High-Profile Focus: Awards
26
July 2022
CRISPR Therapeutics Wins ISPE Award Framingham, MA – CRISPR Therapeutics was selected as the 2022 Facility of the Year Awards (FOYA) category winner for innovation by the International Society of Pharmaceutical Engineering (ISPE) for the CRISPR Therapeutics manufacturing facility in Framingham. CRISPR Therapeutics is harnessing the CRISPR/ Cas9 gene-editing platform to develop gene-based medicines for patients with serious diseases. The project was awarded a FOYA award for innovation based on the design of the facility, which provides an end-to-end solution for production and fills operations. The ISPE FOYA judging committee noted many facets of the submission, which included: • Digital systems and automation at all levels of the operation allow continuous monitoring and efficient product production and release. • A flexible utilization model allows for concurrent production of multiple products at different stages of development. • Independent and/or redundant utilities supplying individual clean rooms allow for continuous production without the need for a facility-wide maintenance shutdown. • The Facility Vaporized Hydrogen Peroxide (FVHP) system supports rapid product changeover and reduction in
the use of environmentally harmful chemicals. Following a series of user group meetings and executive workshops, DPS Group was able to glean CRISPR’s operational needs which were then used to develop a best-in-class cGMP design for cell therapy and AAV production. The DPS team worked collaboratively with CRISPR Therapeutics on numerous process design layouts and scenarios to create spaces that will be flexible for years to come.
CRISPR Therapeutics / Photo courtesy of CRISPR / ISPE
Through group visioning sessions, executive workshops, and focus groups, TRIA identified the spatial and aesthetic needs for the quality labs and office space. The open plan office and amenity spaces are designed to promote interaction and collaboration. The design embraces the abundant natural light and the exposed steel structure of the building. Glass walls are incorporated throughout to provide transparency, natural light and a connection between the office and manufacturing space.
DECCO, Inc. served as process piping contractor for the 55,000sf interior fitout of existing shell space for the new facility, including lab spaces, MST labs, warehouse, utilities, and office space. Supply partners and key participants also include Leggat McCall Properties LLC, owners representative; Commodore Builders LLC, construction manager/ general contractor; and Pare Corp., structural engineer.
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