Gene Therapy and Molecular Biology Vol 7, page 85 polymeric nanospheres for the treatment of restenosis. Gene Ther 9, 1607-1616. Condorelli, G, Aycock, JK, Frati, G, and Napoli, C (2001). Mutated p21/WAF/CIP transgene overexpression reduces smooth muscle cell proliferation, macrophage deposition, oxidation-sensitive mechanisms, and restenosis in hypercholesterolemic apolipoprotein E knockout mice. FASEB J 15, 2162-2170. Cortés, MJ, Díez-Juan, A, Pérez, P, Pérez-Roger, I, ArroyoPellicer, R, and Andrés, V (2002). Increased early atherogenesis in young versus old hypercholesterolemic rabbits by a mechanism independent of arterial cell proliferation. FEBS Letters 522, 99-103. Dartsch, PC, Voisard, R, Bauriedel, G, Hofling, B, and Betz, E (1990). Growth characteristics and cytoskeletal organization of cultured smooth muscle cells from human primary stenosing and restenosing lesions. Arteriosclerosis 10, 6275. Díez-Juan, A, and Andrés, V (2001). The growth suppressor p27Kip1 protects against diet-induced atherosclerosis. FASEB J 15, 1989-1995. Dyson, N (1998). The regulation of E2F by pRB-family proteins. Genes Dev 12, 2245-2262. Dzau, VJ, Braun-Dullaeus, RC, and Sedding, DG (2002). Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med 8, 1249-1256. Ebbecke, M, Unterberg, C, Buchwald, A, Stohr, S, and Wiegand, V (1992). Antiproliferative effects of a c-myc antisense oligonucleotide on human arterial smooth muscle cells. Basic Res Cardiol 87, 585-591. Ehsan, A, Mann, MJ, Dell'Acqua, G, and Dzau, VJ (2001). Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. J Thorac Cardiovasc Surg 121, 714-722. Essed, CE, Van den Brand, M, and Becker, AE (1983). Transluminal coronary angioplasty and early restenosis. Fibrocellular occlusion after wall laceration. Br Heart J 49, 393-396. Frimerman, A, Welch, PJ, Jin, X, Eigler, N, Yei, S, Forrester, J, Honda, H, Makkar, R, Barber, J, and Litvack, F (1999). Chimeric DNA-RNA hammerhead ribozyme to proliferating cell nuclear antigen reduces stent-induced stenosis in a porcine coronary model. Circulation 99, 697-703. George, SJ, Angelini, GD, Capogrossi, MC, and Baker, AH (2001). Wild-type p53 gene transfer inhibits neointima formation in human saphenous vein by modulation of smooth muscle cell migration and induction of apoptosis. Gene Ther 8, 668-676. Gordon, D, Reidy, MA, Benditt, EP, and Schwartz, SM (1990). Cell proliferation in human coronary arteries. Proc Natl Acad Sci U S A 87, 4600-4604. Gorski, DH, LePage, DF, Patel, CV, Copeland, NG, Jenkins, NA, and Walsh, K (1993). Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells. Mol Cell Biol 13, 3722-3733. Gorski, DH, and Walsh, K (1995). Mitogen-responsive nuclear factors that mediate growth control signals in vascular myocytes. Cardiovasc Res 30, 585-592. Gu, JL, Pei, H, Thomas, L, Nadler, JL, Rossi, JJ, Lanting, L, and Natarajan, R (2001). Ribozyme-mediated inhibition of rat leukocyte-type 12-lipoxygenase prevents intimal hyperplasia in balloon-injured rat carotid arteries. Circulation 103, 1446-1452. Guevara, NV, Kim, HS, Antonova, EI, and Chan, L (1999). The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med 5, 335-339.
Gunn, J, Holt, CM, Francis, SE, Shepherd, L, Grohmann, M, Newman, CM, Crossman, DC, and Cumberland, DC (1997). The effect of oligonucleotides to c-myb on vascular smooth muscle cell proliferation and neointima formation after porcine coronary angioplasty. Circ Res 80, 520-531. Guvakova, MA, Yakubov, LA, Vlodavsky, I, Tonkinson, JL, and Stein, CA (1995). Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. J Biol Chem 270, 2620-2627. Hu, WY, Fukuda, N, Kishioka, H, Nakayama, M, Satoh, C, and Kanmatsuse, K (2001a). Hammerhead ribozyme targeting human platelet-derived growth factor A- chain mRNA inhibited the proliferation of human vascular smooth muscle cells. Atherosclerosis 158, 321-329. Hu, WY, Fukuda, N, Nakayama, M, Kishioka, H, and Kanmatsuse, K (2001b). Inhibition of vascular smooth muscle cell proliferation by DNA-RNA chimeric hammerhead ribozyme targeting to rat platelet-derived growth factor A-chain mRNA. J Hypertens 19, 203-212. Hu, Y, Cheng, L, Hochleitner, BW, and Xu, Q (1997). Activation of mitogen-activated protein kinases (ERK/JNK) and AP-1 transcription factor in rat carotid arteries after balloon injury. Arterioscler Thromb Vasc Biol 17, 2808-2816. Hu, Y, Dietrich, H, Metzler, B, Wick, G, and Xu, Q (2000). Hyperexpression and activation of extracellular signalregulated kinases (ERK1/2) in atherosclerotic lesions of cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol 20, 18-26. Iacopetta, B, Wysocki, S, Norman, P, and House, A (1995). The p53 tumor suppressor gene is overexpressed but not mutated in human atherosclerotic tissue. Int J Oncol 7, 399-402. Ihling, C, Menzel, G, Wellens, E, Monting, JS, Schaefer, HE, and Zeiher, AM (1997). Topographical association between the cyclin-dependent kinases inhibitor p21, p53 accumulation, and cellular proliferation in human atherosclerotic tissue. Arterioscler Thromb Vasc Biol 17, 2218-2224. Ihling, C, Technau, K, Gross, V, Schulte-Monting, J, Zeiher, AM, and Schaefer, HE (1999). Concordant upregulation of type II-TGF-beta-receptor, the cyclin- dependent kinases inhibitor p27Kip1 and cyclin E in human atherosclerotic tissue: implications for lesion cellularity. Atherosclerosis 144, 714. Indolfi, C, Avvedimento, EV, Rapacciuolo, A, Di Lorenzo, E, Esposito, G, Stabile, E, Feliciello, A, Mele, E, Giuliano, P, Condorelli, G, and Chiariello, M (1995). Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Med 1, 541-545. Isner, JM (1994). Vascular remodeling. Honey, I think I shrunk the artery. Circulation 89, 2937-2941. Izumi, Y, Kim, S, Namba, M, Yasumoto, H, Miyazaki, H, Hoshiga, M, Kaneda, Y, Morishita, R, Zhan, Y, and Iwao, H (2001). Gene transfer of dominant-negative mutants of extracellular signal- regulated kinase and c-Jun NH2terminal kinase prevents neointimal formation in ballooninjured rat artery. Circ Res 88, 1120-1126. Katsuda, S, Coltrera, MD, Ross, R, and Gown, AM (1993). Human atherosclerosis. IV. Immunocytochemical analysis of cell activation and proliferation in lesions of young adults. Am J Pathol 142, 1787-1793. Kawauchi, M, Suzuki, J, Morishita, R, Wada, Y, Izawa, A, Tomita, N, Amano, J, Kaneda, Y, Ogihara, T, Takamoto, S, and Isobe, M (2000). Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates. Circ Res 87, 1063-1068.
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