Rosalyn M. Sweeting Assistant Professor of Biology Appointed to SVSU in 2005 Ph.D. University of London, UK B.Sc. University of Birmingham, UK
CONFERENCE PRESENTATION Sweeting, R.M. (2011, March). From Philadelphia to Gleevec: The history of a chromosome. Paper presented at the annual meeting of the Michigan Academy of Science, Arts, and Letters, (History of Science and Technology section) Saginaw Valley State University, University Center, MI
FUNDED RESEARCH Sweeting, R.M., Dunbar, G.L. (Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, and Field Neurosciences Institute, Saginaw, MI), Lange, G.M., & Rossignol, J. (Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University) Cytogenetic studies to determine tumorigenicity of rat mesenchymal stem cells. SVSU Faculty Research grant, $5000, November 2011 – October 2012. Stem cells are capable of self-renewal and have the ability to develop into a variety of different cell lineages. Hematopoietic stem cells have been used successfully in the treatment of human hematological diseases for a number of years raising the possibility that stem cell therapy could be used to for various other diseases/injuries which are difficult to treat by conventional means. However, there have been reports in the literature that human embryonic stem cells develop chromosome abnormalities after culturing in vitro, and that transplanted stem cells of animal origin can form tumors in experimental animals. Because the relationship between chromosome abnormalities and tumor development is well established, this indicates the need for the genetic screening of stem cells prior to and after transplantation. Current investigations on mesenchymal stem cells have revealed the presence of chromosomal abnormalities in which increase in number after passaging in vitro.
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Saginaw Valley State University