Software tools to sustain w life science
Tracking the virus around the globe
The study of biologica in diseases, biodiversit Open Science software such as the SIB Resou discover how knowledge and s SARS-C
Through the analysis and sharing of massive amounts of genetic sequences, the evolutionary history of the virus can be unfolded to track it ‘live’, all around the world. Analysis of over half of all sequences generated in Switzerland, from clinical and wastewater samples V-PIPE Enabling real-time tracking of the evolution of the virus and helping public health laboratories understand how cases are connected to each other NEXTSTRAIN
Revealing how it enters our cells
Unravelling its impacts on our bodies Understanding the biological mechanisms of the virus’s entry and interaction with our organism enables the development of treatments and vaccines. Deep insights into the 3D structure and function of viral and host proteins helps pinpoint potential entry-points and binding sites, such as ACE2 UNIPROTKB/SWISS-PROT, NEXTPROT, STRING, SWISS-MODEL
Identifying potential and sometimes intermediate hosts for the virus as well as putative transmission chains, by comparing the receptor ACE2 across multiple species SWISSORTHOLOGY
To grasp the complexities of infection severity or organs affected, zooming in at the molecular level is needed. Understanding the regulatory response to infection by comparing pre- and post-infection gene expression profiles; how diverse the virus’s targets are, especially in long COVID, by revealing the expression of target genes in various organs; how the circadian clock affects the virus’s pathogenicity… ASAP, SWISSREGULON, BGEE, EPD
MORE RESOURCES BY SIB GROUPS SUPPORTING SARS-COV-2 RESEARCH
Gaining insights into the metabolic dysfunctions induced by the virus, or those which put patients at greater risk of developing a severe form of the disease SWISSLIPIDS, RHEA