measuring its presence is a good indication of the organic soil load on a surface, and therefore the possibility that microbial life that may be hidden in that soil. This is particularly important because, without ATP, many facilities are using microbial plating—which is both expensive and slow—to determine if their cleaning efforts are sufficient. With ATP testing, cleaning practices can be tested instantly by measuring how much ATP is on a surface beforehand versus how much is there after cleaning. The question at hand is whether or not no-rinse cleaner/disinfectants left on a surface after cleaning will interfere with ATP measurements and cause inaccurate ATP readings. While surfaces should be cleaned and dried before testing, studies conducted by Neogen (manufacturer of the AccuPoint Advanced) show that the presence cleaner/disinfectant does not alter ATP testing results on properly cleaned surfaces. These tests were run against a variety of cleaner/disinfectants [b1] including quaternary ammonia, chlorine-dioxide and accelerated hydrogen peroxide. They found that none of the cleaners/disinfectants in the study affected the results of the ATP monitoring. A high ATP reading, even when cleaner/disinfectant is still present on the surface, indicates that the test site is dirty, i.e. the soil has not been adequately removed. If the site has been treated with a cleaner, a high ATP reading indicates either poor cleaning execution, or inadequate efficacy of the cleaner/disinfectant. It’s important for researchers and chemical manufacturers alike to take these claims seriously and consider the scientific literature when developing solutions for the constantly evolving microbiological challenges we all face. This Technical Trade Presentation is sponsored in part by Quip Laboratories.

\ Improving Safety and Reducing Costs in Automated Vivarium Doors

3:40 PM - 4:00 PM/Room: 203 Speaker: William R “Bill” Britz Moderator: Frank Herlihy Access to many vivarium spaces, including storage alcoves and cage wash facilities, are controlled via automatic sliding doors. In many places, these doors are high-speed, guillotine-style, industrial roll-up doors. In other areas, horizontal sliding doors are utilized which require significant wall space. This presentation will examine the use of these doors with regard to personnel safety, construction cost, and long-term maintenance and operation costs. Safer and more cost-effective options will be considered. Architects, planners, and those responsible for vivarium design will benefit from this presentation. This Technical Trade Presentation is sponsored in part by Britz & Company.

Animal Welfare, Regulatory Compliance, and Public Education g Biomedical Research, Medicine, and Methodology \Facility Design, Management, and Operation n One Health

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more about the movement of the animal while on study. During this session we’ll introduce the movement responsive caging system, review the types of data that can be collected, explore the effects of reduced stress on the animals, and share protocols which lead to a reduction in animal numbers. This session will be most beneficial for researchers performing awake animal studies that require dosing and sampling, but will have significant impact on those trying to combine protocols including e-phys, EEG, infusion, or repeated sampling. The data will also be relevant to any animal researchers interested in the effects of stress on animals during studies, particularly the stress that comes from human interaction. This Technical Trade Presentation is sponsored in part by BASi (Bioanalytical Systems, Inc).

SUNDAY AFTERNOON

A A L A S 7 0 th N AT I O N A L M E E T I N G

\ The Science and Safety behind the White Suits

4:00 PM - 4:20 PM/Room: 203 Speaker/Moderator: Alex Bradley Providing safer work environments through education, awareness, and training is a critical process. The broad landscape of industry standards, complex regulations, chemical cleaning, or biological safety requirements can be challenging. A wide variety of options ranging from coveralls, sleeves, and shoe covers make the selection of personal protective equipment (PPE) ensembles difficult. Industry advancements ranging from communication technologies, analytical capabilities, and material science allow for continuous improvement in the selection of PPE relative to workplace health and safety. This presentation will address the connection between the science of PPE and the overall application to industry PPE requirements. We will compare selection options driven by the standard operating procedures in a controlled (or sterile) lab environment versus those needed to address pandemic

outbreaks. Some relevant industry hazards influencing the balance of protective apparel design attributes such as protection, durability, and comfort while maintaining the need for compliance will be surveyed. The audience will learn about interactive software tools for desktop or mobile devices that provide data to help them make their informed decisions about PPE. Attendees will see the benefit of having selector resources at their disposal. A demonstration will focus on showcasing different job scenarios that require various levels of PPE applications. Participants will be able to identify appropriate industry standards for selecting PPE as well as recognize the benefits and limitations associated with the intrinsic methodology. In addition, audience members will learn to identify and differentiate protective apparel design attributes by understanding the fundamental aspects of material selection as it relates to the hazard assessment. This Technical Trade Presentation is sponsored in part by DuPont Protective Apparel.

SABLE ENABLES

Full Integration of Behavioral Monitoring and Metabolic Phenotyping Sable Systems is the world leader in metabolic and behavioral measurement, giving you the full picture of animal activity. • Synchronized, 24/7 real-time monitoring of activity, food & water intake; remote options • Home-cage design creates a low-stress enriched environment • Reduces number of animals needed per study

AALAS BOOTH #586

1-800-330-0465 sales@sablesys.com www.sablesys.com

Animal Welfare, Regulatory Compliance, and Public Education g Biomedical Research, Medicine, and Methodology \Facility Design, Management, and Operation n One Health

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MONDAY MORNING

A A L A S 7 0 th N AT I O N A L M E E T I N G

WORKSHOPS g W-01A Microsurgery Skills Training Using Surgical Loupes (offered twice, also Monday 1:00 PM)

8:00 AM - 12:00 PM/Room: 301 Leader: Robert F Hoyt Jr Faculty: Robert F Hoyt Jr, Timothy J Hunt, Karen Keeran, Tom Thomas, Tannia Clark, Elena Kuznetsova, Gayle Nugent, Victoria L Haley, Kenneth Jeffries, Tanya Herzog, Audrey Noguchi Facilitator: TBN Workshop Fee: $250 Workshop Limit: 20 Performing surgical procedures with the aid of magnification has gained widespread use in human medicine over the past 30 years. Using surgical loupes, surgeons can now routinely perform procedures on very small structures that were considered impossible only a few decades ago. Within the past 20 years, the use of magnification to perform microsurgical techniques has also quickly spread to other health care disciplines, including dentists and dermatologists, to increase surgical precision. Using them is now considered the standard of care. The importance of microsurgery to biomedical research has, unfortunately, only just begun to be realized. Because of their small body structures, laboratory animals, such as rats and mice, have generally not been considered as animal models for many types of surgical procedures routinely performed in biomedical research. Investigators have rather elected to use larger species such as dogs, pigs, sheep, rabbits, or nonhuman primates for such modeling because both surgical support equipment is more readily available, and the surgical techniques are more familiar to the support personnel. The recent shift to using genetically engineered rodents, especially mice, has now resulted in increased researcher desires to use these animals in more sophisticated modeling procedures, especially surgery. Rather than being limited to only simple procedures such as IM, IP, or IV injections, researchers using microsurgery can now perform complex surgical procedures on many rodent organ systems, such as the heart, lungs, and the gastrointestinal tract. Training will be conducted in 2 two phases: a) teaching students to develop technical skills by performing exercises using surgical loupes and b) applying these skills to perform simple surgical procedures using rodent and organ surrogates. This Workshop is sponsored in part by Q-Optics, RICA Surgical Products, SurgiReal Products, Inc., and Supramid Suture.

g W-02 Perioperative Anesthetic Monitoring

8:00 AM - 12:00 PM/Room: 302 Leader: Cholawat Pacharinsak Faculty: Facilitator: TBA Workshop Fee: $150 Workshop Limit: 30 General anesthesia alters multiple physiologic responses of the body. Therefore, to have safe anesthesia, anesthetists should monitor patients starting from premedication to recovery. Monitoring requires anesthetists to have a thorough understanding of the various monitoring equipment used, including the interpretation of information generated. One big advantage of anesthetic monitoring is to alert anesthetists regarding arising complications so anesthetists can take the necessary actions to correct the complications before they become irreversible. This workshop will focus on basic laboratory animal monitoring methods, including ECG, blood pressure, ETCO2, %SpO2, and body temperature. This dry workshop is suited for veterinarians, veterinary technicians, IACUC members, and scientists. This Workshop is sponsored in part by Kent Scientific.

\ W-03 Successful Operation of a Gnotobiotics Facility

8:00 AM - 12:00 PM/Room: 304 Leaders: Alton G Swennes and Betty R Theriault Faculty: Stephanie W Fowler, Joshua M Frost, Allison R Rogala, Alton G Swennes, Betty R Theriault Facilitator: Julia R Krout Workshop Fee: $150 Workshop Limit: 50 This workshop is designed to provide guidance to those in the early stages of developing a gnotobiotics program. The workshop will provide background on facility design and requirements, sterilization techniques and their limitations, and the effective use of common equipment. Discussion will focus on the use of flexible film isolators (sterilization, cylinder packing, and port entry) and positive-pressure sealed IVC systems, including key procedural aspects that enable the maintenance of germ-free or gnotobiotic animals. Participants will gain perspective from workshop faculty that have developed large academically oriented programs. This workshop targets those that are currently or might become involved in setting up a gnotobiotics program, including managers, veterinarians, research scientists, and program administrators. Attendees will be introduced to the variety of equipment options available and the current standards in the field of gnotobiology. Participants will leave the workshop with a basic understanding of the central concepts required to operate a gnotobiotics program, including both facility management and basic technical competencies. This will provide a foundation to those that are new to the field. This Workshop is sponsored in part by Tecniplast, Allentown, Class Biologically Clean, Taconic and Charles River.

\ W-04 What Generational Gap? Effectively Working and Leading across Generational Culture Differences

8:00 AM - 12:00 PM/Room: 303 Leader/Faculty: Jamie Mueller Facilitator: TBN Workshop Fee: $150 Workshop Limit: 50 The topic of working across generations is not a new one. However, as potentially five generations will be working side by side by 2020, the question still remains of how to work and lead effectively across generational differences. In addition, the question of how to address the differences, perceived or real, also requires new thinking. To what degree is knowledge of the other generations helpful or hurtful in giving those working across generations the support, skills and wisdom they need to do the hard work of managing and leading with difference at work? This workshop will address these questions as well as consider the balance of (a) knowledge of one’s own generation, (b) the other generations and, (c) skills in dealing with and responding to difference. Participants will increase their overall awareness and understanding of difference across generations as well as learn strategies to communicate and manage conflict in culturally diverse environments. This workshop is targeted to leaders, directors, and managers who manage team members from different generations and cultures, as well as team members who work and collaborate with different generations and cultures.

Exhibit Hall Refreshment Break—Denver Delights! 8:30 a.m.–10:30 a.m. Sponsored by NEPCO

Animal Welfare, Regulatory Compliance, and Public Education g Biomedical Research, Medicine, and Methodology \Facility Design, Management, and Operation n One Health

MONDAY MORNING SEMINARS

Changing Times in the Animal Research Oversight Environment

8:00 AM - 10:15 AM/Room: Mile High Ballroom 1A Leader/Moderator: Lois A Zitzow Facilitator: TBN Change in any organization is inevitable, and programs involved in laboratory animal science are no exception. Advances in technology, improvements in veterinary care, operational efficiency or stressors, and modifications in regulatory guidelines, coupled with scientific progress and institutional change, can create significant alterations in how a laboratory animal program operates. These changes can have a substantial impact, both positive and negative, on employee culture and productivity. The goal of the seminar is to give participants the tools needed to successfully manage change. Participants in this seminar will learn about some key models of organizational change and the impact of change on employees. Providing participants with different approaches and tools used from real-life examples will be central to the seminar. If you are looking to improve your workplace and implement successful change while minimizing stress on your coworkers, this seminar is for you. The target audience is individuals at all organizational levels, including directors, managers, supervisors, and team leaders.

Speakers/Topics: 8:00

Lois A Zitzow

Welcome and Introductions