2010 Pipeline Report

Page 4

Table of Contents Introduction & Executive Summary

1

The Antiretroviral Pipeline Activity since 2008 The Pipeline in 2010 Other Compounds and Targets in Preclinical Research Patent Expiry and Generic Compounds

7

The HIV Diagnostics Pipeline Requirements for Point-of-Care Tests The CD4 Initiative Point-of-Care Viral Load Test

25

The Pediatric Antiretroviral Pipeline 29 Why Not Avoid Pediatric HIV in the First Place? When to Start Children on Antiretroviral Therapy Identifying Children with HIV and Starting Them on Treatment What to Start With? Dosing / Formulations The Innovator Pipeline The Generic Pipeline The Immune-Based Therapies and Preventive Technologies Pipeline 44 Vaccines Vaccine Approaches in Human Trials Preexposure Prophylaxis Immune-based Therapies HIV Cure Box Hepatitis B Drugs in Development Oral Antivirals Immune-based Therapies Preventive Vaccine

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