STRUCTURAL BIOLOGY
FLOW CYTOMETRY
The structural biology core offers central tools used to develop a complete picture of proteins at an atomic level — and gives scientists insights into protein functions, flaws resulting from genetic mutations, and drug interactions. Technologies include nuclear magnetic resonance, crystallography, and protein analysis.
Flow cytometry allows scientists to count and sort cells based on biomarker expression on cell surfaces. The flow cytometry facility provides both analytical and high-speed cell-sorting services.
GENOMICS
BIOINFORMATICS
Genomic studies allow scientists to understand the role that specific genes play in cancer. Our facility provides next-gen sequencing, including experimental design, library prep, and data analysis, as well as full-service microarray and Q-PCR analysis.
Scientific research produces vast amounts of data. Creating knowledge from data requires the use of sophisticated bioinformatics tools. This facility provides the tools and expertise to understand the biological and medical significance of research discoveries through the analysis, integration, mining, and contextualizing of data.
ANIMAL RESOURCES
PROTEOMICS
FUNCTIONAL GENOMICS
Our animal resources include an AAALACaccredited animal facility, with a variety of animal analysis technologies, including animal imaging, analysis of tumor formation, and treatment results.
Researchers use the proteomics facility to understand which proteins are expressed or modified in normal cells compared to cancer cells. Technologies range from mass spectrometry and gel-based simple protein identification to proteome-wide, posttranslational modification analysis.
Functional genomics focuses on the dynamic aspects of genes, such as gene transcription, translation, and protein-protein interactions — as well as the role of noncoding RNA in cell function. This facility provides assay development, RNA and DNA libraries, and high-throughput screening services.
CELL IMAGING AND HISTOLOGY
CHEMICAL LIBRARY SCREENING
CANCER METABOLISM (DEVELOPING SHARED RESOURCE)
In the cell imaging facility, we provide access to many types of microscopes, including bright field, fluorescence, confocal, and multiphoton confocal microscopes. Histopathology services include tissue section analysis, staining, IHC, laser capture microscopy, highresolution slide scanning, and assistance with tissue procurement and pathology analysis.
This core utilizes the extensive resources in the Prebys Center to support chemical biology, drug discovery, and drug development.
The cancer metabolism facility provides analytical services to measure metabolic flux, cellular metabolites, and cellular respiration measurements to better understand metabolic alterations associated with cancers and how they can be therapeutically targeted.
SANFORD-BURNHAM NCI-DESIGNATED CANCER CENTER
16