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THE BIOMEDICAL SCIENTIST
OPINION
One-to-one
THE KNIFE THAT CAN DETECT WOMB CANCER For the first time, researchers have shown how the iKnife can accurately detect endometrial cancer before treatment decisions are made. bout 9700 women and people with gynaecological organs are diagnosed with endometrial cancer every year in the UK. The diagnostic process typically involves sending large numbers of people with abnormal, often postmenopausal bleeding, to urgent assessment clinics for investigations. Usually a scan is performed and a biopsy taken for histological diagnosis. The aim is to rule out endometrial cancer and thankfully more than 90% of people going through the procedure will not receive a diagnosis. But the result of this pathology can take some days and weeks to come back. Everyone awaiting results will likely be very anxious and those with cancer will face delays in treatment. “We wanted to find a way of making the diagnosis on the biopsy at the point of taking the tissue,” says Professor Sadaf Ghaem-Maghami, Chair of Gynaecological Oncology and Honorary Consultant in
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Surgical Gynaecological Oncology at Imperial College London, who has led a research team in diagnosing womb cancer using electrosurgical methods.
Diagnostic accuracy The team used rapid evaporative ionising mass spectrometry (REIMS), the iKnife, to assess biopsy tissue – taken from the uterus using a device called a Pipelle – from 150 women who had endometrial biopsies for abnormal vaginal bleeding. The iKnife works by cutting through tissue while delivering an electrical current, heating as it cuts. It then captures and analyses the vapour that is released to spot any “cancer flags” in the
“It captures and analyses the vapour that is released to spot any ‘cancer flags’”
phospholipids in the tissue sample. “We used the iKnife to burn through the tissue to obtain a mass spectroscopy spectra from the tissues,” GhaemMaghami explains. “We constructed a diagnostic model using the REIMS software and the endometrial tissues and compared the results to histopathological routine diagnostic tests.” The team found the results from the iKnife could differentiate between normal and cancerous womb tissue with a diagnostic accuracy of 89% compared with the “gold standard” for making tissue diagnosis – biopsy. “The sensitivity, specificity, positive predictive value and negative predictive value were 85%, 93%, 94% and 85%, respectively,” GhaemMaghami says. “This means that if the iKnife suggests there is endometrial cancer, we can be quite confident that this is the case, and instigate further tests and start the process of arranging treatment for the patient. We can also reassure women that do not appear to have cancer, so that they do not live with anxiety of their diagnosis
20/01/2023 09:31