Gram-negative Organisms (5) Mycoplasma pneumoniae Pleomorphic (Illust.) Classic cause of atypical “walking” pneumonia (insidious onset, headache, nonproductive cough, patchy or diffuse interstitial infiltrate) X-ray looks worse than patient High titer of cold agglutinins (IgM) Grown on Eaton agar Treatment: macrolides, doxycycline, or fluoroquinolone (N.B. penicillin ineffective since Mycoplasma have no cell wall) o Not seen on Gram stain Bacterial membrane contains sterols for stability Mycoplasmas pneumonia is more common in patients < 30 years old Frequent outbreaks in military recruits and prisons Marc Imhotep Cray, M.D.