Medical Genetics August eMagazine
1
Contents Click below to explore… 3) • Avoiding obsolescence in advanced prostate cancer management: a guide for urologists • Cytogenetic Abnormalities: Chromosomal, FISH, and Microarray-Based Clinical Reporting and Interpretation of Results • Common Dysregulation Network in the Human Prefrontal Cortex underlies Two Neurodegenerative Diseases 4) • Measuring error rates in genomic perturbation screens: gold standards for human functional genomics • Factors associated with reduced accuracy in Papanicolaou tests for patients with invasive cervical cancer • The first surgeon general's report on smoking and health: The 50th anniversary
5) • Submit your Paper to Genes, Chromosomes and Cancer! • Discover Wiley’s range of books and textbooks!
6) • Heme-related gene expression signatures of meat intakes in lung cancer tissues • Implementation of Genomic Medicine • Left-Right Asymmetry: Advances and Enigmas
7) • Search Engine Optimisation For Authors • Publishing Open Access with Wiley
8) • Personalized Medicine and Clinical Genetics • Using VAAST to Identify Disease-Associated Variants in Next-Generation Sequencing Data
2
Avoiding obsolescence in advanced prostate cancer management: a guide for urologists - BJU International Prostate cancer is one of the most common cancers diagnosed in men in the USA and 20 –30% of men treated for localised prostate cancer will fail therapy and develop advanced prostate cancer. Here, we provide a brief overview of advanced prostate cancer medical therapies approved in the past decade, the necessary monitoring procedures and early detection methods needed to safely and effectively manage patients receiving these therapies, and our recommendations for applying these new therapies within different models of urology practice.
Read More Online
Cytogenetic Abnormalities: Chromosomal, FISH, and Microarray-Based Clinical Reporting and Interpretation of Results- S. Zneimer This guide discusses chromosomal abnormalities and how best to report and communicate lab findings in research and clinical settings. Providing a standard approach to writing cytogenetic laboratory reports, the guide further covers useful guidance on implementing International System for Human Cytogenetic Nomenclature in reports. Part one of the guide explores chromosomal, FISH, and microarray analysis in constitutional cytogenetic analyses, while part two looks at acquired abnormalities in cancers. Both sections provide illustrative examples of chromosomal abnormalities and how to communicate these findings in standardized laboratory reports. Read More Online
Common Dysregulation Network in the Human Prefrontal Cortex underlies Two Neurodegenerative Diseases – EMBO Molecular Systems Biology Network analysis of changes in gene co-regulation, between large sets of Alzheimer’s (AD) or Huntington’s (HD) disease vs. control brains, reveals that opposing dysregulation of two interacting processes, chromatin organization and neural differentiation.
Read More Online 3
Measuring error rates in genomic perturbation screens: gold standards for human functional genomics - EMBO Molecular Systems Biology To improve the quality of information derived from these screens, and to provide a framework for understanding the capabilities and limitations of CRISPR technology, we derive gold �standard reference sets of essential and nonessential genes in cancer cell lines.
Discover Online
Factors associated with reduced accuracy in Papanicolaou tests for patients with invasive cervical cancer - Cancer Cytopathology Recent proposals to lengthen the interval in cervical cancer screening highlight the importance of the accurate interpretation of screening tests. Tumor debris present in Papanicolaou (Pap) tests from women with invasive cancer is known to hamper interpretation. The current study was undertaken in an effort to examine the possible effects of the limiting factors in Pap tests from women with invasive cervical cancer and to discuss possible ways to identify these problematic cases in routine practice. Read
More Online
The first surgeon general's report on smoking and health: The 50th anniversary - CA: A Journal for Clinicians Fifty years ago, on January 11, 1964, Luther L. Terry, MD, then Surgeon General of the United States, announced the release of the Surgeon General's report on smoking and health.[1] This report was the culmination of a process that a group of experts began more than 18 months earlier to assess the science related to tobacco use and its effect on humans. The group came to the conclusion that cigarette smoking causes lung cancer and laryngeal cancer. The report also noted that there was suggestive evidence, if not definitive proof, of a causative role of smoking in other illnesses such as emphysema, cardiovascular disease, and various types of cancer. The conclusions reached by this report are arguably the most important and far-reaching in the history of public health and are, perhaps, the classic example of science driving public policy.
Read More Online 4
Submit your Paper to Genes, Chromosomes and Cancer! Rapid publication of original research articles. Only 3 weeks until decision and 5 weeks until online publication.
The main scope of the journal is to communicate new insights into the etiology and/or pathogenesis of neoplasia, as well as molecular and cellular findings of relevance for the management of cancer patients. Topics of particular relevance thus include… • Mutations at the gene and genome levels in benign and malignant disorders • Impact of mutations and genomic rearrangements on gene structure and regulation • Consequences of genomic abnormalities for cell proliferation and differentiation • Correlations between genomic changes and cellular phenotype • The diagnostic and predictive value of alterations at the chromosomal and DNA levels in disease prognosis and in designing and monitoring cancer therapies • Molecular and epidemiologic studies of inherited disorders predisposing to cancer • Novel methods for genomic analyses …and many more! Submit your paper today!
Submit your Research
Click below to discover Wiley’s range of books and textbooks!
5
Heme-related gene expression signatures of meat intakes in lung cancer tissues - Molecular Carcinogenesis Lung cancer causes more deaths worldwide than any other cancer. In addition to cigarette smoking, dietary factors may contribute to lung carcinogenesis. Epidemiologic studies, including the environment and genetics in lung cancer etiology (EAGLE), have reported increased consumption of red/processed meats to be associated with higher risk of lung cancer. Heme–iron toxicity may link meat intake with cancer. The study's results provide preliminary evidence that heme–iron toxicity might be one underlying mechanism linking fresh red meat intake and lung cancer.
Read More Online
Volume 166, Issue 1: Implementation of Genomic Medicine - American Journal of Medical Genetics: Part C Genomic Medicine is beginning to emerge into clinical practice, creating challenges in terms of the best way of implementing change within a medical practice. Each of the articles in this Issue from the American Journal of Medical Genetics: Part C identifies challenges that impact the implementation of genomic medicine, as well as solutions to these challenges. These lessons learned should help to inform others exploring opportunities to implement genomic medicine in their system.
Read More Online
Left-Right Asymmetry: Advances and Enigmas - genesis: The Journal of Genetics and Development This Special Issue encompasses recent research from invertebrates to mammals addressing how the left-right axis is established and maintained, how internal organs become morphologically asymmetric, and the neuroanatomical basis for lateralized behaviors. The goal is to highlight recent advances as well as outstanding controversies on the origins of left-right asymmetry and its functional significance.
Read More Online 6
SEO For Authors Increase visibility to your articles with Wiley’s tips of SEO for authors! Search Engines are the largest source of online traffic to articles, which means they have to be able to find your article easily if you want it to be well-read. Take a look at this guide by Wiley Exchanges for some simple explanation and steps on how you can achieve this!
See More Online
Publishing Open Access with Wiley Want to publish your paper and have it available to read to all as soon as possible? Open Access publishing options exist for a number of Wiley journals. Click on the covers to learn more.
7
Personalized Medicine and Clinical Genetics - Clinical Genetics The term ‘personalized medicine’ encompasses healthcare tailored to the needs of individual patients; a practice which the development of novel ‘next generation sequencing’ (NGS) technologies now promises to accelerate. This Special Issue from Clinical Genetics summarises recent research in genomic personalized medicine, and highlights its application in the treatment of breast cancer, Huntingdon disease, and more. The reviews from the Special Issue are freely available to read online here.
Read More Online
Using VAAST to Identify Disease-Associated Variants in Next-Generation Sequencing Data - Current Protocols in Human Genetics The Variant Annotation Analysis and Search Tool (VAAST) is a freely available software suite for disease gene discovery from next-generation sequence (NGS) data. This unit from Current Protocols in Human Genetics outlines the best practices for variant prioritization using VAAST, using examples and test data. The article is free here to read online.
Read More Online
8
9