Copper Complexes as a Delivery Agent for Medicinal Agents
orated with the National High Field magnet lab (Tallahassee, Florida) and the University of Georgia chemistry department to obtain high resolution Fourier transform-Ion Cyclotron Resonance (FT-ICR), 700 MHZ and 500 MHz Nuclear Magnetic Resonance (NMR) spectra in one and two dimensions for the nuclei of 1H, 13C and 15N. See figures 4 and 5 as sample spectra/data.
Conclusion Several novel medicinal complexes have been developed at VSU using the copper (II) as the delivery agent. Our group developed two tables of drugs that can be delivered using this method. The National Institute of Health (NIH) tests these drugs in vitro. One of our cancer complexes has outperformed some of the most current cancer drugs on the market today. Our copper complex, used for the treatment of TB, has also tested well and has moved on to additional studies at the NIH. Approximately one hundred and fifty amine-containing drugs were taken from the World Health Organizations List of Medicinal Agents and another one-hundred drugs are known amine containing cancer drugs. Considering there are almost two hundred and fifty drugs representing many different MOAs, this suggests we can possibly derive thousands of new medicinal agents using the copper (II) complex as a delivery agent. A copper ion can potentially handle between one and six ligands or molecules, in different ratios. In many cases, these complexes have improved water solubility, stability, and delivery, potentially making this method more efficient than others currently being used.
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mnino 159