Building Better - Monthly Updates

Page 1

Building Better

Operating Plan 22A Progress Update

November 2021 Discover Purposefully — Align our discovery research efforts toward the primary target of patient benefit

Catalyst 3 Initiate Develop a business plan and charter

er v co

4

De lop ve

2

research teams Operationalize GemFinder Conduct the first review of technology for developmentstage readiness

Di s

Around the Patient 1 Organize Operationalize 3 patient-centric

For

for our development incubator Initiate P2E Venture Develop a business plan and charter for P2E Venture

Better Life Build Community — Establish the culture needed to support the model and achieve our mission

ow

Gr

Grow Sustainably — Increase our impact in a financially sustainable manner

Our Cost Structure 7 Streamline Reduce the indirect cost gap by $300,000 Plan Philanthropy 8 Generate Engage five potential participants in P2E and

Bu

2

ild

1

Develop Quickly — Create systems to rapidly demonstrate clinical benefit for our most promising discoveries

Executive Team 5 Build Recruit Chief Financial Officer and

6

a funding commitment from at least one

head of Philanthropy Build Research Team Develop faculty recruitment plan

Operating Plan 22A Goals Six Month Goals Status

Goal status is on target Goal status is behind schedule Goal status not meeting target

Goal status is on target

Monthly Progress Status

Goal status is behind schedule Goal status not meeting target

DEI hosts evening gathering to highlight DEI and welcome folks back to campus Last month the Diversity, Equity and Inclusion task force at Sanford Burnham Prebys sponsored a special gathering to highlight the importance of DEI and welcome all back to campus with a happy hour. Dr. Hud Freeze was our host and Dr. Randy Mills delivered a speech to more than 150 attendees on DEI’s importance to the ultimate success of the Institute. His key message was, the right thing to do Better Scientists Better Research is also the right thing to do, so there can be no argument regarding it being included as a fundamental pillar of both Better Scientists Better Research our culture and our strategy. A big thanks to the DEI Learning Committee for organizingBetter a fun Scientists and Better Research meaningful event. Better Scientists

Better Research

DEI

WELCOME BACK TO CAMPUS

HAPPY Better Life™ HOUR

Better Life™ 2021

OCTOBER 28TH 4:30–6:30 PM

Better Life™

Join us for food, beverages and the chance to win $pecial prizes for your team! RUOSLAHTI WAY BETWEEN BUILDINGS 6&7

Sponsored by

Better Life™

dei@sbpdiscovery.org Register:

https://www.eventbrite.com/e/185011383027

Read the policy and waiver regarding the use of alcoholic beverages at Sanford Burnham Prebys at sbpdiscovery.org/waiver

DIVERSITY, EQUITY, INCLUSION SANFORD BURNHAM PREBYS


For

De

Di s

Discover Purposefully ow

Align our discovery research efforts toward the primary target of patient benefit Bu

Bu

Gr

ow

Better Life

ver co

lop ve

lop ve

Di s

De

ild

ver co

ild

Gr

Goal 1: Organize Around the Patient — Operationalize three patient-centric research teams Goal 2: Operationalize GemFinder — Conduct the first review of technology for development-stage readiness

Di s

The beta review was conducted successfully with our test team of external advisory reviewers. The exercise gave us tremendously valuable guidance on not only how to conduct the upcoming review most efficiently but also identified the ideal materials and information that will aid in that review.

3

The draft thesis tee’d up the issues and fleshed out the content on which our external reviewers will base their evaluation. Getting this nailed down for our first review in December is an essential ingredient for success.

ow

Di s

ow

ild

Gr

ild

Gr

age Guidelines: April, 2021

2

Bu

Bu

3 Complete investment thesis for first GemFinder review

e

1 The candidate teams have been narrowed down to a semi-final pool of six teams from which we will select 3 in December to operationalize. Gr

Di s

October Outcomes ver co D

lop ve

ow

De

lop ve

2 Conduct beta GemFinder review of Institute technology for development-stage readiness Bu

e

1 Refine pool of potential patient-centric research teams within Centers to constitute proof-of- concept teams lop ve

ver co

ild

October Priorities ver co D

November Priorities 3 Schedule December GemFinder Review

1 Finalize and identify the three patient-centric research teams

2 Finalize recruitment of external advisory panel for GemFinder review in December

4 Complete and distribute investment thesis to reviewers and elicit areas of focus for review 5 Finalize GemFinder process for review and review output

News Sanford Burnham Prebys receives said Sacco. “CIRM’s support will our allow $5 million to train the next generation of scientists to learn more about the process regenerative medicine scientists through which stem cell science becomes medicine.” Pier Lorenzo Puri, M.D., Alessandra Sacco, Ph.D., and Evan Snyder, M.D., Ph.D., received $5 million in new funding to launch a multidisciplinary stem cell training program. “We are exceptionally gratefulBetter that Scientists the Better Research Better Life™ California Institute of Regenerative Medicine Better Scientists (CIRM) is supporting this important program,” Better Research Better Life™ Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 2.

Better Life™


De

lop ve

Di s

ver co

For

ow

Better Life

Develop Quickly

Bu

Create systems to rapidly demonstrate clinical benefit for our most promising discoveries

Gr

ild

Goal 1: Initiate Catalyst — Develop a business plan and charter for our development incubator Goal 2: Initiate P2E Venture — Develop a business plan and charter for P2E Venture er

Di s

ver co

De

ow

Gr

ild

Gr

3 Identify initial investor for P2E Investment fund

ge Guidelines: April, 2021

Bu

Bu

2 Finalize charter for Catalyst, our development incubator

ild

ow

1 Finalize P2E Venture charter — the entity that will help fund the work that propels our discoveries into the clinic

lop ve

lop ve

Di s

v co De October Priorities

October Outcomes 1 Completed!

2 Done!

3 This is resequenced pending final development of marketing and business plans for our P2E investment funds.

November Priorities

1 Complete draft business plan for P2E

2 Complete draft business plan for Catalyst

4 Meet with at least 1 funding agency for potential partnership with Catalyst

3 Commitment from three external commercial partners to participate in Catalyst and/or Encore

News Have you considered CIRM funding? CIRM - Partnering Opportunity for Translational TRAN 2: Diagnostic (including medical imaging Research Projects agents) based on stem cells, or critical for stem cell-based or gene therapy development or use The objective of this initiative is to create a highly competitive opportunity for promising TRAN 3: Medical device (non-diagnostic) for regenerative medicine (stem cell-based or gene a stem cell-based therapy or critical for stem therapy) projects that accelerate completion cell-based or gene therapy development or use of translational stage activities necessary for advancement to clinical study or broad end use TRAN 4: Novel tool that addresses a critical for any one of the following product types: bottleneck to the discovery or development Better Scientists Better Research Better Life™ of stem cell-based or gene therapy

TRAN 1: Stem cell-based or gene therapy Better Scientists therapeutic candidate

Better Research

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 3.

Better Life™

Better Life™

Go to CIRM.ca.gov for more details….


Di s

Di s

Build Community

ver co

De

ow

ow

Establish the culture needed to support the model and achieve our mission Bu

Bu

Gr

ild

Bu

Gr

ow

Better Life

De

lop ve

For

ver co

lop ve

lop ve

Di s

De

ild

ver co

ild

Gr

Goal 1: Build Executive Team — Recruit CFO and head of Philanthropy Goal 2: Build Research Team — Develop faculty recruitment plan

October Priorities

October Outcomes

1 Follow-up Leadership Development Program meeting with initial cohort

1 Initial cohort (pilot) completed a 4-hour follow-up development session. A group of 16 additional leaders have been selected to attend the comprehensive nine-month Leadership Development Program and will attend the 2.5-day immersion on Dec 6-8.

2 Host at least one new faculty candidate visit to the Institute

2 A candidate with expertise on gene editing technologies visited in October.

3 Refine scientific priorities for faculty recruitment for each center for the next five years

3 Weekly discussions on recruitment priorities continue between Center/Program Directors.

2 Draft faculty recruitment plan (with alternatives) with Center/Program Directors

age Guidelines: April, 2021 November Priorities

1 Intro to Leadership Standards: Conduct a minimum of 4 “Introduction to Leadership Standards” Workshops with Institute leaders. The workshop is an interactive conversation that covers how to use the Standards to effectively lead people, programs, and processes. This course is a prerequisite for the Institute’s nine–month comprehensive Leadership Development Program.

News Sonali Fonseca, our new VP of Strategic Initiatives, joined Sanford Burnham Prebys in October. Sonali is responsible for building, testing, operationalizing, and leading numerous Better Scientists programs including Better Scientists Gemfinder, Catalyst, and Encore.

Christine Dittmer , our new Chief Development Officer, joined Sanford Burnham Prebys in October.

Better Research

Better Life™

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 4.

Better Life™

Christine is responsible for driving philanthropic gifts by developing and executing effective plans for bolstering relations and with donors, corporations, foundations, and members of the community.


De

Di s

lop ve

For

ver co

Grow Sustainably

lop ve

Di s

De

Increase our impact in a financially sustainable manner ow

ow

Better Life

Bu

Gr

Bu

ild

ver co

ild

Gr

Goal 1: Streamline Our Cost Structure — Reduce the indirect cost gap by $300,000 Goal 2: Generate Plan Philanthropy — Engage five potential participants in P2E and a funding commitment from at least one

October Priorities

October Outcomes

1 Finalize use agreement for underused lab space (BSL 3)

1 In progress. Draft agreement is with our partner for final review. We remain optimistic it will be concluded soon!

2 Finalize license agreement for use of vacant lot

2 See above!

3 Finalize full application to Prebys Foundation, conditioned on invitation from Foundation

3 We’re delighted to report that the Prebys Foundation reviewed both of our letters of inquiry to support these initiatives and invited us to submit full applications this month. The applications are due in the middle of November – fingers crossed for a positive review over the winter.

4 Reduce indirect cost gap by $200K by

4 These cost gap amounts are contingent on numbers 1 and 2 above and will be realized once the agreements are concluded and underway.

November Priorities

1 Finalize use agreement for underused lab space (BSL 3)

3 Submit full applications to Prebys Foundation to support Catalyst and GemFinder initiatives

2 Finalize license agreement for use of vacant lot

4 Generate additional cost savings from optimizing laboratory air changes during times buildings are not or are sparsely occupied

News Don’t forget the shuttle is in service to transport staff between all buildings including the consortium building.

r

g Bette Discoverin

Call 858-245-7440 to arrange a pick-up

ys Lift ham Preb

Burn Sanford

STATUS

SHARE

START

TRIPS

ROUTE

DELIVER

UPDATE

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 5.

Better Life™


Building Better

Operating Plan 22A Progress Update

October 2021 Discover Purposefully — Align our discovery research efforts toward the primary target of patient benefit

Catalyst 3 Initiate Develop a business plan and charter

er v co

De lop ve

2

research teams Operationalize GemFinder Conduct the first review of technology for developmentstage readiness

Di s

Around the Patient 1 Organize Operationalize 3 patient-centric

For

4

for our development incubator Initiate P2E Venture Develop a business plan and charter for P2E Venture

Better Life Build Community — Establish the culture needed to support the model and achieve our mission

ow

Gr

Grow Sustainably — Increase our impact in a financially sustainable manner

Our Cost Structure 7 Streamline Reduce the indirect cost gap by $300,000 Plan Philanthropy 8 Generate Engage five potential participants in P2E and

Bu

2

ild

1

Develop Quickly — Create systems to rapidly demonstrate clinical benefit for our most promising discoveries

Executive Team 5 Build Recruit Chief Financial Officer and

6

a funding commitment from at least one

head of Philanthropy Build Research Team Develop faculty recruitment plan

Operating Plan 22A Goals Six Month Goals Status

Goal status is on target Goal status is behind schedule Goal status not meeting target

Monthly Progress Status

Goal status is on target Goal status is behind schedule Goal status not meeting target

Early-career scientists showcase their work at the 20th Annual Trainee Research Symposium

Better Scientists

Our scientific leaders of tomorrow gathered to showcase their work in a creative environment— the top level of our parking garage! Sanford Burnham Prebys President Kristiina Vuori, M.D., Ph.D., provided welcoming remarks followed by podium presentations, a poster session and prizes for Better Research Better Life™ winners in each category. Many congratulations to all who participated. Better Research Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists


De

Discover Purposefully ow

Align our discovery research efforts toward the primary target of patient benefit Bu

Gr

Bu

ild

ow

Better Life

ver co

lop ve

For

Di s

De lop ve

Di s

ver co

Gr

ild

Goal 1: Organize Around the Patient — Operationalize three patient-centric research teams

1 Finalize checklist for patient-centric research teams against the guiding principles

2 Generate initial pool of potential patient- centric research teams within Centers for consideration

ver co

De September Outcomes

1 The checklist is finalized and will be utilized tested during this operating plan period

3 GemFinder review schedule for this month – however, the EAC pre-read discussion was postponed from September to October

4 Complete sections 1 and 2 of GemFinder pre-read document for first review

4 First two sections are complete

ow

3 Premeeting with core EAC members to finalize process

Bu

Gr

Bu

ild

ow

2 Approximately 18 potential teams have been generated – we will spend the fall narrowing them down to the final three or so

ild

Gr

ow

Bu

ild

Gr

De

lop ve

lop ve

Di s

ver co

lop ve

September Priorities De

Di s

ver co

Di s

Goal 2: Operationalize GemFinder — Conduct the first review of technology for development-stage readiness

Burnham age Guidelines: PrebysApril, Interim 2021 Brand Usage Guidelines: April, 2021

October Priorities

1 Refine pool of potential patient-centric research teams within Centers to constitute proof-of- concept teams

2 Conduct beta GemFinder review of Institute technology for development-stage readiness

3 Complete investment thesis for first GemFinder review

News Peter Adams awarded $13 million to study link Jamey Marth awarded $13.5 million to between aging and liver cancer study sepsis The five-year project, co-led by Salk professor “The need for early diagnosis and better Gerald Shadel, will be a comprehensive study sepsis treatment is critical,” says Jamey Marth, to uncover new approaches to prevent and Ph.D. The five-year NIH award supports the treat liver cancer by targeting age-related continuation of his team’s groundbreaking processes, such as chronic interferon signaling. Better Scientists Better Researchresearch Better aimed Life™ to improve treatment options for this often-deadly syndrome. Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 2.

Better Life™


De

lop ve

Di s

ver co

For

ow

Better Life

Develop Quickly

Bu

Create systems to rapidly demonstrate clinical benefit for our most promising discoveries

Gr

ild

Goal 1: Initiate Catalyst — Develop a business plan and charter for our development incubator Goal 2: Initiate P2E Venture — Develop a business plan and charter for P2E Venture

Di s

De

ow

Gr

ild

Gr

2 Finalize charter for Catalyst, our development incubator

3 Identify initial investor for P2E Investment fund

age Guidelines: April, 2021

Bu

ild

ow

1 Finalize P2E Venture charter — the entity that will help fund the work that propels our discoveries into the clinic Bu

ver co

lop ve

lop ve

Di s

er

v co De Priorities September

September Outcomes 1 The team is leveraging internal and external resources to further refine the structure for P2E venture to ensure maximum impact for investors, inventors and the Institute. Addition of CFO expected to get this caught up.

2 Key personnel unavailable for part of the month

3 Key personnel unavailable for part of the month

October Priorities 1 Finalize P2E Venture charter — the entity that will help fund the work that propels our discoveries into the clinic

2 Finalize charter for Catalyst, our development incubator 3 Identify initial investor for P2E Investment fund

News Institute licenses ULK1/2 inhibitors to Endeavor Biomedicines for the treatment of cancer Nicholas Cosford, Ph.D., professor and deputy director of our NCI-designated Cancer Center, along with Reuben Shaw, Ph.D., professor at the Salk Institute, pioneered early research on the ULK1/2 pathway in cancer. Endeavor plans to complete IND-enabling studies and advance the ULK1/2 program into the clinic for colorectal and lung cancers inBetter the Scientists Better Research next 18 months. Better Scientists Better Research

Better Life™ Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 3.

Better Life™


Di s

Di s

Build Community

ver co

De

ow

ow

Establish the culture needed to support the model and achieve our mission Bu

Bu

Gr

ild

Bu

Gr

ow

Better Life

De

lop ve

For

ver co

lop ve

lop ve

Di s

De

ild

ver co

ild

Gr

Goal 1: Build Executive Team — Recruit CFO and head of Philanthropy Goal 2: Build Research Team — Develop faculty recruitment plan

September Priorities

September Outcomes

1 Hire VP Strategic Initiatives position

1 Exciting news to come….stay tuned!

2 Continue recruitment for VP Philanthropy

2 Great news comes in pairs…

3 Finalize “Intro to Leadership Standards” course and schedule 130 Institute people leaders to attend

3

4 Pilot new Leadership Development Program for Institute’s people leaders

4 The program received incredibly positive feedback from the initial participant group – their feedback has been incorporated and the course finalized. A follow-up session is scheduled for October to continue their learning.

5 Finalize dates and program for two Fall DEI events

5 Mark your calendar! The DEI Learning Committee is hosting a Happy Hour on Thursday, October 28th – details to follow. The DEI Recruitment Committee will be finalizing the date for their event soon.

age Guidelines: April, 2021

The course has now been finalized to train our people leaders to consistently meet four standards: be situationally aware, clear direction setters, great team builders, results driven. All people leaders will receive their invites this month.

October Priorities

1 Follow-up Leadership Development Program meeting with initial cohort

2 Host at least one new faculty candidate visit to the Institute

3 Refine scientific priorities for faculty recruitment for each center for the next five years

News Chemical biologist Eric Wang joins our Cancer Center “I’m thrilled to be joining such esteemed faculty and am looking forward to uncovering new Better Scientists Better Research therapeutic approaches for cancer,” says Better Scientists

Eric Wang, Ph.D., who comes to us from the Dana-Farber Cancer Institute. As an assistant professor, Wang will focus on developing chemical tools that target vulnerabilities in Better Life™ tumor cells or reprogram immune cells to fight cancer. Better Research Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 4.

Better Life™


For

De

Di s

Grow Sustainably ow

Increase our impact in a financially sustainable manner Bu

Bu

Gr

ow

Better Life

ver co

lop ve

lop ve

Di s

De

ild

ver co

ild

Gr

Goal 1: Streamline Our Cost Structure — Reduce the indirect cost gap by $300,000 Goal 2: Generate Plan Philanthropy — Engage five potential participants in P2E and a funding commitment from at least one

September Priorities

September Outcomes

1 Hold first FY22 indirect gap reduction team meeting

1 Kickoff meeting held and process established for regularly scheduled meetings to identify opportunities to reduce our indirect gap

2 Accomplished! Facilities identified $100k in incremental costs for the rest of the year

3 Make initial request to one potential donor for major philanthropic gift

3 Checked!

4 Prepare first draft of full application to Prebys Foundation to support our GemFinder and Catalyst initiatives

4 Full application awaiting invitation for submission by Prebys Foundation

2 Identify an additional $100K in savings

age Guidelines: April, 2021

October Priorities

1 Finalize use agreement for underused lab space (BSL 3)

3 Finalize full application to Prebys Foundation, conditioned on invitation from Foundation

2 Finalize license agreement for use of vacant lot

4 Reduce indirect cost gap by $200K by generating incremental revenue

News We are pleased to welcome David Williams, our new Director of Procurement. Prior to joining the Institute, David worked as Senior Director of Supply Chain at Abzena San Diego Inc. Welcome aboard, David!

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 5.

Better Life™


Building Better

Operating Plan 22A Progress Update

September 2021 Discover Purposefully — Align our discovery research efforts toward the primary target of patient benefit

Catalyst 3 Initiate Develop a business plan and charter

er v co

De lop ve

2

research teams Operationalize GemFinder Conduct the first review of technology for developmentstage readiness

Di s

Around the Patient 1 Organize Operationalize 3 patient-centric

For

4

for our development incubator Initiate P2E Venture Develop a business plan and charter for P2E Venture

Better Life Build Community — Establish the culture needed to support the model and achieve our mission

ow

Gr

Grow Sustainably — Increase our impact in a financially sustainable manner

Our Cost Structure 7 Streamline Reduce the indirect cost gap by $300,000 Plan Philanthropy 8 Generate Engage five potential participants in P2E and

Bu

2

ild

1

Develop Quickly — Create systems to rapidly demonstrate clinical benefit for our most promising discoveries

Executive Team 5 Build Recruit Chief Financial Officer and

6

a funding commitment from at least one

head of Philanthropy Build Research Team Develop faculty recruitment plan

Operating Plan 22A Goals Six Month Goals Status

Goal status is on target Goal status is behind schedule Goal status not meeting target

Monthly Progress Status

Sanford Burnham Prebys BBQ Cookoff. The best smoked BBQ in the west, right here at our campus — and 250 members of our team – for the end of year gathering to enjoy great food, spectacular weather and camaraderie under the Better Scientists Torrey Pines.

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Goal status is on target Goal status is behind schedule Goal status not meeting target


De

Discover Purposefully ow

Align our discovery research efforts toward the primary target of patient benefit Bu

Gr

Bu

ild

ow

Better Life

ver co

lop ve

For

Di s

De lop ve

Di s

ver co

Gr

ild

Goal 1: Organize Around the Patient — Operationalize three patient-centric research teams Goal 2: Operationalize GemFinder — Conduct the first review of technology for development-stage readiness

ow

Bu

Gr

ild

ild

Gr

3 Develop Statement of Principles for patient-centric research teams

Di s

Di s

Di s ow

1 Strategic Initiatives Committee of the Board to review recommendations for first EAC review.

Bu

2 Finalize EAC charter and distribute review guidance to team

ver co

August OutcomesDe Gr

ow

1 Compose Institute decision-making team to receive External Advisory Committee (EAC) recommendations after first GemFinder review Bu

De

lop ve

lop ve

ver co

lop ve

August Priorities De

2 Developed by Drs. Michael Jackson and Nick Cosford

3 Completed by Center directors Ze’ev Ronai, Carl Ware, and Rolf Bodmer

ild

ver co

age Burnham Guidelines: Prebys April, Interim 2021 Brand Usage Guidelines: 202118 4 Scheduled for April, week of October 4 Schedule first GemFinder review

th

September Priorities

1 Finalize checklist for patient-centric research teams against the guiding principles

3 Premeeting with core EAC members to finalize process

2 Generate initial pool of potential patient- centric research teams within Centers for consideration

4 Complete sections 1 and 2 of GemFinder pre-read documents for first review

News Study finds promising therapeutic target for colitis An international research group, led by Jamey Marth, Ph.D., has shown that the Neu3 enzyme is responsible for the onset and progression of colitis—a chronic digestive disease caused by inflammation of the colon. The study was performed in a model of recurrent human food poisoning previously linked with the condition. The findings represent a scientific advance Scientists Better Research toward a targeted therapy to Better help the millions of people worldwide affectedBetter by the disorder. Scientists Better Research

Biomarker could help diagnosis schizophrenia at an early age A study by Evan Snyder, M.D., Ph.D., discovered how levels of a protein could be used in the future as a blood-based diagnostic aid for schizophrenia. The activity of the protein, which is found in both the brain and blood, affects neural connections in human brains and is uniquely imbalanced in people diagnosed with the condition. The research Better Life™ also provides guidance for future analyses into the molecular basis of this serious, disabling Better Life™ mental disorder.

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 1.

Better Life™


De

lop ve

Di s

ver co

For

ow

Better Life

Develop Quickly

Bu

Create systems to rapidly demonstrate clinical benefit for our most promising discoveries

Gr

ild

Goal 1: Initiate Catalyst — Develop a business plan and charter for our development incubator Goal 2: Initiate P2E Venture — Develop a business plan and charter for P2E Venture

ver co

De

Di s

Di s

lop ve

ow

ow

1 Engage two entities about possible partnerships with Encore

Bu

Gr

Bu

ild

De lop ve

August Priorities

ver co

ild

Gr

2 Draft P2E Venture charter — the entity that will help fund the work that propels our discoveries into the clinic

August Outcomes 1 Completed period to date, four entities engaged and three remain actively interested in engaging further

2 Draft completed — our new CFO Amar Duvvur has already completed a draft document, even though he doesn’t officially start until the first week of September!

3 Draft charter for Catalyst, our development incubator

3 Comprehensive business plan drafted and currently under review for legal and compliance

age Guidelines: April, 2021

September Priorities 1 Finalize P2E Venture charter — the entity that will help fund the work that propels our discoveries into the clinic

2 Finalize charter for Catalyst, our development incubator 3 Identify initial investor for P2E Investment fund

News Sanford Burnham Prebys drug enters Phase 1 study for the treatment of tobacco use disorder. A drug discovered in the lab of Nicholas National Institute on Drug Abuse (NIDA) at Cosford, Ph.D., professor and deputy director of the National Institutes of Health (NIH) through our NCI-designated Cancer Center has entered a grant awarded to Sanford Burnham Prebys, a Phase 1 clinical study. The compound, SBPUC San Diego School of Medicine, and Camino 9330, targets a neuronal signaling pathway Pharma, LLC, who will oversee activities underlying addictive behaviors and would be related to the Phase 1 study. a first-in-class oral therapeutic to help people Better Scientists quit smoking. The study is being funded by theBetter Research Better Life™ Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 2.

Better Life™


Di s

Di s

Build Community

ver co

De

ow

ow

Establish the culture needed to support the model and achieve our mission Gr

ild

ild

Gr

Goal 1: Build Executive Team — Recruit CFO and head of Philanthropy

Bu

Bu

Bu

Gr

ow

Better Life

De

lop ve

For

ver co

lop ve

lop ve

Di s

De

ild

ver co

BEHIND SCHEDULE

Goal 2: Build Research Team — Develop faculty recruitment plan

August Priorities

August Outcomes

1 Orientations for Operating Plan

1 Completed — a taped session will be avail- able soon on our intranet for those unable to attend in person or participate online

2 Continue faculty recruitment

2 Interviews continue and a framework of resource needs for recruitment over the next five years has been developed

3 Push out the key elements of the professional and leadership standards to all people leaders in organization

3

4 Pilot new Leadership Development Program for Institute’s people leaders

4 First session complete with great success! Small group sessions will continue this month

5 Determine goals, actions and milestones for the two new DEI committees

5 Completed — our Recruitment and Learning Committees are planning fall events — stay tuned

age Guidelines: April, 2021

September Priorities

1 Hire VP Strategic Initiatives position

2 Continue recruitment for VP Philanthropy 3 Finalize “Intro to Leadership Standards” course and schedule 130 Institute people leaders to attend

The Institute will roll out our new standards applicable to our entire team this month. These standards will capture our individual performance standards as well as what we believe are the highest standards for our people leaders

4 Pilot new Leadership Development Program for Institute’s people leaders

5 Finalize dates and program for two Fall DEI events

News Amar Duvvur will join Sanford Burnham Prebys this month as Chief Financial Officer. Amar most recently spent nine years at Abbvie where he held Scientists the positions of VP Finance Better and VP Treasury.Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 3.

Better Life™


For

De

Di s

Grow Sustainably ow

Increase our impact in a financially sustainable manner Bu

Bu

Gr

ow

Better Life

ver co

lop ve

lop ve

Di s

De

ild

ver co

ild

Gr

Goal 1: Streamline Our Cost Structure — Reduce the indirect cost gap by $300,000 Goal 2: Generate Plan Philanthropy — Engage five potential participants in P2E and a funding commitment from at least one

August Priorities

August Outcomes

1 Complete Prebys Foundation Grant LOI’s and submit

1

2 Reviewed potential aquisition opportunity, which we elected not to pursue

3 Complete! FY22 indirect gap reductions of $140,000 identified and implemented, including savings from a new Café agreement

4 We have decided it makes most sense to maintain the building 11 lease through May of 2023, when our original lease terminates

2 Final determination on strategic partnership opportunity 3 Identify and implement $100,000 FY22 indirect cost gap reduction

4 Create plan for building 11’s lease ending next year

age Guidelines: April, 2021

Two letters of inquiry submitted to support our GemFinder and Catalyst programs. We hope to receive an invitation to submit a full application later in the fall

September Priorities

1 Hold first FY22 indirect gap reduction team meeting

3 Make initial request to one potential donor for major philanthropic gift

2 Identify an additional $100K in savings

4 Prepare first draft of full application to Prebys Foundation to support our GemFinder and Catalyst initiatives

News In other news, the Cancer Center held it’s a and opportunities to get involved with the virtual postdocrecruiting open house at the postdoc association or other leadership end of August. More than twenty attendees roles. Finally, the Office of Education, heard from Sanford Burnham Prebys’s scientific Training, & International Services introduced leaders about the cutting-edge research in the group to the vast array of career and their labs, as well as the opportunity to meet professional development seminars and Better Scientists Better Research Better Life™ with potential postdoctoral training mentors. workshops available to Sanford Burnham Attendees learned about training experiences Betterpostdocs. Life™ Better Scientists Better Research Prebys Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 4.

Better Life™


Building Better

Operating Plan 22A Progress Update

August 2021 Discover Purposefully — Align our discovery research efforts toward the primary target of patient benefit

Catalyst 3 Initiate Develop a business plan and charter

er v co

De lop ve

2

research teams Operationalize GemFinder Conduct the first review of technology for developmentstage readiness

Di s

Around the Patient 1 Organize Operationalize 3 patient-centric

For

4

for our development incubator Initiate P2E Venture Develop a business plan and charter for P2E Venture

Better Life Build Community — Establish the culture needed to support the model and achieve our mission

ow

Gr

Grow Sustainably — Increase our impact in a financially sustainable manner

Our Cost Structure 7 Streamline Reduce the indirect cost gap by $300,000 Plan Philanthropy 8 Generate Engage five potential participants in P2E and

Bu

2

ild

1

Develop Quickly — Create systems to rapidly demonstrate clinical benefit for our most promising discoveries

Executive Team 5 Build Recruit Chief Financial Officer and

6

a funding commitment from at least one

head of Philanthropy Build Research Team Develop faculty recruitment plan

Operating Plan 22A Goals Six Month Goals Status

Goal status is on target

Monthly Progress Status

Goal status is behind schedule Goal status not meeting target

Goal status is behind schedule Goal status not meeting target

These reports provide insight into each of the six monthly segments of our operating plans. We’re able to identify our immediate priorities, achievements, opportunities, and next steps on the horizon, as well as the news that is helping to accomplish our work.

Goal status is on target

additional findings and achievements from the past 30 days, and necessary activities for the subsequent month. In addition, items that you may find interesting and relevant to the work being done to support that particular theme will be included as well to deliver a broad understanding of efforts in that quadrant.

These updates will be a critical tool in navigating

Better Scientists The monthly reports are divided according to ourBetter Research Better Life™ our five-year strategic plans, course-correcting four strategic themes—discover, develop, build and Research Life™ celebrating the successes as Better Scientists Betteralong the Better way, and grow. Each strategic theme has a page reviewing we create them. prior month deliverables, the status of those goals, Better Scientists Better Research Better Life™ Better Scientists

Better Research

Better Life™


For

De

Di s

Discover Purposefully ow

Align our discovery research efforts toward the primary target of patient benefit Bu

Bu

Gr

ow

Better Life

ver co

lop ve

lop ve

Di s

De

ild

ver co

ild

Gr

Goal 1: Organize Around the Patient — Operationalize three patient-centric research teams Goal 2: Operationalize GemFinder — Conduct the first review of technology for development-stage readiness

Di s

Di s

De

1 Received five commitments from external reviewers

ow

lop ve

Di s

ver July Outcomes co

lop ve

ow

De

ow

e

1 GemFinder — Obtain participation commitments from experts for External Advisory Committee (EAC) to assess potential projects for further development lop ve

ver co

Gr

ver July coPriorities D

Gr

Gr

3 Draft GemFinder Charter and review process and output

3 Charter drafted

4 Review internal science projects for

4 Vetted six projects internally for first

5 Finalize agreement on initial GemFinder evaluation criteria to be used by EAC

5 Completed, but evaluation criteria may be modified once projects for first review are finalized

ild

ild

Bu

Bu

2 Completed

2 GemFinder — Craft EAC review schedule for first six months

Bu

ild

prototype GemFinder by EAC prototype GemFinder review age Burnham Guidelines: Prebys April, Interim 2021 Brand Usage Guidelines: April,review 2021

August Priorities age Guidelines: April, 2021

1 Compose Institute decision-making team to receive EAC recommendations after first GemFinder review

3 Develop Statement of Principles for patient-centric research teams

2 Finalize EAC charter and distribute review guidance to team

4 Schedule first GemFinder review

News A strategic partnership with the USC Comprehensive Cancer Center will transition clinically relevant cancer targets to our Prebys Center to identify potential new drugs to improve outcomes for people living with cancer.

The BTLA-Activator, a biologic drug developed by Dr. Ware and Dr. Sedy at Sanford Burnham Prebys was licensed to Cerecor (CERC) for clinical development and trials. The drug reduces damaging inflammation caused by the immune system. The drug will be investigated for use in patients with autoimmune disease and other conditions.

Sanford Burnham Prebys continues the 7th year of collaborating with LILLY in drug discovery and development. The collaboration has been highly productive with an antibody therapeuticBetter Research Better Scientists currently in clinical trials, and the advancement Better Scientists Better Research of another biologic into clinical development with clinical trials being planned.

Better Life™ Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 1.

Better Life™


De

lop ve

Di s

ver co

For

ow

Better Life

Develop Quickly

Bu

Create systems to rapidly demonstrate clinical benefit for our most promising discoveries

Gr

ild

Goal 1: Initiate Catalyst — Develop a business plan and charter for our development incubator

De

Di s

ver co

De

July Outcomes

2 Obtain input from execs from pharma, biotech, PE, finance for Encore

2 Engaged five sources to shape/confirm Encore concepts

3 Evaluate strategic opportunity for acquisition of Catalyst-type entity

3 Completed initial diligence on strategic opportunity

ow

1 This is tailored to specific potential partners

ow

1 Draft Encore (formerly known as “BetterWill”) pitch document to promote the partnership opportunities we provide pharma and biotech to take unwanted IP forward

Bu

Gr

Bu

ild

lop ve

July Priorities

ver co

lop ve

Di s

Goal 2: Initiate P2E Venture — Develop a business plan and charter for P2E Venture

ild

Gr

age Guidelines: April, 2021 August Priorities

1 Engage two entities about possible partnerships with Encore

2 Draft P2E Venture charter — the entity that will help fund the work that propels our discoveries into the clinic

3 Draft charter for Catalyst, our development incubator

News Produced the “Science Behind Women’s Health” series of virtual talks with the Lawrence Family Jewish Community Center in La Jolla—expanding outreach to potential philanthropic partners. Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 2.

Better Life™


Di s

Di s

Build Community

ver co

De

ow

ow

Establish the culture needed to support the model and achieve our mission Bu

Bu

ild

Gr

Bu

Gr

ow

Better Life

De

lop ve

For

ver co

lop ve

lop ve

Di s

De

ild

ver co

ild

Gr

Goal 1: Build Executive Team — Recruit CFO and head of Philanthropy Goal 2: Build Research Team — Develop faculty recruitment plan

July Priorities

July Outcomes

1 Offer Chief Financial Officer

1 Exciting announcement to come…

2 Offer Chief of Philanthropy

2 Search is continuing

3 Offer one new faculty member

3 Succeeded in two recruitments— announcements to come!

4 Develop Leadership and Professional Standards for Institute’s people leaders and team members

4 Checked!

5 Kick off strategic review of educational program and graduate school to identify most impactful educational opportunities moving forward

5 Done!

6 Identify two areas of focus for Diversity, Equity & Inclusion initiatives

6 DEI Council creates two new committees: Recruiting Committee: Objective is to attract, hire, and advance a diverse pipeline of talent; and Learning Committee: Objectives are to build awareness and understanding to foster an inclusive environment where different backgrounds, perspectives, and experiences are valued

August Priorities age Burnham Guidelines: PrebysApril, Interim 2021 Brand Usage Guidelines: April, 2021 1 Orientations for Operating Plan 2 Continue faculty recruitment 3 Push out the key elements of the professional and leadership standards to all people leaders in organization 4 Pilot new Leadership Development Program for Institute’s people leaders 5 Determine goals, actions and milestones for the two new DEI committees

News The annual Post Doc and Grad Student Leadership Development Program will begin in August to provide tools to help early-career Betterleaders Scientists scientists become the biomedical of Better Research tomorrow.

Stay tuned for Operating Plan orientations! We will hold two in-person sessions that will also be broadcast this month to the entire Better Life™ discussing how to use the organization Operating Plan.

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 3.

Better Life™


For

De

Di s

Grow Sustainably ow

Increase our impact in a financially sustainable manner Bu

Bu

Gr

ow

Better Life

ver co

lop ve

lop ve

Di s

De

ild

ver co

ild

Gr

Goal 1: Streamline Our Cost Structure — Reduce the indirect cost gap by $300,000 Goal 2: Generate Plan Philanthropy — Engage five potential participants in P2E and a funding commitment from at least one

July Priorities

July Outcomes

1 Explore strategic infrastructure proposals for Prebys Foundation Grants

1 To be submitted for the winter round of awards

2 Reach out to philanthropy targets for strategic plan support

2 Engaged three promising entities/individuals

3 Close out FY2021 books

3 Completed!

age Guidelines: April, 2021

August Priorities

1 Complete Prebys Foundation Grant LOI’s and submit

3 Identify and implement $100,000 FY22 indirect cost gap reduction

2 Final determination on strategic partnership opportunity

4 Create plan for building 11’s lease ending next year

News First phase of the solar project went live earlier this year and significant progress was made in July. The final phase which includes the parking garage and the battery will go live in late fall.

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research

Better Life™

Better Scientists

Better Research 4.

Better Life™


Issuu converts static files into: digital portfolios, online yearbooks, online catalogs, digital photo albums and more. Sign up and create your flipbook.