15:45-16:45 | Orion Hall (5F)
Friday Poster Session | AGen2023 69126 | The Elderly’s Organs are Ready for Functional Rejuvenation Tae Jun Park, Ajou University, South Korea Hong Seok Kim, Inha University, South Korea Young Hwa Kim, Ajou University, South Korea Young-Kyoung Lee, Ajou University, South Korea Aging has been regarded as a biological process resulting from the accumulation of stressed or damaged cells, so-called senescent cells. However, interestingly, we found that the number of fully senescent cells was not increased significantly in normal tissues of the elderly compared to the young individual. Instead, fibroblasts and smooth muscle cells which are neither proliferative nor fully senescent, were commonly observed in the elderly’s tissue; we called them‘mid-old' status cells. The characteristics of mid-old cells are upregulation of inflammation-related genes and downregulation of antiinflammation related genes. Furthermore, we revealed mid-old cells develops an inflammatory microenvironment in the stroma via upregulation of MMP9 expression which decreases the stability of epithelial cells lying on the basement membrane, resulting in decrease of epithelial cell’s function. Strikingly, the microenvironmental change and the functional decline of mid-old cells can be rejuvenated by a young cell-originated protein. In sum, our data provided a new concept about rejuvenation; it can be achieved by the functional reverse of mid-old cells rather than the elimination of senescent cells themselves. 69472 | Demarcation of Midbrain Structures With Deep Neural Network and Quantitative Susceptibility Mapping Farshad Falahati, Karolinska Institutet, Sweden Jonatan Gustavsson, Karolinska Institutet, Sweden Alireza Salami, Karolinska Institutet, Sweden Grégoria Kalpouzos, Karolinska Institutet, Sweden The atrophy and iron load of the subthalamic nucleus (STN), substantia nigra (SN), and red nucleus (RN) characterize neurological disorders such as Parkinson's disease. Despite their key role in motor control and cognition, they have been overlooked partly due to challenges in imaging these small and deep-seated midbrain structures and lack of accurate and efficient segmentation methods. Quantitative susceptibility mapping (QSM), an MRI technique to estimate in-vivo iron contents, provides a distinguishable contrast of these iron-rich structures. We propose an automated segmentation approach for demarcating STN, SN and RN, based on a deep convolutional neural networks model with U-Net architecture and MRI data. MRI data including T1-weighted, FLAIR, QSM and relaxometry (R2star maps) in addition to manually delineated nuclei masks on QSM images of 40 individuals were used to train a deep learning model in single-modal (using each MRI modality individually) and multi-modal (combinations of MRI data) setups. Five-fold cross validation results revealed that the multi-modal model using QSM and FLAIR performed best (average Dice scores of 0.84, 0.91 and 0.94 for STN, SN and RN, respectively). Subsequently, the best model was applied on a dataset including 208 adults (age range 20-80). Cross-sectional analyses showed significant associations between iron content and age in the STN (r=0.47, p<0.001), SN (r=0.28, p<0.001) and RN (r=0.34, p<0.001). Our automatic segmentation approach using deep neural networks offers a novel tool to access and accurately evaluate volume and iron load of these small midbrain nuclei which can lead to a deeper understanding of their function.
Entrepreneurship/Silver Economy
67746 | Relationship Between Periodontal Disease and Dizziness in Older Patients With Chronic Obstructive Pulmonary Disease Yu-Hsiang Kuan, Chung Shan Medical University, Taiwan Ci-Wen Luo, Chung Shan Medical University, Taiwan Rosa Huang Liu, Chung Shan Medical University, Taiwan Periodontal disease is the neglected syndrome that leads to tooth loss and systemic diseases in older men. Dizziness is a condition with high reported incidences; they worsen with age and can burden the health systems. The present study investigated whether periodontal disease causes dizziness in older patients with chronic obstructive pulmonary disease (COPD). Research data was retrieved from the National Health Insurance Research Database. Older patients with COPD were diagnosed with periodontal disease, dizziness. In the control group, we randomly selected individuals without periodontal disease who were sex and age-matched with the investigated participants. The Kaplan–Meier curve indicated that the cumulative incidence of dizziness was significantly higher among older patients with COPD and periodontal disease compared to the controls. After adjustment, Cox proportional hazards analysis revealed that older patients with COPD with periodontal disease had an increased risk of dizziness. Compared to controls, the risk of dizziness among periodontal disease was higher in women and male patients. Therefore, periodontal disease is not only a risk factor for dizziness, but also an independent risk factor for dizziness in older patients with COPD. 69085 | Action Research on Intergenerational Program of Senior Fitness Fu-An Chung, YUNTECH, Taiwan Wei-Shan Su, YUNTECH, Taiwan This study applied intergenerational learning for the senior fitness, and to conduct the reflection on the teaching process via action research. To inspect the effects of their physical abilities and psychological feelings and also enhanced the professional growth of teaching practice. By intentional sampling,8 preschool's students and 12 members of senior fitness center have done exercise classes for an hour a week for 10 times. The qualitative data were collected via teacher ’s diaries, students’ feedback, video observation and semi-structured interviews.The results have the advantages of benefiting both body and mind, creating fun and happiness, enhancing self-worth, and being economical and sustainable.It is used for the purpose of elderly sports to provide reference for designing intergenerational physical activity courses, and to discover the implementation time as a reference for relevant units to establish and implement intergenerational learning to promote senior exercise policy and follow-up research, it has become a new trend for senior exercise to broaden the curriculum of joint exercise for the elderly and promote the independent exercise mode of the elderly.Also as a resource for the multifarious professionals and students, practitioners, investigators and policy makers.
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