ANTI-AGEING
Reinforce urban skin by reconnecting with the origins Urbanisation has reduced our interaction with nature and triggered the prevalence of inflammatory disorders and skin sensitivity. Lipotec’s new Fensebiome peptide helps strengthen vulnerable urban skin by promoting a healthy microbiome and reinforcing skin’s barrier function. Júlia Comas, Olga Laporta, Marie Ollagnier, Núria Almiñana and Raquel Delgado reveal how. previous contact to modern lifestyles,
the other, twice a day. Several microbiome
provided an opportunity for vital microbiome
parameters were assessed after seven days
research. The research compared the
of treatment.
Yanonami skin microbial genome to
The diversity of skin bacteria was
that of urban individuals, who had a
determined using the Shannon index.
reduced connection to nature and higher
After the active treatment, the index value
antimicrobial practices. Results suggested
showed a higher increment compared to
the exposure to modern lifestyles may induce
the placebo, indicating increased bacterial
alterations in the cutaneous microbiota, such
diversity that leads to improved skin health.
as a reduction in bacterial diversity, which
The relative abundance was evaluated
could make skin prone to sensitivity and
at the phylum and family taxonomic levels.
discomfort.1
At the end of the treatment, the active
A vital function of the skin microbiota is
ingredient helped increase the relative
to contribute to skin’s role as a protective
abundance of the beneficial bacterial
barrier; this can occur through different
phylum of Proteobacteria by 15.2 percent
iscomfort, fragility, dehydration,
mechanisms. Through direct competition for
(p<0.01) and reduce Firmicutes phylum by
scaliness and redness are all
space and nutrients, beneficial bacteria can
21.3 percent (p<0.01). At the family level, it
characteristics of sensitive
cause the exclusion of potentially harmful
helped increase the relative abundance
skin. Its intolerance to external
bacteria2. The reciprocal interaction of
of Moraxellaceae by 6.4 percent (p<0.01).
aggressors has increased in consumers in
microbiota with keratinocytes helps enhance
It also showed a 25.1 percent reduction in
most urban areas. This evidence suggests
the innate immune response, allowing
Staphylococcaceae (p<0.001).
reduced exposure to nature may be related
pathogen recognition to prevent their
to an increase in the risk of inflammatory
invasion, while promoting maintenance.3, 4
D
skin conditions. Yet the skin of our ancestors,
Fensebiome peptide (INCI: Aqua,
A predictive microbial functional profile was obtained and represented by KEGG pathway mapping. The peptide helped
who were in closer contact with nature, was
Caprylyl Glycol, Acetyl heptapeptide-4)
enhance bacterial metabolic pathways
more resilient.
is a heptaptide, available in South Africa
related to energy, lipids, amino acids,
from Savannah Fine Chemicals, which is
carbohydrates and vitamins, which have
hunter gatherer village in the Amazon
intended to strengthen urban exposed skin
been detected in the skin of isolated
jungle, whose people did not have any
by reinforcing microbial and physical barrier
populations and could promote the external
The discovery of an isolated Yanomami
0 Days
7 Days
function and preventing
Placebo
dehydration. The efficacy
supply of nutrients to the skin. A panel of 18 female urban subjects aged
of the active ingredient was
between 26 and 50, who presented dry skin
evaluated through several in
on the legs, applied a cream containing
vivo and in vitro tests.
one percent Fensebiome peptide solution
1% Fensebiome peptide solution
on one shin and a placebo on the other,
In vivo tests and results
twice a day for seven days. Samples of the
A metagenomics analysis
stripping and visualised by fluorescence.
was performed on 21 female
The active treatment decreased sloughed
urban volunteers aged
corneocytes by 18.6 percent (p<0.05),
between 18 and 59. They
reducing scaliness (see Figure 1).
applied a cream containing
Figure 1: Fluorescence microscopy images obtained from different strips before and after each treatment
18
| MAY 2018 | P C Review
stratum corneum were obtained by tape
A group of 20 female urban volunteers
one percent Fensebiome
aged between 22 and 45 applied a cream
peptide solution on the
containing one percent of the peptide
cubital fossa of one arm
solution and a placebo cream on the
and a placebo cream on
forearm, twice a day for seven days. TEWL