PEDIATRIC REFERENCE INTERVALS Carbon Dioxide CO21,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect
Albumin G1,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect Age
Male (g/dL)
Female (g/dL)
Age
Male (mEq/L)
Female (mEq/L)
0− < 15 days
3.3−4.5
3.3−4.5
0− <15 days
5−20
5−20
15 days− <1 year
10−24
10−24
15 days− < 1 year
2.8−4.7
2.8−4.7
1− < 8 years
3.8−4.7
3.8−4.7
1− <5 years
14−24
14−24
17−26
17−26
18−28
17−26
8− < 15 years
4.1−4.8
4.1−4.8
5− <15 years
15− < 19 years
4.1−5.1
4−4.9
15− <19 years
Chloride Specimen Type: Serum Instrument/Reagent: Siemens ADVIA XPT/1800
Age
Male (U/L)
Female (U/L)
0− <1 year
5−33
5−33
1− < 13 years
9−25
9−25
13− <19 years
9−24
8−22
ALP (Alkaline Phosphatase)1,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect
0− <15 days
Male (U/L) 90−273
Magnesium1,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect Age
Male and Female (mg/dL)
0- <15 days
1.99- 3.94
15 days to <1 year
1.97- 3.09
1 to <19 years
1,3
ALT (Alanine Aminotransferase)1,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect
Age
The information in this chart was updated by MLO Staff based on the CALIPER database1 and reviewed by Khosrow Adeli, PhD, FCACB, DABCC, FADLM, Head, Clinical Biochemistry at The Hospital for Sick Children and Principle Investigator of the CALIPER Program. The reviewed chemistries are comparable to those listed in MLO's original Pediatric Reference Intervals chart, last updated in 2022. For reference intervals obtained by other lab instruments, see the CALIPER database.1
Female (U/L) 90−273
Age
Male and Female (mmol/L)
0- <19 years
104-109
C−Reactive Protein- High Sensitivity (hsCRP)1,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect Age
Male and Female (mg/L)
0− <15 days
0.3−6.1
15 days− <15 years
0.1−1.0
15-<19 years
0.1-1.7
15 days− <1 year
134−518
134−518
1− <10 years
156−369
156−369
10− <13 years
141−460
141−460
13− <15 years
127−517
62−280
Age
Male (U/L)
Female (U/L)
15− <17 years
89−365
54−128
0− < 13 years
68-293
68-293
17− <19 years
59−164
48−95
13− <19 years
80-354
48-200
Bilirubin, total1 ,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect Male and Female (mg/dL)
Age
0− <15 days
0.2−16.6
0− <15 days
0.32−0.92 0.32−0.92
15 days− <1 year
0.1−0.7
15 days− <2 years
0.1−0.36
0.1−0.36
1− <9 years
0.1−0.4
2− <5 years
0.2−0.43
0.2−0.43
9− <12 years
0.1−0.6
5− <12 years
0.31−0.61 0.31−0.61
12− <15 years
0.1−0.7
12− <15 years
0.45−0.81 0.45−0.81
15− <19 years
0.1−0.8
15− <19 years
0.62−1.08 0.49−0.84
Calcium1,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect Age
Male and Female (mg/dL)
0− <1 year
8.5−11.0
1− <19 years
9.2−10.5
Male (mg/dL)
Age
Male and Female (mg/dL)
0- <19 years
73-112
Female (mg/dL)
15−42
15−42
12−71
12−71
2.09- 2.84
1− <4 years
32−63
32−63
Potassium1,3 Specimen Type: Serum Instrument/Reagent: Siemens ADVIA XPT/1800
4- <13 years
36−73
36−73
13− <19 years
32−68
32−72
Age
Male (mmol/L)
Female (mmol/L)
0− <1year
4.3-6.7
4.2-6.2
1− <19 years
4.0-5.3
4.0-5.3
Low−Density Lipoprotein− Cholesterol (LDL−C)1,4 Specimen Type: Serum Instrument/Reagent: Abbott Architect Age
Male (mg/dL)
Female (mg/dL)
0− <1 year
13.2-173
13.2-173
1− <10 years
47.2-121
58.8-128
10- <19 years
45.6-131
45.6-131
Age
Male and Female (g/dL)
0− <15 days
5.3−8.3
15 days− <1 year
4.4−7.1
1− <6 years
6.1−7.5
Age
Male (µg/dL)
Female (µg/dL)
6− <9 years
6.4−7.7
0- <14 years
16-128
16-128
9− <19 years
6.5−8.1
14- <19 years
31-168
20-162
Sodium Serum1,3 Specimen Type: Serum Instrument/Reagent: Siemens ADVIA XPT/1800
Female (mg/dL)
Glucose (Random)1,3 Specimen Type: Serum Instrument/Reagent: Siemens ADVIA XPT/1800
Male (mg/dL)
0− <15 days
Creatine Kinase (CK)1,3 Specimen Type: Serum Instrument/Reagent: Siemens ADVIA XPT/1800
Age
Age
15 − <1 year
Protein, Total1,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect
Creatinine (Enzymatic)1,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect
High−Density Lipoprotein Cholesterol (HDL−C)1,2 Specimen Type: Serum Instrument/Reagent: Abbott Architect
Iron Specimen Type: Serum Instrument/Reagent: Abbott Architect 1,2
Total Iron Binding Capacity1,3 Specimen Type: Serum/Plasma Instrument/Reagent: Siemens ADVIA XPT/1800
Age
Male and Female (mmol/L)
Age
Male and Female (µg/dL)
0− <19 years
139- 146
0− <19 years
300- 439
REFERENCES 1. 2.
3.
4.
CALIPER Pediatric Reference Interval Database. CALIPER. Accessed June 10, 2026. https://caliper.research.sickkids.ca/#/. Colantonio DA, Kyriakopoulou L, Chan MK, et al. Closing the gaps in pediatric laboratory reference intervals: a CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012;58(5):854-868. doi:10.1373/clinchem.2011.177741. Tahmasebi H, Higgins V, Woroch A, Asgari S, Adeli K. Pediatric reference intervals for clinical chemistry assays on Siemens ADVIA XPT/1800 and Dimension EXL in the CALIPER cohort of healthy children and adolescents. Clin Chim Acta. 2019;490:88-97. doi:10.1016/j.cca.2018.12.011. Higgins V, Asgari S, Chan MK, Adeli K. Pediatric reference intervals for calculated LDL cholesterol, non-HDL cholesterol, and remnant cholesterol in the healthy CALIPER cohort. Clin Chim Acta. 2018;486:129-134. doi:10.1016/j. cca.2018.07.028.
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