Riesgo de acidosis láctica fatal y no fatal con el uso de metformina para la diabetes mellitus tipo 2
Characteristics of included studies Study
Peacock 1986
Methods
TRIAL DESIGN: Comparative trial DURATION: 6 months
Participants
Country: United Kingdom. Setting: outpatient.Treatment N: 27. Control N: 20.Treatment age: 59.9 +/-2.1. Control age: 56.7 +/-2.1. Treatment sex: 59% men. Control sex: 66% men. Inclusion: Type 2 DM. Exclusions: none listed.
Interventions
TREATMENT: Metformin, dosage unclear, + glibenclamide. COMPARISON: insulin
Outcomes
Platelet reactivity (ADP release, adrenaline release and NaAA threshold), and fasting glucose, HgA1.
Notes Allocation concealment
C
Study
Pedersen 1965
Methods
TRIAL DESIGN: Prospective cohort study DURATION: 18 months
Participants
Country: Denmark. Setting: inpatient and outpatient. Treatment N: 20. Control N: 0. Age: not listed. Sex: not listed. Inclusion: maturity-onset DM. Exclusions: none listed.
Interventions
TREATMENT: metformin, dose titrated up clinically, 1-4g/day. COMPARISON: none.
Outcomes
Plasma glucose
Notes Allocation concealment
D
Study
Pedersen 1989
Methods
TRIAL DESIGN: Double-blind crossover randomised controlled trial DURATION: 1 month
Participants
Country: Denmark. Setting: outpatient. Treatment N: 10. Control N: 10. Age: 53 +/-9. Sex: 20% men. Inclusion: Obese pts with Type 2 DM. Exclusions: renal or liver dysfunction.
Interventions
TREATMENT: Metformin 500mg TID. COMPARISON: placebo
Outcomes
Fasting and postprandial glucose, fructosamine, insulin, c-peptide, and adipocite insulin receptor binding.
Notes Allocation concealment
B
Study
Pirart 1961
Methods
TRIAL DESIGN: Retrospective cohort study DURATION: 3 motnhs
Participants
Country: Belgium. Setting: outpatient. Treatment N: 107. Control N: 0. Age: not listed. Sex: not listed. Inclusion: type 2 DM, poorly controlled on a single agent. Exclusions: obesity.
Interventions
TREATMENT: metformin, unclear dose. COMPARISON: some patients treated with other agents, not analysed.
Outcomes
Glycemia, and glucosuria.
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