2009 KIEC Program Book by Kentucky Science and Engineering Foundation

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TABLE OF CONTENTS

Governor Beshear Welcome Letter…………………………………………………………………………...……

KY CPE President Robert King Welcome Letter…………………………………………………………………

KSTC/KSEF Welcome and Overview…………………………………………….………………………………..

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KSTC Funding Programs and Their Socio-Economic Impact…………………………… ……………………

Conference Schedule………………………………………………………………………………………………..

Session Summaries………………………………………………………………………………………………….

Speaker and Moderator Bios….…………………………………………………………………………………….

Business Spotlight Schedule………………………………………………………………………………………..

Poster Presenters………..…………………….…………………………………………………………………….

Poster Abstracts ……………………………..………………………………………………………………………

List of Attendees …………………………………………………………………………………………………….

Floor Plans………………………………………………………………………………………………..

Menu………………….………………………………………………………………………………………………..

NOTES…………………………………………………………………………………………………………………

Technology Based Economic Development

KENTUCKY SCIENCE AND TECHNOLOGY CORPORATION

KSEF Funding Prog rams and Their Socio-Economic Impact IMPACT:

PROGRAMS:

Follow On Funding: >$10 in Federal and Industrial Funds for Each $1 KSEF Invested NSF CAREER Awards: 9 KSEF Awardees Received CAREER Awards

Kentucky Science and Engineering Foundation (KSEF) builds science and engineering capacity by proactively investing in advanced and application oriented R&D, to strengthen innovative ideas and shape them in to emerging technologies for commercialization.

Million Dollar Faculty: 31 KSEF Awardees Secured $1M or More for a Total of $50M

Kentucky Commercialization Fund (KCF) enables university faculty in commercializing the technologies developed through R&D.

Academic Impact: KSEF Awardees (a Sample of the Top 16) Referenced Over 1,500 Times in the Past Five Years

Kentucky SBIR-STTR Matching Fund (KY SBIR/STTR Matching) program is designed to invest in for-profit Kentucky based companies or businesses that have been granted Small Business Innovation Research or Small Business Technology Transfer funds from any federal agency.

Technological Innovations: • 65 Invention Disclosures • 21 Provisional Patents • 53 Patent Applications • 17 Issued Patents Economic Development: • 10 New Businesses Formed

Number of Awards Funds Awarded Federal Leverage Funds Return on Investment

Source Follow on Funding from R&D Investments Private 3% Federal 92% Public 5%

Program Data Since Inception KSEF KCF 243 35 $ 13,088,861 $ 4,739,410 $ 121,590,131 Not applicable 10:1 New business creation

KY SBIR Matching 62 $ 13,652,179 $ 21,075,397 1.54:1

Sources of Federal SBIR-STTR Grants to Kentuc ky Companies

FIFTH KENTUCKY INNOVATION AND ENTREPRENEURSHIP CONFERENCE April 7, 2009 – Louisville, KY CONFERENCE SCHEDULE

Research Trends

Opening Session

Poster Set-Up

8:00 AM 9:00 AM Ballroom E

Registration, Poster Set-up and Complementary Breakfast

9:00 AM 9:30 AM Ballroom A-D

Welcome to the Fifth KIEC Welcome, Maria Labreveux / Mahendra Jain, KSEF/KSTC Kentucky’s Big Idea, Kris Kimel, KSTC Human Capital and Economic Development, Robert King, CPE President Session 1. Think, Grow: Innovations in Biodegradable and Renewable Products

9:30 AM 10:30AM Ballroom A-D

Speakers: Ramani Narayan, Michigan State University; Jonathan Mielenz, Oak Ridge National Laboratory Moderator: Nancy Cox, University of Kentucky

Success Stories from Innovators & Entrepreneurs

Idea Protection & Start-Up

Networking Environment

Federal Funding Opportunities Parallel Sessions

10:30 AM to 11:00 AM – BREAK / Spotlight on Businesses (Pre-function Area) 11:00 AM - Session 2. Building Partnerships, Creating Innovations 12:00 Noon Ballroom A-B

Speakers: Donald Senich, National Science Foundation; Lorel Wisniewski, NIST – Technology Innovation Program Moderator: Joanne Lang, Advance Kentucky/ KSTC

11:00 AM 12:00 Noon Ballroom C-D 12:45 PM 1:30 PM Ballroom G-F and Prefunction Area

Session 3. Translating the Challenges in Human Health Research Speakers: Susan Old, NIH-National Center for Research Resources Moderator: Manuel Martinez-Maldonado, University of Louisville 12:00 PM to 12:45 PM – LUNCH (Ballroom G-F) Networking: The innovation Environment Mentorship tables – a place for grad students and post-docs to get started in the job market. Job Corner – local companies seeking talent Networking – spend some time with program managers, attorneys, innovators Business spotlights –local innovations being developed and marketed

1:00 PM 1:30 PM Room SHOW

Session 4. Ziplocked IP process

1:00 PM 1:30 PM Ballroom A-D

Session 5. Leveraging University Innovations for Economic Growth

1:30 PM 2:00 PM Ballroom A-D

2:00 PM 2:30 PM Ballroom A-D

Speakers: David Carrithers, Carrithers Law Office Moderator: Mahendra Jain, KSTC

Speakers: Len Heller, University of Kentucky; James Zanewicz, University of Louisville Moderator: David King, University of Louisville Session 6. Impact of State Funds on Innovation and Entrepreneurship Part I; From Innovators at the bench: Stephen Rankin, UK; Steven Koenig, UL Part II: From Entrepreneurs entering the business world: Bruce Webb, UK; Mark Brennan, UL Moderator: Blaine Ferrell, Western Kentucky University Session 7. Innovation Drivers: …High-Tech Entrepreneurial Environment Study Speaker: Mac Werner, Institute for Workplace Innovation, UK Moderator: Linda Linville, Council on Postsecondary Education (CPE) 2:30 PM to 3:30 PM - Poster session EVEN numbers (Ballroom E) 3:30 PM to 4:30 PM - Poster session ODD numbers (Ballroom E) 4:30 PM to 5:00 PM POSTER REMOVAL

SESSION SUMMARIES

Human Capital and Economic Development – Mr. Robert King, KY Council on Postsecondary Education “The secret to America’s success has been its long standing commitment to the development of human capital. That development has been significantly dependent upon broad access to higher education and its linkage to economic development. This conference and its participants are an important expression of this critical relationship and a furthering of this once uniquely American tradition.” Session 1: Think, Grow: Innovations in Biodegradable and Renewable Products Entrepreneurship: An Important “Learning” for Scientists and Engineers – Experiences of a Faculty Entrepreneur in the Bioplastics Space – Dr. Ramani Narayan, Michigan State University Entrepreneurship is the vehicle that fuels economic growth. Entrepreneurs build and grow companies to bring their innovation to market. The words “entrepreneur” and “inventor” do not mean the same thing. Entrepreneurs put together all the resources needed – the capital, the management, the people and the business strategy – to transform an invention into a product, process or service innovation that finds a market and affects the economy. In other words, they build whole companies upon their innovations. More importantly, entrepreneurs create new jobs. New fast growth companies are but a small subset of the U.S. economy, comprising just 350,000 firms out of a total of 6,000,000 current U.S. businesses with employees. Yet these fast growing companies created about two-thirds of new jobs. In today’s climate of manufacturing jobs loss and a global economic slowdown, entrepreneurs can improve our position in global economic competition – using entrepreneurial innovation and thinking in our universities, schools and private citizenry to create new “green jobs”, and

other value-added knowledge based technology manufacturing jobs. This presentation will review the exciting and challenging field of entrepreneurial learning through the experiences of this faculty entrepreneur in the emerging “green” bioplastics and products space. Consolidated Bioprocessing for Improved Biomass Fuels and Chemicals Production – Dr. Jonathan Mielenz, Bioconversion Science and Technology Group, Oak Ridge National Laboratories Technology for production of fuels and chemicals from plant biomass has evolved over the past three decades with ever improving efficiency and simplification. The driver for this process improvement has been primarily to reduce the cost of the final products as in many cases the competing source for these materials has been low cost petrochemistry. The simplification has come through improvements in the (bio)catalysts used in the process which, for biologically-based processes, equates to improved enzymes and microorganisms and improved engineering systems. This presentation will review the progress that has been made in the recent years, and discuss the ideal process for production of biomass-based materials, consolidated bioprocessing. Session 2: Building Partnerships, Creating Innovations Collaborative Research Opportunities – Dr. Donald Senich, Partnership Innovation Program, National Science Foundation (NSF) A major objective of the NSF is to improve the nation's capacity for intellectual and economic growth. It does this by supporting the discovery of new knowledge and the enhancement of a skilled workforce. One mechanism is the Grant Opportunities for Academic Liaison with Industry (GOALI) initiative, which aims to synergize university-industry partnerships by making funds available to support an eclectic mix of industry7

SESSION SUMMARIES

university linkages. A second mechanism is the Partnership for Innovation (PFI) initiative aimed to advance partnering arrangements that lead to sustainable economic and social outcomes through innovation. This session will address objectives, experiences and opportunities in these efforts. Innovating for Critical National Needs – Dr. Lorel Wisniewski, Technology Innovation Program, National Institute of Standards and Technology (NIST) The Technology Innovation Program (TIP) at NIST was established to assist U.S. businesses and institutions of higher education or other organizations, such as national laboratories and nonprofit research institutions, to support, promote and accelerate innovation in the U.S. through high-risk, high-reward research in areas of critical national need. The speaker will discuss TIP funding opportunities and other features of this new public-private partnership, including TIP’s role in the innovation community. Session 3: Translating the Challenges in Human Health Research Opportunities and Challenges for Translating Human Health Research – Dr. Susan Old, National Center for Research Resources, National Institutes of Health The translation of key research discoveries to clinical practice and community adoption is a complex and challenging process. It involves multiple expertise, organizations, and funding options. I will discuss the programs that the National Center for Research Resources supports to facilitate the progress through the translational pipeline. In addition, I will discuss the NIH and NCRR funding opportunities supported through the American Recovery and Reinvestment Act (ARRA).

Session 4: Ziplocked IP Process – David W. Carrithers, Carrithers Law This presentation discusses how to use different types of intellectual property law including patent, trademark, copyright, confidentiality agreements, trade secrets, and licenses to address IP problems which can be avoided if the Small Business Owner can anticipate the need for IP documentation. This presentation is directed toward IP problems faced by the Small Business Owner. Discussion topics will include how to avoid IP problems by implementing contracts and agreements; the Identification and insertion of KEY POINTS in agreements and contracts favorable to the IP owner; when is IP protection needed (point of conception, reduction to practice); what type of agreements are needed with employees, vendors, consultants, student-faculty-university relationships with regard to inventions; and what type of protection is needed. Learn what to ask and when to implement IP measures, and what is cost effective. Sample operating agreements will be presented regarding protection of IP, recordation of invention, employee agreements, consulting agreements, license agreements and confidentiality agreements. Session 5: Leveraging University Innovations for Economic Growth – Leonard Heller, University of Kentucky and James R. Zanewicz, University of Louisville Representatives from the University of Kentucky and the University of Louisville will discuss how they promote and use innovations and entrepreneurship as vehicles to create value for their institutions, as well as economic development in the Commonwealth. The speakers will discuss the creative ways their institutions reach out to and educate their faculty about their role in disclosing, making technologies commercial-ready, involvement in marketing the innovation, and how they can advance 8

SESSION SUMMARIES

innovations through entrepreneurship. The processes of how UofL and UK conduct triage of intellectual property (IP), arrive at a decision to out-license a technology or create a university start-up, and protect the technology while maximizing the return to the public, the institution and the PI will also be discussed. Session 6: Impact of State Funds on Innovation and Entrepreneurship KSTC’s implementation of Knowledge-Based Economy (KBE) programs has continued to focus on building the capacity for innovation and entrepreneurship in the State. At the forefront are two KBE programs - Kentucky Science and Engineering Foundation (KSEF) and the Kentucky Commercialization Fund (KCF), that fuel the engine for innovation. Seed funding from these funds facilitates achieving excellence in science and engineering or transforming an idea into a product or a technology that can be commercialized. Together, KSEF and KCF have invested nearly $18 M since the first awards were made in 2002. This session provides an opportunity to have a preview of how the state funds have helped our awardees. Did the funds serve as a catalyst in developing an idea, advancing the research, attracting the follow-on funding, training graduate and undergraduate students, discovering something new, gaining recognition through publications in journals of high repute, generating intellectual property (IP), and commercializing through technology transfer or creation of a new- start-up business? Basically, in investment terms, are some of these investments (awards) providing returns on the investment (ROI)? At this session, speakers will discuss how the state funds provided by KSTC under a contract with CPE have helped them to become well known researchers and entrepreneurs. They also will discuss how successful competition at the federal level has made them eligible to receive additional state funds through the Kentucky SBIR-STTR matching funds grants program of the Department of Commercialization and Innovation. Blaine Ferrell (Western Kentucky

University) will act as session moderator of talks presented by Stephen Rankin (University of Kentucky), Steven Koenig (University of Louisville); Mark Brenan (University of Louisville) and Bruce Webb (University of Kentucky). Session 7: Kentucky Innovation Drivers: Results of the Bluegrass High-Tech Entrepreneurial Environment Study – Mac Werner, Institute for Workplace Innovation, University of Kentucky This session will recap the results of the Bluegrass High-Tech Entrepreneurial Environment Study conducted by the UK Institute for Workplace Innovation and the Bluegrass Business Development Partnership (BDDP). The study was designed to assess the Region’s strengths and areas for improvement in meeting the needs of high-tech entrepreneurial companies, identify action items for the BBDP in FY2009, and serve as a benchmark for future studies.

SPEAKER AND MODERATOR BIOS

Robert King – President, Kentucky Council on Post Secondary Education Robert King (robert.king@ky.gov) became the third president of the Kentucky Council on Postsecondary Education January 16, 2009. He previously served as president and CEO of the Arizona Community Foundation, a statewide charitable foundation with a strong focus on education, economic development and scientific research. Mr. King is the former chancellor of the State University of New York, one of the largest comprehensive systems of universities, colleges and community colleges in the world. More recently, he served as president and CEO of the Arizona Community Foundation, a statewide charitable foundation with a strong focus on education, economic development and scientific research. Mr. King is very active in community service, and has volunteered and served on numerous boards and organizations. He also has served on the White House Commission on Presidential Scholars; the Education Committee of the U.S. National Commission for the United Nations Educational, Scientific and Cultural Organization (UNESCO); an advisor to the Middle State Commission on Higher Education regarding reauthorization of the Higher Education Act in Congress; the board of directors of the National Soccer Hall of Fame; and the board of trustees of A.T. Still University, a specialized university dedicated to training people for the health care professions, in Kirksville, Missouri and Mesa, Arizona. Mr. King received a Bachelor of Arts degree in 1968 from Trinity College in Hartford, Connecticut and a juris doctor in 1971 from the Vanderbilt University School of Law. He is married to Karen, his wife of 32 years, and they have four grown children. Ramani Narayan – Distinguished Professor, Department of Chemical Engineering and Materials, Science Michigan State University (https://www.msu.edu/~narayan/) Dr. Narayan has 124 refereed publications in leading journals to his credit, 18 issued patents, 10 pending published patents, edited three books and one expert dossier in the area of bio-based polymeric materials. His research encompasses design and engineering of sustainable, biobased products, biodegradable plastics and polymers, biofiber reinforced composites, reactive extrusion polymerization and processing, studies in plastic end-of-life options like biodegradation and composting. His research involves developing carbon and environmental footprint of biobased and biodegradable plastics and products using biocarbon content analysis (ASTM D6866) and LCA (life cycle assessment) methodology respectively. Under his supervision, 20 students have obtained their Master’s degrees, 12 students their Ph.D. degrees and six are working towards Ph.D. He has major research programs with industry and serves as consultant for several companies. He serves as the Scientific Chair and board member of the Biodegradable Products Institute (BPI), North America www.bpiworld.org. He served on the Board of Directors of ASTM International (www.astm.org), a premier international standards setting organization and currently chairs the committee on Environmentally Degradable Plastics and Biobased Products (D20.96) and the Plastics Terminology committee D20.92. He is also the technical expert for the USA on ISO (International Standards Organization) TC 61 on Plastics – specifically for Terminology, and Biodegradable plastics. Dr. Narayan has testified before U.S. congressional hearings on the biodegradable and biobased plastics issues. He serves on the Board of Directors of Northern Technologies International (www.ntic.com ) – a $100 million publicly traded micro cap company, and on the Technical Advisory board of Tate & Lyle (www.tateandlyle.com) – a world leading manufacturer of renewable food and industrial ingredients. 11

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Dr. Narayan has won several awards: Named MSU University Distinguished Professor in 2007 -- the highest honor that can be bestowed on a faculty member by the university. Those selected for the title have been recognized nationally and internationally for the importance of their teaching, research and public service achievements; Governor’s (State of Michigan) University Award for commercialization excellence; University Distinguished Faculty Award, 2006 – awarded to 10 faculty from amongst all the faculties at Michigan State University; 2005 Withrow Distinguished Scholar award -- awarded to one faculty in the MSU College of Engineering based on exemplary research accomplishments, national and international recognition; Fulbright Distinguished Lectureship Chair in Science and Technology Management and Commercialization (University of Lisbon; Portugal); first recipient of the William N. Findley Award for “significant contributions to the application of new technologies within the scope of ASTM Committee D20 on Plastic; Award of Excellence from ASTM committee D 20 on Plastics for exemplary technical contributions, sustained participation and valued leadership 2006; the James Hammer Memorial Lifetime Achievement Award, 2006 for outstanding leadership, and research accomplishments in the field of Degradable Polymers from the BioEnvironmental Polymer Society (BEPS); Research and Commercialization Award sponsored by ICI Americas, Inc. and the National Corn Growers Association. Dr. Narayan is a successful entrepreneur, having been responsible for commercializing several technologies.

Jonathan R. Mielenz – Group Leader, Oak Ridge National Laboratories (http://www.ornl.gov/sci/bst/) Jonathan R. Mielenz received his Ph.D. in Microbiology from University of Illinois at UrbanaChampaign. His research career has emphasized industrial enzymes and renewable materials starting with genetically engineering one of the first GRAS food enzymes, a thermostable α-amylase, for CPC International in their research labs adjacent to their Chicago corn wet mill in Argo, Illinois. Dr. Mielenz has also worked for one of the world’s largest natural plant oil processors, Henkel KGaA, where his staff, and their German counterparts, developed the first renewable polymer feedstock bioprocess for dicarboxylic acids from natural fats and oils. He has served as Biofuels Technology Manager at the National Renewable Energy Laboratory (NREL) in Colorado where he assisted the DOE Biomass Program. In addition, he has been awarded three SBIR grants while part of two different small bio-energy businesses, one affiliated with Dartmouth College which developed technology that was purchased by Mascoma Corporation. Presently, Dr. Mielenz is the Group Leader of the Bioconversion Science and Technology Group and leads the fermentation effort in support of the US DOE Office of Science-funded BioEnergy Science Center (BESC), led by Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee. He is actively involved in research for development of advanced microorganisms for production of biomass ethanol, and bio-hydrogen. Nancy Cox – Associate Dean of Research, University of Kentucky Dr. Nancy Cox is the Director of the Kentucky Agricultural Experiment Station and Associate Dean for Research in the College of Agriculture at the University of Kentucky.

SPEAKER AND MODERATOR BIOS

Dr. Cox’s research area is reproductive physiology of farm animals and she has been involved in consulting with producers and animal health companies. In 1998-1999 she co-chaired, with Senator Robert Dearing, the Task Force on the Environment for the Mississippi Legislature; this task force conducted a year-long study on the scientific issues related to environmental regulations on large swine farms. She joined UK in 2001, and her duties include oversight of Experiment Station state and federal research budgets. She is responsible for the college grants office that managed over $31 million in external awards in fiscal year 2008. She represents the College of Agriculture in a partnership with a newly established federal laboratory in Lexington, the USDA Agricultural Research Service ForageAnimal Production Research Unit. Dr. Cox represents the College on most Kentucky agricultural commodity boards, the Kentucky Clean Fuels Coalition and the Kentucky Rural Energy Consortium. She recently finished terms as Chair of the Science and Technology Committee for the Experiment Station Committee on Policy (National Association of State Universities and Land Grant Colleges; NASULGC) and Director of the American Society of Animal Science. In 2005 she became a member of the Board of Policy Directors for the Board on Agriculture Assembly of NASULGC. In 2007 she was named to the National Advisory Board for Research, Extension and Economics; this board advises the Secretary of the US Department of Agriculture on research priorities. Donald Senich – Program Manager, National Science Foundation Donald Senich is the Program Director for the Grants Opportunity for Academic Liaison with Industry (GOALI), Director of the office for Small Business Research and Development (OSBRD), and Director of the Office of Small and Disadvantaged Business Utilization (OSDBU). Dr. Senich is responsible for implementing academic/industrial collaborative research programs in the Engineering Directorate of approximately $34 M. He is also responsible to the Director, NSF, for procurement interface and actions with the Small Business Administration’s (SBA) Office of Government Contracting for (approximately $450 M.) annual procurement budget. Dr. Senich did his undergraduate education at the US Military Academy and at the University of Notre Dame in Mechanical Engineering (1953). He graduated from Iowa State University with an MS (1961) and a PhD (1966) majoring in Civil Engineering with a minor in Nuclear Engineering. Lorel Wisniewski – Deputy Director, National Institutes of Standards and Technology Lorel Wisniewski has served as Deputy Director of the Technology Innovation Program (TIP) at the National Institute of Standards and Technology (NIST) since December 31, 2007. TIP is a publicprivate partnership that funds the development of high-risk, high-reward R&D in areas of critical national need. Dr. Wisniewski was Deputy Director of the Advanced Technology Program (ATP) at NIST from 2005 through 2007. She joined ATP as Supervisory Economist in the ATP Economic Assessment Office in December 2003. Before joining NIST, Dr. Wisniewski spent over 10 years as Principal with an economic consulting firm in Washington, D.C., and previously managed compensation for a large HMO. She spent three years 13

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as staff economist and manager of the statistical department for a trade association in the electric power industry, and spent nearly 10 years conducting economic analysis in the telecommunications industry. Dr. Wisniewski has taught economics at American University and Trinity College in Washington, D.C. Her career began as a Federal Junior Fellow at NASA Goddard Space Flight Center. Dr. Wisniewski earned a Ph.D. in economics from American University in 1999. She also has an M.A. in economics from George Washington University and a B.A. in economics from Franklin and Marshall College. Joanne Lang – Vice President, Kentucky Science and Technology Corporation Joanne Lang joined Kentucky Science and Technology Corporation (KSTC) in 1996 and is Executive Vice President. She is involved in all aspects of corporate operations and directs several initiatives including AdvanceKentucky, a new statewide effort supported by the National Math and Science Initiative to dramatically accelerate the numbers of students achieving success in rigorous math, science and English courses. She also directed the Kentucky Survey of Critical Technologies among middle and high school science teachers. This was instigated by KSTC’s experience in making some 500 investments since 2002 in new economy research and start-up companies. Other related efforts have included, for example, Kentucky’s Science and Technology Strategy, which created the programs and funding for making these investments in research and entrepreneurship, Cluster Analysis of Kentucky Industries, Policy Audit of Kentucky Policies for the new economy, Kentucky’s New Economy Initiatives, the entreSchools® Initiative, the international IdeaFestival®, and the Partnership for Reform Initiatives in Science and Mathematics (PRISM). Prior to joining the KSTC team, Joanne spent over 17 years at the Kentucky Council on Postsecondary Education during which time she developed and implemented three different five-year, statewide strategic plans for higher education. She holds a M.S. degree from SUNY Buffalo.

Susan Old – Senior Advisor for Translational Research, National Center for Research Resources, National Institutes of Health Prior to joining NCRR, Dr. Old was the acting deputy director for the Division of Cardiovascular Diseases at the National Heart, Lung, and Blood Institute. She has extensive experience in initiating and managing large complex programs, and has led numerous, exemplary translational projects at NHLBI. These included moving genomic strategies and technologies into application (NHLBI Programs for Genomic Applications); developing resources (rat genome project, rat database, NHLBI Mammalian Genotyping Service); developing technologies (NHLBI Proteomics Initiative); and facilitating the sharing of resources, protocols and data in clinical studies (NHLBI Family Blood Pressure Program and clinical trial networks). All of these programs, which have ranged from RO1s to contracts and collaborative agreements, have been multi-institutional, and many have been global. In addition to her duties as acting deputy director of the Division of Cardiovascular Diseases (FY 07 extramural budget of more than $1.3 billion) and her research portfolio, Dr. Old was chair of the NHLBI Data Access Committee for Genome Wide Association Studies and worked with NIH to implement the NIH policy on data sharing for GWAS. She also served as liaison to professional scientific organizations and NIH committees.

SPEAKER AND MODERATOR BIOS

Dr. Old received her undergraduate degree at the University of California, Irvine, and her Ph.D. in the Department of Human Genetics at the University of Michigan. She completed her post-doctoral training at Columbia University in Pediatric Neurology before joining the NIH in 1988. She began her career at NIH as a senior staff fellow at the National Eye Institute, where she studied the mechanisms of diabetic cataracts in the Laboratory of Mechanisms of Ocular Disease. In 1994, she joined the extramural program at NHLBI. Manuel Martinez-Maldonado – Vice President for Research, University of Louisville Manuel Martínez-Maldonado, M.D., MACP, FAHA, FAAAS graduated from Temple Medical School and was President and Dean, of Ponce School of Medicine from 2000 to 2006. From May 1998 to Dec 1999 he was professor of medicine, vice provost and vice president for research at Oregon Health Sciences University in Portland. He was the Vice Chair of the Department of Medicine at Emory University Medical School, and Director of Internal Medicine and Ambulatory Care at the Atlanta VA Medical Center from 1990-1998. He is a board-certified internist and nephrologist, and a Master of the American College of Physicians. He received his nephrology training at the University of Texas Southwestern Medical School in Dallas. He has held professorships at Baylor College of Medicine, the University of Puerto Rico, Emory and OHSU. He has also taught at Harvard and Vanderbilt. He has served on numerous NIH committees, including the Board of Scientific Counselors of the NHLBI. Author of numerous scientific publications, his research interests include disturbances of body fluid composition, the renin-angiotensin system and hypertension and their effects on renal function and kidney damage. For over 10 years Dr. Martínez-Maldonado has been listed in Who’s Who in America, Who’s Who in the World, Who’s Who in Medicine and Health, Who’s Who in the South and Southeast. Dr. MartínezMaldonado is a Fellow of the American Heart Association and the American Association for the Advancement of Science. He holds membership in numerous societies, including the American Society for Clinical Investigation, the Association of American Physicians and the Institute of Medicine of the National Academy of Sciences. He is a foreign honorary member of the American Academy of Arts and Sciences. David W. Carrithers – Attorney, Carrithers Law Office David Carrithers is a registered patent attorney licensed to practice before the United States Patent and Trademark Office and admitted to practice law in the Commonwealth of Kentucky and the federal U.S. District Courts of Kentucky. He specializes in Intellectual Property Law which includes patent, trademark, trade secrets, copyright law, and unfair competition law in the United States and foreign countries. In addition to preparation and filing of patents, copyrights and trademarks, the practice includes patent and trademark search opinions, infringement opinions, validity and invalidity opinions, licenses, cease and desist letters, oppositions before the U.S. Patent and Trademark Office, litigation matters, assistance in designing around valid patents and avoiding infringement, conducting due diligence investigations for acquisitions and mergers, serving as In-house Intellectual Property Counsel and managing the intellectual property portfolios for companies which do not have their own patent attorney, and serving as special advisor and/or co-counsel for general practice trial attorneys in litigation concerning intellectual property matters. Prior to practicing law, David worked for several years in the field of industrial chemical engineering in product and process development. His industrial experience includes experience as Process Development Engineer providing technical service to customers and technical support of manufacturing 15

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operations in the formulation, extrusion, and processing operation for the plastics compounding operations of B.F. Goodrich; Production and Research and Development Engineer for Joseph E. Seagram and Sons specializing in new product and process development of alcohol and distillery byproducts, and biotechnology/biochemical processes for the food and beverage industry; and Research and Development Engineer for Hi-Tek Polymers/Rhone-Poulenc in the Water Soluble Polymers group for the oil, textile and food industry. Mahendra K. Jain (PhD) – Vice President and Executive Director, Kentucky Science and Technology Corporation Dr. Mahendra Jain is the founding Executive Director of the Kentucky Science and Engineering Foundation (KSEF) and Vice President of the Kentucky Science and Technology Corporation (KSTC) in Lexington, Kentucky. In his present position, Dr. Jain is fostering partnerships between academic, industrial and state institutions in building and expanding Kentucky’s scientific and engineering capacity to attract external research funds from all sources, to help advance research ideas and to build a pipeline of technologies. In addition, Mahendra has proactively pursued the growth of the Federal SBIR and STTR Programs in the state through outreach and state-funded assistance programs, and was the recipient of the Tibbetts Award in 2006. Before joining KSTC, Mahendra worked at several universities in the USA, Europe and India. He also worked at MBI International, a biotechnology R&D company in Lansing, Michigan where he was involved in the technology development and transfer. After receiving his Ph.D. in microbiology in 1972, Dr. Jain received and managed research grants and contracts in several million dollars from federal, state and industrial sources. He is the author of 11 United States patents, one Canadian patent and over 120 research papers, articles and book chapters. Leonard Heller –Vice President for Commercialization and Economic Development, University of Kentucky; and President/CEO, Kentucky Technology, Inc. Leonard E. “Len” Heller became Vice President for the University of Kentucky’s new Office for Commercialization and Economic Development on December 12, 2006. Dr. Heller oversees UK’s commercialization and business development resources and builds strategic partnerships to advance economic development initiatives throughout the state. He is responsible for the commercial development of university-based technologies and intellectual properties and streamlining the processes to get UK’s discoveries to market; new and existing business development at UK, in the Lexington-Bluegrass region and throughout Kentucky; the Advanced Science and Technology Commercialization Center (ASTeCC) campus incubator; and the development of UK’s 735-acre Coldstream Research Campus. As President and CEO of Kentucky Technology Inc. (KTI), Dr. Heller directs investment in technology-based businesses through KTI, the Bluegrass Angels and Bluegrass Angels Venture Fund, and venture capital networking. Currently, Dr. Heller is part of The National Academies University-Industry Demonstration Partnership, which brings top research universities together with Fortune 500 companies to develop research and commercialization relationships. He is also on the NASULGC Commission on Innovation, Competitiveness and Economic Prosperity. Dr. Heller holds an Ed.D. in administration and organizational development from Kansas University and 16

SPEAKER AND MODERATOR BIOS

is a former business owner, angel investor, entrepreneur, and Kentucky state government cabinet secretary. He founded WTT Inc., a Lexington startup that developed substance abuse tests for thoroughbred race horses. The company was acquired by Neogen Corp., and Dr. Heller continues to serve on the board of directors. Heller was Secretary of the Cabinet for Human Resources under Kentucky Governor Brereton Jones and chaired the State Commission on Health Care Reform. In addition, Dr. Heller was instrumental in the formation of the Bluegrass Angels, a central Kentucky venture capital fund and served as chairman of the board of managers for the Bluegrass Angels Venture Fund. Since 1996, Heller has been a part-time professor in UK's Martin School of Public Policy and Public Administration. He was on the faculties of the University of Illinois, University of Michigan, Baylor College of Medicine, and UK College of Medicine. James R. Zanewicz – Director Office of Technology Transfer, University of Louisville James R. Zanewicz, J.D., LL.M., started the Office of Technology Development at the University of Louisville in December of 2000, and guided the office's development and growth into the Office of Technology Transfer. He is originally from Kentucky, where he earned a B.S. in Chemistry from Centre College. On his winding path around the USA and back to the Bluegrass State, he has lived in New Orleans where he earned his J.D. from Tulane Law School; New Jersey while he was working as a chemist and a patent law clerk for Rhone-Poulenc; Los Angeles where he handled internet, multimedia, production and intellectual property issues for the Warner Bros. daily syndicated news-magazine EXTRA; and Urbana-Champaign, Illinois, where he first entered the exciting realm of University Technology Transfer and learned much of what he knows from Ann Hammersla and Jill Tarzian Sorensen. James is admitted to practice before both the Kentucky Bar and the U.S. Patent and Trademark Office, and authored a thesis on "Online Data Privacy in the United States: “Analysis and Proposed Regulatory Scheme" as part of earning his LL.M. in Intellectual Property and Media Issues from the University of Illinois at Urbana-Champaign. He co-chairs the Technology Transfer Committee for BIO, is a steering committee member of OVALS (The Ohio Valley Affiliates for Life Sciences), has served on several AUTM committees, and is an active member of COGR. His proudest achievement is his involvement as a disaster services volunteer for the American Red Cross. "The public values the invention more than the inventor does. The inventor knows there is much more and better where this came from." Ralph Waldo Emerson Mark D. Brennan (PhD) – Department of Biochemistry and Molecular Biology, University of Louisville; and SureGene, LLC Mark D. Brennan, Ph.D. is Cofounder and Manager of SureGene LLC, a University of Louisville spin out company specializing in the genetics of psychiatric illnesses. He is lead inventor of the AssureGeneTM test, a genetic test designed to assist with differential diagnosis and choice of pharmacological interventions for schizophrenia, bipolar disorder and related diseases. He is a Professor in the Department of Biochemistry and Molecular Biology at the University of Louisville. Dr. Brennan is a Cofounder of the University of Louisville’s Center for Genetics and Molecular Medicine. SureGene has raised $3.7 million in grant and investor funding since founding in 2004, including $700,000 from various state programs. Dr. Brennan is currently Principle Investigator of a Phase II 17

SPEAKER AND MODERATOR BIOS

SBIR grant from the National Institutes of Mental Health for development of genetic biomarkers for neuropsychiatric illnesses. Stephen Rankin (PhD) – Department Chemical and Materials Engineering, University of Kentucky Dr. Rankin is an Associate Professor in the Chemical and Materials Engineering Department at the University of Kentucky. He received his B.S. in 1993 from Carnegie Mellon University and his Ph.D. from the University of Minnesota (Minneapolis) in 1998, both in Chemical Engineering. After brief postdoctoral appointments in partnership with Dow Corning and at Sandia National Laboratories, he joined the faculty at the University of Kentucky (Lexington) in 2000. Dr. Rankin’s research interests focus on experimental and modeling studies of the synthesis of metal oxide materials, porous materials, and of the interfacial phenomena governing the formation and function of those materials. Recent research interests focus on the design and application of materials with specific separation, catalytic, and photoelectric properties for solar and biomass-derived energy, and the controlled capture and release of biomolecules. Professor Rankin has co-authored 50 peer-reviewed publications and has directed or is directing over $2 million of research grants at the University of Kentucky funded by NSF, DOE and the USDA, in addition to KSEF. Dr. Rankin received a DOE Early Career Scientist and Engineer Award in 2000, an NSF CAREER Award in 2004, and was named a Gill Professor of Engineering at the University of Kentucky in 2007. Steven Koenig (PhD) – Department of Biochemistry and Molecular Biology, University of Louisville; and SureGene, LLC Dr. Koenig is an Associate Professor in the Department of Bioengineering (Cardiovascular Innovation Institute) and the Department of Surgery (Division of Cardiothoracic Surgery) at the University of Louisville. He has 16 years experience with biomedical instrumentation and transducers, and data acquisition and analysis. Since joining UofL in 1996, Dr. Koenig has developed eight data acquisition systems, and physiologic data acquisition (LabVIEW) and analysis (Matlab) software for hemodynamic monitoring, recording, and analysis in support of IACUC approved large animal model and IRB approved clinical protocols. Dr. Koenig developed the engineering component of UofL’s Good Laboratory Practice (GLP) program by authoring standard operating procedures (SOP), implementing a calibration and maintenance program, and completing instrumentation calibration procedures resulting in FDA approval for clinical trials of the AbioCor™ at Jewish Hospital, Louisville. Dr. Koenig’s research focus is on physiological responses to cardiac assist, counterpulsation and mini-pump development projects, and the clinical application of mechanical circulatory support devices to promote myocardial recovery in heart failure patients. Dr. Koenig’s research program has been funded by the Whitaker Foundation, American Heart Association, and NIH SBIR program as well as industry partners Abiomed (Danvers, MA), Thoratec (Pleasanton, CA), and SCR, Inc (Louisville, KY) that has resulted in 53 peerreviewed publications, 17 conference proceedings, four book chapters, 59 abstracts, five technical reports, and four US patents. Bruce Webb (PhD) – Department of Biochemistry and Molecular Biology, University of Louisville; and SureGene, LLC Dr. Bruce Webb co-founded ParaTechs Corp. in 2004 as a spin-off biotechnology company from his lab at the University of Kentucky and currently serves as President for PraTechs. ParaTechs has received 18

SPEAKER AND MODERATOR BIOS

in excess of 2.5 M in Federal and State support and has products on the market in the area of protein expression and mouse transgenesis. Dr. Webb is a professor of Entomology at the University of Kentucky where he has been on the faculty since 1995. Dr. Webb’s laboratory is recognized internationally as a leader in the field of insect DNA viruses. He also currently serves as Director of the Agricultural Biotechnology Program and has been an active contributor to this exceptional undergraduate degree program since arriving at UK. Prior to coming to UK, Dr. Webb was on the faculty at Rutgers University (1991-1994), was an NIH:NRSA postdoctoral fellow at Texas A&M University, received an NIH graduate research award for his doctoral research at the University of Washington and received M.S. and B.A. degrees from the Universities of Kentucky and Virginia respectively. Dr. Webb has a significant publication record, 3 patents and has received in excess of 5 M dollars in competitive federal research support from the NIH, the NSF and the USDA. He has served as a grant review panel manager for the USDA:NRI and a panel member for the NSF, the EPA and the USDA. He has received the Thomas Poe Cooper award for outstanding research in the College of Agriculture and been also received a University of Kentucky research professor award. Dr. Webb is married to Dr. Nancy Webb, also a faculty member at the University of Kentucky in internal medicine and they have two children, Erin and Daniel. He enjoys outdoor non-competitive sports and indoor competitive sports (basketball and volleyball). Blaine Ferrell, (PhD) – Dean Odgen College of Science and Engineering, Western Kentucky University Dr. Blaine Ferrell is Dean of Ogden College of Science and Engineering at Western Kentucky University, Director of the Applied Research and Technology Program of Distinction (ARTP), a and Board Member of the Kentucky Science and Engineering Foundation in addition to other state boards. The ARTP program has faculty and students working in interdisciplinary teams to help constituents meet applied research and technical challenges. The ARTP has worked as a research and development catalyst with high-tech companies in the Central Regional Innovation and Commercialization Center at the WKU R&D Center to expand existing companies and create new ones. These partnerships have created many more applied research projects for our students. Mac Werner – Research Associate, Institute for Workplace Innovation, University of Kentucky Mac Werner is a Research Associate at the Institute for Workplace Innovation (iWin). He has a B.S. in business from the University of Evansville, a M.S.W. from the University of Kentucky and is currently completing course work toward a Ph.D. in social work. His background includes over a decade of experience as a small business owner and substantial experience in program management and design. Mac’s responsibilities at iWin include project management, data management, survey content/design, data analysis, and report writing. His focus has been in the area of applied workplace-based research studying effective workplace practices. Linda Linville (PhD) – Assistant Vice President for Academic Affairs, Kentucky Council on Postsecondary Education Dr. Linville has experience with funded research and programs targeting the resources of postsecondary education and the development of academic policies fostering workforce and economic development. She is engaged with many STEM education and research initiatives in collaboration with 19

SPEAKER AND MODERATOR BIOS

education, government, business and industry. The Council on Postsecondary Education is Kentuckyâ&#x20AC;&#x2122;s coordinating organization for postsecondary and adult education, with priority attention given to advance fundamental, long-term improvement in the quality of life of Kentuckyâ&#x20AC;&#x2122;s citizens and economy through educational policy development, research and implementation throughout the Commonwealth. Dr. Linville holds a doctoral degree in educational psychology from the University of Kentucky

BUSINESS SPOTLIGHT SCHEDULE “Spotlight On Businesses” is a three to five minute presentation in which the company discusses who they are, what their business is, the products/technologies they have in the market or under development, whether statefunded programs have benefited the company, the company’s current technical/business/funding needs and if the company is currently looking for collaborators or recruiting people. MORNING SPOTLIGHT SESSIONS 10:30-11:00 am – Kentucky Ballrooms Foyer Area SPOTLIGHT ONE (10:4010:45 am)

SCR, Inc. www.scrdevelopmentgroup.com Presenter: Daiga Koenig Email: daigakoenig@scrdevelopmentgroup.com Phone: 502-553-2794

SPOTLIGHT TWO (10:4510:50 am)

Transposagen Biopharmaceuticals, Inc. www.transposagenbio.com Presenter: Eric Ostertag Email: ostertag@transposagenbio.com Phone: (267) 259-1086

SPOTLIGHT THREE (10:5010:55am)

ParaTechs Corporation www.paratechs.com Presenter: Bruce Webb Email: bawebb@uky.edu Phone: (859) 257-7415

AFTER LUNCH SPOTLIGHT SESSIONS 1:15-1:25 pm – Kentucky Ballrooms Foyer Area SPOTLIGHT FOUR (1:151:20 pm) SPOTLIGHT FIVE (1:201:25 pm)

Tribo Flow Separations, LLC www.triboflow.com Presenter: John Stencel Email: john@triboflow.com Phone: (859) 523-8782 Naprogenix, Inc. www.naprogenix.com Presenter: John Littleton Email: john.littleton@uky.edu Phone: (859) 257-1127

POSTER PRESENTERS PRESENTER

TITLE

POSTER#

ENVIRONMENTAL AND ENERGY TECHNOLOGIES Deshpande, Rutooj

Modeling Diffusion-Induced Stresses in Nanostructured Lithium Ion Battery Electrodes

Kessler, Bruce

Algorithmic Classification of Active/Inactive Unexploded Ordnance Using Neutron Analysis Data

Tao, Daniel

Next-Generation Triboelectrostatic Separator for Dry Efficient Separation of Particles

BIOSCIENCES Artiushin, Sergey

Development and Evaluation of a Platform for Rapid Simple and Sensitive Detection of Streptococcus Equi

Beeram, Srinivas Reddy

Combining Visible Spectroscopy with Atomic Force Microscopy to Correlate the Optical Properties of Au Nanoplatelets with Antibody\Antigen binding.

Bradley, Luke

A Novel Approach for the Exploration and Design of Neuronal Protein Recognition and Specificity

Burklow, Cindy

Discovering and Optimizing Drugs in Native Plants Using Functional Genomics

Collins, Karen

HD 100453: A Link Between Gas-Rich Protoplanetary Disks and Gas-Poor Debris Disks

Creamer, Trevor

Using Calmodulin to Probe the Role of Intrinsic Disorder in Biomolecular Recognition

El-Baz, Ayman

A Novel Framework for Early Detection of Lung Nodules

El-Baz, Ayman

A Novel Framework for Early Detection of Lung Nodules

Fukushige, Hirotada

Cyclopropane Fatty Acid Accumulation in Plant Oil

PRESENTER Harwood, James

TITLE POSTER# A Molecular Approach to 13 Elucidate the Role of Invasive Mollusk Pests in Kentucky Agriculture

Dampanaboina Lavanya

Characterization of the Plant Polyadenylation Factor FY

Hurtado, Oscar

High Throughput Localization of Fungal Secreted Proteins During Colonization of Rice Leaves

Morris, Joseph P.

A Web-Based Genome Browser For 'SNP-Aware' Assay Design

Yang, S.

Probing Metal Binding to DNA and RNA Nucleobases with High-Resolution Photoelectron Spectroscopy

Lushia, Warren

The Potential of Corn Stalk Rot Fungi for Cellulosic Bioconversion in Fuel Ethanol Production

Ma, Shankang

Copper Regulation of Hypoxia-Inducible Factor-1 Activity in HepG2 Cells

Meenach, Samantha

Synthesis and Characterization of Magnetic Hydrogel Nanocomposites for Hyperthermia-Based Treatment of Cancer

Ngoh, Gladys

O-GlcNAc Signaling Attenuates Mitochondrial Mediated Post-Hypoxic Cardiac Myocyte Injury

Sahi, Shivendra

Development of a Plant Based Antiviral Compound for Herpes Simplex Virus

Sasvari, Zsuzsanna

Identification of Anti-prion Drugs Active Against Plant Viruses

Sawaya, Peter

Mass Spectral Analysis of PTH Peptides from Plasma

Smalle, Jan

Misfolded Proteins and Stress Resistance in Plants

Stencel, John

Biomedical Instrumentation Based on Sound Produced by Microbes

Stinton, Shaun

A Novel Bioemchanical Approach for Preventing Spinal Disorders

POSTER PRESENTERS PRESENTER Tang, Guiliang

TITLE POSTER# MicroRNA Array Technology 28 and MicroRNA Biomarkers for Various Human Diseases

PRESENTER Cloud, Richard

TITLE POSTER# Development and beta testing 40 of Web Assisted Recovery (WAR)

Tang, Guiliang

A Gut Fueling: Termite Lignocellulases Hold the Key for Biomass Pretreatments â&#x20AC;&#x201C; A Pilot Protein Engineering Study Using Directed Evolution Technology

Fister, Emily

Development and Implementation of a Theoretically-Based Intervention to Promote Healthy Caregiver-Child Attachment

Tang, Guiliang

Integration of Double Stranded RNA into a Baiting System â&#x20AC;&#x201C; A Novel Genetic Control Strategy for Termites

Holtman, Joseph

Interaction Between Morphine and Norketamine Enantiomers in Rodent Models of Nociception

Tobin, Thomas

Certified Reference Standards and Stable Isotope Internal Standards for Equine Therapeutic Medication Regulation

Paranthan, Riya

ProteoTAG Systems: Advancing Chemical Proteomics for Therapeutic Development and Diagnosis

Structure-based Drug Design Using Grid Computing

Tickle, Alison

Bone Cement for 21st Century Arthroplasty

Trent, John

Detecting and Modeling the Distribtuion of Japanese Honeysuckle, an Invasive Plant Species

Voor, Michael

Alternative Bone Graft Solutions

Viniard, Jeff

Voor, Michael

Hip Fracture Prevention Technology

Webb, Bruce

Enhancing Protein Expression from the Baculovirus Expression Vector System

Wang, Jianpu

Creation of Long-Term Diabetic Rabbits for Wound Research

Xue, Wanli

Cardiac-specific Hypoxiainducible Factor -1a Overexpression Protects Diabetic Heart in Mice

Mo, Yiqun

Activation of Endothelial Cells after Exposure to Ambient Ultrafine Particles: the Role of NADPH Oxidase

Zhang, Changjiang

Simulation of Pulsatile Flow through a Hollow Fiber Cartridge: Growth Factorreceptor Binding Analysis

Antony, Solomon

Reuse of Data Modeling Patterns

Bryson, L. Sebastian

Zhang, Jun

Generalized Diffusion Simulation-based Fiber Tracking on Synthetic Phantoms

Dynamic, Distributed Realtime System for Geosystems Health Monitoring

Cheng, Fuhua Frank

Portable Digital Mouth and Occlusion Reproducer

Brennan, Mark

Association of Sult4A1 SNPs with Psychopathology and Cognition in Patients with Schizophrenia or Schizoaffective Disorder

Ernest, Andrew

Improving Local Water Supply in Rural Communities via a Sensor Network

Braun, Frank

Business Risk Management / Continuity Planning Software

Hassebrook, Laurence

Scanning 3-Dimensional Facial Expressions in Motion

HUMAN HEALTH AND DEVELOPMENT Brennan, Mark

SureGene Genome Wide Association Study (GWAS) Visualization Suite

POSTER PRESENTERS PRESENTER Losavio, Michael

TITLE POSTER# An Initial Framework For 55 Assessing Legal Risks in Network Forensic Probing and Monitoring – The Issue of Authorized Access

INFORMATION TECHNOLOGY AND COMMUNICATIONS Nasraoui, Olfa

An Introductory Legal Framework for Node Base Probing and Monitoring Investigations

Nasraoui, Olfa

Architecture Analysis of Peerto-Peer Data Exchanges

Oeltgen, Peter

The Use of Deltorphin Dvariant for Treatment of Stroke

Wang, Yin

Fast and High Accuracy Computation of 2D convection Diffusion Equations with Variable Coefficients

Zhang, Jun

Privacy Preservation in Social Networks

Panja, Biswajit

Runway Control Using Smart Sensor Network

MATERIALS SCIENCE AND ADVANCED MANUFACTURING Balk, John

Effects of Annealing on Microstructure of OsmiumRuthenium Thin Films

Balk, John

Nanoporous Nickel As an Alternative to Raney Nickel

Chen, Rong

Impression Creep of Pb

Dasari, Radhika

Electrochemical Method for Fabricating Metal/Molecule/ Metal Junctions and Their Sensing Applications

Druffel, Thad

Nanotechnology in Ophthalmics

Gharaibeh, Mohammed

Laser Spectroscopy of Ultra Cold Molecular Ions

Guduru, Sai

CuInSe2 and CuPc Nanowires for Solar Cell Application

Donev,

Liquid Phase Electron-Beam

PRESENTER Eugene.

TITLE Induced Processing

POSTER#

Hilt, J. Zach

FTIR Imaging for Microscale Spatial Analysis of Hydrogel Patterning Reactions

Hunter, Harry

Generation of Nanodroplets by Coulombic Fissions of Microdroplets

Karaca, Haluk

High Temperature Shape Memory Alloys

Karaca, Haluk

Magnetic Field-Induced Phase Transformations in NiMnbased Shape Memory Alloys

Li, Ding

Indentation Behavior and HCA Growth on Bioglass 45S5

Li, Juchuan

Stress Induced Sn Whisker Growth

Mangu, Raghu

Nanostructured Titania, Tin oxide and aligned CNT Films as Gas Sensors

Moreno, Monica

H2 Reactivity of Pd Nanoparticles Coated with Mixed Monolayers of Alkyl Thiols and Alkyl Amines for Sensing and Catalysis Applications

Rajaputra, Suresh

Commercialization of High Quality Nanoporous Alumina Templates for Nanoscale Devices and System

Rankin, Stephen

Sweetening Kentucky’s Energy Future with Functional Nanoporous Materials Prepared by Sugar-based Surfactant Templating

Rankin, Stephen

Evaporation-Driven Assembly and Tuning of Titania Thin Films with Orthogonally Aligned Hexagonal Channels

Sekulic, Dusan

Metallic and Carbon Bonding

Pu, Z.

Machining of Metal-on-Metal Hip Implants for Improved Performance

Yazdanpanah Mehdi

Self-assembly of Nanostructures and Their Applicability to In Situ Measurements and Manipulations of Soft Biomaterials

POSTER PRESENTERS PRESENTER Zhang, YuMing

TITLE Torch Based Adaptive Intelligent Control for Circumferential Welding of Pipes

POSTER#

PRESENTER

TITLE

POSTER#

POSTER ABSTRACTS ENVIRONMENTAL AND ENERGY TECHNOLOGIES 1. Modeling Diffusion-Induced Stresses in Nanostructured Lithium Ion Battery Electrodes Rutooj Deshpande(1)*; Yang-Tse Cheng (1); Mark W. Verbrugge (2), (1) Chemical and Materials Engineering, University of Kentucky; (2) Materials and Processes Laboratory, General Motors R&D Center, Warren, Michigan Presently, there is an intense, worldwide effort in developing durable lithium ion batteries with high energy and power densities for a wide range of applications, including electric and hybrid vehicles. One of the critical challenges in advancing lithium ion battery technologies is fracture and decrepitation of the electrodes as a result of lithium diffusion during charging and discharging operations. When lithium is inserted in either the positive or negative electrode, a large volume change on the order of a few to several hundred percent can occur. Diffusioninduced stresses (DISs) can therefore cause the nucleation and growth of cracks, leading to mechanical degradation of the batteries. This work is aimed at developing nanostructured electrodes with enhanced durability. With decreasing size of the electrode, the ratio of surface area to volume increases tremendously. Thus, surface energy and surface stress may play an important role in mitigating DISs in nanostructured electrodes. In this work, we establish relationships between the surface energy, surface stress, and the magnitude of DISs in nanowires. We found that DISs, especially the tensile stresses, can decrease significantly due to the surface effects. Our model also establishes a relationship between stress and the nanowire radius. We show that, with decreasing size, the electrode material will be less prone to mechanical degradation, leading to an increase in the life of lithium ion batteries. 2. Algorithmic Classification of Active/Inactive Unexploded Ordnance Using Neutron Analysis Data Bruce Kessler* (1, 2); Phillip Womble (2,3); and Joe Howard (2), (1) Department of Mathematics; (2) WKU Applied Physics Institute; (3) Department of Physics and Astronomy, Western Kentucky University

For over a decade, the Applied Physics Institute at Western Kentucky University has been assisting the U. S. Army to determine the active/inactive status of unexploded ordnance (UXO) using a Pulsed Fast/Thermal Neutron Analysis (PFTNA) technique that indicates the elemental composition of the test item. Typically, their methods require a skilled analyst to interpret the spectral data collected. The author has developed a wavelet-based algorithm that automatically interprets the spectral data and makes a determination as to the substance being tested. The basis being used is a smooth scaling vector and multiwavelet developed by the author with approximation order 4, along with a prefilter developed by the author. Preliminary results from its usage on PFTNA data in UXO determination applications are described. 3. Next-Generation Triboelectrostatic Separator for Dry Efficient Separation of Particles D. Tao, M. Fan, K. Jiang, Department of Mining Engineering, University of Kentucky More than 80 million metric tons of fly ash is produced annually in the U.S. as coal combustion by-product. Fly ash can be converted to value-added products if unburned carbon is reduced to less than 2.5%. However, most of fly ash is currently landfilled as waste due to lack of efficient purification technologies to separate unburned carbon from fly ash. A rotary triboelectrostatic separator has been developed recently at the University of Kentucky with unique features. Several fly ash samples have been used to understand the effects of major process parameters on the separation performance. The results show that compared to existing triboelectrostatic separators, the rotary triboelectrostatic separator has significant advantages in particle charging efficiency, solids throughput, separation efficiency, applicable particle size range.

BIOSCIENCES 4. Development and Evaluation of a Platform for Rapid, Simple and Sensitive Detection of Streptococcus Equi Sergey Artiushin* and John F. Timoney, GERC, Vet. Science, University of Kentucky 27

POSTER ABSTRACTS Strangles caused by Streptococcus equi continues to be highly prevalent in United States and elsewhere accounting for 20% of all cases of equine upper respiratory disease causing serious disruption to training and movement of horses. Prevention and control is highly dependent on knowledge of the infectious status of individual horses. Laboratory diagnosis requires culture and PCR of specimens from the nasal cavity and sometimes from the guttural pouch and other sites. These procedures are expensive and can be performed only in a few specialized laboratories resulting in delays in decisions concerning movement and transportation. Our research has been aimed at development of a S. equi specific assay that can be performed with simple laboratory equipment in less than 2 hours. We have developed a detection platform based on isothermal helicase-dependant amplification (tHDA) of S. equi specific nucleotide sequence and visual detection of this product using disposable lateral flow cassettes. The test was evaluated using nasal swabs and washes from infected ad noninfected horses. Comparison of the sensitivity and the specificity of tHDA with culture and nested PCR as reference standards revealed specificity similar to that of culture and PCR. Culture is the least sensitive of these methods with sensitivity of 85% for tHDA and 74% for PCR. In summary a tHDA based assay that requires only simple equipment and little training of personnel may promote a practical alternative to culture or PCR for rapid detection of S. equi in clinical samples. 5. Combining Visible Spectroscopy with Atomic Force Microscopy to Correlate the Optical Properties of Au Nanoplatelets with Antibody\Antigen Binding Srinivas reddy Beeram* and Francis P. Zamborini, Dept of Chemistry, University of Louisville Gold nanoparticles have interesting optical properties which can be used for applications in biosensing. We synthesized ~200 nm wide Au nanoplatelets on silicon by a seed-mediated growth method and used them for human IgG detection after immobilizing anti humanIgG on the Au nanoplatelets through covalent linking. We used UVvis spectroscopy to monitor the optical changes during antibody/antigen coupling to Au nanoplatelets and Atomic Force Microscopy (AFM) to image the antibody and antigen on the surface of the nanoplatelets. We controlled the location of

antibodies on the edges of the platelets by performing a thiol place exchange reaction between mercaptoundecanoic acid and mercaptoethanol functionalized platelets before coupling the antibodies to the acid groups via EDC and NHS activation. Under certain conditions, we immobilized individual antibody on the platelet surface and imaged them with AFM before and after IgG binding. UV-VIS spectra showed that the surface Plasmon band of the Au nanostructures changes more significantly for antibody/antigen coupling on the place-exchanged surfaces. These studies show that the sensitivity of the optical properties of Au nanostructures depends on the location of the biological receptor. This is an important finding for optimizing these materials for biosensing applications. Future experiments will correlate the number and position of antibody/antigen on the surface with the optical properties by combining AFM imaging and Rayleigh scattering at the single particle level. We want to determine the optimal detection limit of these protein sensors, which is of importance in disease diagnostics and biological studies 6. A Novel Approach for the Exploration and Design of Neuronal Protein Recognition and Specificity Charlotte Randle, Sudipa Chowdhury and Luke H. Bradley*, Departments of Anatomy and Neurobiology, Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY This research utilizes approaches at the interface of chemistry, biochemistry, and molecular biology to advance our understanding of neuroprotein interaction networks. We employ protein design and molecular screening strategies to productively generate new molecules with altered biological activities. Detailed biochemical and biophysical characterization of these molecules validate this approach and contribute towards understanding the molecular basis of the native proteinâ&#x20AC;&#x2122;s function. In addition, these novel molecules will serve as translational platforms for the development of various medical, biotechnical, and therapeutic applications. This work is supported by Kentucky Science and Engineering Foundation (KSEF-07-RDE010); NIH, Center of Biomedical Research Excellence (P2ORR020171); University of Kentucky College of Medicine start up funds. 28

POSTER ABSTRACTS 7. Discovering and Optimizing Drugs in Native Plants Using Functional Genomics John M. Littleton; Trent Rogers; Deane Falcone; Samir Gunjan; Manish Kulshrestha; Noel Monks; May Fu; Baochun Li; Eva Kaplan; Ana Hutton Kehrberg; Cindy Burklow*, Naprogenix, Inc., University of Kentucky, KTRDC Naprogenix proprietary biotechnology, Natural Products Genomics, is designed to optimize drug production in known medicinal plants, or to discover and optimize drugs in previously uninvestigated plants. This poster includes examples in which plant species native to Kentucky have been used for this purpose. The first step is to identify species which are “candidates” for the genomics approach. This is achieved by screening a native plant extract library for unusual biological activity which is relevant to the molecular therapeutic target. Once a candidate species has been identified it is used to create a population of gain of function mutant cell cultures which are then screened for the required activity. Proof of concept studies in tobacco show that this process should produce some clones in which the major active metabolite in the wild-type plant is “over-produced” but also that metabolites with activity not normally found in the wild-type plant can be produced. Repeated rounds of mutation of those clones that show the pharmacology required should therefore drive the cellular “evolution” of plant metabolism toward optimal drug characteristics. The best clonal cultures can then be “mined” for the active compounds they contain, or for the activated genes that produced them. In some cases mutant plants may be regenerated which continue to show the pharmacological phenotype exhibited in culture. 8. HD 100453: A Link Between Gas-Rich Protoplanetary Disks and Gas-Poor Debris Disks K. A. Collins (1,2)*; C. A. Grady (3); K. Hamaguchi (4,5); J. P. Wisniewski (6,7); S. Brittain (8); M. Sitko (9); W. J. Carpenter (10); and others, (1) Physics and Astronomy, U. Louisville; (2) KSEF Grant; (3) Eureka Scientific and GSFC; (4) CRESST and X-ray Astrophysics Lab. NASA/GSFC; (5) Physics, University of Maryland; (6) Astronomy, University of Washington; (7) NSF Astronomy and Astrophysics Postdoctoral Fellow; (8) Clemson U.; (9) Space Science Institute, University of Cincinnati; (10) University of Cincinnati

HD 100453 has an IR spectral energy distribution (SED) which can be fit with a power-law plus a blackbody. Previous analysis of the SED suggests that the system is a young Herbig Ae star with a gas-rich, flared disk. We reexamine the evolutionary state of the HD 100453 system by refining its age (based on a candidate low-mass companion) and by examining limits on the disk extent, mass accretion rate, and gas content of the disk environment. We confirm that HD 100453B is a common proper motion companion to HD 100453A, with a spectral type of M4.0V - M4.5V, and derive an age of 10 +- 2 Myr. We find no evidence of mass accretion onto the star. Chandra ACIS-S imagery shows that the Herbig Ae star has L_x/L_bol and an X-ray spectrum similar to non-accreting Beta Pic Moving Group early F stars. Moreover, the disk lacks the conspicuous Fe II emission and excess FUV continuum seen in spectra of actively accreting Herbig Ae stars, and from the FUV continuum, we find the accretion rate is < 1.4x10^-9 M_solar yr^-1. A sensitive upper limit to the CO J = 3-2 intensity indicates that the gas in the outer disk is likely optically thin. Assuming a [CO]/[H2] abundance of 1x10^-4 and a depletion factor of 10^3, we find that the mass of cold molecular gas is less than ~0.33 M_J and that the gas-to-dust ratio is no more than ~4:1 in the outer disk. The combination of a high fractional IR excess luminosity, a relatively old age, an absence of accretion signatures, and an absence of detectable circumstellar molecular gas suggests that the HD 100453 system is in an unusual state of evolution between a gas-rich protoplanetary disk and a gaspoor debris disk. 9. Using Calmodulin to Probe the Role of Intrinsic Disorder in Biomolecular Recognition Trevor P. Creamer*, Meghan Hamilton, Alexandra Fleischman and Julie Rumi-Masante, Center for Structural Biology, Department of Molecular and Cellular Biochemistry, University of Kentucky In recent years it has become apparent that intrinsically disordered regions (IDRs) within proteins are common and often involved in important biological functions such as transcription, signaling pathways and the immune system. IDRs are implicated in numerous diseases states including cardiovascular and protein aggregation diseases. IDRs can function by undergoing a disorder to order transition when bound by another protein. It has been hypothesized that disordered binding regions 29

POSTER ABSTRACTS have evolved in order to partially decouple binding specificity from affinity. In other words, what is bound is somewhat decoupled from how strongly it is bound. An important system that appears to take advantage of this disorder-mediated decoupling is calmodulin (CaM) and its binding targets (CaMBTs). When CaM binds, it induces, in most cases, alphahelical structure in the disordered CaMBT. We are using this system to test the hypothesis that disorder partially decouples specificity from affinity. Under this hypothesis specificity is determined by the residues that directly contact CaM. Affinity is determined in part by the propensity for the unbound CaMBT to adopt alpha-helical structure. We can modulate the alpha-helicity of CaMBT peptides by changing flanking residues in the CaMBT, thereby altering the affinity without changing specificity. The extent to which we have altered the alpha-helicity of the CaMBTs can be determined using circular dichroism spectroscopy, while binding affinity can be determined using fluorescence anisotropy and/or isothermal titration calorimetry. Should the hypothesis hold, we would expect a positive correlation between the measured alpha-helix contents and the binding affinities. Here we present our preliminary data on modulating the alpha-helical content of a CaMBT peptide by altering flanking residues. This system will serve to generate the preliminary data necessary for future studies of the reasons behind Natureâ&#x20AC;&#x2122;s widespread use of IDRs in critical molecular recognition processes. 10. A Novel Framework for Early Detection of Lung Nodules Tervor Holland (1); Ayman S. El-Baz*(2); Robert Falk (3), (1) Medical School; (2) Bioengineering Department; (3) Department of Radiology, Jewish Hospital, University of Louisville Automatic diagnosis of lung nodules for early detection of lung cancer is the goal of a number of screening studies worldwide. With the improvements in resolution and scanning time of low dose chest CT scanners, nodule detection and identification are continuously improving. In this work we introduce a new template for nodule detection using level sets, which describes various physical nodules irrespective of shape, size and distribution of gray levels. This new template is used in a CAD system for automatic detection and classification of lung nodules which has been under development by the team of this work. The CAD system consists of three main steps:

the first step isolates the lung nodules, arteries, veins, bronchi, and bronchioles from the surrounding anatomical structures; the second step detects lung nodules; and the final step eliminates the false positive nodules (FPNs) using features that robustly define the true lung nodules. We show quantitatively that the new template modeling approach drastically reduces the number of false positives in the nodule detection. We compare the performance of this approach with respect to human experts. The impact of the new template model includes: 1) flexibility with respect to nodule topology â&#x20AC;&#x201C; thus various nodules can be detected simultaneously by the same technique; 2) automatic parameter estimation of the nodule models using the gray level information of the segmented data; and 3) the ability to provide exhaustive search for all the possible nodules in the scan without excessive processing time â&#x20AC;&#x201C; this provides an enhanced accuracy of the CAD system without increase in the overall diagnosis time. 11. A Novel Framework for Early Detection of Lung Nodules Ayman S. El-Baz*(1) and Robert Falk (2), (1) Bioengineering Department Department of Radiology; (2) Jewish Hospital, University of Louisville A pulmonary nodule is the most common manifestation of lung cancer. Lung nodules are approximately-spherical regions of relatively high density that are visible in X-ray images of the lung. Large (generally defined as greater than 1 cm in diameter) malignant nodules can be easily detected with traditional imaging equipment and can be diagnosed by needle biopsy or bronchoscopy techniques. However, the diagnostic options for small malignant nodules are limited due to problems associated with accessing small tumors, especially if they are located deep in the tissue or away from the large airways; therefore, additional diagnostic and imaging techniques are needed. One of the most promising techniques for detecting small cancerous nodules relies on characterizing the nodule based on its growth rate. The growth rate is estimated by measuring the volumetric change of the detected lung nodules over time, so it is important to accurately measure the volume of the nodules to quantify their growth rate over time. Thus, the objective of this proposal is to develop a clinically usable software tool for early diagnosis of lung 30

POSTER ABSTRACTS cancer. This proposal consists of two main steps: (i) improving the accuracy and consistency of the new methods proposed to process and analyze CT images (e.g., registration of successive CT scans, segmentation of lungs, segmentation of nodules, etc. ) for measuring the growth rate of the detected lung nodules through extensive testing and validation. Feasibility of these methods will also be demonstrated. (ii) Developing probabilistic models of the growth rate for both benign and malignant nodules using the patients' data that will be collected through this study at Jewish Hospital and 3DR, Inc., Louisville, KY. These probabilistic models will be implemented in the proposed software system for early Computer Assisted Diagnosis (CAD) of lung cancer. 12. Cyclopropane Fatty Acid Accumulation in Plant Oil David Hildebrand* and Hirotada Fukushige*, Plant and Soil Sciences Department, University of Kentucky There is an enormous need to meet a greater share of our material needs from renewable resources. The worldwide market for lubricants is about 36 Mt including over 20 Mt for motor oils. The demand for renewable oil is increasing. Plant oils can currently be used as automobile engine oils but only for short periods and do not meet automotive manufacturer’s specifications due to the poor oxidative stability of the unsaturated fatty acids. Solutions to this dilemma include converting the double bonds commonly found in plant oils such as soybean oil into cyclopropyl groups. Such groups can have adequate low temperature fluidity and lubricity + the needed very high oxidative stability. Various organisms including plants are capable of synthesizing and in some cases accumulating cyclopropyl groups in seed oil triacylglyceride (TAG). Certain plants have evolved the capability for selective accumulation of as much as 90% of unusual fatty acids in seed oils and such processes are undergoing intensive investigations. The overall goal is to engineer plants to convert common unsaturated fatty acids that accumulate in seed oils into cyclopropyl groups and selectively transfer these moieties from membrane lipids into seed oil TAG. This will convert normal plant oil fatty acids into forms with superior industrial lubricant properties; high oxidative stability with good flow properties over a wide range of temperatures.

Various plant and microbial sources which naturally produce lubricant fatty acids have been identified and the genes needed for both cyclopropyl synthesis and selective transfer to TAG have been cloned from such sources and are being genetically engineered into major oilseeds that can be produced in Kentucky. This research will enhance both agriculture and industry in KY and elevate Kentucky’s contribution to national goals of reducing our dependence on imported oil. 13. A Molecular Approach to Elucidate the Role of Invasive Mollusk Pests in Kentucky Agriculture James D. Harwood*, University of Kentucky Approximately 15% of global food production is lost annually to pests before it reaches the consumer. Of these, pestiferous slugs are among the most important agents attacking crops in many parts of the USA. Currently there are over 80 exotic gastropods with established populations in the contiguous US and Canada, many of which are significant threats to horticulture, agriculture, urban and natural environments. Current slug control measures are either impractical for large areas (e.g., copper barriers) or only successful against certain species (e.g., biological control with nematodes). While molluscicide use is the most widespread, it is not the most effective means of control with many commercial products being overtly toxic to nontarget organisms. Here, a unique molecular approach is described to examine trophic structure and interaction pathways between native biocontrol agents and invasive mollusks, thus identifying the capacity of generalist predators in suppression of economically important pest species in Kentucky. 14. Characterization of the Plant Polyadenylation Factor FY Lavanya Dampanaboina* and Arthur G. Hunt, Plant and Soil Sciences, University of Kentucky FY is an important component of the autonomous pathway regulating flowering time in Arabidopsis. It is a WD repeat containing protein orthologous to the yeast Pfs2p, which is essential for both cleavage and polyadenylation of pre-mRNAs. FY is proposed to act in its function in flowering as a 3’end processing factor, through an interaction with FCA, a repressor of the general inhibitor of flowering FLC. The FY-FCA 31

POSTER ABSTRACTS interaction promotes the alternative polyadenylation of FCA mRNA itself and results in a truncated FCA protein. We have found that FY is a calmodulinbinding protein, and have localized the calmodulinbinding domain. Using the ability of over-expressed FY to speed flowering, we assayed the effects of mutation of the calmodulin-binding site on FY function; the results suggest that calmodulin binding is important for the flowering function of FY. The flowering experiments were done both in long day and short day conditions using the Arabidopsis plants over-expressing FY, mutated FY in the calmodulin binding domain and just N-terminal domain of FY along with Columbia and glabarous controls to know the effect of photoperiod on calmodulin signaling in regulating flowering time. Currently, we are also studying the accumulation of FY in the cell by fusing different portions of the protein to fluorescent reporter proteins. Recent results of these experiments will be presented. 15. High Throughput Localization of Fungal Secreted Proteins During Colonization of Rice Leaves Oscar Hurtado; Melanie Heist; Michael Goodin; Mark Farman, University of Kentucky Plant pathogenic fungi secrete many proteins with diverse roles in plant-microbe interactions. However, information on the temporal and spatial patterns of protein secretion during fungal infection of plants is extremely limited, so in most cases it is not clear which proteins are expressed/secreted at different infection stages. Likewise, it is not known if secretion occurs at specific locations within invasive hyphae, and if secreted proteins are targeted to specific regions of the pathogen-host interface. In our laboratory, we study the globally-important pathogen of rice, Magnaporthe oryzae. Our goal is to gain a comprehensive insight into protein secretion by M.oryzae as it grows within the plant host. With funding from the Kentucky Sciences and Engineering Foundation, we developed firstgeneration vectors for high-thoughput protein localization in fungi. We modified the pSITE vectors originally developed for plant transformation so that they include a selectable marker for fungal transformation. The resulting vectors utilize GatewayTM cloning technology for efficient production of fusions between proteins of interest and various autofluorescent marker proteins. We will present data showing the use of these vectors for

localization of secreted proteins during M.oryzae infection of rice. 16. A Web-Based Genome Browser for 'SNPAware' Assay Design Theodore S. Kalbfleisch Ph.D.(1), Michael P. Heaton Ph.D(2)., Joseph P. Morris*(1), (1)Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine; (2)USDA, ARS, U.S. Meat Animal Research Center (USMARC) Human and animal genomes contain an abundance of single nucleotide polymorphisms (SNPs) that are useful for genetic testing. However, the relatively large number of SNPs present in diverse populations can pose serious problems when designing assays. It is important to “mask” some SNP positions for assay design algorithms to prevent oligonucleotide primer placement over these sites. This avoids the possibility of allelic dropout. For example, NCBI currently reports 10.6 M and 1.68 M SNPs mapped to the human and bovine genomes, respectively. Not all of these SNPs are polymorphic in populations of interest. To address these and other assay design issues, a web service based system was developed with a web based user interface that makes it possible for a researcher to quickly assess the location and minor allele frequency for SNPs in their population of interest, and make an informed decision as to whether or not the SNP should be masked for the assay design process. The web service application programming interfaces provided with this system make it possible to automate this process for high throughput assay design, implementing logic that will determine which SNPs need to be masked in a particular population. 17. Probing Metal Binding to DNA and RNA Nucleobases with High-Resolution Photoelectron Spectroscopy J. S. Lee, S. A. Krasnokutski, Y. Lei, and D. –S. Yang*, Department of Chemistry, University of Kentucky The presence of metal ions in the cell nucleus affects the formation, replication, and cleavage of DNA and RNA. Depending on the type and concentration, metal ions may stabilize the nucleic acid chain through charge neutralization or disrupt hydrogen bonds by attaching to nucleobases. The nucleobases present in DNA and RNA include 32

POSTER ABSTRACTS cytosine, guanine, adenine, thymine, and uracil; each of these bases offers several different coordination sites for metal ions. The nature and site of metal binding influence base pairing and the course of genetic information transfer. In this project, we have developed a novel approach to probe optimal metal locations around these nucleobases in an isolated environment, where interferences from other chemical species are removed. We use laser-assisted reactions to prepare metal-nucleobase complexes in gaseous supersonic jets, mass spectrometry to measure the abundance and distribution of reaction products, and highresolution photoelectron spectroscopy to search for electronic-vibrational spectra. The outputs of this research include precise thermodynamic quantities, metal binding sites, electronic states and molecular structures. With the preliminary results from this KSEF grant, we have obtained a new research grant from the National Science Foundation. We have published several papers in top journals in the fields of physical chemistry and chemical physics and presented numerous papers at national and international meetings. Moreover, we have trained a group of undergraduates, graduates and postdoctoral students. 18. The Potential of Corn Stalk Rot Fungi for Cellulosic Bioconversion in Fuel Ethanol Production Charles Collins (1); Patrick Heist (2); Lisa Vaillancourt (3); Warren Lushia(2)*, (1) Pikeville College School of Osteopathic Medicine; (2) Pikeville College School of Osteopathic Medicine; (3) University of Kentucky, Department of Plant Pathology Our team evaluated three fungal stalk rot pathogens of corn, Colletotrichum graminicola (strain M1.001) and Fusarium graminearum (strains 3639 and PH-1), for their ability to convert biomass in the form of corn stover to fermentable sugars for subsequent fuel ethanol production by yeast. The growth characteristics and parameters were first established on defined media using glucose and various cellulosic carbon sources. The fungi were then used to convert corn stover into fermentable sugars. We used HPLC to monitor sugar conversion and cellulase assays to measure enzyme production. The potential benefits and drawbacks to using these fungi will be discussed.

19. Copper Regulation of Hypoxia-Inducible Factor-1 Activity in HepG2 Cells Wanli Xue1, Wenke Feng1, Fei Ye1, Zhanxiang Zhou1, Y. James Kang1,2, Departments of 1Medicine and 2Pharmacology and Toxicology, University of Louisville School of Medicine There are increasing evidences shown that copper (Cu) plays an important role in tumor angiogenesis. Cu as a cofactor is required for many key mediators in angiogenesis, such as angiogenin, vascular endothelial growth factor (VEGF), acidic and basic fibroblast growth factor (aFGF and bFGF respectively) and interleukin-8 (IL-8). Cu lowering strategy for inhibition of tumor growth has been successful in animal models and used in several clinical trials for various types of cancers. However, the mechanisms remain largely unclear. The heterodimeric transcription factor hypoxia-inducible factor 1(HIF-1) represents the key mediator of hypoxia response. HIF-1 controls numerous genes of pivotal importance for cellular metabolism, angiogenesis, cell cycle regulation and inhibition of apoptosis. HIF-1 overexpression and enhanced transcriptional activity are linked to tumor initiation and progression. Previous studies have demonstrated that Cu up-regulates HIF-1. The present study was undertaken to test the hypothesis that Cu is essential for HIF-1 activation. Treatment of hepatocellular carcinoma (HepG2) cells with a Cu chelator tetraethylenepentamine (TEPA) or siRNA targeting Cu chaperone for superoxide dismutase 1 (CCS) suppressed hypoxia-induced activation of HIF1. Addition of excess Cu relieved the suppression by TEPA, but not that by CCS gene silencing, indicating the requirement of Cu for activation of HIF-1, which is CCS-dependent. Cu deprivation did not affect production or stability of HIF-1?, but reduced HIF-1 binding to the hypoxia-responsive element (HRE) of target genes and to p300, a component of HIF-1 transcriptional complex. Cu likely inhibits factor inhibiting HIF-1 (FIH-1) to ensure the formation of HIF-1 transcriptional complex. This study thus defines that Cu is required for HIF-1 activation through regulation of HIF-1 binding to the HRE and the formation of HIF-1 transcriptional complex. 20. Synthesis and Characterization of Magnetic Hydrogel Nanocomposites for Hyperthermia-Based Treatment of Cancer

POSTER ABSTRACTS Samantha A. Meenach*, J. Zach Hilt, Kimberly W. Anderson, Department of Chemical and Materials Engineering, University of Kentucky Hyperthermia, the heating of tissue to 42 to 45°C, has the potential to provide an additional method of treating cancer in combination with irradiation and/or chemotherapy. This can be done through the development of systems which can be delivered at tumor sites and remotely heated from outside the body. One such material is hydrogel nanocomposites composed of biocompatible polymeric material and nanoparticulates capable of heating upon exposure to an electromagnetic field. In this work, hydrogel nanocomposites have been developed that can be implanted within a tumor site and deliver both heat and chemotherapeutic agents. The nanocomposites studied include a temperature-responsive, poly(Nisopropylacrylamide)-based system and a stealth, poly(ethylene glycol)-based system, both with and without iron oxide magnetic nanoparticles incorporated into the hydrogel matrices. Heating analysis of the gels was completed and showed the capability of the gels to be heated in a magnetic field. Swelling analysis was done and showed the potential of the gels to imbibe high amounts of water in their swollen state. To examine the hydrogels’ cytocompatibility, NIH 3T3 murine fibroblasts were exposed to the hydrogel systems, and the viability of the cells was not affected by the hydrogels. Finally, M059K glioblastoma cells were heated to thermoablative temperatures (above 55°C) with gels exposed to the AMF and cell death was successful. In summary, these systems ability to heat and their capability to deliver drugs to specific sites make them viable systems for treating of deepseated tumors or reoccurring cancer. 21. O-GlcNAc Signaling Attenuates Mitochondrial Mediated Post-hypoxic Cardiac Myocyte Injury Gladys A. Ngoh* and Steven P. Jones, Institute of Molecular Cardiology and Department of Physiology and Biophysics, University of Louisville O-GlcNAc is a dynamic and inducible posttranslational sugar modification of nuclear and cytoplasmic proteins known to act as a stress signal. We recently showed that augmented O-GlcNAc levels reduced infarct size in mice and attenuated post-hypoxic cardiac myocyte injury. To identify potential mechanisms through which O-GlcNAc

confers cytoprotection, we focused on hypoxiainduced mitochondrial death signals. We adenovirally (with AdOGT and AdO-GlcNAcase) and pharmacologically (with PUGNAc) manipulated OGlcNAc levels in neonatal rat cardiac myocytes (n>/=4/group) prior to hypoxia (3 hours) and assessed mitochondrial calcium (via rhod-2AM), reactive oxygen species production (ROS, via DCF) and mitochondrial trans inner membrane potential (via TMRM) during reoxygenation (1 hour) with time-lapse fluorescent microscopy. Hypoxia induced significant (p<0.05) mitochondrial Ca2+ overload, ROS production and loss of mitochondrial membrane potential. Such stress-induced changes were significantly (p<0.05) attenuated when O-GlcNAc levels were augmented by overexpressing O-GlcNAc transferase (adds O-GlcNAc to proteins) or inhibiting O-GlcNAcase (removes O-GlcNAc from proteins) with PUGNAc. Conversely, overexpression of O-GlcNAcase exacerbated hypoxia-induced mitochondrial Ca2+ overload, ROS production and loss of mitochondrial membrane potential. We conclude that blockade of early events during mitochondrial death may be a potential mechanism through which O-GlcNAc confers cardioprotection. 22. Development of a Plant Based Antiviral Compound for Herpes Simplex Virus S. Sahi*, C. White, S. Kumar, Biology Department, Western Kentucky University Herpes is caused by the Herpes Simplex Viruses type 1 (HSV-1) and type 2 (HSV-2). The World Health Organization estimates that in the USA alone, 40 to 60 million people (ages 12 and older) are HSV infected. In developing countries, HSV infection can vary from 2-74% depending upon age, gender, urban verses rural areas, etc. (WHO 2006). Herpes can cause painful genital sores in many adults, and its infection can be severe in people with suppressed immune systems. Herpes can also make people more susceptible to HIV infection (CDC Fact Sheet, May 2004). Presently, there is no direct treatment that can cure herpes, but antiviral medications have been used to shorten and prevent outbreaks. Thus, our laboratory is focusing on the plant-based pharmaceutical enterprise devoted to the development and management of effective Herpes viral infections. We are currently developing a plantbased compound to treat viral infections. Based on early antiviral efficacy data this product offers the promise of developing a new therapeutic drug for 34

POSTER ABSTRACTS oral or topical applications for HSV infection. Our extensive isolation protocol has resulted in fractions with maximum anti-HSV activity. Single spot having highest activity was isolated using preparative TLC. HPLC analysis of the compound showed four peaks in HPLC chromatogram. Currently efforts are underway for isolation and characterization of the all the active compound(s). 23. Identification of Anti-prion Drugs Active Against Plant Viruses Zsuzsanna Sasvari*, Peter D. Nagy, Department of Plant Pathology, University of Kentucky Identification of Anti-prion Drugs Active Against Plant Viruses Prion proteins are malfunctioned host proteins. These proteins when undergo so called amyloid structural changes become self-propagating and infectious causing currently non-curable neurodegenerative diseases in mammals and humans. Though, a few number of drugs active against prions have been developed and tested in mammalian cell lines, the discovery of yeast prions with similar structural and functional characteristics to mammalian prion proteins made it plausible to develop yeast based high throughput drug screening methods (1). Yeast as a model system is also applicable to study the mechanism of the remodeling of the host cell during viral replication. (2.) We found that many host proteins remodeled by the replication of Tomato bushy stunt virus (TBSV) overlap with those affected by amyloid fibril propagation. Although in most cases the mechanism of the effect of the anti-prion compounds has not yet been revealed, in the few unraveled cases it seems indirect, targeting not the malfunctioned protein but a host regular pathway that influences prion propagation. We tested two groups - acridine and recently developed phenanthridine derivatives of anti-prion compounds as putative antiviral drugs against TBSV, a model positive stranded RNA virus. We found that all the tested compounds inhibited TBSV replication both in vivo and in vitro. Our in vitro assay unraveled that some of the derivatives seem to affect directly the viral RNA thereby inhibiting the viral replication at different steps. Others inhibit viral replication indirectly by changing the cellular environment unfavorably for replication. The targeted steps of the viral replication by the different compounds will be displayed on the poster. [1. Tribouillard D, Bach S, Gug F, Desban N, Beringue V, Andrieu T, Dormont D, Galons H, Laude

H, Vilette D, Blondel M (2006) Using budding yeast to screen for anti-prion drugs. Biotechnol J Jan;1(1):58-67. 2. Nagy PD. Yeast as a model host to explore plant virus-host interactions. Annu Rev Phytopathol. 2008;46:217-42. Review.] 24. Mass Spectral Analysis of PTH Peptides from Plasma Peter Sawaya *, MD and Nicholas Koszewski, PhD, Department of Internal Medicine, Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky The funded project focused on developing a means of capturing and analyzing parathyroid hormone (PTH) by mass spectroscopy that would be amenable to characterization of the peptide from human blood samples. Results indicate that the sensitivity needed to characterize PTH from blood samples is well within reach. However, efforts to immunocapture PTH from controlled conditions using commercially available reagents were unsuccessful. Thus, while the technique appears feasible, there is still more work that needs to be done on isolation of PTH from solution. 25. Misfolded Proteins and Stress Resistance in Plants Jasmina Kurepa (1) and Jan A. Smalle(2)*, (1) College of Agriculture, Dept. Plant and Soil Sciences, University of Kentucky; (2) Kentucky Tobacco Research and Development Center During adverse environmental conditions (e.g., heat shock, UV, drought and oxidative stress) proteins are damaged, lose their proper 3D conformation and unfold. If unfolded proteins accumulate in the cell they can form cytotoxic aggregates (e.g., inclusion bodies in bacteria or amyloid plaques in Alzheimer's patients). One of the essential functions of the 26S proteasome (26SP) is to degrade improperly folded proteins, thus helping the cell to cope with various stress conditions. Our main hypothesis is that the up-regulation of 26SP activity in plant cells leads to an increased tolerance to stresses that induce protein unfolding. To test this hypothesis and to identify the components related to the 26SP that confer stress resistance to plants, we pursued a two-tracked strategy. The main results of both approaches will be presented. 35

POSTER ABSTRACTS 26. Biomedical Instrumentation Based on Sound Produced by Microbes John M. Stencel, Tribo Flow Separations, LLC Tribo Flow Separations has proven sound emanates from microbes during their growth and death. This sound is made up of acoustic signatures measurable in real-time that distinguish whether microbes are experiencing nutrient-rich growth or are under duress as a consequence of inhibition via chemical treatment or virus attack. Microbe viabilities are measurable within three hours after treatment with a simulated antibiotic and virus reproduction periods are dependent on whether the host microbe populations are experiencing logarithmic growth or rapid decline. The focus of the R&D to be discussed is on the characteristics of sound emanating from the microbes. This discussion leads to a prioritization of instrumentation development paths which targets MICA™ (Microbe and Cell Assay) instrumentation first for biomedical R&D and then for clinical and point-of-care applications. 27. A Novel Bioemchanical Approach for Preventing Spinal Disorders Robert Shapiro (1); David Pienkowski (2); William Shaffer (2); Ryan Carter Cassidy (2); David Mullineaux (1); Shaun Stinton* (3), (1) Kinesiology and Health Promotion; (2) Orthopaedic Surgery; (3) Biomedical EngineeringUniversity of Kentucky Disorders of the spine are an expensive and debilitating problem that will grow with the aging population and increasing prevalence of osteoporosis. Our central hypothesis is that static (posture) and dynamic (gait) related abnormal loading of the spine interact with age-weakened tissue to produce a series of degenerative effects that culminate in disc degeneration and spine fractures (>300,000 annually). The ultimate goal of our research is to reduce the incidence and severity of spontaneous vertebral compression fractures. This will be achieved by identifying motion and postural patterns that could lead to increased loading of the vertebrae resulting in “spontaneous” vertebral compression fractures over time. Developing a non-invasive method to measure spinal motion would allow a clinical trial aimed at identifying the key parameters of gait or posture that place subjects “at-risk” for developing such fractures via this mechanism. Identifying at-risk subjects could lead to simple, inexpensive,

noninvasive countermeasures (targeted strength training, orthotics, etc.) that could help prevent/retard the development of these debilitating spinal disorders. The specific aims of the proposed study are: 1. Validate our proposed technique for quantifying spine motion by using skin-based video markers. 2. Obtain upper body kinematic data from normal and pathological (spinal) human subjects. 3. Develop a model to predict abnormal spine kinematics from posture and gait data. Correction of any abnormal kinematic patterns would reducing or eliminate the incidence and severity of spontaneous vertebral compression fractures. This would lead to reduced fractures, improved health of the elderly population (especially women) and reduced healthcare costs. 28. MicroRNA Array Technology and MicroRNA Biomarkers for Various Human Diseases Guiliang Tang*, Xiaoqing Tang, and Yiyou Gu, University of Kentucky The year 2006 Nobel Prize recognized the discovery of a novel family of small RNAs, microRNAs (miRNAs), a name was first given in 2001. Since then miRNAs have been demonstrated to control various human diseases including cancers and diabetes. Loss of these small RNAs activates many unwanted genes. On the other hand, overexpression of these small RNAs suppresses many gene expressions. Consequently, human healthy cells become tumorigenic and hormones loose their regulatory roles. Thus various diseases will develop. We have recently developed and established a method to detect all the identified miRNAs in human bodies. This technology has been successfully applied to identify tumorigenic miRNAs in human prostate cancer and unique change of miRNAs in type-II diabetes. Here, we propose to further update this technology with new miRNA probes, upgrade it to be a technological service by a commercialization. This technology is called microRNA array platform that has been protected by a pending patent with the University of Kentucky, and thus can be commercialized and used for identify various small RNA biomarkers in various human diseases. 29. A Gut Fueling: Termite Lignocellulases Ho ld the Key for Biomass Pretreatments – A Pilot Protein Engineering Study Using Directed Evolution Technology 36

POSTER ABSTRACTS Xuguo "Joe" Zhou (1); Guiliang Tang (2); and Ling Yuan (2), (1) Department of Entomology; (2) Department of Plant and Soil Science, University of Kentucky Termites can efficiently convert 95% of the recalcitrant lignocelluloses into fermentable sugars in their tiny bioreactor hindguts in less than 24 hours. Such efficiency and low energy inputs make termite lignocellulases an ideal enzyme source for biomass pretreatments. However, to size it up to the industry scale (e.g. biorefineries) and to massproduce biofuels efficiently and economically is a totally different challenge. Recent genomic and metagenomic efforts identified over 100 genes from termites and more than 600 genes from termite gut microfauna involved in the enzymatic depolymerization of cellulose, hemicelluloses, and lignin, and several key genes in the lignocellulose digestion machinery have been functionally characterized. The research proposed here is a continuation of these efforts. The overall goal of this research is to develop an iterative process to rapidly evolve sequence variants of selected termite lignocellulases with enhanced industrial (biorefinery) potential. The technology employed in this research is called directed evolution, a general term used in protein engineering to describe various techniques for the generation of mutants (variants) and the subsequent selection of desired functions, and it provides a powerful tool for engineering of novel, desired enzyme properties such as increased activity and pH/temperature stability, altered substrate specificity and resistance to inhibition. The specific objectives for the proposed funding period are 1) to create genetic diversity by constructing enzyme variant libraries; 2) to select enzyme variants with improved/desired function(s) using genetic selection and/or high-throughput screening; 3) to produce selected variant recombinants (mutants); and 4) to compare their physical, enzymatic, and genetic properties with the original recombinant protein (wild type). 30. Integration of Double Stranded RNA into a Baiting System – A Novel Genetic Control Strategy for Termites Xuguo "Joe" Zhou (1); Guiliang Tang (2); Michael F. Potter (1), (1) Department of Entomology; (2) Department of Plant and Soil Science, University of Kentucky

There are over 2,500 species of termites patrolling our planet. Because of their unique capabilities of digesting lignocelluloses, termites truly represent a double–edged sword, for without them the earth would be littered with dead wood. On the other hand, wood-eating termites are considered as one of the most destructive insect pests in the world. The annual damage to urban infrastructures is approximately $15–20 billion worldwide. When combining with the damage to agricultural commodities and forestry resources, the overall loses exceed $30 billion per year. The cryptic nature and tenacious foraging behavior of termites pose a real challenge to control efforts. For years, termite treatments have primarily relied on synthetic chemicals. Millions of gallons of liquid soil insecticide have been applied around perimeters of buildings to block all potential entries of termites. Compared to the traditional “barrier” soil treatment, a more environmentally friendly approach is through baiting, which involves recruiting termites to feed on cellulosic substrates impregnated with low concentrations of slow-acting insecticides. To reduce our reliance on broad-spectrum termiticides and expedite the speed of colony elimination through baiting, we invented a genetically active ingredient to replace the insecticide in the bating system. The actual active agent is a double stranded ribonucleic acid (dsRNA), a genetic messenger between DNA and protein. By interrupting the message transferring processes, termites will lose critical functions resulting in colony collapse and/or mortality. This phenomenon is referred to as RNA interference (RNAi), and it is the underlying mechanism of the dsRNA-mediated genetic control. The advantages of this genetic ally active ingredient over an insecticide are its specificity, effectiveness, and more importantly, it has little or no impact on non-target organisms and environment. 31. Certified Reference Standards and Stable Isotope Internal Standards for Equine Therapeutic Medication Regulation Thomas Tobin(1)*, Wojtek Karpiesiuk(1), Job Tharappel(1) and Charlie Hughes(1), Rodney Eisenberg (2), Gluck Equine Research Center, University of Kentucky; (2) ChemPharma Inc. Richmond, Kentucky Regulators of competitive equine events now explicitly recognize the need for regulatory “cut-offs” or “thresholds” for “trace” residues of therapeutic 37

POSTER ABSTRACTS medications, thus requiring accurate forensic quantitation of trace residues of these medications. This in turn creates a worldwide need for certified reference standards and stable isotope internal standards for equine medication regulation. To address this need we have reviewed these 50 equine therapeutic medications/and or equine therapeutic medication metabolites and where a market opportunity exists, we are synthesizing the appropriate certified reference standards and stable isotope internal standards. To date we have synthesized and are marketing 10 unique equine certified reference standards and or equine drug metabolite standards and the appropriate stable isotope internal standards. Unique equine drug/and or metabolite standards synthesized include HydroxyEthyl Promazine Sulfoxide [HEPS], Carboxydetomidine, Hydroxydetomidine, Methocarbamol, Guaifenesin, Pyrilamine, Flunixin, Ketoprofen, Phenylbutazone, Furosemide and Clenbuterol and their corresponding stable isotope reference standards, usually but not invariably as a deuterated analog. This research project has been made possible by research grant KSEF-959-RDE-008 and also by gifts from the National and State Horsemen's Benevolent and Protective Associations in support of Equine Medication Research at the Gluck Equine Research Center of the University of Kentucky and by intellectual property contributions from ChemPharma Inc. Richmond Kentucky. Marketing of these products will take place through ChemPharma Inc. and Neogen Corp., Lexington, Kentucky. 32. Structure-based Drug Design using Grid Computing Chayanendu Hait (1); John O. Trent* (1, 2), (1) JG Brown Cancer Center, (2)Department of Medicine, University of Louisville Cancer drug discovery and drug discovery as a whole are underrepresented disciplines in Kentucky Institutions. This is mainly due to a lack of tools, expertise, and disease specific molecular targets. At the Brown Cancer Center we have a number of new molecular targets for cancer that are highly amenable for drug discovery. Computational virtual screening of large databases (>13,000,000 compounds) of small molecules against the three dimensional structure of a target protein or DNA can dramatically speed up the drug discovery process. This reduces the actual number of candidate

compounds to be physically tested, hence cost and time are also reduced, while increasing the probability of success. As virtual screening comprises millions of independent events, it is ideally suited for distributed computing over a GRID of computers. However, there is a very limited number of software tools for virtual screening that are optimized for a GRID. Those that are available are not generally accessible to researchers due to expense or lack parameterization for specific proteins and DNA. We proposed to develop a robust set of tools that can be used for GRID deployment, monitoring, and data analysis, in the initial instance for virtual screening. We have one drug that we discovered and developed which is currently in two Phase II clinical trials in leukemia and kidney cancer. Using this technology we have discovered and licensed two drug candidates to Advanced Cancer Therapeutics, with another being licensed in 2009. 33. Detecting and Modeling the Distribtuion of Japanese Honeysuckle, an Invasive Plant Species Jeff Viniard (1)*; Qiaofeng Zhang (1); and Kate He (2), (1) Department of Geosciences; (2) Department of Biological Sciences, Murray State University Invasive plant species constitute a considerable threat to existing ecosystems and land use patterns. The damages these plant species deal to biodiversity and the challenges they present to cultivation amount to millions of dollars lost annually to fight their spread. Japanese honeysuckle (Lonicera Japonica), is one such plant found throughout the southeastern United States, including the state of Kentucky. While a number of factors that encourage its spread and growth are well-known, it remains hard to distinguish on remotely-sensed imagery. This study uses very high-resolution satellite imagery acquired March 2005 to test the efficacy of two algorithms for classifying land cover with the intent of locating areas likely to contain Japanese honeysuckle. Additionally, sample points known to contain Japanese honeysuckle, as well as soils and elevation data, are used to model the distribution of this plant species. 34. Enhancing Protein Expression from the Baculovirus Expression Vector System Bruce Webb*; and Jeremy Kroemer, Angelika FathGoodin, University of Kentucky and ParaTechs Corp. 38

POSTER ABSTRACTS The baculovirus expression vector system (BEVS) is a powerful and versatile eukaryotic protein expression system. The BEVS is being used to express and produce antigens for vaccine development, to manufacture human therapeutics, to develop faster acting biopesticides and as a protein expression system for a multitude of research projects. As a lytic viral expression system, the BEVS is limited by death and lysis of infected cells which precludes protein expression and requires repetitive infection cycles. This results in decreased productivity levels and higher production costs to generate recombinant proteins. ParaTechs Corp. has identified a gene family (vankyrins) from an insect virus that significantly delays death and lysis of baculovirus infected cells while enhancing recombinant protein production. ParaTechs’ vankyrin-enhanced BEVS (VE-BEVS) increased recombinant protein production up to 15 fold when when an intracellular protein or a secreted protein were coexpressed with the vankyrin protein from a dual BEVS (VE-BEVS). When monoclonal Sf9 insect cell lines stably expressing vankyrin protein (VE-CL01, 02, 03) were used to provide the protein activity in trans, a 5-fold increase in intracellular protein production and up to 9-fold increase in secreted protein production was obtained. As with VE-BEVS, an increase in cell viability and prolonged protein expression post-infection was also observed with VE cell lines. ParaTechs’ enhanced VE Sf9 cells are commercially available. ParaTechs’ is also offering a VE monoclonal cell transformation service of customer provided cell lines. Furthermore, VE transfer vectors and additional VE insect cell lines are in late stages of development. 35. Cardiac-specific Hypoxia-inducible Factor1a Overexpression Protects Diabetic Heart in Mice *Wanli Xue1, Lu Cai2,3, Patritia Thistlethwaite4, Y. James Kang1,3, Wenke Feng1, Departments of 1Medicine, 2Pediatrics and 3Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, 4Division of Cardiothoracic Surgery, University of California, San Diego, CA Previous studies have observed a defective angiogenesis and glycolysis in the heart of diabetic patients and in experimental diabetic animals. Hypoxia-inducible factor 1 a (HIF-1a) is known to be a critical transcription factor regulating a variety of key genes involving in angiogenesis and glycolysis in

the heart. In this study, we show that genetic elevation of HIF-1a prevents diabetes-suppressed proangiogenic factor-vascular endothelial growth factor (VEGF) and receptor 2 (VEGF-R2), glucose transporter (Glut-1) and glycolysis enzymehexokinase II (HK-II) in the hearts in a murine model leading to the protection of diabetic heart. Cardiac-specific HIF-1a-over-expressing transgenic (HIF-TG) mice and wild-type controls were treated with streptozotocin (STZ) by a single intraperitoneal injection, and both developed diabetes. However, the development of diabetic heart injury, revealed by histopathological examination and biochemical analysis, was significantly observed only in the wildtype, but not in HIF-TG diabetic mice. Diabetes significantly reduced cardiac VEGF, VEGF-R2, HK-II and glucose transporter Glut-1 in wild-type mouse hearts. HIF-1a over-expression increased VEGF both in mRNA and protein levels under non-diabetic conditions and relieved diabetic-suppressed those changes along with enhanced angiogenesis evaluated by CD31 staining. Furthermore, HIF-1a over-expression attenuates diabetic-suppressed Glut-1 expression and HK-II expression and activity associated with enhanced ATP production. Taking together, the results in this study suggest that HIF1a over-expression in the diabetic heart improves angiogenesis and glucose metabolism leading to the protection against diabetic injury. 36. Simulation of Pulsatile Flow through a Hollow Fiber Cartridge: Growth Factorreceptor Binding Analysis Changjiang Zhang(1)*; Michael Fannon (2); Kimberly Forsten-Williams (3); Jun Zhang, (1) Department of computer Science; (2) Department of Ophthamology and Visual Science; (3)Department of Chemical Engineering; (4) Department of Computer Science, University of Kentucky We introduce a mathematical model for simulating FGF-2 and its binding to receptors, dissociation and transport in capillary in a FiberCell bioreactor. It is assumed that FGF-2 binding and dissociation with receptors only take place on the wall of capillary, and it is transported by media flow . The flow in capillary is modeled as Newtonian laminar flow using a set of nonlinear differential equations, and FGF-2 transport is modeled by a general transport equation with a set of ordinary differential equations to describe this complex binding kinetics. In order to obtain a reasonable accuracy of the binding and 39

POSTER ABSTRACTS dissociation from cells, a uniform mesh is used. To handle pulsatile flow, several assumptions are made including neglecting any entrance effects and an analytical solution for axial velocity within the fibers is obtained. Computational results and experimental measurements are compared and observed to agree quite well, indicating that the simulation model and methods could be used as a complementary and even predictable tool for the study of biochemical reactions in a similar flow environment. 37. Generalized Diffusion Simulation-based Fiber Tracking on Synthetic Phantoms Qi Zhuang, Jun Zhang*, Department of Computer Science, University of Kentucky Diffusion tensor magnetic resonance imaging (DTI) tractography is currently one of the best ways for studying human brain white matter fiber tracts. Many DTI methods are based on standard second order diffusion tensor data. Since the development of high angular resolution diffusion imaging (HARDI), there has been growing interest in tractography based on HARDI. One of those methods is the generalized diffusion simulationbased imaging tractography. We propose a new method based on solving the partial differential equation governing the diffusion simulation process in human brain. The high order diffusion tensor data computed from HARDI are used in our model. We also present a new method to create synthetic diffusion tensor data. The method produces high order synthetic diffusion tensor with several fiber crossing phantoms. Some experiments are performed with both the synthetic diffusion tensor data and the real data in order to verify our fiber tractography algorithm. 38. Association of Sult4A1 SNPs with Psychopathology and Cognition in Patients with Schizophrenia or Schizoaffective Disorder HY Meltzer1, MD Brennan2*, ND Woodward1, and K Jayathilake1., 1. Department of Psychiatry Vanderbilt University, Nashville TN; 2. Department of Biocemistry and Molecular Biology, University of Louisville, and SureGene, LLC, Louisville KY A number of genes located on chromosome 22q1113, including catechol-O-methyltransferase (COMT),

are potential schizophrenia susceptibility genes. Recently, the sulfotransferase-4A1 (Sult4A1) locus within chromosome 22q13 was reported to be linked to schizophrenia in a family TDT study. Sult4A1 is related to metabolism of monoamines, particularly dopamine and norepinephrine, both of which have been implicated in the pathophysiology of the psychopathology and cognitive dysfunction components of schizophrenia. An available, prospectively collected data base was interrogated to determine how three Sult4A1 SNPs: rs138060, rs138097, and rs138110, previously shown to be associated with schizophrenia might be associated with psychopathology, cognition, and quality of life in a sample of 86 Caucasian patients with schizophrenia or schizoaffective disorder. The majority of patients met criteria for treatment resistant schizophrenia and had been drug-free for one week or longer at the time of evaluation. The major findings were: 1) patients heterozygous (T/G) for rs138060 had significantly worse Brief Psychiatric Rating Scale (BPRS) Total and anxiety/depression sub-scale scores, and higher Scale for the Assessment of Positive Symptoms (SAPS) Total scores than G/G homozygous patients; and 2) patients heterozygous (A/G) for rs138097 demonstrated significantly worse performance on neuropsychological testing, specifically on tests of executive function and working memory, compared to patients homozygous for the G and A alleles. RS138110 was unrelated to psychopathology and cognition. These results provide the first evidence of how genetic variation in Sult4A1 may be related to clinical symptoms and cognitive function in schizophrenia, and permit future studies to attempt to replicate these potentially important findings.

HUMAN HEALTH AND DEVELOPMENT 39. SureGene Genome Wide Association Study (GWAS) Visualization Suite M. D. Brennan*, C. Patrick III, and Timothy L. Ramsey, SureGene, LLC Louisville, KY The SureGene GWAS Suite is a Windows application that can be used to build, maintain, and visualize databases of single nucleotide polymorphism association results for whole genome association studies. It allows the user to import PLINK association and regression files (for quantitative traits) as well as custom tab-delimited files, and supports Illumina, Affymetrix, and Perlegen 40

POSTER ABSTRACTS platforms. The program allows import, export, and management of data using Microsoft SQL Server 2005 Express, a freeware program available to windows users. Results can be graphed based on chromosomal position or tied to a specific gene name. Results for multiple disease states and/or phenotypes can be graphed simultaneously regardless of the platform. SNP identifiers and active links to the NCBI information for each SNP are available by zooming in on specific graphed regions. If PLINK is installed on the same computer, the graphic interface makes it possible to evaluate runs of homozygosity, haplotypes, and genetic models for the specific region and to create input files for Haploview. If Haploview is installed, the graphic interface allows the generation of SNP-based haplotype data for the specified chromosomal segment. Interested individuals can download a free 30-day trial version of the software from SureGene’s web site at: http://suregene.net/gwas.aspx 40. Development and Beta Testing of Web Assisted Recovery (WAR) Richard N. Cloud (1)*; Dru Kemp (1); Pat McKiernan (1); John Collins (2), (1) University of Louisville Kent School of Social Work; (2) V-Soft Consulting, Louisville, KY Addiction is a chronic relapsing condition affecting the addicted individual, their families, and the public. The annual cost of substance abuse exceeds $181 billion dollars per year to government and $6,000 to the family of the addicted person. While conventional addiction treatment works for some, studies consistently report that a vast majority relapse in the year following treatment. Other research describes significantly improved outcomes from low-intensity monitoring and support extended across the first year or two following treatment. The Web assisted recovery (WAR) project developed and beta tested a unique, low-cost ($5/mo) system, that supports efficient monitoring of recovery risk and progress. The system fully integrates with the current standard of professional treatment; i.e., a 12 step program approach that focuses on “one day at a time” and suggests a written daily 10th step inventory to assess relapse risk and recovery progress. The WAR system daily entry requires five minutes to respond to 60 risk and protective items, which are compiled into multiple reports summarizing trends in 12 recovery domains, across time (longitudinal) and in comparison to similar

others (normative data). Failure of an individual to complete the daily inventory—or automated scoring of relapse prediction scales suggesting elevated relapse risk potential—triggers email notification to preregistered stakeholders (e.g., invested family, concerned others, counselors, case managers, clergy, sponsor, friends, etc.) who are instructed on how to provide timely support and intervention. The WAR system also represents data collection infrastructure to support several lines of future recovery management research. 41. Development and Implementation of a Theoretically-Based Intervention to Promote Healthy Caregiver-Child Attachment Emily M. Fister *; Paulette Flores; Crystal Day; Dr. Barbara M. Burns, University of Louisville, Department of Psychological and Brain Sciences Attachment between a caregiver and child has been shown to have significant importance in the child’s development and later outcomes. Previous work by our Early Intervention for Families Lab funded by KSEF demonstrated that maternal sensitivity is crucial to the development of a secure, healthy caregiver-child attachment and, thus, should be the focus of early intervention. The current research program describes the development and implementation of a sensitivity intervention program with families facing multiple risks due to economic deprivation. Expanded upon from a nationally recognized early intervention curriculum, the Louisville: First Relationships program is a 12-week strength-based group intervention aimed at supporting sensitive caregiver-child relationships to promote healthy social-emotional development of the child. Louisville: First Relationships includes topics on children’s social and emotional needs, the development of trust and security, and the importance of caregiver-child playtime. To accomplish the program goals, sessions incorporate the presentation of educational information, group discussions, and reflections of caregiver-child relationships. Reflections are supported by weekly videotaped reviews of caregiver-child interactions, which allow caregivers to observe and discuss their interactions with their child from a different perspective. To evaluate the effectiveness of the Louisville: First Relationships program, families are currently participating in a randomized-control study. It is hypothesized that families participating in the program will demonstrate increases in caregiver 41

POSTER ABSTRACTS sensitivity and interactive caregiver-child ratings, resulting in a more nurturing relationship with their child, leading to more positive child outcomes. Moderators and mediators include assessments of caregiver depression, stress, and anxiety, and child social and emotional behavior. 42. Interaction Between Morphine and Norketamine Enantiomers in Rodent Models of Nociception Joseph R. Holtman, Jr.*1,2, Peter A. Crooks 2, Jaime Johnson-Hardy 1, Elzbieta P. Wala1, 1 Anesthesiology/ Pain Medicine, College of Medicine; 2 Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Ketamine, one of a few clinically-available N-MethylD-aspartate (NMDA)-receptor antagonists, is known to improve the analgesic efficacy of opioids in humans and rodents. However, the use of ketamine in combination with opioids is mainly restricted to the perioperative setting, due to severe psychotomimetic, sedative and motor side effects. Recent data from our laboratory demonstrated that a major metabolite of ketamine, norketamine, in particular the S(+) enantiomer, had a better antinociception/side effects profile than ketamine in rats. It is unknown if norketamine affects opioid antinociception. In the present study, morphine (a low-dose) was combined with S(+)- and R(-)norketamine (sub-antinociceptive doses) and characterized utilizing rodent models of pain, including: thermal nociception (the tail-flick test), peripheral neuropathy (chronic constriction nerve injury) and tonic inflammatory pain (the formalin test). The data showed that: 1) Norketamine enhanced morphine antinociception and blocked tolerance to this effect; 2) Norketamine potentiated morphine effectiveness in the alleviation of symptoms resulting from injury to nerve (mechanical hyperalgesia, tactile allodynia) and peripheral tissue (formalin-induced nociceptive behavior); 3) S(+)norketamine was more potent than R(-)norketamine; 4) Antinociception was not confounded by significant side effects. Morphine-S(+)norketamine combination drug therapy may prove clinically useful for the alleviation of acute and chronic pain of differing etiology.

43. ProteoTAG Systems: Advancing Chemical Proteomics for Therapeutic Development and Diagnosis Paola Bargagna-Mohan, Riya Paranthan*, Sung Hee Park, Kyung Bo Kim and Royce Mohan, University of Kentucky The global market for identification of novel diseaserelated proteins has unveiled the post-genomic era of proteomics. This field is a complex research undertaking that incorporates multiple stages and utilizes a variety of techniques and technologies to characterize proteins and study their various biomolecular interactions with associated factors. To address this information gap in the cancer and nononcology disciplines of angiogenesis-dependent diseases, we have developed a novel and versatile chemical proteomic reagent ProteoTAG-001. ProteoTAG-001 has been developed from our extensive pharmacological studies with the small molecule inhibitor AG-001, a drug that potently inhibits the growth of pathogenic new blood vessels (angiogenesis), an underlying condition associated with such global pathologies as tumor growth, arthritis, age-related macular denegeration and corneal diseases. Using ProteoTAG-001 as a chemical probe, we demonstrate that the type 3 intermediate filament (IF) protein, vimentin, is targeted. Vimentin is a widely studied target for cancer diagnosis and angiogenic processes. We have exploited ProteoTAG-001 to isolate other key intracellular proteins that associate with vimentin as a means of investigating the pathogenic proteomic environment that facilitates vimentin overexpression. The novelty of ProteoTAG-001 is its versatility for intracellular high affinity binding activity to its binding target, specificity for type 3 IF proteins and the scalability for proteomics applications. Through this Kentucky Commercialization Funding mechanism we want to advance ProteoTAG-001 as a proteomic reagent for the study of type 3 IF proteomics. Our goal is to leverage partnerships on specific fields of use with one or more partners who have the marketing and sales capabilities in the biomedical, pharmaceutical and clinical diagnostic global markets. 44. Bone Cement for 21st Century Arthroplasty Alison Tickle (1); David Pienkowski (1,2) ; Mauro Giordani (2) ; Brock Marrs (3), (1) Center for Biomedical Engineering; (2) Department of 42

POSTER ABSTRACTS Orthopaedic Surgery; (3) Center for Applied Energy Research; University of Kentucky The purpose of this study is to determine if adding multi-wall carbon nanotubes (MWNTs) to antibiotic laden acrylic bone cement will improve the effectiveness of the antibiotics in revision surgeries. Thermal analysis testing will determine whether MWNTs lower the polymerization temperatures of antibiotic bone cement, which may enhance the therapeutic efficacy of the added antibiotics. In vitro quantitative antibiotic elution studies will be used to study the passage of antibiotics out of the cement. Understanding the role MWNTs play on bone cement polymerization temperatures and accompanying antibiotic potency will help reduce the rate of postop infections (especially in revision arthroplasty) and result in reduced healthcare costs and improved outcomes of resurfacing and total joint arthroplasties. 45. Alternative Bone Graft Solutions Michael J. Voor, Ph.D., Eric Yoder, B.S., Jeffery Borden, M.Eng. Robert L. Burden, Jr.,, MEng, E.I.T., Orthopaedic Bioengineering Laboratory, University of Louisville In orthopaedics bone grafts are often used to restore load bearing function when it has been lost. The ideal bone graft should also be implantable through minimum surgical exposure, fill and conform to any irregularities at the implantation site, and promote incorporation and rapid new bone formation by the host. Our objective in this project was to improve upon existing technology that uses hydroxyapatite cement (HAC) as a resorbable bone void filler material. The existing technology is not ideally resorbable not is it strong enough to meet all of the requirements of a bone graft substitute. We have tested the hypothesis that adding processed bone graft particles to an existing HAC improves its strength and rate of incorporation in a rabbit model of cancellous bone defect healing. Our results indicate that our unique combination of HAC and xenograft bone particles does incorporate faster and has the potential to be significantly stronger than currently available HAC. 46. Hip Fracture Prevention Technology Michael J. Voor, Ph.D., Orthopaedic Bioengineering Laboratory, University of Louisville

Hip fractures represent a significant cost to world health both in terms of morbidity and mortality as well as in monetary costs to the health care industry. There will be over 500,000 hip fractures in the US alone in 2010. Over 95% of these fractures occur in the older population and are caused by a fall to the side with impact to the region of the hip. Of these 500,000 patients, nearly 25% will die within one year of their fracture. Thus, preventing hip fractures has the potential to save as many as 125,000 lives per year. Our technology directly addresses the problem of hip fractures caused by a fall to the side. Prototypes are being developed and mechanical testing data are being collected to demonstrate the strengthening effect of our technology in the bones susceptible to fracture under this mechanism. 47. Creation of Long-Term Diabetic Rabbits for Wound Research Jianpu Wang* 1, Rong Wan 1,2, Yinqin Mo 1,2, Ming Li 1, Qunwei Zhang 2, and Sufan Chien 1,, 1 Department of Surgery and 2 Department of Environmental and Occupational Health Sciences, University of Louisville Purpose: Short lived diabetic rabbits (<2 months) have severely limited the diabetic wound research capabilities. This study was to create long time survived rabbits for wound study. Methods: 1. Alloxan (100 mg/kg) was given intravenously to 16 young New Zealand rabbits. Glucose was provided for 2-3 days. Another 12 normal rabbits were used for comparison. 2. Insulin was given daily after diabetes was developed. 3. Blood glucose was measured daily then weekly. Blood chemistries were measured weekly and monthly. 4. Wounds were made on the ears at different times and healing was compared. 5. Six rabbits were sacrificed at 9 or 12 months and histology and molecular biological studies were performed. Results: 1. Hyperglycemia (400-600 mg/dl) developed within 48 hours after alloxan. 2. All the animals developed the typical signs of diabetes gradually. 3. Hypertriglyceridemia, increased blood urea nitrogen and creatinine, and ketoacidosis were found in some animals. 4. Histologically, the pancreas showed marked beta cell damages and thickened arterial walls. The kidney showed thickened afferent glomerular arterioles and narrowed lumens along with glomerular atrophy. 5. There was no difference in wound healing times between 2-week diabetic rabbits and non-diabetic 43

POSTER ABSTRACTS rabbits. Wound healing was delayed gradually in the rabbits with 3-month or longer diabetic times. Conclusion: With careful management, alloxaninduced diabetic rabbits can be kept for a year with reasonably good health for wound study. Wound healing was delayed only in longer diabetic animals. This study is supported by NIH grants DK74566, AR52984, and KSTC matching fund.

further result in endothelial dysfunction through production of cytokines such as IL-6. Our results suggest that endothelial oxidative stress may be an important mechanism for PM-induced cardiovascular effects

49. Reuse of Data Modeling Patterns Solomon Antony *, Murray State University 48. Activation of Endothelial Cells after Exposure to Ambient Ultrafine Particles: The Role of NADPH Oxidase Yiqun Mo*, Rong Wan, Sufan Chien, David J Tollerud, Qunwei Zhang, Department of Environmental and Occupational Health Science, and Department of Surgery, University of Louisville

This presentation describes the design of a website that can be used for (a) developing data models by reusing patterns, and (b) conducting online experiments where task, display and feedback characteristics can be manipulated.

Background. Several studies have shown that ultrafine particles (UFPs) may pass from the lungs to the circulation because of their very small diameter, and induce lung oxidative stress with a resultant increase in lung epithelial permeability. The direct effects of UFPs on vascular endothelium remain unknown. We hypothesized that exposure to UFPs leads to endothelial cell O2.- generation via NADPH oxidase and results in activation of endothelial cells. Methods. We collected UFPs using a nano-MOUDI cascade impactor in the downtown Louisville area, Kentucky. The size of UFPs was analyzed by a JEOL JEM-2010 F field-emission TEM. To determine the chemical makeup in UFPs, elements were analyzed by means of energy-dispersive X-ray fluorescence (XRF) spectrometry. We determined the cytotoxicity effects and the ability of UFPs to generate reactive oxygen species (ROS) on mouse pulmonary microvascular endothelial cells (MPMVEC) in vitro and in vivo. To identify if activation of NADPH oxidase was involved in MPMVEC ROS generation with exposure to UFPs, ROS scavenger N-acetyl-Lcystein (NAC) and catalase (CAT), and the NADPH oxidase inhibitor diphenyleneiodonium chloride (DPI), and mitochondrial inhibitor, rotenone, were selected to pre-treated with cells. p67phox siRNA technique, real-time PCR and gp91phox knock-out mouse were also used in this study. Activation of MAPKs was determined by Western-blot. Conclusions. Our findings confirm that UFPs can cause endothelial cell to generate ROS directly via activation of NADPH oxidase. UFP-induced ROS lead to activation of MAPKs through induced phosphorylation of p38 and ERK1/2 MAPKs that may

50. Dynamic, Distributed Real-time System for Geosystems Health Monitoring L. Sebastian Bryson*; April Barnes; and Tom Lutz, Civil Engineering, University of Kentucky Each year, the U.S. and countries around the world experiences failures of various geosystems as a result of natural or manmade changes to the static equilibrium state of the systems. These geosystems include all geotechnical-based systems such as cut and natural slopes, earth and earth retention structures, embankments, and foundation systems. Failure of these geotechnical based-systems often results in great human suffering and can cause billions of dollars in losses. Geosystem health monitoring (GHM) involves temporal and spatial assessment of system response during manmade or natural environmental change events. From those assessments, forward predictions of geosystem response are developed which can later be used to provide warnings if the system response exceeds systems limits. This research will develop a reliable and cost effective health monitoring system that has the capability of real-time remote monitoring of geosystem response to dynamic changes to the static equilibrium state. A GHM system based on wireless technology is suggested as such a system. This system will form the backbone of a ubiquitous sensor network that will provide an early warning system for emergent problems and will facilitate a better understanding of the underlying geotechnical phenomena.

POSTER ABSTRACTS 51. Portable Digital Mouth and Occlusion Reproducer Fuhua (Frank) Cheng*; Conglin Huang; Yong Li; Fengtao Fan; Jianzhong Wang, Department of Computer Science, University of Kentucky A product consisting of an imaging system, a PC (or a laptop) and supporting computer software that is capable of reproducing the mouth and the occlusion of a dental patient will be developed. These components are mounted on a small wheeled table to ensure easy mobility in a dental clinic and a dental lab. A dentist uses the imaging system to get data points for the reproducing process, instead of using the traditional impression taking approach. The reconstructed 3D computer models can be used as a diagnostic aid for treatment planning. They can also be used for patient education. 52. Improving Local Water Supply in Rural Communities via a Sensor Network Andrew Ernest*(1); Karla Andrew (1); Ni-bin Chang (2); Ammarin Makkeasorn (2); Yuming Fan (2), (1) Center for Water Resource Studies, Western Kentucky University, (2) University of Central Florida There are nearly 60,000 community water supplies in the United States serving over 226 million people. Larger utilities typically protect themselves from accidental, or malicious, discharge of harmful vectors into drinking water supplies by installing complex and expensive real-time monitoring and control technologies. Most online sensors detect physical and chemical parameters. Newer sensor technology attempts to provide real-time detection and identification of microorganisms to significantly reduce the risk of contaminated water reaching the end-users. One of the critical issues in water utility management is how to utilize existing physical/chemical and newly-developed biological sensors to aid in the design of emergency preparedness and response systems in the near future. The proposed research aims to help rural communities efficiently and cost-effectively complete the deployment of sensors and sensor networks for monitoring water supply systems in a user-friendly environment with the aid of a rule-based expert system embedded in a geographical information system (GIS) platform. The design-basis involves developing a customized sensor and control/response network, a rule-based expert system, and the analysis, display and response

methods that enhance a unique spatial visualization leading to promote the interactions between the designers, the operators, and the end-users. System costs will be minimized by using the expert system to design a sensor network that triggers response based on changes in overall system state, rather than the more expensive route of detecting specific intrusions with vector-specific sensors. Data was created using the system utilizing a new tool within the platform developed by CWRS. 53. Business Risk Management / Continuity Planning Software Frank Braun (1)*; Lee Weiner (2); Mark Gallondorn* (3); Logan Newell (2), (1) Business Informatics; (2) Computer Science; (3) Entrepreneurship, Northern Kentucky University Today, with growing organizational dependence on information technology and systems, the potentially devastating impact of man-made and natural disasters on business processes and financial and employee well being is now greater than ever. It is estimated that up to 60 percent of companies without a well-conceived and tested business continuity plan go out of business within two years of a major disaster. Furthermore, with the implementation of legislation such as Sarbanes Oxley (SOX) and the Gramm-Leach-Bliley (GLB) Act, organizations are now required to have documented disaster recovery and continuity plans. These plans must be guided by and based on a risk management process which identifies and ranks (based on probability and severity) events that can impact business operations. These events could range from a weather related power outage, to a total facility loss via a terrorist act. This Business Continuance and Risk Management Software application enables organizations to proactively manage risks that can impact business operations in the event of an unplanned disruption. The software supports the discovery, determination and documentation process that enables organizational risks to be identified and rated for overall business process impact and continuity requirements. There are no inexpensive PC based software applications that help identify and record business risks and mitigation strategies which are part of a business continuity plan. This software application also provides basic business process mapping functionality (also required in a Business Continuity Plan). 45

POSTER ABSTRACTS 54. Scanning 3-Dimensional Facial Expressions in Motion Laurence G. Hassebrook*; Walter Lundby; Mike Troy, University of Kentucky Animation for movies (special effects SFX) and video games is a time consuming, largely manual process requiring skilled animators. The result is an increase in development costs and a scarcity of skilled resources. Attempts to address this problem with technology are extremely expensive and/or results are of unacceptable quality. We have developed an advanced technology suite for capturing 3Dimensional Data of surfaces, either stationary or moving through time. The technique uses Structured Light Illumination which is basically the projection of a pattern onto an object from one angle, followed by the capturing of the pattern from another angle. The distorted image is processed to extract an accurate 3-D representation of the surface. Our systems have been developed to be highperformance in accuracy, capture at video rate and allow for multiple machines to simultaneously scan an object from different directions to get a surround scan. 55. An Initial Framework For Assessing Legal Risks in Network Forensic Probing and Monitoring: The Issue of Authorized Access Michael Losavio8; Olfa Nasraoui; Vincent Thacker; Jeff Marean; Nick Miles; Roman Yampolskiy; Ibrahim Imam, University of Louisville We propose an initial framework for identifying risks of basic legal problems in network forensics across public networks by investigators and researchers. In particular, we examine use of basic TCP/IP and HTTP functions in P2P networks that have been assumed legal but whose legality has not been formally addressed as to the issue of authorized access.

INFORMATION TECHNOLOGY AND COMMUNICATIONS 56. An Introductory Legal Framework for Node Base Probing and Monitoring Investigations Olfa Nasraoui, Michael Losavio, Vincent Thacker, Jeff Marean, Nick Miles, Roman Yampolskiy, Ibrahim

Imam., Department of Computer Engineering and Computer Science, University of Louisville Analysis of possible legal issues for investigations of misuse of networks can help avoid misunderstandings as to the application of law to computer and network conduct, particularly for peer to peer networks. This is important for researchers who wish to avoid legal entanglements in the course of their work. It is critical for investigators working under time deadlines or scope problems without the luxury of extensive, available legal counsel. It is therefore essential that any network research that seeks to address misconduct in the use of networks, whether of contraband transactions or other illegal activity, take into account possible legal restrictions on network activity. We propose an initial framework for identifying risks of basic legal problems in network forensics across public networks by investigators and researchers. In particular, we examine use of basic TCP/IP and HTTP functions in P2P networks that have been assumed legal but whose legality has not been formally addressed as to the issue of authorized access. “Authorized Access” is a sui generis definition of computer-related conduct addressing concerns found with the application of traditional concepts of trespass and invasion of privacy. Criminal and civil prohibitions on trespass sought to protect against physical intrusion or interference with property, yet prosecutions for trespass via electronic interaction with a computer had to address the lack of physical invasion of the property. The idea of “access” as an element was developed for such situations; “authorized access” delineated permitted and unpermitted access to data and system resources. Digital forensics analysis of network distribution of contraband material occurs in a variety of environments. These range from local examination of a local machine on the network to the active harvesting of data by a local machine crawling the network, including through through a node-based probing and traffic monitoring. Active harvesting of network data is the most aggressive. Thus, we examine the legal implications for a local peer machine that may probe or monitor a P2P network. This may be generalized to other types of network investigation.

POSTER ABSTRACTS 57. Architecture Analysis of Peer-to-Peer Data Exchanges Nick Miles, Olfa Nasraoui, Vincent Thacker, Jeff Marean, Michael Losavio, Carlos Rojas, Jim Carreer, Derek Reese, Adel Elmaghraby., Department of Computer Engineering and Computer Science, University of Louisville We examine the architecture of peer-to-peer (P2P) data exchanges for opportunities to capture data on the transfer of contraband data with a focus on node structures. P2P networks offer a very attractive platform for participants in contraband information exchange due to the sense of â&#x20AC;&#x153;anonymityâ&#x20AC;? that prevails while performing P2P transactions. P2P networks vary in the level of preserving the anonymity of their users. The anonymity comes from the idea that in a broadcast-based P2P retrieval, a query is initiated at a starting node, then it is relayed from this node to all nodes in its neighborhood, and so on, until a matching information is found on a peer node, in which case a direct communication is established from the initiating node and the last node to transfer the content. This examination of P2P data architecture has a primary technical focus but is also concerned with reviewing legal aspects of P2P use, leading to new knowledge for the design and testing of digital forensic and investigative tools and protocols. Our computational research includes the following components: 1) Undercover Node-based Probing and Monitoring to Build an Approximate Model of Network Activity. 2) Flagging Contraband Content (key word, hashes, other patterns). 3) Evaluation against different recipient querying, distribution and routing cases. 4) Using the Evaluation results to fine-tune the node positioning strategy. Wellcontrolled experiments that use a simulated network topology with several ground truth scenarios representing different recipient querying, distribution and routing cases will be tested. Legal research will examine the U.S. and transnational legal constraints on the use of particular tools and assure proper exploration of these issues. 58. The Use of Deltorphin Dvariant for Treatment of Stroke Peter R. Oeltgen (1) *; Paul D. Bishop (2); Thomas H. O'Daniel (3), (1) Pathology and Toxicology, Univ. KY Col. Med.; (2) ZymoGenetics, Inc.; (3) HiberNetics, Inc.

Stroke is the third leading cause of death in North America and the chief cause of chronic disability. In 2001, more than 750,000 individuals suffered an acute stroke, and there are as many as 4.8 million chronic stroke survivors. The economic impact on our health care system for acute and chronic stroke care in 2007 was estimated to exceed $50 billion dollars. Effective therapy for stroke remains to be established, despite numerous studies undertaken to elucidate its complex pathophysiology. Intravenous tissue plasminogen activator (tPA), an antithrombolytic agent, is beneficial in ischemic stroke, but is used in less than 5% of all stroke patients because of reluctant physician acceptance due to concerns over the complication of inducing bleeding within the brain. Our research has shown that novel opioid-like hibernation factors originally isolated from skin secretions of the South American frog genus Phyllomedusa referred to as Deltorphins act as metabolic inhibitors and provide protection to organs and tissues exposed to decreased oxygen levels as occurs in stroke, heart attack, and severe hemorrhage by blocking the inflammatory process leading to cell injury and death. We have demonstrated that injection of one of these Deltorphins, Deltorphin Dvariant (Delt-Dvar), can decrease brain injury and limit neurological deficits of mice exposed to stroke-like conditions during 1 hr of middle cerebral artery occlusion (MCAO) and 24 hr of reperfusion without the concern for inducing brain bleeding. Our studies indicate that Delt-Dvar has the potential of becoming a desperately needed therapeutic intervention for stroke. 59. Fast and High Accuracy Computation of 2D Convection Diffusion Equations with Variable Coefficients Yin Wang* and Jun Zhang, Department of Computer Science, University of Kentucky We present an explicit sixth order compact finite difference scheme for fast high accuracy numerical solutions of the two dimensional convection diffusion equation with variable coefficients. The sixth order scheme is based on the well-known fourth order compact schemes, the Richardson extrapolation technique, and an operator based interpolation scheme. For a particular implementation, we use multiscale multigrid method to compute the fourth order solutions on both the coarse grid and the fine grid. Then an operator interpolation scheme combined with Richardson extrapolation technique is 47

POSTER ABSTRACTS used to compute a sixth order accurate fine grid solution. The numerical results show us that the new sixth order scheme is efficient, accurate and robust. 60. Privacy Preservation in Social Networks Lian Liu, Jun Zhang*, Department of Computer Science, University of Kentucky With the development of emerging social networks, such as Facebook and MySpace, security and privacy threats arising from social network analysis bring a risk of disclosure of confidential knowledge when the social network data is shared or made public. We study a situation, such as in a business transaction network, in which weights are attached to network edges that are considered to be confidential (e.g., transactions). We consider perturbing the weights of some edges to preserve data privacy when the network is published while retaining the shortest path and the approximate cost of the path between some pairs of nodes in the original network. We develop a Gaussian randomization multiplication and a greedy perturbation algorithm based on graph theory. In particular, the second strategy not only yields an approximate length of the shortest path while maintaining the shortest path between selected pairs of nodes, but also maximizes privacy preservation of the original weights. We present experimental results to support our mathematical analysis. 61. Runway Control Using Smart Sensor Network Biswajit Panja (1)*; and Siddhartha Bhattacharyya (2)*, (1) Morehead State University; (2) Kentucky State University* Runway mishaps occur due to the lack of real time monitoring and time gap in alerting on diagnosing a severe condition. The event response time gap can be reduced by deploying automated technology to handle constant 24/7 monitoring, and alerting on severe condition detection by transmitting a warning signal. One such technology we propose is the deployment of wireless sensor network to detect errors/faults on the runway and transmit warning messages to the pilot and air traffic controller in real time. With wireless sensor network deployment, crashes like that of Comair 5191 could be avoided as the pilot would be instantly notified of the length of runways based on signals received from the sensors

deployed on different runways in an airport. The wireless sensor network could also detect severe weather conditions which can go undetected by human beings thus preventing further loss of lives. MATERIALS SCIENCE AND ADVANCED MANUFACTURING 62. Effects of Annealing on Microstructure of Osmium-Ruthenium Thin Films Wen-Chung Li (1); Scott Roberts (2); T. John Balk*, (1)Chemical and Materials Eng., University of Kentucky; (2) Semicon Associates A typical dispenser cathode is composed of a barium (Ba) impregnated porous tungsten (W) pellet covered by a thin film of a platinum group metal that reduces the work function for electron emission. To improve cathode lifetime, osmium-ruthenium (OsRu) is an ideal coating material because the OsRu film can lower operating temperature, enabling longer lifetime. In this collaborative study between the University of Kentucky and Semicon Associates in Lexington, KY, the effects of annealing on microstructure, texture and composition of OsRu films (150-550 nm thickness) have been investigated. Films were deposited at UK and compared to standard films produced by Semicon. UK films exhibit significantly different microstructure and texture in the as-deposited and annealed states, as compared to Semicon films. UK films have a denser grain structure and strong {0002} film texture (the {0002} plane has the highest atomic packing density in the hexagonal close-packed structure of OsRu). Formation of this denser OsRu texture component may be related to the high compressive stress in UK films. It is hypothesized that dense OsRu films can inhibit diffusion of W atoms from the substrate through the OsRu film, thus avoiding an excessive W content on the emitting surface, which can shorten the cathode lifetime. In addition, all UK films exhibit higher stability for texture and composition during annealing. UK and Semicon films will be compared and discussed in light of properties for improved cathode lifetime. 63. Nanoporous Nickel As an Alternative to Raney Nickel Lei Wang and T. John Balk*, Chemical and Materials Eng., University of Kentucky 48

POSTER ABSTRACTS

The goal of this project is to develop nanoporous nickel (np-Ni) as an alternative to Raney Ni, and also study the mechanical behavior of the nanostructured nickel. Research to date has focused on determination of optimal alloy composition and fabrication conditions for producing thin film np-Ni. This has yielded np-Ni with pore sizes as small as several nm. Thin films of a Ni-Cu alloy have been deposited by magnetron sputtering and dealloyed in an etchant that preferentially removes copper. As opposed to the traditional leaching method for producing Raney nickel, this process avoids the absorption of hydrogen within the nickel pores (which makes Raney nickel pyrophoric). The optimal composition of a precursor Ni-Cu alloy lies in the range of 30-35 at% Ni. The finest nanoporous structure obtained so far exhibits pores 15-20 nm in diameter, which is the same length scale as Raney Ni. However, the final composition of the nanoporous film is ~45 at% Ni (i.e. slightly copperrich), even though the etchant does not etch pure nickel. Future work will focus on producing higher purity np-Ni nickel by changing the dealloying process and/or the alloy system, and then measuring the mechanical properties of np-Ni thin films. 64. Impression Creep of Pb Rong Chen* and Fuqian Yang, Department of Chemican and Materials Engineering, University of Kentucky The impression creep behavior of Pb was investigated using a flat-ended, cylindrical punch. Impression creep tests were performed over an impression stress range of 11.1-34.6 MPa in a temperature range of 343-443 K. A flat-ended cylindrical steel punch with a diameter of 0.3 mm was used for all the tests. A steady state was observed for low stresses. Recrystallization was observed for high stresses with a sudden jump on the impression time-depth curves. The steady state impression velocity did not change with the recrystallization, suggesting the recrystallization is associated with the release of local residual stress. The steady state impression velocity of Pb followed the power law stress dependence. For the temperature lower than 403 K the stress exponent was in the range of 2.1-3.9, with the activation energy of 25.6-41.6 kJ/mol at low stress region. For high stress region the stress exponent is 7.5-9.0 and

the activation energy is 51.1-63.3 kJ/mol. For temperature higher than 403 K, the stress exponent was 5.6-6.6, with the activation energy of 76.5119.5 kJ/mol which is close to the activation energy for self-diffusion. For the punch size effect, power law relation can be applied to all punches. 65. Electrochemical Method for Fabricating Metal/Molecule/Metal Junctions and Their Sensing Applications Radhika Dasari* and Francis P. Zamborini, Department of chemistry, University of louisville Here we describe a simple electrochemical approach for fabricating Electrode/metal nanowire/molecule or polymer/Electrode junctions for sensing or molecular electronics applications. The general procedure involves depositing a thin film (self assembled monolayer or polymer) on one electrode (E1) and electrodepositing an Ag metal nanowire (NW) on a second electrode (E2) 5-10 Âľm away from E1. Under appropriate deposition conditions, Ag NWs grow from E2 and cross over to E1, forming a E1/(molecule or polymer)/ Ag NW/ E2 junction. We controlled the junction resistance by 1) electrodepositing polyphenol of varied thickness on E1, 2) assembling alkanethiols of varying chain length on E1, and 3) Chemically dissolving the Ag NWs. We functionalized Ag NWs at high resistance E1/polyphenol/AgNW/E2 junctions with Pd nanoparticles and studied their sensing properties. They responded fast and reversibly to H2 concentrations as low as 0.11% in a nitrogen carrier gas by a resistance decrease due to volume expansion of the nanoparticles. Future experiments will involve the assembly of molecules on E1 that exhibit photo- or redox-switchable electronic behaviour. Our strategy is promosing for forming simple, reproducible and miniaturized molecular electronics and sensing devices electrochemically at microgap electrodes with a wide range of potential applications. 66. Nanotechnology in Ophthalmics Thad Druffel*, Optical Dynamics Nanotechnology The ophthalmic industry relies on very clear materials that can alter the direction of light, and plastics have become very important to this industry. Nanotechnology has allowed engineers to alter the refractive index of an optical polymer 49

POSTER ABSTRACTS without affecting the transparence of the polymer matrix. We present here nanocomposites that are capable of being used in thin film coatings for plastic eyeglass lenses. The coatings have very similar mechanical properties and so do not exhibit the same failures as traditional coatings. 67. Laser Spectroscopy of Ultra Cold Molecular Ions Mohammed Gharaibeh* and Dennis Clouthier:, Department of Chemistry, University of Kentucky Molecular ions are of great importance because they are involved in a large variety of chemical reactions including etching and fabrication of semiconductors, materials science, and advanced manufacturing processes. In the present work laser spectroscopic methods have been employed to study the electronic spectra of Cl2+ and CO2+ cations. The cations were produced in a supersonic expansion using a pulsed electric discharge technique and probed using a tunable dye laser at resolution of 0.2 cm-1. The laser-induced fluorescence (LIF) spectrum of the Cl2+ molecular ion was collected in the range from 20000 to 33000 cm 1 which corresponds to the A2PIu-X2PIg transition. The spectrum was found to be rotationally cold (estimated to be about 15 K) resulting in well resolved spectra with the three isotopologues of Cl2+ clearly identified in most of the bands. The vibrational energy levels and the isotopic shifts in the upper state are perturbed due to mixing with levels arising from other electronic states close in energy to the A2PIu state. New bands were detected in this work, and a proposed assignment was made. The LIF spectrum of the CO2+ cation was recorded 28000 to 38000 cm 1. The upper A2PIu state showed complex vibrational structure due to the Renner-Teller effect and Fermi resonance. Due to extensive cooling in the supersonic expansion, this spectrum provided previously unknown details about the electronic spectroscopy of the carbon dioxide cation. 68. CuInSe2 and CuPc Nanowires for Solar Cell Application Vijay P Singh, Suresh Rajaputra, Piao Liu, Goutam Chintakula, Sai Manohar Reddy Guduru*, Sandeep Mard, Center for Nanoscale Science and Engineering, Department of Electrical and Computer Engineering, University of Kentucky

Nanostructured Semiconductor materials, including films and nanowires (NWs) have recently received a great deal of attention due to their interesting electro-optical properties. The possibility of size tailoring these properties is of great interest for nanoscale device applications in microelectronics and optoelectronics. In particular, nanostructured solar cells offer two advantages (i) size dependent quantum confinement driven enhancement of the effective energy band gap in inorganic semiconductors and (ii) A short path (few nm) to hetero-interfaces where excitons can split into electrons and holes resulting in higher short-circuit currents and higher efficiencies in organic semiconductor solar cells. To this end, nanowires of inorganic semiconductor Copper indium diselenide (CuInSe2) and organic semiconductor (CuPc) were fabricated by electrodeposition in nanoporous alumina templates. Al-CuPc nanowire, Al-CIS nanowire Schottky diode solar cells were fabricated. The devices were characterized by XRD, SEM, UVVis absorption and electro-optical measurements. Copper indium diselenide (CIS), a p-type semiconductor with direct band gap of about 1 eV is a leading absorber material for commercial thin-film photovoltaics. Templates assisted synthesis of CIS nanowires will allow us to overcome the intrinsic nature of CIS to grow into larger grains. CIS nanowires were electrodeposited into AAO pores. 69. Liquid Phase Electron-Beam Induced Processing E. U. Donev* and J. T. Hastings, Department of Electrical and Computer Engineering, University of Kentucky Focused electron-beam induced deposition (EBID) allows the direct formation of metal and dielectric nanostructures using gaseous precursors. These processes have been widely investigated for nanoscale device prototyping and for lithographic mask repair. However, focused electron-beam induced processes using liquid-phase reactants remain almost entirely unexplored and unexploited. Here we report the first direct electron-beam induced deposition of nanostructures using a liquid precursor. Specifically, sub-50 nm platinum dots and wires have been deposited from an aqueous chloroplatinic acid solution and characterized by SEM, AFM, and EDS. The process exhibits greatly improved material purity and higher deposition rates than traditional gas-phase processes. 50

POSTER ABSTRACTS 70. FTIR Imaging for Microscale Spatial Analysis of Hydrogel Patterning Reactions Dipti Biswal; Hari Chirra; and J. Zach Hilt, Department of Chemical and Materials Engineering, University of Kentucky This project has focused on the development and application of a method for real-time FTIR imaging characterization of patterning polymerization processes with microscale spatial resolution. These novel methods enable for the control and optimization of processes for the integration of intelligent polymer networks with silicon, glass, and gold surfaces of devices with microscale control. The ability to optimize the integration of these polymers is critical for the fabrication and development of platforms that harness the unique abilities of intelligent polymer networks, including diagnostic devices, therapeutic devices, tissue engineering, microarray, and diagnostic and therapeutic clinic-ona-chip. In these studies, the micropatterning reactions of intelligent polymer networks, which are entirely synthetic and tailored to have various properties and function, have been characterized and optimized for integration as functional components of microdevices. The specific objectives of this project have been to develop a novel method based on FTIR imaging to characterize the patterning polymerization reaction kinetics of intelligent polymer networks on silicon, glass, and gold substrates with microscale spatial resolution, characterize the polymeric networks postpolymerization to determine their physical and response properties (AFM, SEM, etc. analysis at micro- and nanoscale) to develop correlations to reaction conditions, and then optimize microscale polymerization reactions (e.g. micropatterning) to allow for the reproducible and controlled integration of intelligent polymer networks with silicon, glass, and gold surfaces in microdevices. 71. Generation of Nanodroplets by Coulombic Fissions of Microdroplets Harry Hunter* and Asit Ray, Department of Chemical and Materials Engineering, University of Kentucky During evaporation, charged droplets undergo Coulombic fission at a critical charge density wherein they emit a portion of charged mass via progeny droplets. Until now, there existed no means to predict or control the size of the progenies formed.

We investigated the role of electrical conductivity on the characteristics of progeny droplet formation by observing the fissions of single charged droplets suspended in an electrodynamic balance. We manipulated the conductivity of a droplet by addition of either an ionophore or an ionic liquid to the bulk solution the droplet was generated from. As the ion concentration of a droplet was increased, we observed the fractions of mass and charge emitted during fission to respectively decrease and increase. We found that the charge density of the emitted fraction is linearly related to the surface conductivity and the radius of the primary droplet immediately prior to fission. We also found that the size of a progeny droplet is inversely proportional to the surface conductivity raised to the power of 2/3 to be well predicted from the characteristics of the primary droplet. By increasing the conductivity of the mother drop we were able to reduce the size of the progenies formed during fission from a micrometer range to a nanometer range. The results of this study suggest that tailored nanoparticles of desired size can be synthesized from charged drops generated by electrospray techniques, and by controlling the fissions through the drop size and the ion concentration level. 72. High Temperature Shape Memory Alloys H. E. Karaca (1)*, G. Ded (1), A. Hatemi (1); R. Noebe (2), (1) Department of Mechanical Engineering, University of Kentucky, (2) NASA Glenn Research Center Conventional shape-memory alloys are limited to use at temperatures below 100 Â°C due to their low transformation temperatures (TTs), poor material strength and ductility, unstable cyclic behavior, or unsatisfactory shape memory properties. As an example, NiTi, the most widely used SMA with outstanding properties (high specific work output with good dimensional stability and ductility), cannot be utilized as a HTSMA since its TTs are limited by 100 ÂşC. Development of a HTSMA with properties similar to NiTi is needed for a broad range of applications in the aerospace, automotive and oil industries. Ternary elements are added to NiTi alloys to increase their TTs with the hope to maintain its good mechanical properties. It has been found that the addition of Hf, Zr, Pd, Pt, Au elements results in an increase in the TTs. Due to its relatively low cost and moderate ductility, NiTiHf seems to be the most promising HTSMA for use up to temperatures of ~ 51

POSTER ABSTRACTS 200 Â°C. In this study shape memory properties of thermomechanically treated Ni-rich NiTi(Cu,Pd)-(20 at.%)Hf alloys are studied. It is shown that formation of precipitates by aging can be used to tailor shape memory and mechanical properties in Ni-rich NiTiHf alloys. Precipitates significantly improves the shape memory behavior, by serving as barriers to dislocation motion where stable cyclic phase transformation in the 100-200 ?C temperature range can be achieved in these alloys. Furthermore, it has been observed that the critical stresses for phase transformation and dislocation slip, transformation strain levels, and temperature hysteresis are all thermomechanical treatment dependent. The results of this study indicate that Nirich NiTiHf alloys are promising shape memory materials for high temperature applications. 73. Magnetic Field-Induced Phase Transformations in NiMn-based Shape Memory Alloys H.E. Karaca*, Department of Mechanical Engineering, University of Kentucky In recent years, magnetic shape memory alloys (MSMAs) have attracted interest because of their ability to obtain one order of magnitude higher magnetic field induced strain than magnetostrictive materials and faster dynamic response than conventional shape memory alloys. Moreover, they can also be used for sensing and energy harvesting by utilizing the changes in magnetization upon the application of fluctuating mechanical forces or displacements. It has been shown that field-induced phase transition is possible in NiMn-based MSMAs and it can be reversible or irreversible depending on the magnitudes of transformation hysteresis, magnetocrystalline anisotropy and saturation magnetization of transforming phases, and crystal orientation. In this study, systematic experiments are conducted on NiMnGa and NiMnCoIn single crystals in order to identify the physical and microstructural parameters that are critical for fieldinduced phase transformations. A thermodynamical framework based on microstructural, mechanical and magnetic requirements for field-induced phase transformation is constructed and will be discussed to provide guidelines to increase the actuation stress levels and possible future directions for research on magnetic shape memory alloys will be presented.

74. Indentation Behavior and HCA Growth on Bioglass 45S5 Ding Li*, Fuqian Yang, Department ofChemical and Materials Engineering,University of Kentucky Bioactive glasses have been used as the bone replacement implants for several decades. It generally prefers that the materials remain the glass state without presence of crystallinity for the implant applications. Due to heat treatment and mechanical stresses, it is possible to have crystal phases in bioactive glasses which could alter the bioactivity and biofunctionality of the implanted materials. In this work, a bioglass 45S5 was crystallized at temperature of 650ÂşC. Microindentation was used to examine localized mechanical deformation of the crystallized-bioglass 45S5 and the effect of crystallization on the dissolution in phosphate buffer solution. Both the indentation hardness and the fracture toughness were determined as a function of the indentation load. The crystallization had a strong effect on the indentation fracture toughness and a less effect on the hardness. The indentation fracture toughness of the crystallized-bioglass 45S5 is less than that of the corresponding material at the glass state. 75. Stress Induced Sn Whisker Growth Juchuan Li *, Fuqian Yang, Yang-Tse Cheng., Department of Chemical and Materials Engineering, University of Kentucky Sn whisker growth has been investigated for more than 60 years. However, the driving force for whisker growth is still under debate. Various possible mechanisms of whisker growth exist in the literature. Previously, it was generally accepted that intermetallic compound was considered the driving force for whisker growth. Imtermetallic alloys played the role of generating internal compressive stress in the Sn layer. In this work, Sn was coated on Si and Al substrate respectively to avoid the formation of intermetallic compound. Different kinds of external stresses (indentation and bending) were applied to the two systems. Whiskers and hillocks were observed in the area affected by the applied stress. 76. Nanostructured Titania, Tin oxide and aligned CNT films as Gas Sensors Suresh Rajaputra1, Raghu Mangu1 *, Vijay P. Singh1, Piao Liu, Satish Kumar Kandala, Patricia 52

POSTER ABSTRACTS Clore1, Dali Qian2, Rodney Andrews2, 1Department of Electrical and Computer Engineering, University of Kentucky 40506-0046, 2Center for Applied Energy Research Vertically aligned multi walled carbon nanotube (MWCNT) arrays fabricated by xylene pyrolysis in anodized aluminum oxide (AAO) templates without the use of a catalyst, were integrated into a resistive sensor design. The AAO templates were fabricated by a two-step Anodization of high purity Al tape in a 0.3M oxalic acid. Thin layers of amorphous carbon were grown as a byproduct of the CNT growth on the top and bottom surfaces of the template. These layers are conductive, and their thickness was varied from 5 to > 50 nm which plays a crucial role in the resistive sensor design. For gas sensing experiments, the CNT/AAO arrays with 25 nm CNT inner core diameter and wall thickness of 5 nm were incorporated into a resistive gas sensor design, where, contact electrodes (Au bus bars) were deposited by e-beam evaporation technique. In our device configuration, the MWCNTs are open ended on both sides, which allows the gas molecules to permeate through the tubes and adsorb on the inner walls. These sensors were highly responsive to both oxidizing and reducing gases with steady state sensitivities of 5% and 10% for 100ppm of NH3 and NO2 respectively, at room temperature. 77. H2 Reactivity of Pd Nanoparticles Coated with Mixed Monolayers of Alkyl Thiols and Alkyl Amines for Sensing and Catalysis Applications Monica Moreno* and Francis. P. Zamborini, Department of Chemistry, University of Louisville Our group recently demonstrated the use of metal nanoparticles (Pd, Pd/Ag and Pd/Au) protected with different organic groups for electronically sensing H2 at low concentrations. Alkyl thiol-coated Pd nanoparticles are not reactive to H2, requiring high temperature, treatment and conditioning in pure H2 gas to obtain an operational device. Alkyl aminecoated Pd, Pd/Ag or Pd/Au nanoparticles react with H2 without ozone or high temperature treatment, but undergo large irreversible changes in morphology and loss of organic material. In order to improve the reactivity to H2 while minimizing the number of pretreatment steps and preventing large morphology changes, we evaluated Pd nanoparticles containing different ratios of hexanethiol and

octylamine ligand on their surface, synthesized by liquid-phase place-exchange. At optimized ratios these films respond reversibly to H2 down to 0.50% without significant conditioning, multiple treatments or irreversible morphology changes as determined by electronic measurements and verified by spectroscopy measurements of Pd nanoparticles in solution. The use of Pd nanoparticles with mixed monolayers offers H2 reactivity, while maintaining structural stability necessary for sensing or catalysis applications. 78. Commercialization of High Quality Nanoporous Alumina Templates for Nanoscale Devices and System Suresh Rajaputra*, Raghu Mangu, Allen Hermann, Dennis Field and Vijay Singh, Department of Electrical and Computer Engineering, University of Kentucky The progression of nanostructures and nanodevices from the R&D labs to manufacturing environment is the next great challenge that must be met if these devices are to become commercially viable. This project has laid the groundwork to commercialize nanoporous metal oxide templates whose pores are controllable in size and spatial uniformity over large areas. These templates enable the development and production of other nanotechnology based devices currently undergoing R&D, including sensors, filtration membranes, nanoscale solar cells, nanowire based devices, display devices and memory devices. These templates are also useful for biological cell growth, DNA separation and drug delivery applications. The advantages of AAO templates are uniform, highly ordered pore arrays with controllable diameter and spacing; Vertically aligned pore arrays with high aspect ratio in an insulating matrix, providing an ideal platform for nanotube and nanowire based devices; High reproducibility of the film structure for samples of large sizes. These templates can be filled with (i) semiconductors to fabricate heterojunction devices, (ii) magnetic materials for nanowire based recording applications, (iii) carbon nanotubes for nanoelectronic devices and sensor applications. 79. Sweetening Kentuckyâ&#x20AC;&#x2122;s Energy Future with Functional Nanoporous Materials Prepared by Sugar-based Surfactant Templating 53

POSTER ABSTRACTS Stephen E. Rankin*, Mohammed S. Rahman and Saadia T. Khan, University of Kentucky, Department of Chemical and Materials Engineering Carbohydrate (sugar) molecules are extremely important constituents of all biological systems with diverse roles in energy storage, tissue structure, and cell recognition / signaling. The specificity of carbohydrate binding comes from the variety of ways that their many polar organic groups (such as hydroxyls) can be arranged. Recently, our group began using surfactant (detergent-like) molecules derived from carbohydrates as templates for nanoporous metal oxide materials. The hydroxyl groups of the surfactants have advantages for pore templating because they can bind transition metals or organic groups to generate specific adsorption or catalytic sites. At the same time, the surfactants assemble into aggregates (micelles) that serve as templates for nanometer-scale pores. However, to form ordered materials with well-defined imprinted sites, the sugar surfactants must be diluted with conventional cationic surfactants used to make these materials. Thus, in a project started under KSEF, we developed a materials design methodology based on (1) measuring properties and assembly of mixed surfactants in water, (2) preparing metal oxides with the same structure as the aqueous surfactant systems by replacing water with an equivalent volume of metal oxide, and (3) binding transition metals to the sugar to generate functional materials. We first discuss the preparation of nanoporous silica with isolated, tetracoordinated titanium catalytic sites. We also introduce a new collaborative project that uses this strategy to prepare materials for selective binding and separation of 5-carbon sugars (such as xylose) released during processing of lignocellulosic biomass for fuel production. 80. Evaporation-Driven Assembly and Tuning of Titania Thin Films with Orthogonally Aligned Hexagonal Channels Stephen E. Rankin*, Qingliu Wu and Venkat R. Koganti, University of Kentucky, Department of Chemical and Materials Engineering In our group, we have pioneered a self-assembly approach to the preparation of thin metal oxide films with close-packed nanopores (4-12 nm in diameter) that are oriented orthogonal to the film. The strategy is a â&#x20AC;&#x153;bottom upâ&#x20AC;? synthesis based on the spontaneous assembly of commercially available

surfactant molecules and small precursors to metal oxides. When the synthesis solutions are cast into thin films by spin or dip coating, loss of solvent drives the assembly of the surfactants into cylindrical aggregates (micelles) which pack together into liquid crystal-like structures surrounded by metal oxide precursors. Continued aging and curing of the films followed by removal of the surfactant micelles leads to metal oxides with ordered, well defined nanopore arrays. One of the main innovations in our group was to show that by chemically modifying the surface of the substrate with materials based on either the surfactant or a random copolymer with a similar composition to the surfactant, the nanopore arrays in the final material can be oriented orthogonal to the substrate. The nanoporous films thus can be prepared either as supported membranes or as functional transparent layers. We are tuning our evaporation-driven approach to prepare titanium dioxide films with orthogonally oriented nanopore arrays as low-cost solar cell components. When the pores are infiltrated with a p-type semiconducting polymer, they are hypothesized to act as efficient solar cells due to the high surface area of contact, straight channels, and short conduction paths in the hybrid films. 81. Metallic and Carbon Bonding Dusan P. Sekulic (1); Hui Zhao (2); Wen Liu (1, 3); Maoai Chen (2), 1) Department of Mechanical Engineering; (2) UK Center for Manufacturing, University of Kentucky; (3) Creative Thermal Solutions, Urbana-Champagne Metal and/or carbon foams have been used at a rapidly increasing rate for applications involving structural and/or thermal tasks. An entirely new realm of manufacturing technologies, capable of achieving desired integrity at the micro level, must be introduced to accommodate these new applications. However, use of materials in combination with foams may fail to offer successful bonding at the macro scale due to an inherent need to form all the joints at spatially macro-distributed micro-locations. Open cell foam material cannot take an advantage of a surface tension driven molten metal flow along macro capillary paths of bonded mating surfaces because these paths simply do not exist. As a consequence, joint formation during either brazing or soldering (in particular lead-free) of novel foam materials must be considered in detail at the micro level. Our laboratory has developed a 54

POSTER ABSTRACTS unique experimental capability using the hot stage microscopy real-time in situ studies of the joint formation evolution at the micro scale. This research effort is aimed at investigating new bonding solutions based on the use of filler paste made of true alloy macro particles with polymer binders and with/without nano-particle doping. We plan to analyze behavior of molten metal at the micro level and joint formation of foam-substrate structures. The related applications involve automotive, electronics and aero space applications (nontraditional heat exchangers, and electronics cooling).

machining parameters play a significant role in altering the wear characteristics of the pins and prove that advanced machining methodologies can be used to reduce implant wear without timeconsuming and costly post-machining treatments.

82. Machining of Metal-on-Metal Hip Implants for Improved Performance A. Deshpande (1); Z. Pu (1)*; D. Pienkowski (2); O. Dillon Jr. (1); I.S. Jawahir (1); D. Puleo (2); S. Yang (1), (1) Department of Mechanical Engineering and Center for Manufacturing; (2) Center for Biomedical Engineering

We have developed a unique nanofabrication technology to grow individual nanoneedles of silvergallium at selected location and orientation. These nanoneedles have stiffness that is well-matched to the viscoelastic properties of complex fluids and biological materials and are electrically conductive. We are in the process of integrating this technology into platforms for combined electrochemical and viscoelastic probing of live cells and subcellular organelles within live cells. Specific progress towards this system includes our recent demonstrations of using silver-gallium nanoneedletipped probes to (1) make precise AFM measurements of rheological properties of polymeric liquids, (2) puncture individual live cells and measure viscoelastic response.

Modern metal-on-metal joint replacements demonstrate improved wear resistance, but they do not avoid wear debris generation. The objective of this project is to develop protocols for machining metallic implants to induce desired material properties to reduce implant wear/debris generation. Implant grade Co-Cr-Mo alloy pin specimens were prepared using different machining conditions. Wear testing was conducted using a custom-made tribological testing system (pin-on-disc tester). Pin mass and surface roughness readings were taken at regular intervals of 100,000 cycles to track wear under simulated physiological conditions. Residual stress measurements are taken by using X-ray diffraction technique. Experiments show that wear reduces with increasing feed rate and cutting speed in machining of pins, but increases with increasing depth of cut and nose radius. The axial residual stresses become more compressive with increasing cutting speed, feed, nose radius and depth of cut; whereas the circumferential residual stresses become more tensile with increasing cutting speed and nose radius. The microhardness change due to the facing operation was significant comparing to prefacing and polishing operations. Surface and subsurface microhardness values for the pin specimens show significant variations in between the experiments, confirming that the wear rates of the pins are affected by the surface and subsurface material property changes caused by different machining conditions. The results show that the

83. Self-assembly of Nanostructures and Their Applicability to In Situ Measurements and Manipulations of Soft Biomaterials Mehdi M. Yazdanpanah and Robert W. Cohn, University of Louisville ElectroOptic Research Institue and Nanotechnology Center

84. Torch Based Adaptive Intelligent Control for Circumferential Welding of Pipes YuMing Zhang, Xiangrong Li, Kun Qian, Weijie Zhang, Yi Lu, Adaptive Intelligent Systems LLC This project aims at the development of commercial systems which can adaptively adjust welding parameters based on an observation on the weld pool surface like a skilled welder but does not require the torch to be moved smoothly/evenly. One of the major innovations associated with this technology is a so-calledâ&#x20AC;Ś

LIST OF ATTENDEES LAST NAME

FIRST NAME

POSITION

Adams

(Ty) Sumner

Director Industrial Design

Adams:Kinkade Design, LLC

ty@invizn.com

Andrew

Karla

IT Manager

Western Kentucky University

karla.andrew@gmail.com

Antony

Solomon

Assistant Professor

Murray State University

solomon.antony@murraystate .edu

Artiushin

Sergey

University of Kentucky

scarti1@email.uky.edu

Bachman

Daniel

Co-op student

SCR Inc.

drbach01@gmail.com

Baker

Christopher

Director, Information Technology

Kentucky Science and Technology Corporation

cbaker@kstc.com

Balk

Thomas (John)

Professor

University of Kentucky

balk@engr.uky.edu

Beeram

Srinivas Reddy

Postdoc

University of Louisville

s0beer02@louisville.edu

Best

Dr. W. Scott

Chief Scientist

MPD, Inc.

wsbest@mpdinc.com

Bhattacharya

Siddhartha

Assistant Professor

Kentucky State University

s.bhattacharyya@kysu.edu

Bradley

Luke

Assistant Professor

University of Kentucky

lhbradley@uky.edu

Braun

Frank

Faculty

Northern Kentucky University

braunf@nku.edu

Brennan

Mark

SureGene LLC

mdbren01@louisville.edu

Bryson

Lindsey

University of Kentucky

bryson@engr.uky.edu

Burkhead

Robert

Blue Heaven Technologies

bob@blueheaventech.com

Burklow

Cindy

COO

Naprogenix, Inc.

cindy_burklow@yahoo.com

Carrithers

David

Private Attorney

Carrithers Law Office PLLC

carritherslaw@yahoo.com

Carrithers

Stephen

Vice President/PI

Sequela, Inc.

SequelaSteve@yahoo.com

Castlen

Eric

Technology Transfer Officer I

University of Louisville, Office of Technology Transfer

eric.castlen@louisville.edu

Chen

Maoai

Visiting Scholar Postdoc

University of Kentucky

mchen0@engr.uky.edu

Chen

Rong

Postdoc

University of Kentucky

rong.chen@uky.edu

Cheng

Fuhua (Frank)

Professor

University of Kentucky

cheng@cs.uky.edu

Chien

Sufan

Professor

University of Louisville

s0chie01@louisville.edu

Assistant Professor

INSTITUTION/COMPANY

LIST OF ATTENDEES LAST NAME Cloud

FIRST NAME Richard

Cohn

Robert

Collins

Charles

Collins

John

Collins

POSITION Associate Professor

INSTITUTION/COMPANY University of Louisville

EMAIL rick.cloud@louisville.edu

University of Louisville

rwcohn@uofl.edu

Ferm Solutions

ccollins@ferm-solutions.com

Director of Applicatons Development

V-Soft Consulting Group, Inc

johncollins@vsoftconsulting.c om

Karen

Postdoc

University of Louisville

karen.collins@insightbb.com

Cox

Gerald

CEO

Hi-Tech Mold and Tool, LLC

gcox1@hi-techmold.com

Cox

Nancy

Assoc. Dean

University of Kentucky

nancy.cox@uky.edu

Creager

Mitch

Director of Accounting

Kentucky Science and Technology Corporation

mcreager@kstc.com

Creamer

Trevor

Associate Professor

University of Kentucky

Trevor.Creamer@uky.edu

Croley

Shawn

Graduate Student

University of Louisville

shawn.croley@gmail.com

Dampanaboi na

Lavanya

Postdoc

University of Kentucky

ldamp2@uky.edu

Dasari

Radhika

Postdoc

University of Louisville

r0dasa01@louisville.edu

Deschatelets

Pascal

Chief Operating Officer

Potentia Pharmaceuticals, Inc.

pascal@potentiapharma.com

Deshpande

Rutooj

Postdoc

University of Kentucky

rutooj.deshpande@uky.edu

Desmarais

Normand

Founding Partner

TiER1 Performance Solutions

n.desmarais@tier1performan ce.com

Dittakavi

Nagendra

Research Scientist

Advanced Dynamics, Inc.

nagendra.dittakavi@gmail.co m

Dominick

Steve

Commercialization Engineer

University of Kentucky

steve.dominick@gmail.com

Druffel

Thad

Mechanical Engineer

Vision Dynamics

TDruffel@opitcaldynamics.co m

East

Melea

Deputy Director

University of Louisville Office of Technology Transfer

mkeast01@louisville.edu

Eisenberg

Rod

Director

ChemPharma International, LLC

reisenberg@chempharma.co m

El-Baz

Ayman

Assistant Professor

University of Louisville

aselba01@louisville.edu

Ernest

Andrew

Director, Center for Water Resource Studies

Western Kentucky University

Andrew.Ernest@WKU.edu

Donev

Eugene

PostDoc

University of Kentucky

eugene.donev@uky.edu

Professor

LIST OF ATTENDEES LAST NAME Feigel

FIRST NAME Phil

Feng

Wenke

Ferrell

POSITION Owner

INSTITUTION/COMPANY Vision21 Consulting

EMAIL prfeigel@gte.net

Professor

University of Louisville

wenke.feng@louisville.edu

Blaine

Associate Dean

Western Kentucky University

blaine.ferrell@wku.edu

Fick

Chris

Officer Tech.Transfer

University of Louisville

chris.fick@louisville.edu

Fister

Emily

Postdoc

University of Louisville

emily.fister@louisville.edu

Foreman

Chris

Postdoc

University of Louisville

jchrisf@louisville.edu

Fuchs

Jason

Synlabs

jason.fuchs@gmail.com

Fukushige

Hirotada

Research Associate / Postdoc

University of Kentucky

hfuku1@uky.edu

Gallondorn

Mark

Postdoc

Northern Kentucky University

gallondornm@nku.edu

Gharaibeh

Mohammed

Postdoc

University of Kentucky

gharaibeh@uky.edu

Guduru

Sai

Graduate Student

University of Kentucky

sai.guduru@uky.edu

Harwood

James

Assistant Professor

University of Kentucky

James.Harwood@uky.edu

Hassebrook

Christopher

Postdoc

University of Kentucky

clhass2@uky.edu

Hassebrook

Laurence

Professor

University of Kentucky

lgh@engr.uky.edu

Heist

Patrick

Chief Scientific Officer

Ferm Solutions

eheist@ferm-solutions.com

Heller

Leonard (Len)

Vice President

University of Kentucky Off. Commercialization / Econ. Development

lehell2@uky.edu

Hilt

J. Zach

Assistant Professor

University of Kentucky

hilt@engr.uky.edu

Holtman

Joseph

University of Kentucky

jrhol2@email.uky.edu

Houtz

Robert

Professor

University of Kentucky

rhoutz@uky.edu

Howard

David

Research Director

DAE LLC

farmer@concord.edu

Liang

President

3H Company, LLC

lianghu59@yahoo.com

Patrick

President and Chairman

Advanced Dynamics, Inc.

patrick.g.hu@advanceddyna mics-usa.com

Hunt

Arthur

Professor

University of Kentucky

aghunt00@uky.edu

Hunt

Henry

Dataseam

henry.hunt@kydataseam.com

Hunter

Harry

Postdoc

University of Kentucky

hhunter_01@yahoo.com

Hurtado

Oscar

Postdoc

University of Kentucky

ophurtado@gmail.com

Jackson

Michael

Network Manager

National Weather Service

via bawebb@uky.edu 59

LIST OF ATTENDEES LAST NAME Jackson

FIRST NAME Samuel

Jain

Mahendra

Jawahir

POSITION Student

INSTITUTION/COMPANY Falls Church High School

EMAIL c/o bawebb@uky.edu

Vice President and Executive Director

Kentucky Science and Technology Corporation

mjain@kstc.com

I.S.

Professor

University of Kentucky

jawahir@engr.uky.edu

Jeong

Rae-Dong

Postdoc

University of Kentucky

raedongjeong@uky.edu

Kalbfleisch

Ted

President

Intrepid Bioinformatics

ted.kalbfleisch@intrepid.com

Karaca

Haluk

Assistant Professor

University of Kentucky

karaca@engr.uky.edu

Kessler

Bruce

Assistant Dean,

Western Kentucky University

bruce.kessler@wku.edu

Khatri

Rajesh

Research Scientist

Topasol LLC

khatri@topasol.com

Kimel

Kris

President

Kentucky Science and Technology Corporation

kkimel@kstc.com

King

David D.

Director

University of Louisville

ddking01@louisville.edu

King

Robert

President

KY Council on Postsecondary Education

robert.king@ky.gov

Knapp

Liz

Program Manager

Kentucky Science and Technology Corporation

lknapp@kstc.com

Koenig

Daiga

Executive Director

SCR Inc

daiga.koenig@scrdevelopme ntgroup.com

Koenig

Steven

Assistant Professor

University of Louisville

sckoen01@gwise.louisville.ed u

Koszewski

Nicholas

PhD

University of Kentucky

jmwyat2@uky.edu

Labreveux

Maria

Program Manager

Kentucky Science and Technology Corporation

mlabreveux@kstc.com

Lang

M. Joanne

Executive Vice President

Kentucky Science and Technology Corporation

jlang@kstc.com

Lau

Daniel

Faculty

University of Kentucky

acrouch@engr.uky.edu

LeCroix

Charles

Ph.D.

Prime DP

lecroixcd@axellerate.com

Lee

Jung Sup

Postdoc

University of Kentucky

jslee3@uky.edu

Ding

Postdoc

University of Kentucky

liding@engr.uky.edu

Juchuan

Graduate Student

University of Kentucky

jlin@engr.uky.edu

Linville

Linda

Assistant VP of Academic Affairs

KY Council on Postsecondary Education

linda.linville@ky.gov

Littleton

John

Chief Scientific Officer

Naprogenix, Inc.

john.littleton@uky.edu

Liu

Wen

Postdoc

University of Kentucky

wliu0@engr.uky.edu

Losavio

Michael

University of Louisville

michael.losavio@louisville.ed 60

LIST OF ATTENDEES LAST NAME

FIRST NAME

Lundby

Walter

Lushia

Warren

Shankang

Mangu

POSITION Researcher

INSTITUTION/COMPANY

EMAIL u

University of Kentucky

lundby@vis.uky.edu

Pikeville College

wlushia@pc.edu

Postdoc

University of Louisville

s0ma0002@louisville.edu

Raghu

Graduate Student

University of Kentucky

raghumangu@gmail.com

Marrs

Brock

Vice President for Research

NuForm Materials, LLC

brock.marrs@nuformmaterial s.com

Marshall

R. Gary

Director

Estern Region ICC

gary.marshall@eku.edu

MartinezMaldonado

Manuel

Executive Vice President for Research

University of Louisville

m0mart10@louisville.edu

Meenach

Samantha

Research Assistant / Postdoc

University of Kentucky

samantha.meenach@gmail.c om

Metry

Kristin

Toxicologist

WIL Research Laboratories, LLC

kmetry@hotmail.com

Mielenz

Jonathan

Group Leader

Oak Ridge National Labs

mielenzjr@ornl.gov

Miles

Nicholas

Postdoc

University of Louisville

namiles@gmail.com

Miller

James

KSEF Adv. Board

Transylvania University

jmiller@transy.edu

Mims

Steven

Professor

Kentucky State University

steven.mims@kysu.edu

Yiqun

Postdoc

University of Louisville

Yiqun.Mo@louisville.edu

Moreno

Monica

Postdoc

University of Louisville

mamore01@gwise.louisville.e du

Narayan

Ramani

Professor

Michigan State University

Narayan@msu.edu

Nasraoui

Olfa

Associate Professor

University of Louisville

olfa.nasraoui@gmail.com

Ngoh

Gladys

Postdoc

University of Louisville

gnafor01@gwise.louisville.ed u

Oeltgen

Peter

Professor of Pathology and Toxicology

University of Kentucky, College of Medicine

proelt1@email.uky.edu

Oestertag

Eric

Speaker

Transposagen Biopharmaceuticals, Inc.

oestertag@mail.med.upenn.e du

Old

Susan

Senior Advisor

National Institutes of Health

OldSE@mail.nih.gov

O'Leary

Sean

Director, Kentucky New Energy Ventures

Kentucky Science and Technology Corporation

soleary@kstc.com

LIST OF ATTENDEES LAST NAME Panja

FIRST NAME Biswajit

Paranthan

Riya

POSITION Assistant Professor

INSTITUTION/COMPANY Morehead State University

EMAIL b.panja@morehead-st.edu

Research Assistant / Postdoc

University of Kentucky

rrpara2@email.uky.edu

Zhengwen

Postdoc

University of Kentucky

zpu2@engr.uky.edu

Rajaputra

Suresh

Senior Research Scientist

University of Kentucky

suresh.rajaputra@uky.edu

Ramsey

Timothy

CEO

SureGene, LLC

tim.ramsey@suregene.net

Rankin

Stephen

Associate Professor

University of Kentucky

srankin@engr.uky.edu

Reese

Derek

Postdoc

University of Louisville

derekreese77@gmail.com

Rempfer

Debbie

Administrative Assistant

Kentucky Science and Technology Corporation

drempfer@kstc.com

Robinson

R.J.

Technical Services Manager

University of Kentucky

rjr@mfg.uky.edu

Robl

Tom

NuForm Materials LLC

tom.robl@nuformmaterials.co m

Rojas

Carlos

Postdoc

University of Louisville

ccroja01@gwise.louisville.edu

Ronald

Kenneth

Program Manager

Kentucky Science and Technology Corporation

kronald@kstc.com

Sahi

Shivendra

Professor

Western Kentucky University

shiv.sahi@wku.edu

Sasvari

Zsuzsanna

Postdoc

University of Kentucky

zsasv2@uky.edu

Sawaya

Peter

Professor, MD

University of Kentucky

PeterSawaya@uky.edu

Sayre

Kim

Engineering Services Manager and Asst Director for Administration

University of Kentucky

sayre@engr.uky.edu

Seiffert

James

Member

Stites & Harbison

jseiffert@stites.com

Sekulic

Dusan

Professor

University of Kentucky

sekulicd@engr.uky.edu

Senich

Donald

Program Director

National Science Foundation

dsenich@nsf.gov

Shapiro

Robert

Professor

University of Kentucky

rshap01@uky.edu

Singh

Vijay

Professor

NanoTech Solutions LLC

vsingh@engr.uky.edu

Smalle

Jan

Assistant Professor

University of Kentucky

jsmalle@uky.edu

Song

Yongwook

Software Engineer

University of Kentucky,

diehard98@gmail.com

Stencel

John

President

Tribo Flow Separations, LLC

john@triboflow.com 62

LIST OF ATTENDEES LAST NAME Stiening

FIRST NAME Chad

Stinton

Shaun

Talbott

POSITION Executive Director for New Business Development

INSTITUTION/COMPANY Nucleus: Kentucky's Life Sciences and Innovation Center

EMAIL chads@nucleusky.com

Graduate Assistant

University of Kentucky

stinton@gmail.com

Debra

Accounting Specialist

Kentucky Science and Technology Corporation

dtalbott@kstc.com

Tang

Guiliang

Assistant Professor

University of Kentucky

gtang2@uky.edu

Tao

Daniel

Professor

University of Kentucky

dtao@engr.uky.edu

Tickle

Alison

Student

University of Kentucky

Alison.tickle@uky.edu

Timoney

John

University of Kentucky

jtimoney@uky.edu

Tobin

Thomas

Professor

University of Kentucky

ttobin@uky.edu

Townsend

Scott

Associate

Stites & Harbison, PLLC

stownsend@stites.com

Trent

John

Assoc. Professor

University of Louisville

john.trent@louisville.edu

Troy

Mike

FlashScan3D

mtroy@flashscan3d.com

Turner

Daniel

University of Louisville

mrdgarrett@yahoo.com

van Gilse

Margaret

Veer

Purna

Vice President

V-Soft Consulting Group, Inc.

purna@vsoftconsulting.com

Viniard

Jeff

Postdoc

Murray State University Geosciences Department

jeffrey.viniard@murraystate.e du

Voor

Michael

Associate Professor

University of Louisville

mike.voor@louisville.edu

Walton

Lee Ann

Wang

Jianpu

Postdoc

University of Louisville

j0wang19@louisville.edu

Wang

Yin

Postdoc

University of Kentucky

Yinwang@uky.edu

Warrick

Debra

CEO

DAE LLC

dhfwarrick@yahoo.com

Warrick

Don

Marketing Director

DAE LLC

donwarrick@daewv.com

Webb

Bruce

President

ParaTechs Corp.

bawebb@uky.edu

Wehrle

John

Chief Financial Officer

Kentucky Science and Technology Corporation

jwehrle@kstc.com

Werner

Mac

Research Associate

Institute for Workplace Innovation

mac@iwin.uky.edu

Williger

Gerard

Dr.

University of Louisville

williger@physics.louisville.edu

Wisniewski

Lorel

Deputy Director

National Institute of Standards and

lorel.wisniewski@nist.gov

Postdoc

margaret.vangilse@primedp.c om

UK Institute for Workplace Innovation (iwin)

LIST OF ATTENDEES LAST NAME

FIRST NAME

Xue

Wanli

Yang

Ruigang

Yang

Shu

Yazdanpanah

POSITION

INSTITUTION/COMPANY Technologies

University of Louisville

w0xue002@louisville.edu

University of Kentucky

ryang@cs.uky.edu

Research Assistant / Postdoc

University of Kentucky

shu.yang@uky.edu

Mehdi

Research Faculty

University of Louisville

mmyazd01@louisville.edu

Zamborini

Francis

Associate Professor

University of Louisville

f.zamborini@louisville.edu

Zanewicz

James

Director, OTD

University of Louisville

james.zanewicz@louisville.ed u

Zhang

Changjiang

Student

University of Kentucky

czhanb@csr.uky.edu

Zhang

Jun

Professor

University of Kentucky

jzhang@cs.uky.edu

Zhang

Qunwei

Assistant Professor

University of Louisville

Qunwei.Zhang@louisville.edu

Zhang

YuMing

President

Adaptive Intelligent Systems, LLC

ymzhang@engr.uky.edu

Postdoc

FLOOR PLANS Marriot Downtown Louisville – First Floor Plan

FLOOR PLANS Networking, Display, Food and Functions area

SHOW Ballroom

1. University of Louisville (RDE Awardee: Nasraoui)

2. UK Institute for Workplace Innovation

3. V-Soft Consulting Group, Inc.

4. University of Kentucky Center for Manufacturing

5. University of Louisville/Nauga Needles, LLC

6. CommFund

7. Intrepid Bioinformatics

8. Hi-Tech Mold and Tool, LLC

9. SCR Inc.

10. Naprogenix, Inc.

11. NuForm Materials, LLC

12. Advanced Dynamics, Inc.

13. University of Kentucky (CommFund Awardee: Tobin) 14. Multi-Projector Display (CommFund Awardee: Yang)

FLOOR PLANS

Poster Displays: KY Ballroom Salon E

Continental Breakfast and Morning Break Assorted Fruit Breads, Croissants, Muffins, Breakfast Pastries Freshly Brewed Regular and Decaffeinated Coffee, Assortment of Hot Teas All American Midwest Lunch Buffet Mixed Field Greens with Roasted Corn, Cheddar Cheese, Sliced Black Olives, Croutons and Blue Cheese Dressing or Garlic and Herb Vinaigrette (Vegetarian) Rice and Red Bean Salad with Smoked Cheese, Green Onions and Romano Cheese Vinaigrette (Vegetarian) Grilled Sausage, Pasta and Roast Pepper Salad with Sweet Onions and Garlic Basil Emulsions Mixed Citrus Segment Salad (Vegan) Whole Roast New York Strips with Red Wine Demi-Glace and English Cut Fried Onions Parmesan-Crusted Chicken Breast with Basil and Three Cheese Sauce Eggplant Parmesan (Vegetarian) Roasted Red-Skin Potatoes and Assorted Fresh Vegetables Drizzled with Butter and Sprinkled with Parmesan Cheese (Vegetarian) Assorted Pies and Cakes Freshly Brewed Regular and Decaffeinated Coffee, Sweet Tea and Assortment of Hot Teas Rolls and Butter Afternoon Break Freshly Popped Buttery Popcorn Freshly Baked Assorted Cookies Iced Tea, Sweet Tea, Lemonade

KIEC 2009 NOTES