CONTINUING EDUCATION DRUG/ STRENGTH(S)/ MANUFACTURER(S)
BOLUS
DOSE DRUG KINETICS (MCG/KG) (T 1/2-ELIMINATION INFUSION HALF-LIFE) RATE (/MIN)
EFFECTS
POSSIBLE ADVERSE REACTIONS
COMMENTS
PHOSPHODIESTERASE INHIBITOR Mechanism of Action: a bipyridine with positive inotrope and vasodilator, and little chronotropic activity Milrinone
Various manufacturers (Primacor®)
no
0.125 to 0.75
2.5 hours
- Increased Cardiac Decreased Output blood pressure - Increased Heart rate Tachyarrhythmia - Decreased Systemic vascular resistance - Decreased Pulmonary vascular resistance
Metabolism-hepatic Renal impairmentsignificantly increases the terminal elimination half-life-Reductions in infusion rate may be necessary
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Insight
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