Catalyst Magazine V 4.2 by CATALYST MAGAZINE College of Chemistry, UC Berkeley

F09/W10

V 4.2

Catalyst

COLLEGE OF CHEMISTRY

Fall 2009/Winter 2010 Volume 4 • Issue 2 •

UNIVERSITY OF CALIFORNIA, BERKELEY

Bringing it all back home to Berkeley A lab of her own New worlds for NMR Pulling the veil from Mars

Catalyst COLLEGE OF CHEMISTRY UNIVERSITY OF CALIFORNIA, BERKELEY dean Richard A. Mathies cocdean@berkeley.edu chair, department of chemistry Michael A. Marletta marletta@berkeley.edu chair, department of chemical engineering Jeffrey A. Reimer reimer@berkeley.edu acting assistant dean Mindy Rex 510/642.9506; rex@berkeley.edu principal editor Michael Barnes 510/642.6867; m_barnes@berkeley.edu contributing editor Karen Elliott 510/643.8054; karene@berkeley.edu

alumni relations director Camille M. Olufson 510/643.7379; colufson@berkeley.edu circulation coordinator Dorothy I. Read 510/643.5720; dorothy.read@berkeley.edu

design Alissar Rayes Design printing University of California Printing Services

20 ON THE COVER

The scientific artwork of Ming Hammond, assistant professor of chemistry, graces this issuesâ&#x20AC;&#x2122;s cover. For more on Hammond and her work with RNA, see page 6.

all text and photos by michael barnes unless otherwise noted. for online versions of our publications please see: chemistry.berkeley.edu ÂŠ 2009, College of Chemistry, University of California, Berkeley

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Fall 2 0 0 9 / W i n t e r 2 0 1 0 Volume 4 • Issue 2

DEAN’S DESK

SPECIAL FEATURE: MARINER MISSION

CHEMISTRY NEWS

NEW & NOTABLE

CHEMICAL ENGINEERING NEWS

CLASS NOTES

FACULTY PROFILE

IN MEMORIAM

ANNUAL REPORT

8 NEW WORLDS FOR NMR 10 A VERY GOOD YEAR 14

ROLLING THE DICE

College of Chemistry, UC Berkeley

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New facilities for exploring the frontiers of knowledge In past columns, I have described our plans to renew our undergraduate teaching facilities and curriculum. I’m happy to report that, with initial funding in hand, we were able to move forward with renovations in the Hildebrand Student Learning Center and Library, and we are nearing completion of three new presentation rooms for student discussions, seminars and group meetings. The next phase of our initiative will involve renovating the undergraduate teaching laboratories and developing an undergraduate advising facility.

RICHARD A. MATHIES Dean and Gilbert N. Lewis Professor

The College is also pursuing federal resources for major new facilities and research projects. We have submitted a large proposal to the National Institute of Standards and Technology to create the Berkeley Center for Attosecond Science, a complex of renovated laboratories in Hildebrand Hall. Under the co-direction of professors Stephen Leone and Daniel Neumark, the BCAS will be a world-class laboratory for research into the fundamental dynamics of electron motion in atoms and molecules on the ultra-ultrafast time scale of attoseconds.

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Core Facility. Consisting of renovated lab space for cell biology, probe synthesis and cellular microscopy, the complex will enable researchers to understand living cells on the molecular level. Co-directed by professors Matthew Francis and Christopher Chang, the facility will foster collaboration among faculty members from several academic departments. We are progressing on the establishment of the Berkeley Synthetic Biology Institute (SBI). The goal of the SBI is the production of new biological components and systems that serve society’s needs. Building upon the success of conventional biotechnology, synthetic biology is the next generation of genetic engineering, with the capacity to design and produce cells, tissues, and ultimately even organisms with specially tailored properties. Inspired by the pioneering work of chemical engineering professor Jay Keasling, the SBI is a collaborative effort between UC Berkeley, the California Institute for Quantitative Biosciences (QB3) and the Lawrence Berkeley National Laboratory that promises to sustain Berkeley’s international leadership in this important new field. The College of Chemistry continues to explore the frontier of knowledge and remains one of the world’s most dynamic centers for scientific education and research.

We have also submitted a proposal to the National Institutes of Health to establish the Berkeley Single Cell Chemical Biology

Students stop to chat on their way to class in Pimentel Hall, named for beloved chemistry professor George C. Pimentel, who died in 1989 (see page 18 for more on his work). Fall 2009/Winter 2010 Catalyst

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Good news in the midst of many concerns You are probably becoming somewhat immune to news about the demise of the University of California. Serious problems remain, but as Mark Twain might have said, the news of the university’s death is greatly exaggerated. We are ever vigilant, and we are finding workable solutions to the budgetary strains. There has been some good news, too. Last August, late on a Friday evening, I took one final look at my email and found a message from a reporter from Inside Higher Ed. He had requested an interview with me for a story he was doing on job placement rates for female chemistry Ph.D. students (insidehighered.com/news/2009/08/17/ chemistry).

My initial reaction was to erect a wall around my weekend, but I decided to see what he had on his mind. The reporter had attended the American Chemical Society (ACS) meeting in Washington, DC, and had seen some very compelling data

presented by ACS board member Valerie Kuck, a chemist who had worked in both academia and industry. The data showed that among women earning chemistry

College of Chemistry, UC Berkeley

Ph.D. degrees, those from Berkeley had the most success in landing tenure-track jobs at leading universities. The numbers were stunning (and incidentally, quite good for our male students as well). Kuck focused on women who obtained Ph.D. degrees between 1994 and 2003. She found that 54 percent of those hired, a total of 63, came from just 12 top universities. In that group, Berkeley’s star shone very brightly—21 of the 63 hires were from Berkeley. Next closest were Caltech with 7 and MIT with 6. Women who completed a Berkeley postdoc also did well. Kuck noted, “I don’t have direct evidence, but I have to believe that the environment at Berkeley is different. If we look at the top six schools, why is it that Berkeley all by itself can place almost half of the pool of women that got jobs? Something is going on.” The reporter asked me what I thought was going on. I admitted that, like Kuck, I did not have direct data, but I commented on what I have seen in my eight years at Berkeley (four of them as chair). I mentioned that we have a critical mass of female students and that our lofty ranking sets a tone of quality for all. I believe that our dedication to our public mission adds another level of difference. But I think most important is that our facult expect all students to thrive and succeed and that we convey that message to all of our students.

MICHAEL A. MARLETTA Chair, Department of Chemistry, Joel B. Hildebrand Distinguished Professor and Aldo DeBenedictis Distinguished Professor

Perfection or close to it—right? Wrong! Although our female graduates are successful on the job market, our department has had less success in attracting female applicants trained by other institutions. The shortage of women in our faculty applicant pool continues to dismay me. However, we have been successful recently in hiring talented female chemists, primarily by selecting from among our own former students and postdocs. Our last two appointments were Michelle Chang, who was formerly a postdoc in the lab of chemical engineer Jay Keasling, and Ming Hammond, who was Paul Bartlett’s final Ph.D. student. In addition, Ting Xu, who earned her Ph.D. at UMass Amherst, holds a primary appointment in materials science and engineering and a joint appointment in chemistry. These successes give me hope that we are building some momentum toward more equal gender representation, but only constant vigilance will keep us moving forward. So indeed, I am very pleased by recent trends—but there remains much to be done. by michael a. marletta

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The unsung heroes of teaching Jim (not his real name) came strolling into my office one morning. An alumnus showing up at my door is not unusual, though in Jim’s case the timing was interesting. I was staring at my computer screen, wondering about the teaching and GSI (Graduate Student Instructor) assignments for the coming academic year. Jim explained that he wanted to tell me how much he appreciated his time at Berkeley, some decades ago. We mused for a few minutes about the people and times that marked his undergraduate studies. I knew several of his favorite professors, and we shared a few laughs. His next comment caught me off-guard. “You know, Professor Reimer, I really appreciated that my professors were involved in research. Their involvement in really big ideas, ideas way beyond our classroom, was thrilling.” “But,” I said, “didn’t it bother you that there was little individual attention given to you from your professors?”

And why should it not be so? Our graduate students have achieved every possible measure of academic success in their undergraduate programs, as measured by grades, test scores, internships and research experiences. Reading the application files for our graduate program is humbling: one often finds that, in addition to the usual academic successes, our applicants are accomplished poets, writers, artists and musicians. In recent years they have showed increasing commitment to causes that bring science and engineering to children and youth, the disadvantaged and to non-governmental organizations.

PEG SKORPINSKI

Jim did not even hesitate in his response. “I had the best GSIs ever. They were incredibly smart and always available.”

The unsung heroes of teaching in ChemE are our graduate students. Their one moment of recognition comes at our first colloquium of the academic year, during which we present outstanding GSI awards. This ceremony is marked by public readings of excerpts from the written nominations provided by our undergraduates and faculty. These excerpts often tell of topics made clear, the un-confounding of difficult concepts, and the time and care given to the needs of individual students. It is not unusual to hear testimonies about how good teaching changed lives.

The winners of the 2007-08 Berkeley Teaching Effectiveness Award pose with Graduate Division Dean Joe Duggan. Winners include ChemE GSI Ladan Foose (front left, in green), and Chemistry GSI Nicholas Stephanopoulos (rear, third from left).

JEFFREY A. REIMER Chair, Department of Chemical Engineering, Warren and Katharine Schlinger Distinguished Professor

In short, our graduate students are remarkable. They are well prepared for teaching. All first-time GSIs attend a day-long teaching training session sponsored by the campus, and they are required to take a semesterlong course in how to teach engineering. During this course, they study theories of learning and the crafting of teaching sessions while they undergo the scrutiny of their peers in mini-teaching sessions. Everyone knows that physician training includes an internship with experienced doctors in a clinical setting. The GSI position is part of our analogy to the medical internship: having demonstrated understanding of the course material, having studied and practiced the theory of teaching, the graduate students work closely with our faculty in a mentor relationship when they serve as GSIs for our courses. I have tremendous respect and admiration for our graduate students. They serve on the front lines of teaching engineering: leading discussion sections, holding office hours and helping to interpret the results of lab experiments. Jim got it exactly right. Berkeley’s winning combination pairs visionary faculty members with extraordinary emerging scholars who have the talent and time for hands-on teaching. by jeffrey a. reimer Fall 2009/Winter 2010 Catalyst

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A LAB OF HER OWN

Ming Hammond returns to the Department of Chemistry Ming Hammond was the final graduate student of retiring Berkeley chemistry professor Paul Bartlett. In 2005, after completing her Ph.D., she gave away the lab equipment, turned off the lights and locked the door behind her. She departed the Bay Area for a postdoctoral position at Yale University.

be a member of the first class of Beckman Scholars, a national program funded by the Arnold and Mabel Beckman Foundation designed to encourage undergraduate research. Hammond graduated with a B.S. in chemistry in 2000.

Although her undergraduate chemistry research was blossoming, physics was a bit tougher. In her first year, says Hammond, “I was in the section for the unfortunate freshmen who entered Caltech without having already taken calculus-based physics.

Four years later, her postdoc complete, Hammond returned to the College of Chemistry, walked into an empty lab, turned on the lights and began ordering equipment as the chemistry department’s newest assistant professor.

Born Ming Chen in 1978 in Taipei, Taiwan, Hammond came to the United States with her parents in 1984. After living for a few years near relatives in Baton Rouge, LA, the family settled in Owings Mills, MD. Hammond’s father still works nearby as a civil engineer for one firm and her mother works as a CAD (computer aided design) technician in a competing civil engineering firm. “We learned to enjoy eating crawfish when we lived in Louisiana and blue crabs once we moved to Maryland,” says Hammond. In high school, Hammond enjoyed her biology and chemistry classes, including her AP chemistry class. Her experience was unique. Many U.S. high schools have been forced to abandon laboratory instruction due to budget cuts. But Hammond’s high school chemistry teacher had taught at the local community college, and he gave her access to the chemistry labs there. By the time she was ready for college, Hammond had caught the bug for lab work. Hammond entered Caltech in Pasadena, CA, in 1996. She studied chemistry and began her research career as an undergraduate in the group of professor Barbara Imperiali. While at Caltech, Hammond was chosen to College of Chemistry, UC Berkeley

The Department of Chemistry's newest assistant professor, Ming Hammond, unpacks equipment as she sets up her lab in Lewis Hall. Hammond earned her chemistry Ph.D. at Berkeley with Paul Bartlett and returns to the department after completing her postdoc at Yale University.

Hammond’s undergraduate research project in the Imperiali group, “Exploring the structure of the eukayotic enzyme oligosaccharyl transferase via a localized cross-linking reaction,” was part of a research program to produce chemical probes and inhibitors to better understand protein glycosylation, a series of enzymatic processes which links sugars to proteins. In particular, reactions that link sugars to nitrogen atoms in the amino acid asparagine are important in biology. These N-linked glycans have major roles in most living organisms.

But I had a good TA, so I made it through.” Even as an undergraduate, Hammond was being drawn into UC Berkeley’s orbit. When Imperiali, her undergraduate research advisor, moved to MIT in 1999, Hammond spent that summer in Cambridge, MA, finishing her Beckman Scholars research project. On a particularly fateful day, members of the Imperiali group drove to a clam bake at the summer home of another MIT professor, JoAnne Stubbe.

new proteins. Now we realize that the genome is more like a computer program that controls how genetic information is expressed. Some really interesting and sophisticated controls of the genomic program are enacted at the RNA level.”

HA M MO ND

Stubbe is a former member of the College of Chemistry advisory board who earned her Ph.D. at Berkeley in 1971 and recently won the 2009 National Medal of Science. Hammond carpooled with Michelle Chang, an MIT grad student who in 2007 joined the Berkeley chemistry faculty. Chang married one of Hammond’s teaching assistants at Caltech, Chris Chang, who is now a Berkeley chemistry associate professor. Five days after graduating from Caltech, Hammond married her college sweetheart, Mark Hammond, who had also graduated from Caltech with a B.S. in 2000. His degree was in engineering and applied science, and he works as a software engineer. Ming Hammond joined Bartlett’s research group at UC Berkeley in the fall of 2000. The group emphasized the application of organic synthesis to biological problems, with a focus on the synthesis and study of enzyme inhibitors and metabolic intermediates. For her dissertation, “Development and evaluation of beta-strand peptide mimics as inhibitors of protein-protein interactions,” Hammond worked in collaboration with Baruch Harris and Wendell Lim of UCSF. She earned her Ph.D. in bioorganic chemistry in 2005. “Protein-protein interactions play a key role in virtually every process of living systems,” says Hammond.

Left: Arabidopsis seedlings growing on a solid media. Above: An X-ray crystal structure of the RNA-based riboswitch that specifically binds S-adenosylmethionine (SAM).

“Inhibitors for protein-protein interactions have potential as new medications, but so far they remain elusive targets.” Says Bartlett, “Ming Hammond was the final student to study for a Ph.D. in my group—number 63. The phrase that leaps immediately to mind when asked for a characterization of her is, ‘They save the best for last.’ Even as a student she demonstrated an amazing facility in synthetic chemistry, biochemical analysis, and computation— whatever it took to address the problem at hand.” According to Hammond, “Becoming a one-person research group had some advantages. I sat in on the Ellman and Francis group meetings, and I interacted a lot with the other research groups on my floor, especially the Bertozzi group. Carolyn Bertozzi ended up being my thesis committee chair.” As a postdoctoral fellow at Yale, working in the lab of biochemist Ronald Breaker, Hammond helped analyze a critical RNA molecule that functions as a Boolean logic gate to control the expression of a metabolic gene in bacteria. “People used to think that the genome was like a data tape,” says Hammond. “The data were transcribed from DNA to messenger RNA and fed to ribosomes to produce

For example, Hammond is interested in splicing regulation, or the way that introns (the non-coding segments of RNA) are removed, while exons (the segments that code for proteins) are spliced together. “If splicing is misregulated, the result can be errors in the way proteins are built, and that may lead to disease,” she says. Says Hammond’s mentor Bartlett, “Ming’s tour of duty as a postdoc outside Berkeley enabled her to develop an even broader set of skills in molecular biology. I am enthusiastic that she is back here, because our cross-disciplinary outlook at Berkeley is a great match for the type of research program that she wants to pursue. I have no doubt that her work will bring exciting and unexpected results and be a terrific asset to the students here.” As a Berkeley chemistry professor, Hammond foresees continuing her work on RNA gene control elements, with a focus on how these elements work in plants. “We are trying to understand the chemical interactions that drive RNA-based gene regulation, with an eye toward applying that knowledge to the discovery of ‘natural interactors’ and to the design of ‘artificial interactors’ with improved functional properties. Our research questions require us to bring to bear tools from the fields of molecular biology, synthetic chemistry and bioinformatics.” Hammond imagines her lab as “a place for discoverers and tinkerers, with an emphasis on computational discovery and experimental validation. I am very happy to be here,” she continues. “It’s already beginning to feel like home again.”

Fall 2009/Winter 2010 Catalyst

PINES / WEMMER

new worlds for

berkeley chemists enhance the biomedical potential of NUCLEAR MAGNETIC RESONANCE

College of Chemistry, UC Berkeley

f e a t u r e

by michael barnes

Some technologies have so many practical applications and have become so widespread that we tend to forget they haven’t been with us all that long. Laptops, cell phones and the Internet are good examples. For many scientists, another example is nuclear magnetic resonance spectroscopy. NMR is based on a characteristic of neutrons and protons called spin. It was well into the 20th century before scientists who explored the strange new world of quantum mechanics began to ponder the implications of spin. It wasn’t until after WWII that simple NMR spectroscopy became possible, helped along by wartime developments in radar and other radio frequency applications. In the 1970s NMR techniques were perfected to study solids. The application of NMR to proteins and other complicated biological molecules did not become routine until the 1980s. Today we take for granted NMR techniques that have become indispensable for chemists, chemical engineers, materials scientists and biologists. Yet these techniques are roughly the same age as the Berkeley grad students and postdocs who are using them. 9

Despite its roots in quantum mechanics, NMR has become a bread-and-butter tool that is practical, reliable and mathematically tractable. Visiting a modern NMR facility is something like watching an Olympic figure skating competition. It all seems so easy that we overlook the years of hard work and practice that went into its perfection. Some of that hard work has taken place in Berkeley’s College of Chemistry, in the research groups of chemistry professors Alex Pines and David Wemmer. Pines came to Berkeley in 1973 and quickly became one of the world’s most creative leaders in the field of solid state NMR. Wemmer was Pines’s second graduate student, and he returned to Berkeley and joined the faculty in 1985 as an expert in using NMR to decipher the complex structure of proteins. About 10 years ago, the two colleagues began to work together to use the inert gas xenon to increase signal strength in NMR and extend its usefulness in the realm of medical imaging. Pines and Wemmer are developing new techniques that someday may become as valuable and routine as NMR is today.

Fall 2009/Winter 2010 Catalyst

PINES / WEMMER

A very good year A L E X P I N E S on wine, chess and chemistry

Fertile soils and gentle rains do not develop the character of wine. Nor does a carefree youth necessarily develop the character of a scientist. Difficult growing conditions can allow good scientists, like good wines, to deepen their character and continue to develop subtleties for many decades. For both wine and science, 1945 was a vintage year. In the Bordeaux region of France, frost, drought, heat and the hardships of WWII led to a small harvest, but one that would produce exceptional wines. In the same year, Felix Bloch at Stanford and Edward M. Purcell at Harvard independently developed the basic techniques of nuclear magnetic resonance, a feat for which they would share the Nobel Prize in Physics in 1952. 1945 was notable for another reason. In that year Berkeley chemistry professor Alex Pines, who would become a seminal figure in the development of NMR, was born in Tel Aviv. His parents had met in Egypt during WWII, where they both fought with the British Army against the Germans in North Africa. Pines’s father Michael, born in Warsaw, had fled his home in the Baltic city of Vilnius as the Nazis rose to power in the 1930s. He settled in Southern Rhodesia, a British colony in Africa, and served in WWII as part of the Rhodesian Brigade. Pines’s mother Neima lived in Palestine, where she joined the British Women’s Auxiliary Air Force. When Pines was four months old, his family returned to Southern Rhodesia. Pines was raised in the city of Bulawayo, located 20 degrees below the equator. It is the second largest city in Zimbabwe, the name taken by the former colony when it achieved full independence in 1980. Bulawayo sits on a high rolling plain or veld at an altitude of 4,500 feet, giving it a moderate sub-tropical climate. “My father started a produce store with his brother Simon that is still in business today,” says Pines. “I remember the huge African avocados at the store, so big you could eat them with a tablespoon. I had devoted parents, three younger brothers and a circle of friends from school.” Pines played chess and practiced the piano, excelling at both in national competitions. Although the location was unusual, in some ways he had a typical 1950s suburban childhood.

College of Chemistry, UC Berkeley

What made the household unique were the intellectual talents of Pines’s parents, many of which were passed on to their four sons. “My father had pursued law and mathematics but was excluded from further study by anti-Semitic restrictions,” says Pines. “He was a brilliant mathematician and chess player—for many decades he was the national champion of the Federation of Rhodesia and Nyasaland.” His chess mentors included Akiba Rubinstein, one of the world’s best players in the early decades of the 20th century. Rubinstein believed that had Pines’s father been able to stay in Europe, he could have been a great Grandmaster. Says Pines, “My father was an intimidating presence at the chessboard—chain-smoking, staring with a piercing gaze. Although I am quite a good chess player myself, and I was the under-21 champion at our local club, I was never able to beat him. Not once.” Pines’s mother was a talented musician who sang, played the piano and gave concerts in Bulawayo. She made the Pines home a center of classical music performances. From her, Pines inherited his musical abilities. He was a gifted pianist as a child who auditioned for London’s Trinity College at age 15. Bulawayo was a temporary home for an eclectic group of people who were escaping the devastation of WWII and the dismantling of Great Britain’s colonial empire. Among their circle of friends the Pines family counted the author Doris Lessing, who won the Nobel Prize for Literature in 2007. Best-selling Scottish author Alexander McCall Smith, creator of the The No. 1 Ladies’ Detective Agency novels, was born in Bulawayo in 1948. Chess world champion Max Euwe visited Bulawayo, stayed at the Pines home, and played chess with his host and other local masters. Southern Rhodesia’s geographical isolation did not protect Pines from the epidemic of polio that swept across the globe during the 1950s. The Salk vaccine had just become available, and Pines had received two of the four shots when he contracted polio at age 11. As Pines recollected in a 1999 interview, “I was disabled for quite a while and spent many months in a convent isolation ward, subsequently recovering almost completely. I recall the isolation

f e a t u r e P I N E S ’ S G R E AT E S T H I T S Time reversal and violation of the spin-temperature hypothesis Cross polarization and protonenhanced NMR of dilute spins in solids NMR studies of molecular structure and dynamics of liquid crystals Multiple-quantum spectroscopy and selective high n-quantum excitation Berry’s phase and gauge kinematics in magnetic resonance Iterative quantum control of spins Zero-field NMR and MRI by magnetic field cycling SQUID detection of NMR and MRI at ultralow magnetic fields Amplification of magnetic resonance with a laser magnetometer and remote detection

Clockwise from above: Alex Pines sets up a classic chess opening in his Stanley Hall office. A 1945 Bordeaux from Chateau Calon-Ségur, the bottle of wine presented to Pines on his 60th birthday. Pines playing piano in his childhood home of Bulawayo, Southern Rhodesia, and milking a cow as an agricultural high school student in Israel. Pines’s father Michael at the chessboard in a painting by artist Udi Peled.

and uncertainty as quite traumatic. Only the love and support of my family made it at all bearable.” It was an important observation for a young man who would be torn between his mathematical and musical talents as he sought his path in life. It was not math or music, but scientific research that had produced the vaccine that had saved him. Yet science per se had not been enough—the human connection mattered, too. Later in his life, Pines’s devotion to both science and the human connection— his regard for both research and teaching—would become a hallmark of his career. By age 15, Pines was growing restless. The world of Europeans in Southern Rhodesia was a small one. While other former colonies in Africa were granted independence, Southern Rhodesia remained a segregated state dominated by a white minority government. Over time, the country would become more like South Africa, its neighbor to the south. As Pines matured, life in a segregated society weighed more heavily on him. In 1961, at an age when most young people are settling into high school and dreaming of learning to drive a car, Pines left home, enrolling in an agricultural high school in Israel. “My family didn’t have enough money to send me to a conventional boarding school,” he says, “so I got up at 4:00 a.m. to milk cows and do other farm

Laser polarization and development of a xenon-based biosensor Imaging of heterogeneous catalysis with enhancement by parahydrogen Microfluidics and NMR/MRI on a chip

labor in exchange for room and board. Fortunately, I have a good ear for languages, because I arrived not knowing any Hebrew—English was my native language.” The school lacked instruction in higher math, physics and chemistry. Pines studied these subjects on his own and passed an external matriculation exam with an outside examiner sent from Tel Aviv. His test results allowed him to enroll in the Hebrew University of Jerusalem. But the multi-talented student still wasn’t sure what to study—law, math, science? The answer came in the form of a book, Linus Pauling’s classic, The Nature of the Chemical Bond, first published in 1939. “Pauling’s book was a profound influence,” says Pines, “literally the catalyst that allowed me to see how chemistry brought together the rigor of mathematics, the beauty of music, the prospect of scientific progress. After reading Pauling, I knew I wanted to do chemistry.” Pines left Israel for a new adventure in a new country—a Ph.D. program at MIT in Cambridge, MA. Ironically enough, among all his choices, only UC Berkeley’s College of Chemistry had not accepted him. At MIT, it didn’t take long for Pines to find his way to the lab of John Waugh. Pines still recalls their first meeting. “When I told Waugh I was interested in joining his group, Waugh, who was also Fall 2009/Winter 2010 Catalyst

associated with the MIT Research Electronics Lab, handed me a circuit board and instructed me to find a postdoc to help build a single sideband amplifier circuit. So that’s what I did.” “At that time,” says Pines, “Waugh’s lab was the center of the world of high-resolution NMR. He was doing spectacular work on solid state NMR, just as the related techniques of magnetic resonance imaging (MRI) were being developed. For a budding scientist, it was an incredibly exciting place to be.” In the words of National Institutes of Health NMR scientist (and Pines lab alumnus) Robert Tycko, “Around that time, Waugh’s group included Ulrich Haeberlen, Michael Mehring, Bob Griffin and others who went on to become world leaders in various areas of magnetic resonance. But even in that illustrious group, Alex Pines’s brilliance, creativity, and strength of personality stood out.” Waugh’s group was extending the use of NMR to solids. This led Pines to attempt to detect carbon-13, an isotope that should, under the right conditions, yield a precise NMR signal. Unlike the abundant isotope carbon-12 which is “spin silent,” or magnetically inactive, the relatively rare carbon-13 (only about one percent of naturally occurring carbon) will produce an NMR signal. Pines learned how to use a series of radio frequency pulses to align or polarize the spin states of the protons in hydrogen and then transfer this polarization to carbon-13, greatly amplifying its signal. Along with Waugh and fellow student Michael Gibby, Pines coauthored a paper on the technique that appeared in 1973 in the Journal of Chemical Physics. To date, the article has been cited 1,985 times—one of the most highly cited papers in the scientific literature on NMR. “I was very fortunate to have worked with John Waugh,” says Pines. “He is a great scientist and a great person.” Pines completed his Ph.D. at MIT in 1972 and came to UC Berkeley for a prestigious Miller Fellowship with physicist and NMR pioneer Erwin Hahn. However, the College of Chemistry, not wanting to miss a second chance to attract him, persuaded Pines to join its faculty instead, where he has been a professor ever since. “Thankfully, Erwin Hahn took the change of plans in stride, and he has continued to be a mentor and colleague all these years,” says Pines. Having traveled from Africa to the Middle East and then to North America, Pines found a home in Berkeley, and his career quickly blossomed. Even though he lacked the experience of a postdoctoral appointment, he set up a working lab and earned tenure in three years. Says Pines, “Solid state NMR became a huge success, with many talented practitioners.” Today, chemists, chemical engineers and materials scientists routinely use NMR hardware that incorporates concepts first developed in Pines’s lab. “After several years, the point came where I began to feel that the field had matured and was dominated by a new generation, including many of my former students who had become tenured professors. I was waking up in the mornings without new ideas in

College of Chemistry, UC Berkeley

solid state NMR.” Never one to jump on a bandwagon, Pines recognized that even though he had participated in creating the solid state NMR bandwagon, it was time for something new. With the same restless spirit that had propelled Pines across the globe earlier in his life, he set out to explore new areas in NMR. Success in this new journey would require both a profound understanding of the nature of NMR, and a creative vision of what innovative applications were possible. “The real beauty of NMR,” says Pines, “is that unlike other spectroscopy techniques, with NMR you can see inside bits of matter, including living organisms, without interfering with their chemistry. And with NMR, the information comes directly from the molecules themselves. The disadvantage of NMR is its low sensitivity. NMR interrogates molecules with relatively low-energy radio waves, and raising the signal intensity requires huge, powerful magnets.” The Pines group set out to harness the strengths of NMR while overcoming its weaknesses. “We are seeking the best of both worlds,” says Pines, “the fidelity and penetration of NMR with the sensitivity of optical spectroscopy techniques.” Vikram Bajaj is a postdoc in the Pines lab. Like Pines, he earned his Ph.D. in chemistry at MIT. When asked why he chose to work with the Pines lab, he summarized its accomplishments this way: “Alex has contributed significantly to at least three areas of NMR. First, in the NMR of solids, he has developed some of the basic tools by which structural and chemical information can be teased from the interactions experienced by spins in the solid state. Second, some of his most elegant work has probed the fundamental quantum mechanics and quantum statistics of ensembles of nuclear spins, including methods for their coherent control. Finally, Alex has helped developed many applications of NMR, including zero-field NMR, portable NMR, the use of hyperpolarization in chemistry, biology and medicine, and recently, the combination of MRI with microfluidics.” In 1984, two of Pines’s mentors, John Waugh and Erwin Hahn, won the Wolf Prize, an international award that in chemistry and physics is second only to the Nobel Prize in prestige. Seven years later, in 1991, it was Pines’s turn. He shared the Wolf Prize in chemistry with Richard Ernst because, according to the award committee, he, “while still a graduate student, helped engineer in 1972 (together with John Waugh) one of the most important revolutions in modern NMR.…His later works in Berkeley have continued to profoundly influence modern NMR spectroscopy.” In 2002, Pines was appointed a foreign member of the Royal Society, the United Kingdom’s equivalent of the U.S. National Academy of Sciences. He won the Russell Varian Award in 2008, the highest award given by the European NMR research community to one of its own. Pines cherishes most these two awards, along with the Wolf Prize and honorary doctorates from the universities of Paris and Rome.

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Right: College of Chemistry demonstration specialist Lonnie Martin and Pines filming on the set of the eChem educational project. Below: A diagram showing atoms of hyperpolarized xenon as they are depolarized inside a cryptophane cage. The xenon acts as a contrast agent to enhance the NMR signal.

“The real beauty of NMR is that unlike other spectroscopy techniques, with NMR you can see inside bits of matter, including living organisms, without interfering with their chemistry.”

In 2005, Pines’s life and career were celebrated at a Symposium of the 4th Alpine Conference on Solid State NMR in Chamonix, France, held in honor of his 60th birthday. But there the award was of a different nature. At the conference, a rare 1945 Bordeaux from the Château Calon-Ségur was uncorked. Like Pines’s research, it had aged well over the years, developing complexities and subtleties with time. One of the many speakers at the conference was Berkeley physicist Erwin Hahn, Pines’s long-time mentor and friend. Says Hahn, “Whenever something new comes along, Alex sees the implications before anyone else. He is a great thinker with a good overview of how to integrate new discoveries over a wide range of applications. He is a star attraction for students, especially postdocs. He has been a fountain of inspiration for the NMR community. I find him continually refreshing and always on the ball.” Throughout his career, Pines has never lost sight of the human dimension of his scientific pursuits—mentoring and teaching his students. In 1986, he won Berkeley’s highest teaching honor, the

Distinguished Teaching Award. He has spearheaded the development of the undergraduate chemistry curriculum, has regularly taught undergraduate chemistry courses and is currently working on the eChem project, a series of videotaped chemistry demonstrations, lectures and quizzes that can be used for online instruction. Pines credits his research group and collaborators for all of his achievements. In 2000, he was the College of Chemistry’s commencement speaker. At the end of his speech, he summarized what he had learned from decades spent pursuing scientific knowledge. He quoted Ta’anit, one of the central texts of the rabbinic literature:

Harbe lamad’ti mirabotai, umichaverai yoter mirabotai, umitalmidai yoter mikulam “From my teachers have I been enlightened, more from my colleagues, but most have I learned from my pupils.”

Fall 2009/Winter 2010 Catalyst

PINES / WEMMER

Rolling the dice D A V I D W E M M E R on the rise of biological nmr

It’s now more than a quarter-century since Berkeley chemistry professor Dave Wemmer first came to Berkeley. Although he joined the College of Chemistry faculty in 1985, he originally came to the campus in 1974 and left four years later, the second student of Alex Pines to complete his Ph.D. The paths of Wemmer and Pines diverged for several years, both in terms of geography and research interests, but in the last decade, their paths have come together again, thanks to the collaborative environment of the new Stanley Hall and to some useful properties of the inert gas xenon. Born in 1951 in Sacramento, CA, Wemmer graduated from high school in 1969 and attended Sacramento City College in his freshman and sophomore years. Like many of California’s college students today, he transferred from community college to the University of California after two years, graduating from the Davis campus in 1973. “When I was at Sacramento City College,” says Wemmer, “I really enjoyed chemistry and math, and I transferred to Davis as a math major. But I discovered there is a huge difference between lower and upper division math. Lower division math is more practical, about solving problems. Upper division math is more abstract, and I found myself less drawn to that type of mathematics. Meanwhile, I had been enjoying my chemistry classes, so I added chemistry as a major and graduated with a double major in math and chem.” Wemmer started graduate school in chemistry at UC Berkeley in January 1974. He had worked with NMR as an undergraduate, and when he met Pines, something clicked. Wemmer’s Ph.D. thesis, “Some double resonance and multiple quantum NMR studies in solids,” was part of the growing literature on the application of NMR to solids, a topic pioneered by the Pines group. There was no sign yet of the pending revolution in NMR techniques that would take Wemmer in the direction of studying biological molecules. Although he filed his dissertation officially in 1979, Wemmer left in 1978 for a postdoctoral appointment in Dortmund, Germany, with physicist Michael Mehring. “I had taken some German in high school and college,” says Wemmer, “but for the first three months, it was tough to understand the people around me.” After a year overseas, Wemmer decided to jump back into the job market in the

College of Chemistry, UC Berkeley

United States. He landed a job at Stanford University as a staff member in the solution NMR facility, where he helped researchers conduct studies in the emerging field of biological NMR. “In grad school in the Pines lab,” says Wemmer, “we built our own equipment, so I was strong in instrumentation. At Stanford, they needed help with hardware, but over time I became more interested in the applications to biomolecules. I was in the right place at the right time. The field was starting to explode, due in part to the work of Swiss scientist Kurt Wüthrich.” Wüthrich, who had been a postdoc at Berkeley with the college’s Robert Connick in 1965-67, spent two years at Bell Labs and returned to Zurich, Switzerland, in 1969. There he worked out the principles of how to systematically apply NMR to complex proteins and other biomolecules, and a new field was born. Wüthrich won the 2002 Nobel Prize in Chemistry for his research. Wemmer left Stanford in 1983 for an academic appointment as an assistant professor of chemistry at the University of Washington, where he stayed for three years. In 1985, with support from Berkeley biophysical chemists John Hearst and Ignacio Tinoco, Wemmer joined the College of Chemistry faculty. “John and Nacho liked the idea of having an expert in the biological applications of NMR on the faculty,” says Wemmer. “If I stayed at UW, I was pretty sure I would get tenure, but it was much less of a sure thing at Berkeley. For me the difference between the two schools was clear-cut, and I wanted to be in the best place to do research. So I took my chances and returned to Berkeley.” As NMR began to be applied to determine the structure of ever more complex proteins, techniques were needed to expand beyond the typical one-dimensional spectra of that era. In one-dimensional NMR, the output is a line graph with characteristic peaks at certain frequencies that help determine the composition of the sample. “That works for relatively simple compounds,” says Wemmer, “but not for large complicated biological molecules like proteins and DNA. For these biomolecules, we absolutely need the higher resolution and higher information from two-dimensional NMR.” Two-dimensional NMR shares similarities with topological maps. From the Bay Area, you can scan the horizon north-to-south and detect a few prominent peaks on the horizon—Mt. Tamalpais, Mt. Diablo and the ridgeline of the coastal hills. But as you head

f e a t u r e

Above: The Wemmer research group uses NMR , X-ray crystallography and other biophysical techniques to detail the conformation of complex proteins. Below: A xenon atom trapped in a cryptophane cage has been attached to a linker that makes it water-soluble. Various ligands can be fine-tuned to bind the caged xenon to specific proteins, including unique cancer proteins, to allow tumors to be detected using NMR.

Above: Chemistry professor David Wemmer at the controls in the Stanley Hall NMR facility. Behind him is the largest NMR magnet on campus, which is cooled to approximately two degrees above absolute zero and capable of producing a magnetic field of 21 Tesla, 400,000 times more powerful than that of planet Earth. Right: Wemmer in the early 1970s as a graduate student in the research group of Alex Pines.

east, you are initially confronted by the solid gray band of the Sierras, where the peaks seem so tightly compressed together that you can’t tell one from another. Yet when you fly over the Sierras in an airplane, you can make out how the peaks are spread out along both the north-south and east-west directions. A topological map shows the locations of all the peaks in two dimensions and indicates the intensity of the peaks (their altitude), as well. Says Wemmer, “Two-dimensional NMR creates a topo map of a protein’s characteristics, allowing you to discriminate features in much greater detail. A protein has a structure with a main trunk or backbone, and many branches. NMR tells you about the environment of the chemical bonds in proteins, and where nuclei are positioned along a branch. “Using a technique called Nuclear Overhauser Effect you can also measure how far nuclei are apart in physical distance, even if

they are not on the same branch. If a protein is folded, the nuclei of amino acids that are far apart along a branch can lie very close to each other in space, and this distance can be determined by using Nuclear Overhauser Effect Spectroscopy, or NOESY.” Today computers can take the results from multi-dimensional NMR and NOESY and reconstruct the structure of very complex proteins of more than 50 kiloDaltons (which contain 50,000 grams per mole, or about 500 amino acids). The analysis of these complex biomolecules requires NMR spectrometers like those available in the Stanley Hall NMR facility. The largest of these superconducting NMR magnets uses over 60 miles of wire, is cooled to two degrees above absolute zero through the evaporative cooling of liquid helium, and produces a magnetic field of 21 Tesla, or 400,000 times as strong as that of the planet Earth. Wemmer works closely with Jeff Pelton, the manager of the NMR facility. Pelton earned his Ph.D. with Wemmer and began Fall 2009/Winter 2010 Catalyst

managing the facility after a postdoc at the National Institutes of Health and a position as a staff scientist at Lawrence Berkeley National Laboratory. Wemmer is also a faculty scientist at LBNL. Says Wemmer, “Although it is an essential tool, my group’s research is not confined to NMR. We do structural biology using NMR in conjunction with other techniques like X-ray crystallography and mass spectroscopy. We also collaborate with other groups that would like to apply NMR to their structural biology problems.” Over the past few years most of the group’s studies of proteins have focused on those involved in regulation of genetic expression. Several of these proteins are transcription factors, which are structures that recognize DNA and help assemble the other proteins necessary for transcription. During transcription, genetic information from DNA is transferred to messenger RNA to begin the process of creating new proteins. Among these transcription factors are response regulators that include a DNA-binding domain. The Wemmer group studies the structure and mechanisms of these response regulators from the extreme thermophilic bacteria Aquifex aeolicus using a combination of NMR spectroscopy, X-ray crystallography and other biophysical techniques. Says Wemmer, “Aquifex aeolicus naturally occurs in water from geothermal pools and is happy to live at 85 degrees Celsius. Its proteins are very robust at room temperature, and that makes it a good candidate to study.” In particular, the Wemmer group studies the structure and function of a set of proteins that regulate the start of transcription, called sigma54 activators. The researchers investigate the structure of individual domains, the structural requirements for function and DNA-binding activity. “In bacteria,” says Wemmer, “these proteins bind near the beginning of gene sequences in the DNA and pull the ‘starter cord’ on RNA polymerase that activates transcription, creating messenger RNA. But how do these proteins bind to DNA, and what signals them to pull the starter cord? That’s what we are trying to understand.” Another area of interest for the Wemmer lab is metabolomics, the systematic analysis of products of cellular reactions. “Basically,” says Wemmer, “you feed sugar to bacteria and trace where it goes. There are lots of metabolic pathways—how much goes through each one? There is tremendous interest in harnessing metabolic pathways in bacteria by using synthetic biology techniques to produce new drug candidates and biofuels. Yet we really don’t understand the metabolic pathways as well as we could.” Wemmer cites as an example the work of Sydney Kustu, a Berkeley professor of plant and microbial biology, who recently discovered a previously unknown metabolic pathway in E. coli that allows it to consume its own DNA nucleotides when starved for nitrogen. “That’s like burning your house for warmth if you are freezing,” says Wemmer, “but E. coli has the pathway to do it. This is the most extensively studied organism in biology, and its genome has been fully sequenced for years. Yet no one saw this coming. We

College of Chemistry, UC Berkeley

are working with the Kustu group to identify the chemical products created by this pathway.” “A major advantage of NMR-based techniques in biology and medicine is that they do not require radioactive materials,” says Wemmer. One of the most famous studies of plant metabolism was the work of Berkeley chemist Melvin Calvin, who won the Nobel Prize in Chemistry in 1961 for his photosynthesis research. LBNL had developed techniques to produce sufficient quantities of radioactive carbon-14 for research, and Calvin used the isotope to trace how plants take up carbon dioxide to produce carbohydrates. “Today,” says Wemmer, “we could do the same experiment without relying on radioactivity. The standard form of carbon, carbon-12, is not radioactive. It is also ‘spin-silent,’ which means that it is magnetically inactive and can’t be detected using NMR techniques. However, carbon-13, which is not radioactive, can be detected using NMR technology. We could feed plants carbon dioxide enriched with carbon-13 and recreate Calvin’s Nobel Prize-winning experiments with NMR, using no radioactivity at all.” Because NMR interrogates the spin-states of nuclei, a process that doesn’t affect the chemistry, it can be used as a non-invasive biosensor to monitor biological processes within the body. The potential of NMR biosensors is the topic that brought together the research of Wemmer and that of Alex Pines, his former research director. “About 10 years ago,” says Wemmer, “Alex Pines and I were discussing hyperpolarized xenon, which then was being used for NMR analysis of surfaces. We wondered if hyperpolarized xenon would leave enough of a trace of ‘spin flips’ that we could use it to detect binding pockets in proteins.” Pines and Wemmer needed an adaptor molecule to make xenon interact with targets of interest, and so they consulted with chemistry colleague Peter Schultz (now a professor at the Scripps Research Institute near San Diego, CA). “Although he warned us it would take a lot of work,” says Wemmer, “Schultz had a postdoc start on creating an artificial binding pocket for xenon. The effort was a success, and the Schultz group created a cryptophane cage, capable of trapping a single xenon molecule, with an attached linking arm that made the cage water-soluble.” Since then, Wemmer and Pines have worked with the research groups of colleagues Jean Fréchet, and most recently, Matt Francis, to create ligands that will bind the xenon cages to specific targets in the body, including certain proteins that are unique to cancer cells. “Xenon has lots of advantages,” says Wemmer. “There is no naturally-occurring xenon in the body to interfere with the biosensor. The hyperpolarization creates a very strong signal, and unlike X-ray based techniques like CAT scans, a doctor could monitor these biosensors frequently without any risk to the patient. Since it is a noble gas, xenon is chemically inert inside the body, although for reasons not well understood, its binds to nerve receptors, giving it mild anesthetic properties.”

f e a t u r e The Wemmer and Pines research groups have developed a technique for using hyperpolarized xenon gas as an NMR contrast agent. Chemical exchange saturation transfer (CEST) starts with xenon gas that has had its spin-states aligned (hyperpolarized). When trapped in a cryptophane cage and subjected to a burst of radio frequency energy, the hyperpolarized state is reversed. Eventually, a cloud of depolarized xenon builds up around the cage and yields a shifted resonant frequency when interrogated with NMR. If the cyptophane cage is linked to a protein that is unique to cancer or another disease, NMR techniques can be used as very precise diagnostic tools.

“A major advantage of NMR-based techniques in biology and medicine is that they do not require radioactive materials.” 17 One likely application for the xenon biosensors will be to monitor the effectiveness of cancer chemotherapy. Continues Wemmer, “Cancer is not just one disease—even lung cancer can be caused by several different cancers, each of which will respond to treatment differently. A xenon biosensor could bind to particular types of proteins secreted by certain cancer cells, and the sensors could be monitored over the course of several days or weeks to detect the shrinkage of even very small tumors. We continue to work with the Pines group to develop the xenon biosensors, and we hope to start experiments in living cells soon.” The Wemmer group’s interdisciplinary approach to its research is no accident. Interaction between researchers from many different Berkeley departments and other UC campuses was part of the design of the California Institute for Quantitative Biosciences (QB3), housed in Stanley Hall. Says Wemmer, “QB3 has been a great success. I can interact with chemists, biochemists and biophysicists without leaving the building. Plus, the Pines group is just downstairs.” John Kuriyan, a QB3 colleague in the chemistry department, is taking advantage of Wemmer’s expertise. Kuriyan is analyzing the structural basis for resistance to imatinib, an important anti-cancer chemotherapy agent. According to his website, “The only way to obtain definitive insights into these conformational transitions is likely to be through the use of nuclear magnetic resonance, and this is a

major goal of our future work in collaboration with David Wemmer.” Says Kuriyan, “Dave Wemmer has made me appreciate how useful NMR is for determining protein structure. It helps that here at QB3, we have one of the nation’s best NMR facilities, and manager Jeff Pelton has been invaluable. I’m looking forward to continuing our work with Pelton and the Wemmer group.” In 1985, Wemmer had needed to make a decision—stick with a sure thing, or roll the dice and try for a higher, but riskier payoff. Wemmer rolled the dice. It was a good bet. At Berkeley, the biological applications of NMR and Wemmer’s career have both flourished, due in part to the specialized facilities Wemmer helped create. “Back in 1985, I made the right call when I decided to come back to Berkeley. The combined resources of the college, LBNL and QB3 are hard to beat. And Stanley Hall has become a special place on a special campus.” Perhaps Wemmer’s choice is not so surprising. Scientists are by nature explorers and risk-takers. The world that Wemmer explores, the intricate structures of biological molecules like DNA and complex proteins, is still a world full of mysteries. Solving those mysteries, and creating a better understanding of that world, will continue to yield tremendous benefits for humanity.

Fall 2009/Winter 2010 Catalyst

MARINER MISSION

Pulling the veil from Mars Forty years ago, Berkeley’s Mariner 6/7 IRS group sent a unique infrared spectrometer to Mars In the early 1960s, Berkeley chemistry professor George Pimentel forged a reputation as a leader in the area of infrared spectroscopy. His research group included Kenneth Herr, a talented instrumentalist who was designing a new interference-filter spectrometer. Together they won a grant from NASA to develop a prototype of an instrument that was accepted in 1966 for the Mariner Mars missions.

NASA balked at a grad student being designated a principal co-investigator. Herr hunkered down and wrote his thesis in six weeks, and he became the director of the project’s day-to-day activities. The Mariner infrared spectrometer (IRS) was designed by a team hand-picked by Pimentel and Herr. The team built the instruments with help from the Berkeley Space Sciences Laboratory (SSL), the NASA Jet Propulsion Laboratory (JPL) in Pasadena, CA, and the college shops. The most controversial aspect of the Mariner IRS would prove to be its active cooling system. Pimentel and Herr wanted to record the long-wavelength infrared data with the highest signal-to-noise ratio possible. That required a detector that would only function at extremely low temperatures, far lower than the spectrometer’s other infrared sensor, a short-wavelength detector that was cooled by radiating heat into space. The design of the cooling system fell to Les Hughes, an undergrad physics major who had been making ends meet by working at a drug store while building oscilloscopes at home. Hughes saw a job posting at the UC Berkeley employment office and contacted Herr and Pimentel, who agreed that talent and enthusiasm were more important than formal training and experience. Hughes designed a cryostat system that used pressurized nitrogen and hydrogen to cool the long-wavelength detector to 22 degrees above absolute zero. College of Chemistry, UC Berkeley

The NASA bureaucrats weren’t quite sure what to make of this young rag-tag group. The clashes between JPL’s managers and Pimentel were relentless. In early 1968, Pimentel sent a letter to a NASA administrator. Never one to mince words, Pimentel fiercely protected the independence of his young team:

The Mariner IRS data set remains unique, not only because of the quality of the instruments, but because the team did their homework—extensive, well-documented tests with an identical instrument in the lab, calibrated with mineral and gas samples similar to those likely to be found on Mars, tested in a simulated Martian environment.

“We are again encountering the abrasive recurrence of the perennial and understandable difficulty JPL has in accommodating its rather rigid management procedures to an individualistic, independent and highly competent University research group. They would be much more comfortable with a more submissive organization producing an instrument of far less capability and correspondingly fewer new problems to be solved.”

At the time, however, the procedures for archiving the data tapes had not been worked out. Although some information was transferred to microfiche, during the following years the NASA funding dried up, members of the Mariner IRS group disbanded and moved on to other careers, and the data tapes were relegated to a storage locker and forgotten.

At the top, Pimentel and the JPL managers learned to work together. In the trenches, the IRS team found the JPL engineers and technicians far more enthusiastic and willing to help, and the IRS team relied on their expertise. Mariner 6 encountered Mars on July 31, 1969, while Mariner 7 reached the planet five days later on August 5. Aboard Mariner 6, the cryostat unfortunately failed to cool the long-wavelength sensor, making it inoperable, although the short-wavelength sensor was unaffected. But on Mariner 7, both detectors worked flawlessly. The elation of the team when the Mariner 7 IRS began cooling was recorded in a NASA documentary (available at marinermars69.weebly.com/nasavideos.html). The IRS team confirmed the presence of water ice in the southern polar ice cap, along with frozen CO2. They also detected higher concentrations of frozen water at the edge of the cap, but could not confirm the presence of ammonia, methane or other organic compounds.

The story of the Mariner missions might have ended there, except for the arrival of a final and unexpected member of the Mariner IRS team, a kindred spirit whom the others had never met. That’s because at the time she was just entering elementary school. Laurel Kirkland is not the sort of person who gives up easily. Born in the Houston, TX, area in 1962, Kirkland joined the U.S. Coast Guard after completing high school. She worked first as a diesel mechanic and later as an electrician. After her tour of duty was completed, she worked in shipyards in Virginia before returning to Houston, where she enrolled at Rice University and earned a degree in planetary geophysics in 1994. As a Ph.D. in geophysics at Rice, she began her thesis research on the mineral composition of the surface of Mars. “One day—it must have been in 1995,” says Kirkland, “I was looking through some articles, and I saw a graph from an infrared spectrometer of the Martian surface. I could tell it was a very good instrument from the

s p e c i a l

f e a t u r e

Clockwise from above: The Mariner IRS team prepared the instrument for its 1969 flight: (l. to r.) Wayne Morris, Harry Gee, Ken Herr, Don Renfro and Jim Shand. Ken Herr and George Pimentel discuss plans for the Mariner mission in Pimentel’s Hildebrand office. Laurel Kirkland in 1997 with the Mariner data tapes. She restored the data and has made it available to other researchers. In a recent photo, Dean Richard Mathies, Jeanne Pimentel and Les Hughes examine the college’s proof test model of the Mariner IRS. Maps of Mars reveal the scan paths for the Mariner 6 and 7 missions. Mariner 7 scanned the southern Martian ice cap, revealing the presence of water ice.

precision of the graph—in the same way you can spot a good camera by the quality of the photos it takes.” The graph that Kirkland saw that day had been generated with data from the 1969 Mariner 6 and 7 missions to Mars. Excited by the possibility of using the Mariner IRS data for her thesis, Kirkland was stunned when she learned that most of the IRS data from the missions were missing. Like a detective in a mystery story, Kirkland set out to find the data. George Pimentel had died in 1989, but Kirkland found an important ally in Jeanne Pimentel, George’s widow, who had donated his papers to the Berkeley campus’s Bancroft Library. In late 1996 Kirkland contacted Jeanne Pimentel, and a few months later they found the missing data tapes in a dusty, dark basement storage area of UC’s Marchant Building in Berkeley. The tapes, along with prototypes of the instrument, had been sitting in storerooms for over two decades. Kirkland shipped several cases of tapes to Houston, where she set about having them

decoded. The tapes were old and brittle, but she found a solution to that problem at Texaco, where she was interning. Like many oil companies, Texaco occasionally needed to recover geological data from fragile older tape. Texaco generously paid for the IRS data to be handled by specialists who used a low-speed, low-tension tape drive to successfully read the tapes. With the data transferred, Kirkland realized she faced yet another obstacle. “All we had were zeros and ones,” she says. “The tapes were not in a standard format. Without the details of how the data were coded, it would be almost impossible to reconstruct.” By that time, Kirkland was in touch with Herr, project scientist Paul Forney and other former members of the IRS team. Don Stone, the IRS missions’ data technician, was working with Herr at Aerospace Corporation in Los Angeles. Stone volunteered to fly out to Houston, and Aerospace agreed to pay his costs. “All those years later, he still remembered the data format,” says Kirkland. “We were

sitting in the Rice library, using an old Unix work station. Don had worked out how to interpret the format and graph the results. As soon as the graphs popped up, I could see the CO2 spectral lines. Don’s memory, patience, and computer skills were amazing.” Kirkland not only wrote her dissertation with the IRS data, she helped complete partially written articles with the group members, wrote new articles herself, and ensured that the data were properly archived for other researchers’ use. Kirkland now works with Herr at Aerospace Corporation. Recently, the Mariner 6/7 IRS group gathered at the Berkeley SSL for their 40th anniversary reunion. Kirkland was there, as she had been 10 years earlier at the 30th reunion. “I’m sorry I never got to meet George Pimentel,” she says. “He died before I became interested in the Mariner missions. In some ways we do things fancier now, but the Mariner 6/7 missions were the first to pull the veil from Mars—they were the ones that took us from not having a clue what was there to a pretty good idea what Mars is all about.”

Fall 2009/Winter 2010 Catalyst

NOTABLE NEW& RESEARCH•VIEWS DISCOVERIES•AWARDS

Superheavy element 114 confirmed: a stepping stone to the island of stability For decades nuclear scientists have searched for an island of stability among notoriously short-lived artificial elements. Now researchers at the Lawrence Berkeley National Laboratory’s Nuclear Science Division (NSD) and UC Berkeley have made a step forward in the quest by confirming the production of the superheavy element 114, 10 years after a group in Russia at the Joint Institute for Nuclear Research in Dubna first claimed to have made it.

Microbe metabolism harnessed to produce fuel

LBNL NUCLEAR SCIENCE DIVISION

Microbes such as the yeast we commonly use in baking bread and fermenting beer are now being engineered to produce the next generation of biofuels. Jay Keasling, professor of chemical engineering and CEO of the Joint BioEnergy Institute (JBEI), is leading a team of scientists in an effort to manipulate the chemistry within bacteria so they will produce fuel from sugar. At JBEI, one of three research centers set up by the Department of Energy for the research and development of biofuels, Keasling is using synthetic biology techniques involving chemistry, genetic engineering and molecular biology. Foundational work being done at the Synthetic Biology Engineering Research Center (SynBERC), where Keasling is director, will underpin the research at JBEI. SynBERC is funded by the National Science Foundation. JBEI

College of Chemistry, UC Berkeley

Don’t FRET over broken polymers

BERKELEY CHEMICAL ENGINEERING

Professor of Chemistry Heino Nitsche, head of the Heavy Element Nuclear and Radiochemistry Group in NSD and Ken Gregorich, a senior staff scientist in NSD, led the team that independently confirmed the production of the new element, which was first published by the Dubna Gas Filled Recoil Separator group.

Fluorescent proteins could one day help identify microscopic cracks and damage in polymer materials, allowing them to be monitored to prevent failure in load-bearing applications such as in aerospace and biomedical devices. ChemE professor Douglas Clark and colleagues encased two fluorescent proteins inside two halves of a protective protein shell and embedded them into a polymer matrix. How far the two halves of the shell are pulled apart affects the fluorescence resonance energy transfer (FRET) of the two proteins. Monitoring the fluorescence could indicate where the polymer is being deformed or cracked.

Chemistry professor Jamie Cate and co-workers have for the first time captured elusive nanoscale movements of ribosomes at work, shedding light on how these cellular factories take in genetic instructions and amino acids to churn out proteins.

“Inside the ribosome, antibiotics and viruses are using chemistry to either fight or promote disease,” said Cate, who conducted the work with research specialist Wen Zhang and graduate student Jack Dunkle, both co-lead authors of the study, in his lab at UC Berkeley. “But what sort of chemistry? The short answer is that we still have a lot to learn. Once we find out, that knowledge could lead to more effective antibiotics, or new treatments against devastating diseases like hepatitis C.”

AWARD

Chris Chang wins AstraZeneca Award Professor of Chemistry Chris Chang has won the 2009 AstraZeneca Excellence in Chemistry Award. Chang was selected by a team of AstraZeneca senior scientists, in consultation with world-leading academic scientists. The award includes a $50,000 unrestricted research grant intended to foster continued growth and development of research programs.

LBNL

Ribosomes, which number in the millions in a single human cell, have long been considered the “black boxes” in molecular biology. “We know what goes in and what comes out of ribosomes, but we’re only beginning to learn about what is going on in between,” said Cate.

Gold solution for enhancing nanocrystal electrical conductance In a development that holds much promise for the future of solar cells made from nanocrystals, and the use of solar energy to produce clean and renewable liquid transportation fuels, researchers at the Lawrence Berkeley National Laboratory (LBNL) have reported a technique by which the electrical conductivity of nanorod crystals of the semiconductor cadmium-selenide was increased 100,000 times. “The key to our success is the fabrication of gold electrical contacts on the ends of cadmiumselenide rods via direct solution phase-growth of the gold tips,” says Paul Alivisatos, Berkeley chemistry professor and the newly-appointed director of LBNL, who led this research. “Solution-grown contacts provide an intimate, abrupt nanocrystal-metal contact free of surfactant, which means that, unlike previous techniques for adding metal contacts, ours preserves the intrinsic semiconductor character of the starting nanocrystal.”

BERKELEY CHEMISTRY

Gene transcribing machine takes halting, backsliding trip along the DNA

COURTNEY HODGES, BUSTAMANTE LAB

BERKELEY CHEMISTRY

New images capture cell’s ribosomes at work

The body’s nanomachines that read our genes don’t run as smoothly as previously thought, according to a new study by Berkeley researchers in the group of chemistry professor Carlos Bustamante (Ph.D. ’81, Biophysics; Postdoc ’82). When these nanoscale protein machines encounter obstacles as they move along the DNA, they stall, often for minutes, and even backtrack as they transcribe DNA that is tightly wound to fit inside the cell’s nucleus. The Berkeley researchers developed an optical tweezers assay to directly watch individual nanoscale protein machines as they move along single molecules of DNA. The measurements are reported in the July 31 issue of the journal Science. Fall 2009/Winter 2010 Catalyst

Dear Alums, Once again, it has been a busy fall! The Alumni Association’s fall activities got off to an early and energetic start with the Senior Class dinner on September 9. Now in its second year, this event kicks off both the senior year and the growing Senior Class Campaign. The college’s participation in Homecoming Weekend was a big success, including a continental breakfast and an overflowing crowd for the lecture by chemistry professor Richmond Sarpong on October 3. Our Free Radicals group (1964–79) combined their annual event with a Campaign Kickoff on October 30. College lecturer Mark Kubinec gave the group a sneak preview of a new online eChem curriculum. The Free Radicals have set an endowed professorship and renovations to the undergraduate labs as their campaign goals.

Please check the website (chemistry.berkeley. edu/alumni) for the latest news from your alumni association. We hope to see you soon. Go Bears!

Berni J. Alder (M.S. ChemE) is among nine eminent researchers to receive the 2009 National Medal of Science, the highest honor bestowed by the United States government on scientists, engineers and inventors for their outstanding contributions to science and engineering. A retired physicist from Lawrence Livermore National Laboratory (LLNL), Alder is widely regarded as the founder of molecular dynamics, a computer simulation used to study motions and interactions of atoms over time. While working on his Ph.D. at Caltech, he and computer designer Stan Frankel developed a computer technique, now known as the Monte Carlo method, for calculating results from random sampling. His subsequent work at the newly-established Lawrence Livermore lab led to publication of his pioneering work on molecular dynamics. In 1963, Alder helped found the UC Davis Department of Applied Science.

and sales and marketing committee. He also writes articles to promote both Bentley Village and Junior Achievement of SW Florida and is a member of Bentley’s men’s golf association. Before retirement he worked for Schering-Plough in New Jersey.

’48

In July, Edwin T. Strom (M.S. Chem) was among the 162 fellows selected from the American Chemical Society’s 154,000 members to be named inaugural American Chemical Society Fellows, chosen for “true excellence in their contributions to the chemical enterprise coupled with distinctive service to ACS or to the broader world of chemistry.” He was also elected Chair-Elect of the American Chemical Society Division of the History of Chemistry. Strom serves as an adjunct professor at the University of Texas, Arlington, where he teaches organic and polymer chemistry. He and his wife, Charlotte, make their home in Dallas.

’61

Henry M. Neumann (Ph.D. Chem) retired this year from the faculty of Georgia Institute of Technology in Atlanta. He makes his home in Decatur.

’50

Frederick M. Peterson (B.S. ChemE) is president of Probe Economics Inc in Hanover, NH, providing clients with chemical industry planning, forecasting and consulting services.

’64

Max J. Kalm (Ph.D. Chem) and his wife, Lila, enjoy retirement at Bentley Village in Naples, FL, where he serves on their resident council

’54

After 35 years in the engineering/ construction industry with Fluor and Jacobs, where he started as a process engineer, Richard C. Delaney (B.S. ChemE) retired as an engineering group manager. He now enjoys “a life of golf and leisure” in Indio, CA.

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—REBECCA ZUCKERMAN

Ph.D.’00, Chem Chair, Chemistry & Chemical Engineering Alumni Association Steering Team

JoAnne Stubbe (Ph.D. Chem) was awarded the prestigious National Medal of Science this year for her work on enzymes involved in DNA replication and repair. A professor of chemistry and biology at MIT, Stubbe was elected to the National Academy of Sciences in 1992. She has served on the College of Chemistry Advisory Board and will be the college’s 2010 commencement speaker.

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STEPHANIE WONG

More than 150 friends, alums and faculty members attended the AIChE reception in Nashville, TN, on November 11, and we held the Alumni of the G. N. Lewis Era luncheon on November 19.

Class Notes

Free Radicals Alumni Event and Campaign Kickoff: (l.) Mark Wegner (Ph.D. ’77, Chem) chats with Tom (M.S. ’73, Chem E) and Marty De Jonghe in the remodeled Bixby Commons. (r.) Kirk Lao (B.S. ’09, ChemE) and Baljit Kaur (B.S. ’11, ChemE) enjoy the balmy weather and great food at the 2nd annual senior class dinner.

College of Chemistry, UC Berkeley

c l a s s

n o t e s

Sabrina G. Sobel (Ph.D. Chem) continues to serve as a full professor and chair of the chemistry department at Hofstra University in Hempstead, NY.

’93

Last May, Daniel J. Sullivan (Postdoc Chem) took the position of manager of the failure analysis lab at ISE Labs in Fremont, CA, which offers analytical services, including X-ray, acoustic and optical microscopy, de-capsulation, and cross-sections. Early this year, he and his wife, Christie, welcomed a daughter, Cashel, to the family. He also runs a business called Earwig Enterprises and has recently published a new card game, “Go Knights! Go Dragons!,” which is on sale at game stores and at earwig.net. Another game still available from Earwig is, “Infection: A light-hearted and educational game of human afflictions.”

’94

In summer 2008, Jeffrey S. Kieft (Ph.D. Chem) was promoted to associate professor with tenure at the University of Colorado Denver School of Medicine. In October 2008, he was named director of their Biomolecular Structure Program, and this September, he began his appointment as a Howard Hughes Medical Institute Early Career Scientist. He and his wife, Birgit, live in Denver.

’97

A senior research scientist for microelectronics technology at Lord Corporation in Cary, NC, Sara N. Paisner (Ph.D. Chem) was elected president of the International Microelectronics and Packaging Society (IMAPS) Carolinas Chapter in June 2009. Before joining Lord Corp, she worked at GE’s Global Research Center, focusing on developing new materials for the electronics industry. At Lord, she leads projects to develop the company’s next generation of thermal interface gels, greases and adhesives for the microelectronics industry. She is also an active member of the American Association for

’01

Free Radicals Alumni Event and Campaign Kickoff: College demonstration specialist Lonnie Martin burns a donut in liquid oxygen while alums estimate the wattage of the resulting light.

the Advancement of Science, the American Chemical Society and Iota Sigma Pi. Since earning his Ph.D. in bioengineering from the University of Pennsylvania in spring 2009, Richard K. Tsai (B.S. ChemE) has been doing postdoctoral research in Penn’s Department of Chemical and Biochemical Engineering. He and his wife, Joy Lee, make their home in Philadelphia.

’02

Having worked as a research associate in UCSF’s Cell Culture Facility since last year, Theresa N. Canavan (B.S. ChemBio) is very excited about being accepted to their Class of 2013 M.D. program.

’08

Jesse Dashe (B.S. ChemBio) is in his second year of medical school at UC San Diego. Michael E. Grass (Ph.D. Chem) started doing postdoctoral research in September 2008 at Lawrence Berkeley National lab’s Advanced Light Source division. Kihoon Kim (B.S. '03 Chem; Ph.D) remained at Berkeley after graduation to pursue a Ph.D. in comparative biochemistry, conducting research in the field of infectious diseases and antiviral therapy.

He then accepted a position as senior consultant with Entrue Consulting Partners in Seoul, South Korea, where he is currently working in areas of corporate finance and strategic transactions of major corporations, both inside and outside Korea. Amanda B. Marciel (B.S. ChemBio) is doing graduate work in biophysics at the University of Illinois. Eric J. Shen (B.S. ChemE) has taken a position as an associate process engineer with Valero Energy Corp in Martinez, CA. Chelsea I. Teall (B.S. ChemE) is working as a failure analysis engineer at SunPower Corp in Richmond, CA. Benjamin D. Weil (B.S. Chem and EECS) is in the Materials Science M.S./Ph.D. program at Stanford University. Tawni T. Koutchesfahani (M.S. ChemE) is in the Operational Development Program at Baxter Healthcare Corp’s Bioscience Division and makes his home in San Diego, CA.

’09

Joseph J. Zakzeski (Ph.D. ChemE) is in the Netherlands doing postdoctoral research in inorganic chemistry at Utrecht University.

Fall 2009/Winter 2010 Catalyst

In Memoriam Friends of the college MARINA BOUDART Marina Boudart passed away on May 18, 2009. The wife of Michel Boudart, a lecturer in our chemical engineering department and the William M. Keck Professor of Chemical Engineering, Emeritus, at Stanford, she was an artist in many media and active in the Stanford University Women’s Club. Besides Michel, she is survived by their daughter, three sons, and five grandchildren. HUBBARD C. “BARD” HOWE, JR.

Hubbard C. “Bard” Howe, Jr. (B.S. ’50, Business Administration), a close friend of the College of Chemistry, died on October 2, 2009, one day after his 81st birthday. At the time of his death, he was serving on the UC Berkeley Foundation Board of Trustees and was a member of the University’s Benjamin Ide Wheeler Society and “Bears in the Mountains.” He was particularly interested in the potential of biochemical engineering and synthetic biology, and he asked for “homework assignments” in that field from our faculty. Bard and his wife, Gene, generously established and funded the College of Chemistry’s Hubbard Howe Jr. Distinguished Professorship in Biochemical Engineering, currently held by Professor Jay Keasling. They have also contributed to the support of chemical biology in the college, as well as to the Haas School of Business. A former partner of Clayton, Dubilier and Rice, a private equity firm, Bard also had been a managing partner of the Nevada Management Group and had served on the boards of some 60 companies, many of

College of Chemistry, UC Berkeley

which had been financially troubled before he turned them around. He was an avid tennis player, sailor, fisherman and hunter. When Gene called to give us the news of his passing, she stressed how important Cal had been to Bard. In addition to Gene, Bard is survived by his three sons and their families.

Alumni ’34

Eldor R. Lehfeldt (B.S. ChemE) passed away on May 24, 2007.

We recently learned from Shulamis “Shelly” Bickoff (B.A. ’40, PoliSci), the widow of Emanuel “Mel” Bickoff (B.S. Chem), that he passed away on November 18, 2001.

’37

Clair A. Weast (B.S. Chem; Ph.D. ’43, Agricultural Chem), who made his career in the food science and technology industry, passed away on April 27, 2009. He is survived by a daughter, five granddaughters, seven great-grandchildren, and three greatgreat-grandchildren, and was preceded in death by his wife, Elsie (M.S. ’40, Food & Nutrition Science), and one daughter. Charles A. “Charlie” Anderson (B.A. Chem) earned an M.B.A. from Harvard Business School. His career included positions as assistant professor of business at Harvard, VP of Magna Power Tool Company, associate dean and professor of business administration at Stanford Business School, VP of finance of Kern County Land Company, president and CEO of two of KCL’s subsidiaries, and president and CEO of SRI International, from which he retired in 1980. Besides obtaining his private pilot license and enjoying barbershop quartet music, he served on numerous boards, including the Kansai Research Institute of

’38

Kyoto, Japan, and the UC Berkeley International House. He also devoted time to Lucille Salter Packard Children’s Hospital and the Board of Directors of California State Chamber of Commerce, among other volunteer public service. He passed away on April 17, 2009, preceded in death by his wife, Betty, and survived by three children, four grandchildren, and three great-grandchildren. Thomas H. Schultz (B.S. ’34; Ph.D. Chem) made his career with the U.S. Department of Agriculture and, in retirement, was a welcome guest at G.N. Lewis Era Alumni Luncheons. He passed away on June 1, 2009, survived by his wife of 72 years, Florence (B.A. ’36), his son, Roger (B.S. ’66, Mech Eng), two granddaughters, and two great-granddaughters. Lowell V. Coulter (Ph.D. Chem) was a group leader on the Manhattan Project and taught briefly at the University of Idaho before joining Boston University’s chemistry faculty where he served for over 35 years. As chemistry chair at BU in the early ’60s, he greatly expanded the department and built its research programs. His own research in the area of thermodynamic properties of compounds known as clathrates earned him election to the American Association for the Advancement of Science. He retired in 1977. A supporter of the College of Chemistry, he died on May 2, 2009, predeceased by his wife, Leona, and survived by their daughter and son, four grandchildren and two great-grandchildren.

’40

Jacklyn B. “Jacky” Melchior (B.S. Chem) passed away on July 18, 2009. An East Bay resident, she and her late husband Norten C. Melchior (B.S. ’44, Ph.D. ’46, Chem) were College of Chemistry supporters and regular and welcome attendees at college events. A Long Beach resident for 78 years, Lee F. Warner (B.S. Chem) served as a radar technician in World War II followed by a 35-

i n

year career at Shell Chemical. He died on June 1, 2009, survived by Kay, his wife of 62 years. During his WWII Navy service in the South Pacific, Victor M. Burkman (B.S. Chem) survived the sinking of the Hornet. After medical school at Northwestern, he joined Glyer Medical Group in Mountain View, CA, where he practiced family medicine for 35 years. In retirement, he traveled as a ship’s doctor and became an award-winning multi-media artist. He passed away on January 20, 2009, survived by his wife, Virginia, a daughter, and two grandchildren.

’41

William H. Taplin III (B.A. Chem), a resident of Twain Harte, CA, passed away on May 28, 2009. Jacklyn T. “Jackie” Bort (B.S. Chem) and her husband, Joseph P. “Joe” Bort (B.S. ’39, EECS; JD ’42), raised three children in the East Bay, where she was an active volunteer in the Berkeley Public Schools and the Boy Scouts and Girl Scouts. She was a longtime active member of the Christian Science Church of Berkeley and of many civic organizations. Joe died in 1995, and Jackie passed away on May 14, 2009, survived by two sons, one daughter, and six grandchildren.

’42

A veteran of the Manhattan Project, Gerhart Friedlander (Ph.D. Chem) made his career at Brookhaven National Laboratory (BNL) where he was head of the chemistry department. His collaborative, pioneering research on how highenergy particles cause nuclear reactions laid the groundwork for computer-generated calculations of nuclear reaction mechanisms, which form the basis for theoretical models still in use today. He co-authored the classic textbook, Nuclear and Radiochemistry, and he was the first editor-in-chief of Science Spectra. After retirement in 1981, Friedlander

remained active at Brookhaven, most notably to form a BNL team that collaborated with European researchers on the Gallex experiment, for which a Nobel Prize was awarded to Brookhaven team member Raymond Davis Jr. in 2002. Friedlander passed away on September 6, 2009, predeceased by his first wife, Gertrude Maas, and survived by Barbara Strongin, his wife of 28 years, two daughters from his first marriage, four stepchildren, four grandchildren, six step-grandchildren, and two great-grandchildren. Victor P. Van Der Sterre (B.A. Chem) of Millbrae, CA, passed away on March 10, 2009. After working on molecular spectroscopy with G. N. Lewis, Robert V. Nauman (Ph.D. Chem) did postdoctoral research from 1947 to 1953 with Peter Debye at Cornell and taught briefly at the University of Arkansas, before joining the chemistry faculty at Louisiana State University, Baton Rouge, where he spent his career. He passed away on April 25, 2009, survived by his wife, Jean, two daughters, two sons, and six grandchildren.

’47

Herschel D. Davis (B.S. Chem) worked as a consulting archaeologist and made his home in Palm Desert, CA, where he died on March 2, 2009. He is survived by his wife, Nancy, and a daughter.

’48

Berton H. Wilson (B.S. ChemE) made his career in petroleum refining at Chevron and, as part of the implementation of his tanker fuel conservation program, traveled with their shipping fleet. He lived in Kensington, CA, and passed away on April 11, 2009, survived by his wife, Patricia, six sons, two daughters, eleven grandchildren, and one great-grandchild.

m e m o r i a m

Thomas C. Beiseker (B.A. Chem) worked at General Dynamics Convair after graduation and went on to co-found Data-Design Laboratories in Ontario, CA. The company, which later relocated to Rancho Cucamonga, worked with the submarine-launched Polaris strategic weapons system and provided personnel and training to the subsequent Poseidon and Trident programs. He died on August 12, 2009, at his home in Chesterfield, MO, survived by his wife, Ethel, two children, five grandchildren, and eight great-grandchildren.

’49

Escaping Nazi Germany in the mid-1930s, Lieselotte J. “Lilo” (Kamm) Templeton (B.S. ’46, Ph.D. Chem) came with her family to live in the Bay Area on the advice of her uncle, Otto Stern, the Nobel Prize-winning physicist who had spent a sabbatical here years earlier. After earning her doctorate, Lilo did research into techniques for explosives detection, working with chemistry professors William Gwinn and Chester O’Konski, as well as for the Department of Materials Science and Engineering. She later conducted joint research with her husband, Professor Emeritus David H. Templeton (Ph.D. ’47, Chem), using X-ray diffraction at various wavelengths to determine crystal structures of large, complex molecules, for which they were jointly awarded the A. L. Patterson Award. The strategies and techniques they developed have benefitted the field of crystallography and the area of research concerned with determining complex protein structures. In addition to their scientific contributions, Lilo and David generously contributed to the well-being of the college and graciously attended numerous alumni and donor events. Her family gave us the news of her passing on October 10, 2009, at the age of 91. In addition to her husband, she is survived by their two children, Diana Killen and Alan Templeton. All who knew this remarkable woman will miss her.

’50

Fall 2009/Winter 2010 Catalyst

i n

m e m o r i a m

John M. Boyles (B.S. Chem) worked as a chemist at Chevron in Richmond, CA. He passed away on May 16, 2009, in Silver Springs Township, PA, predeceased by his wife, Nadya, and survived by two daughters and three grandchildren.

’51

We recently learned that Albert T. Bottini (B.S. Chem) died on Feb. 3, 2002, in Davis, CA. After earning his Ph.D. in chemistry at Caltech, he joined the UC Davis chemistry faculty, where he made his career. He is survived by his wife, Marilyn, three sons, and eight grandchildren.

’54

Emil J. Volcheck Jr. (Ph.D. Chem), a supporter of the College of Chemistry, made his 34-year career with DuPont, primarily in fabrics, retiring as manager of the DuPont Experimental Station in Wilmington, DE. In retirement he avidly pursued astronomy and computing as hobbies and later expanded these interests into community service. He managed the Mount Cuba Astronomical Observatory, hosting and lecturing at its Public Nights and overseeing a research effort on the observation of white dwarf stars. He founded the Main Line Computer Users Group (MLCUG) and ran the "Computer Forum” at the West Chester, PA, Area Senior Center. Volcheck died on January 24, 2009, survived by his wife, Diana, two sons, and a daughter.

’55

Before starting college, Walter M. Gibson (Ph.D. Chem) had already worked as a shepherd, done stunts for Western movies, and played saxophone in a dance band. In 1958, he went to work for Bell Telephone Laboratories in New Jersey, where he did groundbreaking research in semiconductor detectors, radiation effects, and ion channeling, which led to the success of the Telstar satellite. In 1976, he took a position as the chairman of the physics department at SUNY Albany, where he also served as

’57

acting vice president for research, dean of graduate studies, and the director of the Center for X-Ray Optics. After retiring, he co-founded X-ray Optical Systems in East Greenbush, NY, and served as its chief technology officer until his death on May 15, 2009. A College of Chemistry supporter, he is survived by his wife, Alice, five children, 20 grandchildren, and four great-grandchildren, and is predeceased by a daughter. Teresa (Nakahara) Appel (B.S. Chem) worked for more than 20 years as a chemist for Anamet Laboratories while raising two children with her husband, Bruce Appel (B.S. ’58, Chem). After 30 years in Berkeley, they retired to La Jolla, CA, enjoying 15 years of travel and time with grandchildren. She passed away on June 9, 2009, survived by Bruce, their two children and four grandchildren.

’58

1969, moved with his wife, Marjorie, to Massachusetts where he worked as a professional safety engineer at Factory Mutual Research Corp., Harvard University, Northrop Grumman, and, most recently, Mitre Corp. They retired to Wellfleet, MA, in 1998 where he was on the Board of Health. He died on March 10, 2009, and is survived by his wife. Peter Sheldrick (Ph.D. Chem) dedicated his career to the study of herpes viruses and is best known for a fundamental discovery he made at the Institut Pasteur in France that became a foundation for all molecular analyses of these viruses. He made his home in France, and we recently learned that he passed away on January 7, 2008.

’63

William “Bill” Breivogel (Ph.D. Chem) served on the chemistry faculty of Chipola College in Marianna, FL, for over 20 years. He died on January 19, 2009, survived by his wife, Carmen, two children, and three grandchildren.

’65

During his career at Stauffer in Richmond, CA, Don R. Baker (Ph.D. Chem) patented many inventions and co-authored and edited numerous books on the synthesis and chemistry of agrochemicals. He died April 24, 2009, predeceased by his first wife and survived by his wife, Shirlee, eight children, 25 grandchildren, and three great-grandchildren.

’59

During his interesting and varied career Richard M. Lessler (M.S. ’54, Ph.D. Chem) worked at Lawrence Livermore lab, the U.S. Nuclear Regulatory Commission, the United Nations, Bechtel, TRW, Aerospace Corporation, and, most recently, the Environmental Protection Agency in San Francisco. He and his wife Lillian, who survives him, have made generous provisions for the future creation of the Richard M. and Lillian Lessler Endowed Chair in Chemistry. He passed away on August 12, 2009.

’60

Following graduation, David E. Breen (B.S. Chem) spent several years in the U.S. Navy and, in

At the California Department of Public Health Services in Berkeley, Howard S. Okamoto (M.S. Chem) made many contributions as a research scientist, including analytical methods that have been adopted by the EPA. He passed away on May 16, 2009, survived by wife, Charlene, a son, and a granddaughter.

’73

Gregory D. Granger (B.S. ChemE) died on July 21, 2009. He earned a law degree from McGeorge School of Law in Sacramento, CA, and practiced law in the Los Angeles area. At the time of his death, he was a sole practitioner in The Granger Law Firm in Newport Beach, CA. Preceded in death by his mother, he is survived by his father and stepmother, one sister, four brothers, and his three children.

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compiled by dorothy read

College of Chemistry, UC Berkeley

Catalyst Alumni Questionnaire chemistry.berkeley.edu Date

Name title

first name

middle name

last name

previous name

degree(s)

year

department

degree

year

dept/major

UC Berkeley degree(s) Degrees from other institutions Spouse/Partnerâ&#x20AC;&#x2122;s name Home address (New info?

) street

city

state

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zip

phone

) position

job function

name of organization

start date academic department or company division

street city

state

Preferred mailing address: Preferred email address:

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zip

phone

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FOR CLASS NOTES Tell us your news: recent promotions, family additions, an exciting trip . . .

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I want to join the Alumni Association (itâ&#x20AC;&#x2122;s free!) and receive announcements I want to help by: Participating in future planning for the association Planning events in my area (with the assistance of the college) I am interested in participating in the following: Lectures or Symposia Career Networking

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f i r s t c l a s s postage h e r e

university of california berkeley

College of Chemistry College Relations and Development 420 latimer hall #1460 berkeley, ca 94720-1460

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a n n u a l

r e p o r t

of private giving 2009

all colors are fading, classes are in full swing and our increased enrollment shows that students recognize the chemical sciences as the portal to a wide variety of careers in science, engineering and medicine. While the seemingly never-ending budget challenges continue to demand our attention, we have nonetheless worked together in the College of Chemistry to advance a number of projects aimed at improving teaching, research and facilities. I want to express my thanks to the numerous alumni, parents, friends, faculty and staff who are recognized in this annual report for their support. I feel a deep sense of gratitude knowing that support from our constituents is something we can always count on. The College continues to provide fertile ground for the advancement of bold new instruction and research ideas in the chemical sciences. As we look toward the future and the exciting possibilities ahead, I find a great sense of satisfaction knowing that you support us. As an alum and parent of a newly admitted student said recently, “In times like these, you know who your friends are.” I’m proud to count you among our friends.

f i n a n c i a l s 1.4%

5.5% 4.2% 7.9% 17.2%

16.7% 50.2%

22.9% 13.7% 61.2% 72.2% 26.9%

S O U R C E S O F P R I VAT E F U N D S

Individuals

$1.35 M

26.9%

Corporations/ Corporate Foundations

$2.52 M

50.2%

Private Foundations/ $1.15 M Nonprofit Organizations

22.9%

Total

$5.02 M

100%

U S E S O F P R I VAT E F U N D S [ O P E R AT I N G ]

U S E S O F P R I VAT E F U N D S [ENDOWMENT] $0.52 M

72.2%

Research

$2.63 M

61.2%

Student Support

$0.12 M

16.7%

Student Support

$0.59 M

13.7%

Unrestricted

$0.03 M

4.2%

Unrestricted

$0.74 M

17.2%

Research

$0.04 M

5.5%

Capital

$0.34 M

7.9%

Capital

$0.01 M

1.4%

Total

$4.30 M

100%

Total

$0.72 M

100%

Chairs

annual report ’09

donors to the college

The first three donor clubs listed—the California Benefactors, the Blue and Gold Society and the 1868 Society—are cumulative clubs. Donors’ lifetime giving to the College of Chemistry determines their club level. The remaining clubs are annual—the club level shows each donor’s giving during the 2008-2009 year.

Cumulative Clubs California Benefactors $1,000,000 and more.

Anonymous Norbert C. and Florence M. Brady Dr. and Mrs. Nirmal Chatterjee Chen Yu-How T. Z. and Irmgard Chu Aldo DeBenedictis Estate Dr. Melvin J. Heger-Horst Trust Mr. and Mrs. Hubbard C. Howe, Jr. Gunawan Jusuf Ross McCollum Trust Jean Mosher Pitzer Pitzer Family Foundation Dr. and Mrs. Warren G. Schlinger Ann E. Shiffler Estate Dr. and Mrs. James R. Tretter Robert Tsao

The Blue and Gold Society $500,000 to $999,999. Anonymous Larry and Diane Bock Chen He Tung Dr. James O. Clayton Estate Warren E. Clifford Gus D. Dorough Henry F. Frahm Estate Richard M. and Lillian Lessler Irma McCollum Trust Dr. Reid T. Milner Trust Beatrice Thomas Estate Marie W. Woodward Estate

College of Chemistry, UC Berkeley

The 1868 Society $100,000 to $499,999. Anonymous (5) Mary Arnett Usman Atmadjaja Leo A. Berti Estate Bud Blue Thelma Buchanan Estate Sunney Ignatius Chan Chng Heng Tiu Mrs. Antonio T. Chong Robin D. Clark and Mary Mackiernan Chester W. Clark Estate Frank and Janice Delfino Drs. Thomas J. Dietsche and Laura J. Dietsche Dr. Sam H. Eletr William and Janet Gerhardt Suhargo Gondokusumo G. Douglas and Regina Gould Prof. and Mrs. John E. Hearst Prof. Darleane C. and Dr. Marvin Hoffman Robert and Yasuko Ikeda Stephen T. Isaacs and Kathryn Macbride Harold and Mary Ella Johnston Kiong Yo Kian Engr. Joseph L. Koo and Helen C. Koo, M.D. Prof. Daniel E. Koshland, Jr. Joseph M. and Dorothy K. Kunkel Lee Sheng Peng Annie L. Li Liem Sioe Liong Wesley and Elizabeth Lindsay Estate Tony K. and Louisa Ling Lie Shiong Tai Prof. Bruce H. Mahan Estate Mr. and Mrs. Alan C. Mendelson

Dr. and Mrs. Joon S. Moon Dr. Robert N. Noyce S. M. “Jack” Olsen Marjorie Pape Crandall Pearce Jonathan S. Powell Dr. Mochtar Riady Milton H. and Ethel M. Ritchie Klaus and Mary Ann Saegebarth Patricia M. Schreter Mr. and Mrs. John W. Scott, Jr. William H. Shiffler Dr. Charles E. Stehr and Mrs. Dorothy H. Stehr Tan Keong Choon Henry K. Tom Mrs. Theodore Vermeulen Doris H. Welles Estate Eka Tjipta Widjaja Charles R. Wilke Estate Eugene T. C. Wu

Annual Giving Clubs

The Latimer Associates $10,000 to $49,999. Anonymous Dr. Nirmal and Mrs. Ellen Chatterjee Robin D. Clark and Mary Mackiernan Warren E. Clifford Dean and Becky Draemel William and Janet Gerhardt Vic and Faye Gunther David G. Karraker David E. Kepler Ed Kim Donald M. Leslie Estate Richard M. and Lillian Lessler Arturo Maimoni Gus Malmquist Estate Dean Richard and Mrs. Jo Anne Mathies Carlos and Patricia Nuila Patricia M. Schreter Prof. David and Dr. Lieselotte Templeton

Gifts received in 2008–2009

The Lewis Associates

The Giauque Associates

$50,000 and more.

$5,000 to $9,999.

Anonymous (2) T. Z. and Irmgard Chu Gus D. Dorough Drs. David S. Gee and Caryn C. Q. Lum Mr. and Mrs. Alan C. Mendelson Pitzer Family Foundation

Charles E. and Marianne Auerbach Prof. Paul A. Bartlett and Dr. Yumi Nakagawa Edwin D. Becker Norman Bonner Ardra C. Brodale Tim and Valerie Bruemmer Sunney Ignatius Chan Ronald L. Clendenen William A. Daniels Thomas and Martha De Jonghe Frank G. Delfino

benefits of

private giving

THE TONG AWARD Calvin Huynh was born and raised in San Jose. He’s an undergraduate working with the research group of Chris Chang, where he is developing new sensors for detecting H2O2 in living cells. He plans on attending a graduate program in pharmacy after his graduation from Berkeley in the spring of 2010. The James Y. and Harriet P. Tong Chemistry Award encourages outstanding undergraduate research. The award was established by Ohio University Professor Emeritus James Y. Tong (B.S. ’50, M.S. ’51, Chem) and his wife Harriet, who met each other at the UC Berkeley International House.

“The Tong Award allowed me to continue my research during the summer of 2009, through which I have been able to grow intellectually and develop my understanding of the role of hydrogen peroxide in normal physiology and diseased states.” Calvin Huynh

Tim Montgomery Herb Nelson Joan Friedman Newmark and Richard Newmark William R. Parrish Prof. Norman and Mrs. Paula Phillips Darwin and Donna Poulos Prof. and Mrs. John M. Prausnitz Frank and Annette Rahn Klaus and Mary Ann Saegebarth Steven Sciamanna Jane N. Scott Sher G. Singh Eric R. Sirkin Mr. and Mrs. John R. Skinner Clinton D. and Sharon Snyder Richard M. Teeter Bruce T. Vermeulen Raymond Vermeulen Rita Wieland

The Wilke Associates Drs. Thomas J. Dietsche and Laura J. Dietsche Pete Dragovich and Pei-Pei Kung Julianne Elward-Berry Rocky L. Freel and Nancy Skilling Dr. and Mrs. Theodore H. Geballe Gene I. Iwamoto Prof. Harold and Mrs. Mary Ella Johnston Dr. and Mrs. Andrew Kaldor Chi-Tzu Kao Edward F. Kleinman LaRoc and Linda Kovar Prof. Stephen R. Leone and Dr. Mary K. Gilles David Lieu, M.D., M.B.A.

Gary and Irene Masada Curtis Lee Munson Albert Narath Daniel and Ellen Neumark Prof. Heino Nitsche and Ms. Martha Boccalini Louise Lyon Quenon and Michel Quenon Prof. Jeffrey A. and Ms. Karen B. Reimer Ann E. Shiffler Estate Tonny and Fay Soesanto Dr. Charles E. and Mrs. Dorothy H. Stehr Barbara A. Tenenbaum Prof. Don and Mrs. Rosemary Tilley Michael G. Valentine Willard M. Welch

The Seaborg Associates $2,500 to $4,999. Anonymous (2) Ronald J. and Sue A. Banducci John H. Birely John B. Bush Danny Chen Robert Chinn John F. Heil Joseph R. Homler Herbert Hooper Victor W. T. Huang Kiyoshi and Irene Katsumoto Stanley Kelly William A. Kleschick Virginia and Frank Lew

$1,000 to $2,499. Profs. Juana V. and Andreas Acrivos Keith Alexander, Ph.D. Mr. and Mrs. Myron Andrews Dennis P. Bauer Richard Behrens, Ph.D. William Benjamin, Ph.D. Prof. Robert and Ms. Wendy Bergman Prof. Harvey W. Blanch M. Robert Blum R. R. Breckenfeld Michelle Brodale Richard Brodzinsky Marilee Brooks David and Donna Brown Charles Buse annual report ’09

benefits of

private giving

THE DORSEY AWARD Born in Honolulu, HI, Jane Wang graduated from Caltech with a B.S. in chemistry, where her mentor was Robert Grubbs, 2005 Nobel laureate in chemistry and College of Chemistry Advisory Board member. As a member of the research group of Dean Toste, she explores new avenues of research that use organic and organometallic chemistry to tackle problems in biochemistry and material science. The Andrew D. Dorsey Memorial Award was established by David and Klara Dorsey to honor the memory of their son Andrew, a chemistry graduate student who died suddenly of a brain hemorrhage in August 2001.

“Teaching as a graduate student instructor at Berkeley has been a really unique experience, and I think it’s wonderful that the Dorsey Award supports us in this area!” Jane Wang

William H. Calkins Prof. Joseph and Mrs. Susan Cerny Edmund Chambers David Chan S. Kumar and Uma Chandrasekaran Yuenyee M. Cheng Fannie Chong Dr. Tung-Jung Chuang Prof. Robert and Dr. Frances Connick Robert S. Crowder Eric Darmstaedter Thomas and Cynthia Delfino Walter and Eleanor Dong Clelland R. Downs Marissa Drouillard Helen M. Elliott Walton Ellis Gail G. Engerholm

College of Chemistry, UC Berkeley

June S. Ewing Virginia and Larry Faith Steven and Terri Fantazia William E. Fogle Jennifer Fujii Shun C. Fung Man K. Go Wataru and Tuyet Goishi Charles and Karen Goss G. Douglas and Regina Gould Joan T. Green Elaine and Arnold Grossberg Fanqing Guo Eric Haas Dr. David R. Hansen Prof. Charles B. Harris Barry P. Hart Prof. Clayton Heathcock and Dr. Cheri Hadley Joel Hill

Robert P. Hohmann William and Hoi-Ying Holman Richard W. Hyman Yasuko Ikeda Mark J. and Alice H. Isaacson Ernest Jacobson Stephen and Elizabeth Johnson Darren C. Jones John Jost, Jr. Gary and Patricia Kaiser Dr. Max J. Kalm Paul H. Kasai Prof. Hyun Yong Kim Prof. and Mrs. C. Judson King Dr. and Mrs. Fred Kirby Kevin A. Klotter Henry F. Koopmann P. G. Kosky J. Clark Lagarias

James and Barbara Lago Peter W. Lee Soo-Ying Lee Robert and June Lindquist Dayna and Peter Lucas Dick and Myra Lynch Scott and Annette Lynn Prof. Samuel and Mrs. Lydia Markowitz Prof. Michael Marletta and Ms. Margaret Gutowski Michael McCormick, M.D. Alison McLean Thomas J. Meyers Richard D. Newman Kenneth Otteson Sunil Patel Chin-Tzu Peng Dr. Donald D. Phillips Llad Phillips Jeanne Pimentel Jacob Plattner John A. Ragan David L. Rehder John L. Robbins David B. Sable Marcia Sable Prof. Richard Saykally and Ms. Chris Read Fritz and Karen Schaefer Georgieanna L. Scheuerman Bill Schriver William and Virginia Schultz Gary P. Schwartz Manesh and Margarita Shah Karen and Scott Sibbett Ronald E. Silva Randy Snurr Jeffrey P. Solar and Rosalyn Furukawa Mike Solomon and Ellen Lee Mrs. Judith and Prof. Gabor Somorjai George and Maradel Sonnichsen Linn Specht Thomas M. Stachelek Peter J. Stang Bruce E. and Susan J. Stangeland

donors to the college Donna R. Sterling Ms. Carolyn North and Prof. Herbert L. Strauss Prof. Andrew Streitwieser and Ms. Joyce Hessel Michael J. Sullivan and Ellie Y. Yieh J. and K. Surya Bruce Gerald Szczepankiewicz Kong-Heong Tan Anne Friend Thacher Huijun Tian Curtis M. Tong Charles C. Tran Harvey S. Trop Constantine Tsonopoulos Dale E. Van Sickle Mrs. Theodore Vermeulen James P. Vokac and Stacey T. Baba Andrew Wang Raymond Chiu and Stephanie Wang Kathleen M. Welsh, M.D. David and Joanne Wemmer Keith R. Westcott Robert Wilhelm and Sun Hee Wilhelm Roger G. and Molly W. Williams Gar Lok Woo Frank Woolard Stephen Worland Sung C. and Gia K. Yi Steve Young William R. Young

The Calvin Club $500 to $999. Anonymous (3) Arthur and Frances Abramson Carlo and Barbara Alesandrini Prof. Paul and Mrs. Nicole Alivisatos Steven M. Bachrach Michael L. Barry Nader Bayat Marvin and Judith Brafman

Timothy, Susan and Thor Breece Matthias Bremer Michael J. Buckley Lucinda F. Buhse and Steven A. Kinsley Joel Burley Michelle and Jeffrey Chang Andrew Y. Cheng J. Peter and Nancy L. Clark John W. Collette Donald R. Colvin Peter Connolly and Pauline Ting John E. Crider Matthew Shane Croughan Sheryl and Kenneth Dahl Timothy and Suzanne Devitt Ronald Dickenson Rochelle and Robert Dreyfuss Arthur K. Dunlop William E. Dunn Rudolph H. Dyck Victor and Louise Engleman Nicholas A. Fedrick George A. Fisk Michael and Mary Flaugh Prof. Graham Fleming and Ms. Jean McKenzie Stanley W. Fong Philip R. Friedel Friends of Eric Abramson Scholarship Fund Drs. Thomas R. Gadek and Katherine Neldner Frank P. Gay Michael B. Gentzler Walter M. Gibson Grant W. Haddix Mr. and Mrs. SoonKap Hahn Marlin D. Harmony Scott J. Hecker Duane Heyman Toshiaki Hino Dennis and Dale Hirotsu Keelung Hong Judy C. Huang and Ken A. Nishimura David R. and Karen W. Johnson

Prof. Jay D. Keasling Jack Kelly Chung-Pai Kim Prof. Sung-Hou and Mrs. Rosalind Kim Andrei W. Konradi Deanne C. Krenz Jessica Lam Rich Lawton Marc and Tsun-Tsun Levin Mark T. Lewellyn Edward S. Lewis James W. Lewis and Dale A. Roche Kwang-Chi and Shin-Shin Liang Wes Liang Arnold A. Liebman David A. Lightner Richard M. Lim and Terate B. Nalukas Nelson Lin Peter and Rachel Lipowicz Mr. and Mrs. Henry Loo Xiaojun Ma and Xiaodong Wu Jane and Michael MacDonald Mary M. Mader Prof. Bruce H. Mahan Estate Craig Markey Thomas A. Massaro, M.D. Dr. Eugene D. McCarthy James A. McHugh Ron Meeker Drake and Jayne Michno Michael J. Miller Capt. Peter W. Miller Lingfung Mok Paul E. Morrisroe Estella K. Mysels Allen Ng Douglas Ng Kenneth T. Ngo David A. Oâ&#x20AC;&#x2122;Brien Edward John Palkot Garry Lain George Parton Joe and Ann Pease David B. Phillips Joan and Rich Phillips Andrew Ramelmeier Gurdeep S. Ranhotra

Elmer and Helen Reist William G. Rixey Joel W. Rosenthal Arnold and Janice Seidule Stephen and Lila Shain Henry B. Sinclair Gerald Smolinsky Southern California Engineering Alumni Association David F. Starks David Stern Mark and Nancy Stoyer Jack D. Swanburg James S. Symanski Sugihiko Tada Masato and Miyeko Tanabe The Tellers Family Prof. Ignacio Tinoco and Dr. Bibiana Onoa Petra N. Turowski Emil Volcheck, Jr. Family Leigh M. Warren Karen M. Webster Mark Wegner and Mary Korn Charles W. Wei Greg Went Dr. Richard J. Wilcox Phillip A. Wilmarth Ray Won William Allen Wood Fonda B. Wu Katsumi Yamamoto Sachio Yamamoto Eric Pao Yan Yang Jianbo Zhang and Shiyi Ren

The Tobias Club $250 to $499. Christina C. Almendrala Anonymous (2) Daniel and Shelley Arenson Burke and Carole Baker Karen Jernstedt and Jim Barkovich Bruce N. Bastian Stacey Bent and Bruce Clemens

annual report â&#x20AC;&#x2122;09

donors to the college

Klaas Bergmann Steven and Sandra Bernasek Constantine G. Boojamra Marie T. Borin, Ph.D. John and Claire Boursalian Lawrence J. Bowerman John J. Brodbeck Gina Buccellato William H. Buchan James D. Burke C. Hackett Bushweller Halbert H. Carmichael Michael F. Carolan Frank D. Cervantes Joseph and Sara Chan Philip L. Chan Edward Robert Chanezon Chu-An Chang Shih-Ger (Ted) Chang Shiuan Chen Marina M. Chin Leland J. Chinn Michelle Claffey and Stephane Caron Maria T. Clark Ronald N. Clazie Geoffrey K. Cooper Harold Cota Robert and Debora Couey

Dr. Calvin J. Curtis Christopher Dateo Jed E. Davidow Stephen G. DiMagno Stephen E. Dinizo Galen Downton Dr. Lawrence H. Dubois Carol Dunbar Michael J. Duret Lois J. Durham Prof. Jon and Mrs. Pam Ellman Kenneth G. Felton Elisa Fernandes Bruce A. Firestone, Ph.D. Ian Fisher Reyes M. Fragoso Tim Frederick Pete Fullerton Kent Fung Norman L. Garfield Marjorie M. Gasser Peter Gates Wilbur Y. W. Lew and Bertha M. Gee-Lew David J. Godbey Abraham Goldhaar Samuel L. Graham Joseph M. Greendorfer William Guilford

Lara A. Gundel Paul H. Gusciora William Guthrie Guenter Hafelinger David J. Hart Derek J. Hei Robert and Ellen Hempton Dr. and Mrs. Frank Hernandez Frank Hershkowitz Robert Hickman Don Hildenbrand Jason Ho Elvin L. and Donna I. Hoel Richard and Patricia Hoff Mei-Shel Hon Richard Honnell R. F. Humphreys William Y. Ja Paul J. Jansen Jack Jew Patricia A. Jones Michael J. Kaufman Esayas Kelkile Brian D. Kelley John Kindsvater Edward L. King James A. Klein Prof. Judith Klinman Camey Ku

Howard Lacheen Karen W. Lai Stephen M. Lambert Bart Larrenaga Frances Lee Daniel Leva Traci A. and Timothy A. Lewis Steve and Helen Lim Glenn Lipscomb Dr. Francis J. Lovas Guowen Lu and Zheng Zhang Robert Lundin Patricia D. Mackenzie Jon Maienschein Gregory S. Girolami and Vera V. Mainz Kevin McAlea Patrick McGrath Kenneth E. Meeker Prof. and Mrs. Howard C. Mel John G. Mengshol Richard L. Merson Michael Milos David W. Moreland Sean P. Mullen Richard J. Nagle, Jr. John B. Nash James W. Neely Harry T. (Tom) Nelson

College of Chemistry Annual Donor Clubs

Lewis Associates

Latimer Associates

Giauque Associates

Seaborg Associates

$50,000 and more

$10,000-$49,000

$5,000-$9,999

$2,500-$4,999

(formerly California Associates)

(formerly Berkeley Associates)

(formerly Gold Sproul Associates)

(formerly Blue Sproul Associates)

Named for Gilbert Newton Lewis, the collegeâ&#x20AC;&#x2122;s first dean.

Named for Wendell Latimer, professor of chemistry.

Named for Nobel laureate and chemistry professor William F. Giauque.

Named for Nobel laureate and chemistry professor Glenn Seaborg.

College of Chemistry, UC Berkeley

Dr. David R. Nethaway Nancy Norem John J. O’Brien John F. O’Connell Camille and Jim Olufson Ogbemi and Cecilia Omatete Stephen ONeil Kent Opheim Keith Pang James Papanu Axel Helmut Paul Sundiep (Tehara) Phanse Richard C. Pilger, Jr. Bava Pillay Austin and Marjorie Prindle Frank T. Prochaska Roland Quong Jack M. Rademacher Prof. Clayton Radke Ronald Ratcliffe Mindy Rex and John Dischinger Neil Lawrence Ricker James A. Roe Ferenc and Diane Rosztoczy Prof. Harry N. and Mrs. Jane L. Scheiber Erika Schneider, Ph.D. Alan and Gail Searcy

Frederic T. Selleck, Ph.D. John L. Shafer Stephen Shapiro Anita J. Shaw Yaoming Shi Donald and Carmen Shiosaki Prof. Kevan Shokat Jerry Richard Shuper Ab Siadati, M.D. Hugh C. Silcox John A. Smegal Joseph P. Smith Travis L. Smith Shinji and Masuko Soneda Drew V. Speer Julie Stewart Neil C. Stipanich Dr. John B. Swartz Jeffrey Tane Jerome H. and Selma E. Targovnik David G. Taylor David and Deborah Thompson John F. Thompson Ken Tokunaga Tracy Phuong Tuyet Tram, M.D. Richard Underwood Jung Ku and Tetsuo Uno

Jack Van Den Bogaerde Drs. Robert and Susanne E. Vandenbosch James and Jennifer Varley Erich R. Vorpagel Deane Stefan Walker Timothy P. Walker Lisa Wang Sheldon A. Weber Fred and Cristel Wemer Charles T. White Heather D. Whitley James D. Willett Jack Wong Richard F. Wormsbecher Robert Zahler William T. Zimmerman Paul F. Zittel

Abhay Acharekar and Nirupama Pujare Dr. Raul E. Acosta John E. Adams

Jeffrey and Tracy Adkins Rodel and Beverly Agresor Anonymous (4) Dr. and Mrs. David Altman James and Jacqueline Ames Allan Anderson Edward and Florence Aoyagi Evan and Mary Appelman Dr. John D. Arenivar Morris and Stephanie Argyle Don W. Arnold Dr. John Arnold and Ms. Jennifer Shaw Frank and Lucille Asaro Lucienne Ash J. William Aubry Steven C. Avanzino Samuel D. Bader Douglas J. Bamford Elizabeth Hodgins Bartky Craig P. Baskin Russell H. and Carolyn C. Batt Dr. David Beach and Ms. Roxana Beach James R. Beck John Bedbrook and Pamela Dunsmuir Gay Bell Robert and Jackie Bellerose

The Hildebrand Club $100 to $249.

Wilke Associates

Calvin Club

Tobias Club

Hildebrand Club

$1,000-$2,499

$500-$999

$250-$499

$100-$249

(formerly Robert Gordon Sproul

(formerly Sather Gate Club)

(formerly Carillon Club)

(formerly Campanile Club)

Associates)

Named for Nobel laureate and chemistry professor Melvin Calvin.

Named for chemical engineering professor Charles Tobias.

Named for chemistry professor Joel Hildebrand.

Named for Charles Wilke, professor of chemical engineering.

annual report ’09

Janet E. Bercovitz Marina Berdichevsky Carl M. Berke Richard N. Biagioni Jacob Bigeleisen Paul Bigeleisen Ryan Bise Paul D. Bisio Robert Bittman Mary Frances Blackwell Patty and Bill Blanton Todd A. Blumenkopf Richard Boden Jerome V. Boots George A. and Syble F. Boswell David E. Breen Robert J. Breuer Leo D. Brown Sandra M. Brown Edward Bruggemann Frederick L. Burnett III Carol J. Burns Gary P. Burns Kristina M. Burow Thomas and Eileen Busching Charles Nicholas Buser John H. Bushweller Prof. and Mrs. Elton J. Cairns James L. Caley Mark Camenzind Wayne M. Camirand Jonathan O. Carlson John P. Carr Emily A. Carter David C. Castagnola James L. Chao Roger and Eileen Chao Mu Jung Chen Grant Chin Collette Ching Yong-Hwee Chua Dick T. Co Kenneth E. Coates F. Warren Colvin Morgan P. Conrad Mary M. Conway David and Abbey Cook Fred F. Coons John F. Cooper

College of Chemistry, UC Berkeley

benefits of

private giving

THE DOW EXCELLENCE IN TEACHING AWARD Jarred Ghilarducci was born in Bakersfield, CA, and earned his B.S. in chemical engineering at UCLA. As a Berkeley chemical engineering graduate student, he studies rational catalyst design with professors Alex Katz and Enrique Iglesia. The Dow Excellence in Teaching Award is an annual gift from the Dow Chemical Company to recognize outstanding graduate student instructors in the Department of Chemical Engineering.

“Getting to work closely with the students has made being a GSI the most rewarding experience I’ve had at Cal. I often drew from my own experiences as an undergrad to help my students avoid the same pitfalls I once encountered. Although the students have been my real inspiration, it is nice to have my hard work recognized by Dow.” Jarred Ghilarducci

Paul A. Cornelius Tucker Coughlen Kerry Cray Efren and Maribel Cuevas David L. Cullen Richard C. and Janet L. Cummings Bo Curry Chollada Darakananda David C. Darwin Drs. Cameron and Jean Dasch Pravin and Jyoti Dattani Dr. Jefferson C. Davis, Jr. Kenneth E. De Bruin John and Nancy Devincenzi Shyamal P. Dharmasena Henk Dijong Charles Do, M.D.

Phuong Nhu Sy Dong Michelle Christine Douskey Denis and Donna Drapeau Steven F. Drury Doug Edwards Ernest Ehnisz, Jr. David J. Ellis Mark R. Etzel John Fabera Stephen Falling Eric Fallon Heather Fan Simon Fang and Jie Long Maria Fardis, Ph.D., M.B.A. Jim and Nina Farjadi Peter and Sharon Fedkiw J. Leonard Fick Dwight A. Fine

Milton Finger Brian Fischer Jay and Leslie Fishman Warren W. Flack Fred and Helen Fong Bruce M. Foreman Girard (Jerry) Foster Mary M. Fox Elizabeth Francois Valerie Jue Francuz Loyd D. Frashier Allen H. Frederick Craig S. Frial Charles R. Gahr Ethan C. Galloway Terry Galloway Don Gartner Steven and Hillary Garwin

donors to the college Ted and Deborah Germroth Kevin R. Geurts and Angela R. Smith Peter Giannousis Jack T. Gilmore Gary M. Goncher Judson E. Goodrich Mark and Valerie Goodwin Bruce A. Gordon Daniel M. Gorecki George W. Goth Harold and Margaret Granquist Ronald W. Grant Beth and Timothy Grasel Laura Greenfield Ruth Grimes Charles E. "Ched" Grimshaw William A. Guillory Robert Gunther Hari B. Gupta William R. Haertle Howell A. Hammond Robert W. Hand Andrew Harautuneian John and Angela Harder George L. Hardgrove, Jr. J. Ronald Hargreaves William and Janet Hargreaves Everette Harris Ian Harris Steven Leopold Hartford, M.D., Ph.D Tom Harvey Michal and Timothy Hawk Auda K. Hays Zesheng He and Yuelan Zhou James and Jeannine Healy Sue Heinemann Max and Audrey Helix Adam Heller Ray and Cathy Heller Robert T. Hendricks Robert W. Hermsen Lloyd Hile Paul V. Hinman Eric Hintsa Hansel Ho Robert B. Holden

Al and Juli Hong Ji Sun and Myeongsook Hong David W. Hoover Limin Hsueh Chung-hwa Huang E. Kenneth Hulet John T. Hunt Penny L. Hunter John and Louisa Hwa Anthony T. Iavarone Denise C. Jamin Hanisee Mr. and Mrs. Thomas J. Jarvis Craig Jensen Ronald Jensen John A. Jensvold Jon A. Johnsen Audrey Johnson Gary and Ann Johnson Patricia W. and Russell L. Jones Eileen M. Julian Shee Lup Jung Drs. John and Kristy Jurchen Andreas V. Kadavanich Richard A. Kahlstrom James S. Kane Abdul R. Kassir Alexis I. Kaznoff Andrea L. Keaton Eric R. Keim Ellen Kick Habtemariam T. Kifle John S. Killian Kathleen V. Kilway Chung Wha Kim Andrew Kindler Todd Kindorf Baldwin King Jeffrey L. Klaus Alice N. S. Ko Arkady and Lyudmila Kokish Trudy Kong Alan and Tracy Koretsky Kenneth Kraus Marvelle E. Krenz Kamala R. Krishna Shailaja Krishnamurthy Paul J. Krusic Samuel S. Kurita and Mary Anita Long

Alex and Maria Kutas Heemun Kwack Harrison and Jeong Ok Kwon Justin Kwong Cam-Mi La Randel and Sheralin Lafferty Felix S. C. Lai John R. Lai Edward D. Lally Larry P. Lam Arnold Lamb William E. Lambert Lee Latimer William J. Lawrence Luong H. and Sophie L. Le Christina J. Lee Chun-Yue Lee Cindy Lee Jess and Kiet-Nghi Lee Marianne Asaro M. K. Carol Lee Terrance Y. Lee Allen and Phyllis Lefohn Theodore J. Leitereg James R. Lemley Prof. and Mrs. William A. Lester, Jr. Albert C. H. Leung Cissy Leung Keith Leung Tak Leung Dr. William G. Light Bernard Joseph Lilly, Jr. Chee M. Lim Hong and Uong Lim James Lim Jack Lin Jon and Ren-Chih Lin Dr. and Mrs. T. Joseph Lin Tim Lin Nancy J. Linck Manfred Lindner David Lindsay Norma B. Linsky Benjamin T. Liu Pamela Liu Yan and Yvonne Liu David A. Lloyd Zhi-Heng Loh

Harold R. Lohr Dr. Wayne D. Luke Ka Lum Xuan Hung and Van Gia Ly Luzviminda and Ramonito Mac Tom Mac Phee Khorshed Madan Rajinder K. Mahendroo Ben and Kazako Makishima Doug Mandel Nolan Mangelson W. Paul Martin Con and Mary McCormick Dr. William R. McDonell James W. McFarland Anne E. McGuire Keith and Liz McLaughlin Tanya and Michael McManus Ashish J. Mehta Shu-Hua Meng John Mersch III J. Hoyt Meyer Richard Michelman and Karen Meyer Alwin S. Milian Donald G. Miller Richard R. Miller Prof. and Mrs. William H. Miller G. Mitra Barbara and Dennis Morrell Shawn J. Morrissey Lester R. Morss Earl M. Mortensen Robert Mortlock Jim Muirhead Robert and Susan Mullen Barry T. Murphey Thomas F. Murphy Dr. and Mrs. Louie A. Nady Tatsuhiko and Mihoko Nakashige Masato Nakashima Marshall Douglas Nelson Madeline M. Netto Thomas W. Newton King T. Ng Steve Ng and Lynn Tangudtaisuk

annual report â&#x20AC;&#x2122;09

donors to the college

Yu Sim Ng Felix G. Ngan Tuan Ngoc Nguyen Jiu X. Ni Kendall Novoa-Takara Teiichiro Ogawa Miles Okino Timothy and Bobbi Olson Howard K. Ono Patrick J. Orme Tim Owens James Oziomek Spyridon Papadakis Rudolph Pariser Dr. Christopher C. Parks Alan D. Pasternak Colonel Douglas A. Patterson Charles W. Paul Charles Paulson Chih-Yuan and Shiau-Shiau Pei Arnold Leo B. Peneda Charles and Marilyn Perrin Jaan Pesti Dr. Eric C. Peters Frederick M. Peterson, Ph.D. Leonidas Petrakis Paul A. Petruzzelli Jason Ploeger Matthew Plunkett J. Kenneth Poggenburg Max Y. Pong Gary and Lily Poon Dr. J. Winston Porter Kristala Jones Prather Max Pray Elisabeth M. Price Susan Puglia David Rabb Donald L. Raimondi Chakkodabylu and Sukanya Ramesha Tom and Betty Ransohoff Stephen and Greta Register Manfred G. Reinecke Richard A. Reinhardt Edgar and Rowena Reyes Antonio J. Ricco Jed Richardson

College of Chemistry, UC Berkeley

Alice and Rudolph Rico John and Annette Riordan Gene Roberts Patrick A. Rodgers Mark Roebuck David P. Rogers Lois V. Roland Gerry Rollefson Esther H. Rose Albert J. Rothman Robert J. Rothway Steven P. Rucker and Rebecca L. Hoff David S. Rumschitzki Edna (Sugihara) Sakai Robert E. Santini Prof. Richmond Sarpong Alexander Sassi Rob Scarrow Robert A. Scherrer Francis and Phoebe Schmitz Joseph Schohn Nick R. Schott Joshua A. Schrier Peter Schubart Stephen E. Schwartz Gretchen M. Schwenzer William J. Scott Richard Searle John M. Seelig and Helen Zelt-Seelig Pi-teh Shen Lillian R. Shepherd George S. Sheppard Albert E. Sherwood Martin D. Shetlar James S. Shirk Robert D. Simpson Wade and Avril Sisk Kin and Monita Siu Myron Siu Elliott B. Slamovich Arthur C. Smith Michael E. Smith Mercedes Snider Sabrina G. Sobel Lee G. Sobotka Steven G. Sogo John E. Sohn

Harry and Margaret Spencer Carla St. Laurent, M.D. William L. Stanley Virginia Stark Raymond C. Stewart Joel A. Stiner Steven and Gloria Stoltz Elaine Blatt Stoner Michael S. Story Manolis Stratakis Pieter Stroeve E. Thomas Strom Warren C. Stueben Louis S. Stuhl John P. Sullivan Chris Tagge James Takasugi and Karen Brown Gordon Tam Sarah Luchansky and Kian Tan Fred Tanaka Tony Tang Marc E. Tarrasch James G. Taylor Reema K. Thalji Klaus H. Theopold Jack Thomas Kimberly and Kenneth Thomas Jeffrey Tom Connie C. Tong Lee Karl Jan Tong Paul Tong Prof. Dirk Trauner Michael Trenary Gail A. Trimble James H. Tsai Kao-Tai and Nancy Tsai Noel H. Turner John P. Unik Melvin C. Vail Nikhil and Manisha Varaiya David L. Wagger, Ph.D. Frederick T. Wagner Gregory J. Wagner Jennifer S. Wakita Alexander K. C. Wang Bennet M. Wang Francis T. Wang Hsu-Kun Wang

Stanley Wang Robert Waterhouse Mark Weidenbaum and Lisa Berke Robert F. Weimer Robert B. Welch William J. Welch Dwight D. Weller Peter H. Wendschuh Dr. William C. Wernau Carolyn A. Westerdahl David Whitmore Gina Whitney James Thor Williams Richard Q. Williams Peter B. Wilson Thomas and Betty Winfield Stephen F. Wolf Daryl B. Wong Eric K. Wong Patrick Wong Richard L. C. Wong Sharon M. Wong Mabel Lowe Woo Barbara A. Wood Benjamin and Nichole Wood Kevin D. and Virginia M. Woodburn J. D. Wordie Ronald Wright Albert H. Wu Bo Yang Weidong Yang Zhen-Yu Yang Paul C. J. Yeh Shan J. Yeh Anissa and Gary Yeung Kenneth and Nicole Yi Jackson Yu Marsha Yuan and Michael Chaisanguanthum Petros D. Zavitsanos Jenny Zhu Zai Xin Zhu and Ya Hua Wang Robert D. Zimmerman

The Honor Roll $1 to $99. Joselle Abagat Marc J. Adler Kevin L. Alexander Dr. Habib Amin Phyllis and Larry Anderson Anonymous (4) David Arnosti Zaid A. Astarabadi Robert and Yadja Bacher Leif M. Backlund Kyoung Y. Baek Joseph K. Bailey Stan Barnett Edward M. Barrish George H. Batchelder Brian and Lori Beaudoin Dean Bender Ronald S. Besser Onita Bhattasali Yashodhan Bhawe Joleine M. Bigcas Richard W. Borry Gregory B. Boursalian Dale C. Bowyer Jonathan H. Boyce R. E. Bozak Mitchell C. Brenner Rob Broekhuis Steven Bromberg Charles R. Brown Harmon and Elizabeth Brown William H. Brown Mark A. Burlingame Bruce A. Capron Ronald M. Carn John W. Carroz Ada Woo and Joe Carson Donald A. Cass Robert P. Chambers Erik Chandra Angela Y. Chang Mary Pin Chang Jonathan D. Chapple-Sokol John J. Chen Pei-Shiun Chen Yung Cheng

Mr. and Mrs. Thomas J. C. Chew Mark and Dora Chien Gary and Charissa Chock Tracey Chow Han S. Chueh Janis K. Chun Robert D. Clay Mary E. Clifford James L. Cole John B. Collins, Ph.D. Rosemary M. Conrad Kyla D. Cook Virginia Cornish Douglas H. Cortez William M. Cwirla Sean Dabel Howard E. Davis, Jr. Jacob M. Davis Colonel Oak H. DeBerg Andrew and Carol DeGraca Celicia D. Della Beatrice A. Dimpfl James R. Douglass Irena Dragojevic Ronald P. Drucker David P. Duberow Tam Thi Ngoc Duong John W. and Marlene Jensen Eastman Robert E. and Suzanne Emberton Kin Eng and Gail Escalona-Eng Felicia A. Etzkorn Winny A. Fam Watson Fearing H. G. Featherstonaugh A. Edward Fenn Jack Finney George Fitzgerald George M. Fohlen Henry Fong Erik M. Freer Janet Frick Craig Gates J. Daniel Gezelter Edward Gillan Michael D. Gillespie Gwen M. Ginley

David Glueck Alex Goretsky Gail L. Gray Michael L. Greenfield Frank Greer Xun Gu Jondi Gumz Kenneth and Carol Hamilton Neil S. Hanabusa John E. Hanson Prof. and Mrs. Robert A. Harris Jennifer A. Hart Kathleen Heng Bruce Michael Henkin Kay and Theresa Herbert James and Shih-Min Holland Vu P. Hong David Horner Nancy Johnsen Horton and John Douglas Horton Yoko Hsueh Shirai Chae Sim Huang Chu Liang Huang Cynthia Huang Camden R. Hubbard Kyung Hugh Sabrina Huynh Mary Lee Hyde Ugonna Ihenacho Brian Aki Ikkanda Janice S. Javier Jonathan N. Jaworski Sriharsha Jayanti Michael and Elizabeth Jellen Tiffany Jen Vivian Jiang Franklin and Rose Jin Brian Johnston Berardo Jurado Timothy B. Karpishin Na Young Kim Matthew Cameron Kinne Roland Koestner Stanley Koshan Tawni Koutchesfahani Georgina Garbutt Kratzer Cynthia Krieger Frank B. Krivohlavek

James H. Krueger Romesh Kumar Douglas S. Kuramoto Denis and Linda Kurt Y. R. Kwan Peggy McMahan Lareau John F. Lathrop Tsun Yin Lau Cliff A. Lay Amy S. Lee Donald W. Lee Martin and Nailin Lee Stacy Lee Yoon Sup Lee Colin W. Lees Andrew S. Lemoff Joshua Leonard Wai Man Leong Gabriella Lestari Anita Leung Jason Lewis John D. Leyba Michelle Kong and Jun Li Xue Li Thomas and Janet Lichterman Connie Lim Jin-Ping Lim Elaina Lin Gene C. Lin Jie Hua Lin Kevin Guangcheng Liu Shaoyong and Tong Liu Lisa Lobree and Cameron Abrams Ann L. Long Larry Loomis-Price Thomas J. Lowery Eric Lu Charles Ludvik Alfred Lyanto Richard A. MacPhail Sussie Mah Frank A. Mahler Anil Mallya Joseph J. Marlin Helen and John Matthews Frank and Catherine McCarthy Karen and Steven McDonald Barry and Donna McElmurry

annual report â&#x20AC;&#x2122;09

donors to the college

Jonathan McLeod Richard T. Meyer Albert and Loretta Monaco Terry Moody Karl T. Mueller Sarah Mullins William Murray Marcel W. Nathans Randy P. Neisler Norman T. Nelson Caroline Nguyen Kristine A. Nolin James and Georgiana Nygaard Jodie M. Nygaard Hiroko Ohtani Jon and Susan Okada Robert Oller Marjorie Olson Jacqueline Orbon Morton Orentlicher William H. Orttung Bruce W. Page Priya S. Parikh Dilworth Y. Parkinson Christine K. Payne Libbie S. Pelter QiQi Peng Merritt H. Peterson Joseph P. Phillips John and Judi Pohl William Polik and Joanne Stewart Morgan Ponder Bing T. Poon Patrick J. Purcell Haibo Qi Jesse Qi and Jimei Tian Guohua Mao and Jie Qian Christina L. Quigley Leila A. G. Ranis Craig L. Reeder Patrick J. Reilly Ronald and Monica Reimer Gordon and Sharon Renkes Keith Rickert Gary E. Ritchey Gerald and Maureen Ritter Gary L. Robison

College of Chemistry, UC Berkeley

Glen A. Rogers Dobbie L. Roisen Peter R. Rony Michael W. Rowe Sanford A. Safron Cleo Salisbury Diane and Andy Santamaria Rebecca and Matthew Scheck Vinod K. Shah Charlton Shen Tae Soo Shin Sara and Bakthan Singaram Harmeet Singh Steven W. Sinton James T. Slama Shepard J. Smithline Ferry and Melani Soendjojo Aaron Bradley Solin Timothy Spence Susan Stanton Sarah G. Stewart Elise C. Stone Bryan Stubbert Joel Susskind Debra M. Suzuki Jon T. Swanson Robert and Linda Swofford Vazken Tashinian Geoffrey A. Theiss Joel A. Thornton Talar Tokatlian Charlotte H. Tran Henry Hiep Tran Michael and Susan Tranquilla Dale Trowbridge Victor and Susan Tsai Family of Margaret M. (Schultz) Tsiang Michael W. Tsiang Ricardo Unikel Marijke H. C. Van Spyk Mathias van Thiel Paul Verderber David J. Vieira Diana N. Viet Mary F. Vondrak Michael A. Walker Pam Wang

Ken Waterman Clayton A. Webb Adam Z. Weber John B. Wheeler, Jr. Donald W. Whisenhunt, Jr. Ralph E. White Claire M. Woodburn Adam and Shannon Woolley Cindy Hsin-I Wu David Tai-Wei Wu Pei-Hua Wu Alexander L. Xenakis Lei G. Xing Liub-Chii Yang Chen Laura Yee Ronald Yeh Albert Fu-Ding Yen Geibao Yin Krystine Nichole Yu John Zelinsky Ray R. Zhang John and Renate Zinn

Tributes Gifts have been received in honor of: Prof. Paul A. Bartlett Prof. Robert G. Bergman Prof. Harvey W. Blanch Mr. Samuel W. Calvert Prof. Joseph Cerny, Jr. Dr. Michael D. Grimes, DPM Prof. Charles B. Harris Prof. Clayton H. Heathcock Prof. Harold S. Johnston Prof. C. Judson King Dr. Deanne C. Krenz Prof. Emeritus Scott Lynn Dean Richard A. Mathies Mrs. Camille Olufson Prof. John M. Prausnitz Prof. Richard J. Saykally Mrs. Jane L. Scheiber Prof. Gabor A. Somorjai Prof. Andrew Streitwieser Jr.

Gifts have been received in memory of: Mr. Samuel Abrahams Mr. Eric B. Abramson Dr. Ian R. Bartky Mr. E. Morse Blue Dr. Benjamin P. C. Boussert Dr. Gary E. Brodale Prof. Melvin Calvin Alicia M. Cervantes Prof. William G. Dauben Mr. Peter Di Muro Prof. Alan S. Foss Mr. LeRoy G. Green Prof. William D. Gwinn Dr. Heinz Heinemann Ms. Lina Hirzel-Wirz Dr. Robert H. Iwamoto Ms. Margaret Jorgenson Prof. George Jura Dr. Frank Howard Kratzer Mr. Daniel J. Lucas Prof. David N. Lyon William H. McAdams Prof. Emeritus Donald S. Noyce Dr. Axel R. Olson Prof. Eugene E. Petersen Prof. George C. Pimentel Prof. Kenneth S. Pitzer Dr. Paul B. Plouffe Prof. Henry Rapoport Dr. Charles B. Roland Dr. Robert Scarborough Dr. Thomas H. Schultz Prof. Glenn T. Seaborg Dr. Ashraf Shalaby Dr. Deepak K. Sharma Prof. Mitchel Shen Clayton Conner Shepherd Mr. George D. Snider Mrs. Ann Stewart Prof. Emeritus Charles W. Tobias Dr. Himanshu B. Vakil Mrs. Theodore Vermeulen Prof. Theodore Vermeulen Dr. Emil J. Volcheck, Jr.

college advisory board John H. Abeles MedVest Inc. William Banholzer The Dow Chemical Company Paul F. Bryan Ph.D. ’85, ChemE Chevron Technology Ventures Sunney I. Chan B.S. ’57, ChemE; Ph.D. ’61, Chem Caltech (emeritus) Nirmal Chatterjee M.S. ’68, Ph.D. ’71, ChemE Air Products and Chemicals, Inc. (retired) Carl P. Decicco Bristol-Myers Squibb Sam H. Eletr Ph.D. ’68, Chem Population Genetics Stephen P. Fodor Post-doc ’91, Chem Affymetrix Inc. Richard A. Gottscho Lam Research Corporation Christopher A. Haskell Bayer HealthCare Pharmaceuticals Victoria F. Haynes B.A. ’69, Chem RTI International Herbert H. Hooper Ph.D. ’90, ChemE Ampersand Ventures F. Emil Jacobs ExxonMobil Research and Engineering Company M. Ross Johnson Postdoc ’71, Chem Parion Sciences, Inc. Yuan T. Lee Ph.D. ’65, Chem Academia Sinica and UC Berkeley (emeritus) Richard A. Lerner Scripps Research Institute John H. Markels Ph.D. ’93, ChemE Merck & Company Gary M. Masada B.A. ’66, Chem Chevron Corporation (retired) Alan Mendelson Latham & Watkins, LLP Terry J. Rosen Ph.D. ’85, Chem Amgen Charles V. Shank UC Berkeley, LBNL (emeritus) Darlene Solomon Agilent Technologies James A. Trainham B.S. ’73, Ph.D. ’79, ChemE Sundrop Fuels, Inc. R. Stanley Williams M.S. ’76, Ph.D. ’78, Chem Hewlett-Packard Company Steven D. Young Ph.D. ’82, Chem Merck Research Laboratories

volunteers Alumni Association Steering Team Gilbert T. Basbas, B.S. ’04, ChemE Gordon G. Chu, B.S. ’03, ChemE Laurie J. Dockter, B.A. ’71, Chem Dean C. Draemel, B.S. ’70, M.S. ’75, ChemE Marissa Drouillard, B.S. ’00, Chem Mark W. Ellsworth, Ph.D. ’93, Chem Lara A. Gundel, Ph.D. ’75, Chem Deanne C. Krenz, B.S. ’94, Chem Lawrence B. Perry, B.S. ’56, ChemE Daisy Y. Quan, B.S. ’47, Chem Steven F. Sciamanna, B.S. ’79, Ph.D. ’86, ChemE Lucinda A. Vejar, B.S. ’85, Chem Rebecca Zuckerman, Ph.D. ’00, Chem

Alumni Era Volunteers The following have volunteered their time to the Alumni Association’s “era groups.” G. N. LEWIS ERA: 1945 AND EARLIER

G. Douglas Gould, B.S. ’42 Chem CUPOLA ERA: 1946-1963

Frank G. Delfino, B.S. ’51 ChemE E. Kenneth Hulet, Ph.D. ’53 Chem David N. Lyon, Ph.D. ’48 Chem Mary F. Singleton, M.S. ’59 Chem

Dean (B.S. ’70, M.S. ’75, ChemE) and Becky Draemel enjoy the Dean’s Dinner, held annually at The Faculty Club. THE FREE RADICALS: 1964–1979

Laurie J. Dockter, B.A. ’71 Chem Robert P. Hohmann, B.S. ’78 ChemE Curtis L. Munson, B.S. ’76, Ph.D. ’85 ChemE Carolyn M. Orelli, B.S. ’70 Chem Steven F. Sciamanna, B.S. ’79, Ph.D. ’86 ChemE Bruce E. Stangeland, Ph.D. ’67 ChemE THE CHEMILLENNIUMS: 1980–1999

Marilee M. Brooks, M.S. ’88 ChemE Paul V. Burke, B.S. ’81 ChemE Grace F. Chou, Ph.D. ’88 ChemE Daisy J. Du Bois, Ph.D. ’94 Chem Mark W. Ellsworth, Ph.D. ’93 Chem Maria S. Fardis, Ph.D. ’98 Chem Thomas R. Gadek, Ph.D. ’86 Chem Deanne C. Krenz, B.S. ’94 Chem Susan M. Miller, Ph.D. ’83 Chem Walter H. Moos, Ph.D. ’82 Chem Alyssa L. Roche, B.S. ’87 ChemE Steven F. Sciamanna, B.S. ’79, Ph.D. ’86, ChemE Michael M. H. Yang, B.S. ’92 Chem & ChemE

Sheila W. Yeh, B.S. ’80, Ph.D. ’85, Chem YOUNG ALUMNI: 2000 AND BEYOND

Stephen Chan, B.S. ’01 ChemE Marissa Drouillard, B.S. ’00 Chem Rebecca Zuckerman, Ph.D. ’00 Chem

Fundraising Volunteers The following assisted the College in fundraising efforts in 2008–2009. Keith Alexander, B.S. ’78, Ph.D. ’83, ChemE John Brauman, Ph.D. ’63, Chem J. Peter Clark, Ph.D. ’68, ChemE Dean C. Draemel, B.S. ’70, M.S. ’75, ChemE Tarric El-Sayed, Ph.D. ’87, ChemE John Hecht, Ph.D. ’99, ChemE Joon S. Moon, Ph.D. ’64, ChemE Curtis Munson, B.S. ’76, Ph.D. ’85, ChemE Janet Tamada, Ph.D. ’89, ChemE Rodney Thompson, Ph.D. ’86, ChemE Bill Young, Ph.D. ’67, Chem annual report ’09

corporate, foundation and organizational gifts

It is our pleasure to acknowledge the many companies and other organizations that continue to invest in the collegeâ&#x20AC;&#x2122;s future. These donations represent a major source of funding for our graduate, research and teaching programs. Contributions for 2008â&#x20AC;&#x201C;09 are listed below.

Industrial Friends Program Membership in the College of Chemistry Industrial Friends Program is open to any firm, regardless of size or location. Annual support of $25,000 or more can come in the form of unrestricted funds, departmental fellowship funds, start-up funds for non-tenured faculty, support for facilities or research funds for tenured faculty.

3M Abbott Laboratories Agilent Technologies Air Products and Chemicals Amgen, Inc. Arkema, Inc. AstraZeneca Bayer Healthcare Pharmaceuticals Bristol-Myers Squibb Canon Inc. Chevron Corporation CrystalGenomics Dow Chemical Company DuPont Eli Lilly and Company General Motors Corp Genentech, Inc. Gilead Sciences GlaxoSmithKline Hitachi Honda R&D Americas, Inc. Johnson & Johnson Lam Research Corporation Merck & Company Novartis, Inc.

College of Chemistry, UC Berkeley

Procter & Gamble Company Robert Bosch Corporation Roche Palo Alto Rohm and Haas Company Schlumberger Showa Denko K. K. SpectraWatt Toyobo America, Inc. Tyco Electronics

Gifts of $100,000 and more American Cancer Society Agilent Technologies Amgen, Inc. Bristol-Myers Squibb Camille and Henry Dreyfus Foundation Dow Chemical Company Gilead Sciences Lam Research Corporation Novartis, Inc. Q-Chem Roche Palo Alto

Gifts of $50,000 to $99,000 Abbott Laboratories AstraZeneca Chevron Corporation DuPont Eli Lilly and Company Genentech Inc. Hitachi Honda R&D Americas Inc. Robert Bosch Corporation

SpectraWatt Tyco Electronics

Gifts of $25,000 to $49,000 American Chemical Society, Division of Organic Chemistry Arkema Inc. CrystalGenomics Merck & Company Schlumberger Showa Denko K. K. Toyobo America, Inc.

Gifts up to $24,999 American Chemical Society, Division of Medicinal Chemistry Bayer Healthcare Pharmaceuticals Centre Europeen de Calcul Atomique et Moleculaire Clorox Company Daiichi-Sankyo Co. Ltd. Dainippon Sumitomo Pharma Co, Ltd. Eastman Chemical Company ExxonMobil Genencor, A Danisco Division Giauque Scientific Papers Fdn. GlaxoSmithKline Intel Corporation JSR Corporation KLA Tencor Corporation Newry Corp. Organic Syntheses, Inc.

Pfizer, Inc. Powervision Procter & Gamble Company Rohm and Haas Company Royal Society of Chemistry Takasago International Corporation U.S. Civilian Research & Development Foundation

Matching Gifts 3M Foundation, Inc. Accenture Agilent Technologies Air Products and Chemicals, Inc. Altria Inc. Applera Corp. BASF Corporation Baxter Healthcare Beckman Coulter Bridgestone/Firestone Trust Fund Bristol-Myers Squibb CBI Foundation Chevron Corporation Cisco Clorox Company Foundation ConocoPhillips Dow Chemical USA Eli Lilly & Company Esterline Technologies C0rp. ExxonMobil Foundation Fair Isaac Fidelity Foundation Genencor Genentech General Electric Foundation General Motors Foundation

GlaxoSmithKline Hess Corporation Hospira IBM Corporation IFF Foundation Intel Foundation Johnson Controls Foundation Lam Research Corp. Lockheed Martin Lubrizol

Lyondell Chemical Co. Medtronic Menasha Corp Foundation Merck Microsoft Millipore Foundation Monsanto Fund MRW & Associates Northrop Grumman Corp OSIsoft

Pacific Gas & Electric PepsiCo Pfizer Inc. Pharmacia & Upjohn Foundation Pioneer Hi-Bred International PNM Foundation Procter & Gamble Fund Raytheon Company

Science Applications Int’l. Shell Oil Company Foundation Sun Microsystems Takeda Tektronix Foundation Valero Energy Corporation Washington Group Foundation Wells Fargo Wyeth (American Home Products)

(rear, l. to r.) Chevron’s Rebecca Brafman (B.S. ’00, ChemE), ChemE chair Jeff Reimer and Chevron’s Alyssa Roche (B.S. ’87, ChemE) pose with the winners of the Chevron Scholarship in Chemical Engineering, (front, l. to r.) Cindy Xu, Liliana de la Paz and Fei Chu.

Bob Lamoreaux, instructional support manager for the College of Chemistry, inspects equipment and software given by Agilent Technologies with Chris Hahn, a graduate student instructor in Chem 4 and member of Professor Peidong Yang’s research group.

Dean Richard Mathies presents Steve Lindsay of Lam Research with a plaque to express Berkeley’s gratitude for a generous gift to set up a Lam Research Chair in Semiconductor Processing. (l. to r.) Prof. Tsu-Jae King Liu, Jeff Marks, Dean Richard Mathies, Dragan Podlesnik, Steve Lindsay, Mark Retzer, Prof. David Graves, Tamara Croyts, Shail Kumar, Dave Hemker.

annual report ’09

giving to the college of chemistry college funds T H E A N N U A L F U N D provides essential monies that can be used, at the discretion of the dean or of the chairs, to meet needs that are not supported by the state budget. These unrestricted funds are particularly valuable because of their flexibility. The annual fund is vital for financing ongoing programs and special projects. E N D O W E D F U N D S provide a permanent source of income to meet the needs of faculty and students in perpetuity.

M E M O R I A L F U N D S commemorate individuals while benefiting the college and the departments of chemistry and chemical engineering. Donations may also be given to the annual fund in memory or in honor of an individual, and the college will notify the family that a contribution has been made.

forms of giving benefits for the college—and for the donors Many different kinds of gifts can benefit both you and the University. Some of them can offer particular estate planning advantages, including income for life. Our professional staff would be pleased to discuss these gift vehicles with you; however, the University urges you also to consult your attorney or financial advisor. If you wish your gift to benefit the college, any legal documents or instructions should specify that the gift is for the College of Chemistry (or the Department of Chemistry or the Department of Chemical Engineering) at the University of California, Berkeley. C A S H Checks should be made payable to the UC Berkeley Foundation (UCBF), with a notation designating the name of the fund. Gifts to memorial funds should be made payable to the specific fund. Contributions may also be made with your Visa or MasterCard credit card by phone (510/642.9506), or online at givetocal.berkeley.edu/chem/. S E C U R I T I E S In most cases, gifts of appreciated securities may be deducted at full market value as of the date you make the gift, and the donor does not have to pay capital gains taxes. Gifts of appreciated stock are most easily handled by the UC Berkeley Foundation and should not be sold prior to transfer. You or your broker may contact Acting Assistant Dean Mindy Rex in the college (510/642.9506) or Ms. Sylvia Worthington, Securities Steward in University Relations (510/642.4123), for

College of Chemistry, UC Berkeley

further information. Stock can often be transferred electronically. If you wish to give a gift of depreciated stock, you should first sell it and give the proceeds to the Foundation. You can then use the loss to offset any gains and also claim a charitable deduction. R E A L E S TAT E Gifts of real property may be deeded to UC Berkeley for the benefit of the College of Chemistry, providing significant tax advantages to the donor in most cases. It is also possible to deed a property to the University and continue to occupy it for life. L I F E I N C O M E G I F T S A number of options are available by which you may transfer assets to a trust (to be managed either by the University or a trustee of your choosing) and receive income for yourself and/or a designated beneficiary for life, as well as immediate tax benefits. The college ultimately receives the trust property. B E Q U E S T S A fixed amount or a percentage of your estate may be designated for the benefit of the College of Chemistry in your will or living trust. M AT C H I N G G I F T S Hundreds of firms match their employees’ (and sometimes retirees’) contributions on a 1:1, 2:1 or even 3:1 basis. If your company has such a policy, forms—hard copy or electronic— to assure that your gift will be matched can be obtained from your personnel or employee relations office. Matching gifts are added to your individual gift in determining the donor club to which you belong.

archive THE REPORT OF PRIVATE GIVING COLLEGE OF CHEMISTRY 2008â&#x20AC;&#x201C;2009

The preceding report acknowledges all donors to the College of Chemistry from July 1, 2008 through June 30, 2009. We have made every attempt to include all donors accurately. We apologize for any errors or omissions and would appreciate hearing from you with any comments or corrections regarding this publication.

acting assistant dean Mindy Rex director of annual giving and corporate and foundation relations Nancy Johnsen Horton director of alumni relations Camille Olufson development services manager Dorothy Isaacson Read

For further information about giving to the College of Chemistry, please contact College Relations and Development College of Chemistry #1460 University of California, Berkeley Berkeley, CA 94720-1460 Phone: 510/642.9506 Fax: 510/642.4419 Email: rex@berkeley.edu

In a five-page letter to NASA administrator John E. Naugle, dated January 16, 1968, Berkeley chemistry professor George Pimentel defends the group of young researchers building the Mariner infrared spectrometer and argues for the necessity of the contributions of outside scientists to NASA missions.

nonprofit org. u.s. postage paid university of california

Catalyst university of california berkeley

College of Chemistry 420 latimer hall #1460 berkeley, ca 94720-1460

Upcoming 2010 Alumni Events Cupola Era Alumni Luncheon Watch for a separate mailing in late January/early Date TBA February for the Cupola Era alumni event. This era includes friends and alumni from the graduating years 1946–63.

Cal Day April 17

Springfest April 29

This annual campus-wide open house has something for everyone! As the date draws closer, check out berkeley.edu/calday for the complete listing of events and programs.

6:00–7:30 p.m. Jupiter Beerhouse, 2181 Shattuck Ave. Berkeley We hope that you will join us as we celebrate our 2010 graduating undergraduate and graduate students! As the time approaches, check out our homepage at chemistry.berkeley.edu/alumni/events.html for more details. This is a complimentary event, and reservations are not required.

Nanotechnology Forums Date TBA Berkeley Nanotechnology Forum The Berkeley Nanotechnology Forum 2010 (BNF 2010) features leading scientists, entrepreneurs and academics presenting their views on the current achievements and future opportunities in the field of nanotechnology. For more information, visit nanoclub.berkeley.edu.

Upcoming Seminars and Lectures Go to the College of Chemistry’s website at chemistry.berkeley.edu and select Seminars and Events to view the college’s seminar calendar.

+ For alumni events, visit chemistry.berkeley.edu/alumni/events.html

background image: rayograph courtesy of mic helle douskey