PRESERVATIVES & ANTI-MICROBIALS
Effective, market ready Triclosan alternative With the worldwide ban on the use of Triclosan, formulators are searching for safer alternatives to prevent microbial growth in personal care products. In response to this need, Salicylates and Chemicals presents a new anti-microbial solution, Salibact.
A
nti-microbial protection and the related technologies are becoming more relevant today than ever before. There have
be anti-fungal. This is where
been many concerns over the nature of
the properties of undecylenic
certain actives, such as Triclosan, and
acid help in making Salibact a
their biodegradability.
potent antimicrobial, which can
Salicylates and Chemicals has envisaged
be used at a wide pH range.
a novel anti-microbial Salibact, which brings
When compared to Triclosan,
together the antibacterial properties of
Salibact is more effective at one third the
Chlorhexidine and the antifungal property of
required dosage of Triclosan (0.1 percent
Undecylenic Acid in a single molecule. The
Salibact versus 0.3 percent Triclosan – see
prevalence of both of these ingredients have
Tables 1 to 5).
increased in personal care formulations as
Salibact is available in
many previously known molecules have been
a powder form and in a 20
placed under the regulatory radar.
percent Propylene Glycol
Salibact is a promising broad spectrum
solution. Although it is not
active, which is oil soluble and, more
compatible with anionic
importantly, biodegradable. It works across
surfactants, Salibact is
multiple applications, such as oral care
compatible with amphoteric
(toothpaste and mouth washes), hair care
surfactants Coco Betaine, Lauryl
(anti-dandruff shampoos) and skin care
Betaine and Cocamidopropyl
(handwashes, bar soaps, deodorants and
Betaine; the cationic surfactant
talc powders).
Cetrimonium Chloride; and
The properties of undecylenic acid help in making Salibact a potent antimicrobial
the following non-ionic surfactants – Lauryl
A potent antimicrobial
Glucoside, Decyl Glucoside, Caprylyl/
While some other salts like chlorhexidine
Capryl Glucoside, Alkyl Polyglucoside,
gluconate are also being used in certain
Coco-Glucoside, PEG-32, PEG-75, PEG-8,
formulations – the key missing activity would
PEG-90, Poloxamer 407 and Poloxamer 184. Table 2: Inhibitory concentration of 20 percent Salibact in a Propylene Glycol solution
Table 1: Minimum inhibitory concentration of Salibact in the powder format
Test organism
MIC
Staphylococcus aureus
Test organism
<0.0001
Salibact 20% + EG
Escherichia coli
0.05
Escherichia coli
0.001
Pseudomonas aeruginosa
0.05
Pseudomonas aeruginosa
0.001
Staphylococcus aureus
0.05 0.05
Salmonella typhi
0.0005
Salmonella typhi
Aspergillus niger
0.1
Aspergillus niger
0.7
Candida albicans
0.3
Candida albicans
0.05
Table 3: Kill test
Test organism
Minimum inhibitory concentration (µg/mL) Benzalkonium Chloride
PCMX Escherichia coli
Benzethonium Chloride
Triclosan
Salibact
10
>200
10
>10
10
Staphylococcus aureus
>200
10
10
10
0.001
Pseudomonas aeruginosa
0.001
>200
>200
10
10
Aspergillus niger
100
10
10
10
10
Candida albicans
100
10
10
10
0.05
The efficacy of Salibact versus other market leading anti-microbials
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| JULY 2019 | P C Review
