SECTORLANDSCAPES
RESEARCH TOOLS 2015
Leading the conversation.
SECTOR LANDSCAPES: RESEARCH TOOLS Copyright Š 2015 by LifeScience Alley. All rights reserved.
About Sector Landscapes Publications The Sector Landscapes provide in depth analysis of emerging and established industry sectors in Minnesota. The reports highlight global industry insights, Minnesota core and supporting assets, unique positioning, company lists, and industry trends. Identified sector areas include: neuromodulation, cardiac active implantables, tissue based products, research tools, animal health, diagnostics, vascular technologies, and digital health.
List of Contributors PLEASE DIRECT CORRESPONDENCE TO:
Cheryl Matter, PhD, Vice President of Research & Intelligence, LifeScience Alley cmatter@lifesciencealley.org | 952.746.3817 Emily Tubman, Market Analyst, LifeScience Alley University of Minnesota Biomedical Engineering PhD Candidate Primary Researcher & Author Bridget Wall, PhD, LifeScience Alley Consultant Secondary Researcher & Author Amanda K. Weber, Design & Research Associate, LifeScience Alley Research Visualization & Design LifeScience Alley's intelligence and research work is generously supported by our Foundational and Sustaining Members.
Foundational Members
Sustaining Members
About LifeScience Alley LifeScience Alley is a global leader in enabling health technology and care organizations to innovate, succeed and influence the evolution of healthcare. By influencing policy, delivering actionable information and intelligence and connecting members with critical resources, we work to ensure that Minnesota's Medical Alley remains the world's strongest health technology community.
EXECUTIVE SUMMARY The Research Tools sector in Minnesota is composed of 27 companies distributed among the following fields, with the largest proportion in the cell biology space.
+ + + +
Cell Biology (13) Instrumentation (4) Materials / Chemistry (3) Supporting (7)
The sector is bolstered by the success of R&D Systems, a mature Minneapolis-based research tools company that started in the 1970’s. However there are a number of emerging, innovative companies that started in the 2000s.The University of Minnesota, the Mayo Clinic, and the technical workforce generated by the existing medical device and engineering industries provide an excellent talent pool of potential employees and development partners. Lastly, incubators that provide affordable wet lab and office space, as well as tax credits for R&D and angel investors, promote growth and investment in this burgeoning industry. MINNESOTA RESEARCH TOOLS INDUSTRY GROWTH OVER 100 YEARS 1915-2015
fifteen companies
1999
ten companies
five companies
1971
[1] NATIONAL CONTEXT OF AVAILABLE RESEARCH TOOLS
1
The US is the world leader in the Research Tools sector, with revenues from the top seven companies reaching nearly $50 billion in 2014. US RESEARCH TOOLS COMPANIES
2
[2] MINNESOTA RESEARCH TOOLS COMPANIES
5
Minnesota has twenty-seven Research Tools companies and has been growing drastically since the early 2000s. MINNESOTA INDUSTRY
6
DEFINITIONS OF RESEARCH TOOLS COMPANIES BY CATEGORY
6
SPOTLIGHT ON R&D SYSTEMS
8
SPOTLIGHT ON EMERGING RESEARCH TOOLS COMPANIES
9
[3] INSIDE THE MINNESOTA RESEARCH TOOLS SECTOR
11
The diversity of technical expertise, concentration of incubators and new tax incentives have encouraged a robust start-up economy in Minnesota. STATE & REGIONAL CLUSTERS OF RESEARCH TOOLS
14
TECHNICAL EXPERTISE
15
SUPPORTING INFRASTRUCTURE
18
INCUBATORS
20
TAX INCENTIVES
21
[4] MINNESOTA RESEARCH TOOLS DIRECTORY
23
LIST OF FIGURES FIGURE 1.
The Top Seven Research Tools Companies in the US
2
FIGURE 2.
Map of Minnesota Research Tools by Category
7
FIGURE 3.
Timeline History of R&D Systems
8
FIGURE 4.
Minnesota Research Tools Company Breakdown
12
FIGURE 5.
Minnesota Company Clusters
14
FIGURE 6.
NIH Awards & Funding + "IBRC" Corridor
16
FIGURE 7.
Minnesota's Biology to Engineering Spectrum
19
1. NATIONAL CONTEXT OF RESEARCH TOOLS
Text
1
Research tools companies develop products that facilitate life science research. Examples of products include cell biology products and instrumentation, analytical testing equipment and laboratory parts. The US is the world leader in research tools companies, with revenues from the top seven companies reaching nearly $50 billion in 2014. Although none of the nation’s largest research tools companies are headquartered in Minnesota, Thermo Fisher Scientific’s Product Inspection Division is located in Coon Rapids, MN, and Beckman Coulter's Immunoassay Division is located in Chaska, MN.
FIGURE 1. THE TOP SEVEN RESEARCH TOOLS COMPANIES IN THE US
"Map of United States of America with States - Outline by FreeVectorMaps.com" (page 2 and 16).
2
Sector Landscapes: Research Tools | LifeScience Alley
THE
TOP SEVEN COMPANY
HEADQUARTERS
REVENUE
EMPLOYEES
1
Thermo Fisher Scientific 1
Waltham, MA (MN operations)
$17 Billion
5000 (~120 in MN)
2
Becton Dickinson 2
Franklin Lakes, NJ
$8.4 Billion
3000
3
Beckman Coulter Brea, CA (MN operations) (Danaher Corp) 3
$6.9 Billion
24000 (~1000 in MN)
4
Agilent Technologies 4
Santa Clara, CA
$7.0 Billion
21400
5
VWR 5
Randor, PA
$4.2 Billion
8400
6
Sigma Aldrich (subsidiary of Merck) 6
St. Louis, MO
$2.7 Billion
9000
7
BioRad 7
Hercules, CA
$2.1 Billion
7750
1 SOURCE: Thermo Fisher Scientific. http://wwwthermofisher.com/en/about-us.html SOURCE: Becton Dickinson. (2014). Annual Report 2014. Retrieved from http://bd.com/ar2014/ 3 SOURCE: Danaher. (2013). Annual Report 2013. Retrieved from http://media.corporate-ir.net/media_ files/IROL/82/82105/Danaher_2013_Annual _Report.pdf 4 SOURCE: Agilent. (2014). Annual Report 2014. Retrieved from http://www.investor.agilent.com/ 5 SOURCE: VWR. (2013). Form 10-K 2013. Retrieved from http://investor.vwr.com/secfiling 6 SOURCE: Sigma Aldrich. (2013). Annual Report 2013. Retrieved from http://files.shareholder.com/downloads/SIGMA 7 SOURCE: Biorad. (2013). Annual Report 2013. Retrieved from http://www.bio-rad.com/webroot/web/pdf/ corporate/literature/Bio-Rad_2013AnnualReport.pdf 2
Section 1 | National Context of Available Research Tools
3
2. MINNESOTA RESEARCH TOOLS COMPANIES
Text
5
The Research Tools sector in Minnesota is small but growing, with a total of 27 companies occupying the space. Growth of research tools companies started in the 1970s and expanded in the 2000s, with cell biology tools companies, instrumentation companies, materials and chemistry companies and other companies that support research technology.1
DEFINITIONS OF RESEARCH TOOLS COMPANIES BY CATEGORY Cell Biology Tools Companies
Stem cells, proteins, peptides, reagents, assays and kits
Instrumentation Companies
Fluorescence plate readers and array tape
Materials / Chemistry Companies
Medical device coatings and specialty chemicals
Supporting Companies
Filter media, bioreactors, metallic and rubber parts, valves and tubing
R&D Systems, Biovest International and Lifecore Biomedical are Minnesota’s only large, public research tools companies. Other public companies that develop products that support research technology are the Donaldson Company, ATMI / Entegris and Protolabs. The majority of the research tools companies are emerging, private and small, with at least ten of the companies having 100 or fewer employees, suggesting that this is an area of growth in the life sciences.
1
6
See Research Tools Directory (p 21).
Sector Landscapes: Research Tools | LifeScience Alley
FIGURE 2. MAP OF MINNESOTA RESEARCH TOOLS BY CATEGORY
CELL BIOLOGY (13 COMPANIES) INSTRUMENTATION (4 COMPANIES) MATERIALS / CHEMISTRY (3 COMPANIES) SUPPORTING (7 COMPANIES) Text
7
SPOTLIGHT ON R&D SYSTEMS R&D (Research and Diagnostics) Systems was founded in Minneapolis in 1976 and became a public company in 1984. It is one of three major brands of Bio-Techne, which had sales of more than $350 million in 2014. The small company that started in Minneapolis now has branches in Germany, England and China; combined with Bio-Techne’s other brands, they have more than 24,000 products with 95% of them manufactured in-house.1,2 Bio-Techne’s main product lines include immunoassays, antibodies and kits. Today, the company employs more than 650 Minnesotans. R&D Systems was the first cell biology company in what has been a growing industry in Minnesota. It paved the way for companies such as Kingfisher Biotech, Neuromics and ImmunoChemistry Technologies, employing some of these companies’ founders. “Many companies share the common history or link of R&D Systems, not only biotech companies, but even medical device companies" says Joanna LaBresh, President of Kingfisher Biotech. FIGURE 3. TIMELINE HISTORY OF R&D SYSTEMS 2015
$357 M
Implemented new brand, Bio-Techne Acquired six new companies
2005
$190 M
1995
$50 M
Acquired Amgen and Genzyme research businesses Established R&D Systems Europe Formed Growth Factor Division
1985
Released first research reagent, TGF-beta 1 Acquired by Techne Corporation Released whole blood control with platelets Sold first hematology control
1975 1 2
8
SOURCE: Techne Corporation (2014). Form 10-K 2014. Retrieved from https://www.sec.gov/ SOURCE: R&D Systems. http://www.rndsystems.com/about_us.aspx
Sector Landscapes: Research Tools | LifeScience Alley
SPOTLIGHT ON EMERGING RESEARCH TOOLS COMPANIES Minnesota has a number of early-stage research tools companies founded in the early 2000s. Among the most innovative are Douglas Scientific, Fluorescence Innovations, Inc. and ISurTec.1,2,3 In 2014, Fluorescence Innovations, Inc. received more than $180,000 from the National Institutes of Health and from 2011 to 2013, ISurTec received more than $2,000,000 in Small Business Innovative Research (SBIR) grants.3,4 Fluorescence Innovations, Inc. has developed instrumentation that utilizes their proprietary Direct Waveform Recording Technology™ to measure the lifetime fluorescence decay, which significantly reduces noise and improves fluorescence measurements. It was founded in 2006 in Bozeman, MT, and has since moved to a new location in Minneapolis, MN. Innovative Surface Technologies (ISurTec) developed a temperature-responsive cell growth surface for the gentle, non-invasive release of cells from cultureware and microcarriers, which eliminates the need for trypsin or other harsh reagents. ISurTec was founded in 2004 and is located in St. Paul, MN.
ImmunoChemistry Technologies (ICT) provides high quality research reagents and laboratory services. ICT supplies in vitro apoptosis assays, caspase kits, fluorescent reagents for intracellular analysis and other critical detection tools to help biomedical researchers understand metabolic pathways and cure disease. ICT also offers a line of ELISA development solutions including coat buffers, conjugate stabilizers and sample diluents. As a CRO, ICT specializes in custom immunoassay development, conjugation, lyophilization and consulting services.
1 SOURCE: Douglas Scientific. http://www.douglasscientific.com/ SOURCE: Fluorescence Innovations, Inc. http://www.fluorescenceinnovations.com/ 3 SOURCE: Innovative Surface Technologies. http://www.isurtec.com/ 4 SOURCE: National Institutes of Health RePorter (2014). http://report.nih.gov/award/index.cfm 2
Section 2 | Minnesota Research Tools Companies
9
With operations in 17 countries worldwide, Douglas Scientific is a fastgrowing laboratory automation company based in Alexandria, Minnesota (two hours northwest of the Twin Cities). Their novel Array Tape速 technology has radically increased throughput of PCR reactions while simultaneously decreasing reaction volume and overall experiment cost. Their ultra-high throughput solution, Nexar速, was first utilized by agriculture companies to perform SNP genotyping on plant samples. They reinvested profits in research and development, and have adapted their technology into two smaller-scale instruments.The IntelliQube速 is the first fully automated system that integrates liquid handling, thermal cycling, detection and analysis into one instrument. It too is optimized for Array Tape and is used for both end-point and quantitative PCR applications. The other is the AmpliFire速, a point-of-use, hand held instrument that leverages isothermal chemistry to facilitate sample to answer responses in minutes. It is easily employed out in the field to test plant, animal, food and for research use in diagnostics of human samples for diseases. Most notably, the AmpliFire contributed to the global effort to address the ebola virus. Douglas Scientific currently has 115 employees mostly based in Alexandria and a satellite office in Hopkins, MN. As demand for the Array Tape Platform continues to grow and revolutionize labs, Douglas Scientific is expanding operations in the US and international markets specially focusing on India, China and Brazil.
3. INSIDE THE MINNESOTA RESEARCH TOOLS SECTOR
CELL BIOLOGY Ancell [1] BRTI Life Sciences [2] Imanis Life Sciences [3] Immuno Biologic Lab. [4] ImmunoChemistry Tech. [5] Kingfisher Biotech [6] Lifecore Medical [7] Microbiologics [8] Mill Creek Life Sciences [9] Neuromics [10] R&D Systems [11] Surrogen [12] Verge Bio [13]
SUPPORTING Dagan Corporation [1] Donaldson Company [2] ATMI / Entegris [3] Gamma Vacuum [4] Inclined Biomedical Tech. LLC [5] Protolabs [6] Test Resources [7]
12
Sector Landscapes: Research Tools | LifeScience Alley
FIGURE 4. MINNESOTA RESEARCH TOOLS COMPANY BREAKDOWN
INSTRUMENTATION [1] Biovest [2] Fluorescence Innovations, Inc. [3] Douglas Scientific [4] iLAB LLC
MATERIALS / CHEMISTRY [1] Harland Medical [2] ISurTec [3] LKT Labs
Section 3 | Inside the Minnesota Research Tools Sector
13
STATE AND REGIONAL CLUSTERS OF RESEARCH TOOLS The majority of Minnesota research tools companies reside in the Twin Cities Metro. However, there are a handful of companies in other regions in the state, including southwest of the Twin Cities (Gibbon, Shakopee and Waconia), Rochester, Bayport, Alexandria and St. Cloud (Figure 5). Minnesota is also part of what Greg Gillispie, President of Fluorescence Innovations, Inc. calls the Inland Biomedical Research Corridor (IBRC) that runs from the Twin Cities to Pittsburgh. Using the NIH RePORTER Tool, he compared different geographical regions in 2011 and 2012 and discovered that the top institutions in the IBRC have more funding than those in California.
"The top 12 [institutions in the IBRC] have greater National Institutes of Health funding cumulatively than the top 12 institutions in California!" Gregory Gillispie, President of Fluorescence Innovations, Inc. Gillispie moved his company from Bozeman, Montana to Minneapolis in 2012 to capitalize on the opportunities in the region.
FIGURE 5. MINNESOTA COMPANY CLUSTERS
1 COMPANY 2 COMPANIES 3 COMPANIES
17 COMPANIES
14
Sector Landscapes: Research Tools | LifeScience Alley
TECHNICAL EXPERTISE Minnesota is home to one of the largest medical device clusters in the world, with companies such as Medtronic, St. Jude Medical, Boston Scientific and 3M either headquartered in Minnesota or with significant operations in the state.
“The advantage here is the concentration of medical device companies. There really isn’t a better place to be from that perspective.” Eric Guire, Senior Scientist at Innovative Surface Technologies
The University of Minnesota (UMN) is a major research institution with campuses in the Twin Cities, Crookston, Duluth, Morris and Rochester. Together, UMN-Twin Cities and UMN-Duluth received more than $300 million in federal funding from the National Institutes of Health and the National Science Foundation in 2014. The College of Biological Sciences (CBS) and the College of Science and Engineering (CSE), both on the Twin Cities campus, have 129 CBS and 430 CSE tenure and tenure-track faculty, and 2693 CSE and 313 CBS graduate students.1,2 These colleges contributed to the accolades the University recently received when it was named the 29th “Best Global University” by US News and World Report in 2014.3 Besides providing a technical workforce, the University also houses many facilities that provide access to equipment useful to research tools companies.4
SOURCE: The University of Minnesota College of Biological Sciences. http://www.cbs.umn. edu/explore/about/cbs-glance 2 SOURCE: The University of Minnesota College of Science and Engineering. http://cse.umn. edu/aboutcse/CSE_CONTENT_192612.php 3 SOURCE: US News and World Report. http://www.usnews.com/education/best-global-univer sities/rankings?page=3 4 See Research Tools Directory (p 21). 1
Section 3 | Inside the Minnesota Research Tools Sector
15
AWDS FUNDING AL
593
$273,600,407
AK
17
$10,793,647
AZ
404
$158,598,561
AR
104
$46,767,479
CA
7731
$3,499,391,307
CO
922
$313,993,551
CT
1122
$467,188,982
DE
67
$38,759,337
D.C.
380
$194,613,257
FL
1104
$476,217,118
GA
1161
$482,742,805
HI
86
$47,415,169
ID
17
$10,687,130
IL
1885
$733,227,259
IN
589
$210,731,457
IA
411
$169,772,206
KS
238
$109,462,489
KY
386
$153,050,665
LA
278
$140,203,878
ME
113
$72,949,821
MD
2296
$1,333,845,959
MA
4924
$2,404,091,828
MI
1423
$577,502,620
MN
1050
$504,952,618
MS
79
$43,166,617
MO
1073
$490,212,280
MT
67
$36,014,739
NE
218
$88,610,327
NV
45
$25,543,601
NH
203
$96,944,063
NJ
547
$246,964,069
NM
217
$96,781,115
NY
4808
$2,125,150,125
NC
2192
$1,067,282,781
ND
29
$15,893,123
OH
1564
$670,092,509
OK
174
$88,105,625
OR
673
$303,963,471
PA
3377
$1,516,874,603
84
$42,352,575
P.R. RI
439
$132,043,025
SC
422
$147,391,886
SD
36
$21,577,280
TN
1076
$466,225,823
TX
2527
$981,024,135
UT
459
$175,427,096
VT
108
$58,132,718
V.I.
3
$1,760,298
VA
770
$327,737,296
WA
1585
$906,173,368
WV
42
$18,958,353
WI
883
$386,436,340
18
$7,485,353
16 WY
Sector Landscapes: Tissue & Biologics | LifeScience Alley
FIGURE 6. NIH 2014 AWARDS & FUNDING 1 + "IBRC" CORRIDOR
1
SOURCE: http://www.report.nih.gov/award/index.cfm
SUPPORTING INFRASTRUCTURE The Mayo Clinic, with locations in Rochester, MN, Scottsdale and Phoenix, AZ, and Jacksonville, FL, received the highest honor by US News and World Report when it was named “Best Hospital in 2014/2015.” The Mayo Clinic, Rochester received more than $203 million in funding from the National Institutes of Health in 2014 and the entire clinic has an annual research budget of more than $625 million.1,2 The Mayo Clinic has more than 200 investigators in seven academic research areas. Imanis Life Sciences, located in Rochester, MN, was founded and is currently run by Mayo Clinic professors.
“The media still does not accept Minnesota as a place for cell culture companies. We are constantly asked why we are here. When we tell them we are in Rochester, then it makes sense.” Judy Lundy, President and COO, Mill Creek Life Sciences When asked about the workforce in Minnesota, every company president and CEO interviewed emphatically stated that it is a strength of the region. Therefore, it is not surprising that companies (both big and small) in Minnesota span the range from cell and molecular biology to mechanical engineering, making it an ideal location for research tools companies seeking a highly-skilled technical workforce.
1 2
18
SOURCE: The National Institutes of Health RePorter (2014). SOURCE: The Mayo Clinic. http://www.mayo.edu/mgs/programs/faculty
Sector Landscapes: Research Tools | LifeScience Alley
FIGURE 7. MINNESOTA'S BIOLOGY TO ENGINEERING SPECTRUM
R&D Systems
L CU LE MO OGY & LL BIOL
CE
Neuromics
AR
Immunochemistry Technologies
Kingfisher Biotech
Surrogen
Apogen Biotechnologies
CS MI EO ICS OT OM PR GEN &
Immunobiologic Laboratories
Biovest
Beckman Coulter
LS RIA TE CE MA CIEN S
3M
Harland Medical
ISurTec Douglas Scientific
AL DIC NG ME ERI BIO INE G EN
North Central Instruments Medtronic
Fluorescence Innovations, Inc.
Boston Scientific
L ICA AN ING CH ER ME GINE EN
St. Jude Medical
Sciencix
Protolabs Test Resources Applied Vacuum Technology
Section 3 | Inside the Minnesota Research Tools Sector
19
INCUBATORS Incubators encourage early-stage companies by providing wet-labs and office space at affordable prices, and by hosting events to bring together the life science community. The two most prominent are University Enterprise Laboratories (UEL) and the Mayo Clinic Business Accelerator, which house multiple life science companies. Both ISurTec and Kingfisher Biotech are located in UEL, where tenants individually applied for and received more than $45 million in new investments and research grants in 2013.1 Business Enterprise Center The Business Enterprise Center (BEC) is an accelerator located in Cottage Grove, MN. It offers affordable work space and support services to startups.2
Mayo Clinic Business Accelerator Based in Rochester, MN, the Mayo Clinic Business Accelerator opened in 2013 with a focus on medtech and healthtech. As of August 2015, there have been a total of 20 company tenants.3
MinnWest Technology Campus 2006 marked the founding of the MinnWest Technology Campus in Willmar, MN, a biobusiness incubator focusing on agribusiness and biotechnology. More than 30 companies currently reside as tenants (2015).2,4
The SEED Partners The SEED Partners is a newly opened biosciences incubator, accelerator and investor in the North Loop. Their 27,000 square foot space includes a 5,000 square foot wet lab facility, including fume hoods, cell culture space, and other basic & specialized life science equipment. In addition to providing shared lab and collaborative work spaces, SEED can assist clients from the early stages of an idea to product concept, as well as provide business support, office support and laboratory support services.5
University Enterprise Laboratories University Enterprise Laboratories (UEL) is a life science incubator in St. Paul, MN, with a focus on biotech, medtech and special university departments. More than 30 companies have been tenants since its opening in 2005.2,6
Worthington Biotechnology Advancement Center The Worthington Biotechnology Advancement Center is an incubator located in Worthington, MN, with a focus on agribusiness and animal health companies.2 See Research Tools Directory (p 21). SOURCE: Leightner, Amanda. June 2015. "MN Business Incubators and Accelerators." Life Science Nexus. Retrieved August 2015. 3 SOURCE: www.mcbusaccel.com. Retrieved August 2015. 4 SOURCE: www.mnwesttechnology.com. Retrieved August 2015. 5 SOURCE: www.theseedpartners.com. Retrieved August 2015. 6 SOURCE: www.uelmn.org. Retrieved August 2015. 1 2
20
Sector Landscapes: Research Tools | LifeScience Alley
TAX INCENTIVES To encourage innovation in the state and investment in startup companies, the State of Minnesota has implemented the R&D Tax Credit and the Angel Tax Credit. R&D Tax Credit Eligible recipients receive a 10% credit on qualifying expenses up to $2 million, and 2.5% for expenses surpassing that amount.1
Angel Tax Credit Rewards investors 25% for investing in startups focusing on new and innovative technology.2
"The biggest advantage (of conducting my business) in Minnesota is the Angel Tax Credit. For small start-ups, this is HUGE!" Judy Lundy, President and COO, Mill Creek Life Sciences
1
SOURCE: Minnesota Revenue. http://www.revenue.state.mn.us/ 2 SOURCE: Minnesota DEED. http://mn.gov/deed/
Section 3 | Inside the Minnesota Research Tools Sector
21
IN CONCLUSION, The Research Tools sector in Minnesota is small but growing. R&D Systems, the oldest, largest and most established tools company, has paved the way for cell biology companies. Additionally, a number of companies exist that support research tools companies, such as engineering companies that develop manufactured parts. Today, there are a number of innovative companies developing tools and instrumentation to facilitate research. Minnesota’s strong biomedical industry, academic institutions and a world-class clinic have provided training for generations of scientists and engineers that make up Minnesota’s technical workforce. Minnesota is committed to building and keeping innovative companies in-state, demonstrating its commitment by implementing programs to support research and development and early-stage venture. With its solid infrastructure in the biosciences and engineering, programming to encourage investment in early-stage companies and recent emergence of small, private tools companies, the Research Tools sector in Minnesota is poised for growth in the upcoming decades.
CONTRIBUTORS Thank you to the company presidents, CEOs, and others who generously contributed their time and shared their perspectives on the industry: Chris Echeverri, Greg Gillispie, Eric Guire, Patrick Guire, Joanna LaBresh, Judy Lundy and Donna Pinotti.
4. MINNESOTA RESEARCH TOOLS DIRECTORY
Text
23
MINNESOTA RESEARCH TOOLS COMPANIES
24
Company
City, State
Founded Summary
Ancell
Bayport, MN
1992
Produce immunology research tools.
ATMI / Entegris
Bloomington, MN
1966
Provides products and materials used in high-technology manufacturing.
Biovest International, Inc.
Minneapolis, MN
1983
Protein manufacturing instruments utilizing proprietary hollow fiber technology.
BRTI Life Sciences
Two Harbors, MN
2003
3D- cell culture tool & matrix that creates a microenvironment for multiple applications.
Douglas Scientific
Alexandria, MN
2009
Designs and manufactures laboratory instrumentation.
Dagan Corporation
Minneapolis, MN
1974
Produces scientific instruments including voltage and cell patch clamps.
Donaldson Company
Bloomington, MN
1915
Filtration manufacturer.
Fluorescence Innovations, Inc.
Minneapolis, MN
2006
Instrumentation that measures fluorescence lifetime properties of biological systems.
Gamma Vacuum LLC
Shakopee, MN
2003
Ion pumps, titanium sublimation pumps, non-evaporable getters and their controls.
Harland Medical
Eden Prairie, MN
2003
Product solutions for healthcare surface enhancement market.
iLAB LLC
Maple Grove, MN
-
Design and development of biomedical instrumentation.
Imanis Life Sciences
Rochester, MN
2012
Non-invasive reporter systems - cell lines, lentivirus and contract imaging solutions.
Immuno Biological Laboratories
Minneapolis, MN
1997
Clinical laboratory reagent assays for research and clinical testing.
ImmunoChemistry Technologies
Bloomington, MN
1994
Protein chemistry lab. Apoptosis assays and ELISA detection reagents.
Sector Landscapes: Research Tools | LifeScience Alley
MINNESOTA RESEARCH TOOLS COMPANIES Company
City, State
Founded Summary
Inclined Biomedical Technologies LLC
Minneapolis, MN
-
Develops lab tools for academia, med / pharma, hospitals and government facilities.
Innovative Surface Technologies (ISurTec)
St. Paul, MN
2004
CRO; develops scaffolds and matrices, drug delivery and surface coatings.
Kingfisher Biotech
St. Paul, MN
2008
Research reagents for variety of species.
Lifecore Biomedical LLC
Chaska, MN
1986
Manufactures Hyaluronan and other biomaterials for various medical applications.
LKT Labs
St. Paul, MN
1988
Specialty chemicals for cancer chemoprevention.
Microbiologics
St. Cloud, MN
1971
Ready-to-use high quality lyophilized microorganisms.
Mill Creek Life Sciences
Rochester, MN
2010
Products to supplement cell culture used in stem / primary cells.
Neuromics
Edina, MN
2003
Reagents and methods for Neuroscience Research Community.
Protolabs
Maple Plain, MN
1999
Plastic injection molding parts.
R&D Systems
Minneapolis, MN
1985
Produces human cytokines for genetic engineering.
Surrogen, Inc.
St. Paul, MN
2013
Genetically-tailored large animal models of disease.
Test Resources
Shakopee, MN
1998
Materials testing equipment.
Verge Bio
Minneapolis, MN
2014
Designs and engineers diagnostic cellpermeant tracers and dyes.
Section 4 | Minnesota Research Tools Directory
25
UNIVERSITY OF MINNESOTA FACILITIES UMN Facility
Director
Summary
Characterization Facility
Greg Haugstad haugs001@umn.edu
Materials research spanning from nanotechnology to biology and medicine.
Magnetic Transport Laboratory
Dan Dahlberg dand@physics.umn.edu
Applications and advancement of Magnetic Force Microscopy (MFM).
Tissue Mechanics Laboratory
Robert Tranquillo tranquillo@umn.edu
Specialized instruments for soft biological materials.
Supercomputing Institute
Jorge Vi単als vinals@msi.umn.edu
Provides access to high-performance computing resources.
Nano Center
Steve Campbell campb001@umn.edu
Small-scale devices, nano materials and biomedical applications of nanotech.
NMR Center
Gianluigi Veglia vegli001@umn.edu
Research and education in implementation of NMR techniques to biomedical research.
Imaging Center
Mark Sanders msanders@umn.edu
Advanced optical imaging and basic electron microscopy.
MINNESOTA INCUBATORS
26
Company
City, State
Founded Summary
Business Enterprise Center
Cottage Grove, MN
-
Work space and supportive services.
MinnWest Technology Campus LLC
Willmar, MN
2006
Biobusiness incubator focusing on agribusiness and biotechnology.
Mayo Clinic Business Accelerator
Rochester, MN
2013
Collaborative space for new companies, venture capital firms and entrepreneurs.
The SEED Partners
Minneapolis, MN
-
Collaboration between business professionals & entrepreneurs in life science tech & medtech.
University Enterprise Laboratories
St. Paul, MN
2001
Collaborative research center, advancing biology and biotechnology.
Worthington Biotechnology Advancement Center
Worthington, MN
-
Focus on agribusiness & animal health companies.
Sector Landscapes: Research Tools | LifeScience Alley