re
negotiating
awake
Ribonucleic acid (RNA) is a polymeric molecule implicated in various biological roles in coding, decoding, regulation, and expression of genes. RNA and DNA are nucleic acids, and, along with proteins and carbohydrates, constitute the three major macromolecules essential for all known forms of life. Like DNA, RNA is assembled as a chain of nucleotides, but unlike DNA it is more often found in nature as a singlestrand folded onto itself, rather than a paired double-strand. Cellular organisms use messenger RNA (mRNA) to convey genetic information
Many viruses encode their genetic information using an RNA genome.
In 1967, Carl Woese hypothesized that RNA might be catalytic and suggested that the earliest forms of life
(self-replicating molecules) could have relied on RNA both to carry genetic information and to catalyze biochemical reactions—an RNA world.
on jumping in the middle (aka: starting ish) here: intrigue with Siddhartha’s mechanism/model/metaphor to ..
re juvenate the natural process of self-organization. . rather than kill by some med
the emperor of all maladies - p 343 the genesis of proteins from genes requires an intermediary step a molecular cell .. *rna
and jumping on within the middle (aka: ending ish) here: intrigue with Jennifer’s crispr to.. zone in on and get rid of and/or restore mutations via rna et al
and intermixing throughout the middle (aka: dancing ish) here: intrigue with Vinay’s intrigue with blockchain to.. coordinate
interoperability ness
with a ton of other stuff in the middle.. (aka: everything is misc) p 27
Siddhartha Mukherjee’s mechanism from his ted… mechanisms, models, metaphors so.. imagining the metaphor where the cell is a human – (ie: most efficient repairer of fractures in our humanity) – and wondering if setting enough of us free (in a petri dish of sorts – rat park ish) we might facilitate a mechanism/model/metaphor – that is deep/simple/open enough to regrow/organize all of us toward a more natural (and less unhealthy) state. toward systemic change ..vision versions toward self-organizing humans p6 cancer, we now know, is a disease caused by the uncontrolled growth of a single cell. this growth is unleashed by mutations – changes in dna that specifically affect genes that incite unlimited cell growth. in a normal cell, powerful genetic circuits regulate cell division and cell death . in a cancer cell, these circuits have been broken, unleashing a cell that cannot stop growing that this seemingly simple mechanism – cell growth without barrier – can lie at the heart of this grotesque and multifaceted illness is a testament to the unfathomable power of cell growth. “Cell division allows us as organisms to grow, to adapt, to recover, to repair—to live. And distorted and unleashed, it allows cancer cells to grow, to flourish, to adapt, to recover, and to repair—to live at the cost of our living. Cancer cells can grow faster, adapt better. They are more perfect versions of ourselves” malignant growth and normal growth are so genetically intertwined that unbraiding the two might be one of the most significant scientific challenges faced by our species.. or.. perhaps.. learning .. as you say.. to prevent malignant growth. cancer is built into our genomes: the genes that unmoor normal cell division are not foreign to our bodies, but rather mutated, distorted version of the very genes that perform vital cellular functions……… if we seek immortality, then so, too, in a rather perverse sense does the cancer cell.
this isolation was key to farbers’ early success. insulated from the spotlights of public scrutiny, he worked on a small, obscure piece of the puzzle.. minot had shown that replacing a single molecule could restore the normalcy of blood in this complex hematological disease. p. 38 cancer, in contrast, is riddled with more contemporary images. the cancer cell is a desperate individualist, ‘in every possible sense, a nonconformist,’ as the surgeon-writer sherwin uland wrote. the word metastasis, used to describe the migration of cancer from one site to another is a curious mix of meta and stasis – beyond stillness in latin – an unmoored, partially unstable state that captures the peculiar instability of modernity..
if tb once killed by hollowing out lungs.. cancer kills by filling body w/too many cells.. the pathology of excess. cancer is an expansionist disease; it invades through tissues, sets up colonies in hostile landscapes, seeking sanctuary in one organ and then immigrating to another , it lives desperately, inventively, fiercely, territorially, cannily, and defensively – at times, as if teaching us how to survive. to confront cancer is to encounter a parallel species, one perhaps more adapted to survival than even we are. learning from cancer.. cancer is phenomenally successful invader and colonizer in part because it exploits the very features that make us successful as a species or as an organism. cancer, we now know, is a clonal disease. p 46
p 19
the idea mesmerized farber. in the 1940s and 50s, young biologists were galvanized by the idea of using simple models to understand complex phenomena. complexity was best understood by building from the ground up. single-celled organisms such as bacteria would reveal the workings of massive, multicellular animals such as humans. fractal thinking… toward systemic change ness.
p 143
wilde… most people are other people
A patient, long before he becomes the subject of medical scrutiny, is, at first, simply a storyteller, a narrator of suffering—a traveler who has visited the kingdom of the ill. To relieve an illness, one must begin, then, by unburdening its story.” self-talk as data
p 48 Depression and cancer, the psychic and physical diseases of black bile, were thus intrinsically intertwined.) depression – also something we often treat w/in silence and shame so.. story is part (perhaps first step) to curing illnesses .. and one’s we can’t seem to cure have been silenced by shame.. hippocrates siad once … that cancer was best left untreated, since patients live longer that way. the problem w/treating cancer surgically, galen suggested, was that black bile was everywhere, as inevitable and pervasive as any fluid. you could cut cancer out, but the bile would flow right back, like sap seeping through the limbs of a tree. the surgical removal of tumors – a local solution so a systemic problem – was thus perceived as a fool’s operation. deep enough ness… p. 68 the ultimate survival from breast cancer, in short, had little to do with how extensively a surgeon operated on the breast; it depended on how extensively the cancer had spread before surgery. as george crile, one of the most fervent critics of radical surgery, later put it, if the disease was so advanced that one had to get rid of the muscles in order to get rid of the tumor, then it had already spread through the system – making the whole operation *moot. huge… irrelevant ness p 87 with cancer it was the similarity of the cancer cell to the normal human cell that made it nearly impossible to target. p 140 what we needed was quite the opposite of a systematic approach – an intuitive and inspired leap of faith into the deadly abyss of deadly drugs.. leap frog – for (blank)’s sake…
doctors are men who prescribe medicines of which they know little, to cure disease of which they know less, in human beings of whom they know nothing. – voltaire
p 238 Since the illness was man-made, its solution could also be man-made. p 305 my task was to repossess imagination from death. (after.. if a man die.. it is because death has first possessed his imagination.. – william carlos williams easy to repossess imagination w/false promises; much harder to do so with nuanced truths. p 343 in late 50s..from paris and caltech and cambridge.. discovered the genesis of proteins from genes requires an intermediary step – a molecular cell .. *rna
or perhaps chip as aa/ai/? rna
RNA is the working copy of the genetic blueprint. It is through RNA that a gene is translated into a protein. This intermediary RNA copy of a gene is called a gene’s “message.” Genetic information is transmitted from a cell to its progeny through a series of discrete and coordinated steps. first, genes located in chromosomes, are duplicated when a cell divides and are transmitted into progeny cells. next, a gene, in the form of dna, is converted into its rna copy. finally, this rna message is translated into a protein.
This unidirectional flow of genetic information—DNA → RNA → protein— was found to be universal in living organisms, from bacteria to slime molds to fruit flies to humans. In the mid-1950s, biologists termed this the “central dogma” of molecular biology.
p 347
1:16 – a crisis of faith – siddhartha
mutants.. from copying error.. during cell division..
when you treat cancer important to know what you can/can’t be sure of – juliano – uncertainty is part of treating cancer
link between x rays and mutations..radiation causes cancer.. since x rays also cause mutations.. could cancer be a disease of mutations.. p 348 what caused mitosis to turn so abruptly from such an exquisitely regulated process to chaos…. what had failed was a kind of biological imagination...
p 351 temin imagined creating cancer in a petri dish… in 1958 .. succeeded… (previous could only look at rous’s because only way you could see.. like looking for keys..lost in house.. under street corner lampstand..) temin’s imagination that allowed him to look… and re imagine temin believed that the cell and its interaction with the virus, had all the biological components necessary to drive the malignant process. the ghost was out of the organism. biological info, the dogma proposed, only travels down a one way street from dna to rna to proteins.. how on earth, temin wondered, could rna turn around acrobatically and make a dna copy of itself, driving wrong way Temin made a leap of faith; if the data did not fit the dogma, then the dogma— not the data—needed to be changed. from documentary – episode 2 52 min – the fact that sarc existed in all – birds, chickens, emu, people… see through the darkness a glimpse. of clear theory of cancer. ie: there are genes in your body that control normal cellular growth and if you disrupt these genes.. you essentially begin to unleash cancer.. important thing.. viral/chemical.. weren’t wrong. just not sufficient.. like blind men and elephant… siddhartha –
vepisode 3
pointed out genes are much more complex.. – sidd abnormalities not oncogenes but tumor suppressor gene – fail to stop cells from dividing.. oncogene like an accelerator.. tumor suppressor like breaks.. all cells have both defects dealing w/tip of iceberg.. push cures even further away.. could see more clearly .. but chaotic.. like rubix cube.. one side can be fine.. but rest are now toxic – ldk work for a while.. then stop working… because of: resistance…. cancer cells are constantly mutating.. so genetic diversity of cancer grows… transforms idea of treatment from static idea to dynamic idea – sidd may not be the same disease in anyone.. a moving target.. cancer becomes resistant to whatever drug we are using 1:11 – immune system: cancer is literally evolution in a bottle. all forces.. all history in life.. that plays out at billion times speed of evolution. if cancer exploits the power of evolution to survive.. perhaps only a commensurate weapon can overcome it.. the human immune system.. an extraordinary set of defenses… first explored 19th cent surgeon … william coley.. tumor seemed to vanish of own accord after serious infection.. birth of cancer immunotherapy.. hoping to trigger fever that would overwhelm the cancer.. steven rosenberg since 1970s… self-cure.. answer had to lay in patients own immune system…. sooo.. 1:16 try to identify cells that were attacking the cancer and use them to develop a cancer treatment..
1:17 – could you educate to attack cancer cell and not normal cell. sidd
crisper tech
remove tumor.. find t cells fighting tumor… take cells out.. grow them out.. turn a few cancer fighting sells into an army.. then put them back in
when viruses infect a cell they inject their dna.. in a bacterium.. the crispr system allows that dna to be plucked out of the virus and inserted in little bits into the chromosome dna of bacterium.. these integrated bits get inserted at a site called crispr…
1:22 – immune system might be holding itself back from attacking cancer cells – allison – can remove breaks.. free immune system to attack cancer..
crispr – a mechanims that allows cells to record over time the viruses the have been exposed to… those bits of dna are passed on to the cell’s progeny…
on being attacked for saying such things as.. i think immune system might solve this..
blockchain ness
for many decades we’ve concentrated on the tumor.. rather than the host immune response… ie: patient and tumor..
1:25 – another novel approach.. immune system as surveillance… but often blind.. and miss them… so we have to redirect that t cell.. a new gene forces it to see.. ie: taking off blindfold.. re engineering t cells.. let the cells do the work they were designed to do.. on educating immune system to see/kill cancer immune system is there for whole trip.. patience that respond to it will respond for a long time..
Jennifer Doudna’s crispr intro’d to Jennifer via wef 2016 panel… staying human [i was intrigued when she talked of the ability to zone in on and get rid of mutations.. thinking.. great.. but won’t help.. if we don’t also get rid of mutant living.. that produced them in the first place. and perhaps in similar way..thinkings/ponderings from siddhartha et al.. placebo rna – toward a nother way to live]
1:05 – this coordination problem 43 min – turning governance into degovernance systems is kind of radical.. but over and over again find possible once to loop… so no need for governance.. policy evaporate.. begs systemic change.. where the b ness becomes irrelevant.. what if the only governance/b we need is getting us out of the mess/mistrust/mutations.. we’ve accumulated over the years of ie: manufactured consent et al.. a nother way
this allows cells to keep a record of infection… a genetic vaccination card… once bits of dna inserted into dna chromosome.. makes copy … exact replicate.. of viral rna.. a chemical cousin of dna… little bits of rna from crispr bind to protein.. called cas9 and form a complex that functions like a sentinal.. searches to find match… when sites found… this complex associates and allows cas9 to cut up the dna.. so like a pair of scissors that can cut dna… and importantly.. this is programmable… to make break in dna at that site… could be harnessed for genome engineering… analogous to way we use word processing to fix typing in document cells have ability to detect broken dna and repair it… by pasting together or integrating new… we can trigger cells to repair breaks by disruption or incorporation of new… crispr is like software.. can re program clinical application w/in next 10 yrs
Vinay Gupta and bockchain intro’d to blockchain thinking beyond.. mostly via vinay 37 min – hub and spoke efficient for moneys… but not autonomy…. that’s why people were so excited about bitcoin.. didn’t go through hub… so best of hub & spoke (cheapness of interoperability) and p2p (autonomy)…. in single unit io dance ness 43 min – turning governance into degovernance systems is kind of radical.. but over and over again find possible once to loop… so no need for governance.. policy evaporate.. begs systemic change.. where the b ness becomes irrelevant.. what if the only governance/b we need is getting us out of the mess/mistrust/mutations. (jennifer/siddhartha) … we’ve accumulated over the years of ie: manufactured consent et al. back to – 1:05 – this coordination problem and letting go of thinking we have to control the coordination… rather.. we have to get rid of the things blocking the natural coordination. perhaps blockchains biggest purpose is as a placebo ish rna.. yes.. helpful beyond that… but we may need it less the more we are us (as opposed to what we are today – not us)
51 min since no real order (physics/relativeity)… we sequence in arbitrary and take order an publish as block.. if everyone ok.. move to next block… not magic.. the magic is the selection mech by which we pick the person to order the blocks that is fair and incentivized that people would do it.. such a tiny sliver of magic… :05 that’s where we were… computer science had given up on this coordination problem… relativity says no.. the reason you need bitcoin is relativity… you get rid of the mining by using: proof of stake.. people prove serious about doing this stuff.. by betting reputation on the fact they’ll do it.. a trust and verify system… but not finished yet… 1:07 – on technical back end.. it looks like a web site..
or rna..?
who verifies data is accurate in first place… 1/ take names… if lying .. prosecute.. solve trust problems w/ big stick 2\ use lots of software mech’s ie: have to sign each transaction… so can identify you
blockchain… via seth http://sethgodin.typepad.com/seths_blog/2016/01/3d-printers-the-blockchain-and-drones.html Most of the stories of Bitcoin haven’t been about the blockchain. They’ve been about speculators, winning and losing fortunes. And most of the stories of 3-D printers have been about printing small, useless toys, including little pink cacti. And most of the stories about home drones have been about peeping toms and cool videos you can watch after other people make them. Choose your stories carefully.
..
et al ad infinitum
so thinking.. if rna is link/message between dna and protein… and it is where the mutation resides, ie: if copy from dna gets mutated.. then fixing.. that rna.. by deleting/removing mutants… or waking rna up.. to noticing the mutants… will kickstart the system back into its natural order of things… self-organizing to immune itself.. regenerate itself.. in health.. again.. and if self-talk (chip) is link/message between heart and world… and it is where the mutation resides, ie: if copy/representation of person gets mutated.. then fixing.. that self-talk.. by deleting/removing mutants.. or waking self-talk up.. to noticing the mutants.. will kickstat the system back into its natural order of things… self-organizing to immune itself.. regenerate itself… in health.. again..
perhaps rna-ish/self-talk will get us back to eudaimonia.. a ginormously smaller us, that uses less energy, is less mutant, ‌ more alive.
if rna is a copy of our dna.. and can carry mutations that cause ie: cancer.. the emperor of all maladies.. and we could augment/uncover natural ness (close enough rna copy to kill/restore mutants) restoring synthesis so that the dance (dna via rna to protein) can dance..
imagine self-talk as a copy of our being.. and how that convo could carry/perpetuate mutations that cause.. ie: not us ness.. the emperor of the emperor of all maladies‌ and we could augment/uncover natural ness (quiet enough to hear\t) restoring conversation so that the dance (eudaimoniative surplus/oneness via whimsy/curiosity) can dance..
perhaps giving a jumpstart (ie: replacing a turtle’s shell).. and most of all.. trusting the natural process of self-organizing ness (so either from the get go.. or helping with detox/mutation removal first..)
we can wake up our listening.. to the rhythm.. already in each one of us.
searching..
to get to the root of everyone’s problem/cancer/mutation/desire
searching..
to be doable/accessible to all
searching..
to set/keep us free.. ie: room enough for leapfrog to.. re new all
searching..
searching..
we’re all just..
redefineschool.com/curecity/
perhaps the emperor\est of all cures begs we set
all people free