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U P DAT E A U G U S T 2 0 1 3 From our labs to your patients: New clinical trials available Groundbreaking scientific research and discoveries are happening at the University of Michigan Comprehensive Cancer Center. And now we are testing these discoveries in clinical trials, providing potentially new treatment options for your patients. At any given time we have more than 100 cancer clinical trials open for accruals. A phase Ib clinical study (HUM00052808) is testing a drug that has been found in preclinical studies to attack cancer stem cells – the 1% to 5% of cells that fuel the tumor’s growth and metastasis. The drug, reparixin, will be used in combination with standard chemotherapy for women with HER2-negative metastatic breast cancer. cells and signs of inflammation. The study will also look at how effective this treatment combination is at controlling the cancer and impacting survival. U-M is one of three sites conducting the study and is the only site in Michigan. For men with castration-resistant metastatic prostate cancer, an NCI-sponsored phase 2 study (HUM00060473) will test whether patients who possess a genetic anomaly will respond better to abiraterone and whether combination therapy with a PARP inhibitor can maximize the anticancer effects in general but particularly in patients whose tumors harbor the genetic anomaly. The clinical trial is based on scientific findings that half of prostate cancers harbor a gene fusion in which two genes translocate and fuse together to create a hybrid gene. Researchers believe this fusion is the triggering event for prostate cancer and may represent a novel therapy target. “We hope this study will help us understand why certain patients respond to therapy and certain patients do not. By better understanding the evolving biology of prostate cancer, we will have the ability to better treat the disease,” says the study’s principal investigator, Maha Hussain, M.D., professor of internal medicine and urology, and associate director of clinical research at the U-M Comprehensive Cancer Center. The study is being conducted at 11 sites across the country, with U-M the only site in the state. “This is one of only a few trials testing stem cell-directed therapies in combination with chemotherapy in breast cancer. Combining chemotherapy with stem cell therapy has the potential to lengthen remissions for women with advanced breast cancer,” says principal investigator Anne Schott, M.D., associate professor of internal medicine at the University of Michigan. The study is primarily intended to test how patients tolerate the combination of reparixin, which is taken orally, and paclitaxel. Researchers will also look at how reparixin appears to be impacting markers for cancer stem   M-LINE I 800-962-3555 I

University of Michigan Comprehensive Cancer Center Update - August 2013

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