o f t i t l e s , v i s i t u s a t w w w. c r c p r e s s . c o m
CRC Handbook of Chemistry and Physics 90th Edition
Design of Caspase Inhibitors as Potential Clinical Agents Edited by
Tom O’Brien
Sunesis Pharmaeuticals, San Francisco, California, USA
Steven D. Linton
National Institute of Standards & Technology (Retired), Gaithersburg, Maryland, USA
San Diego, California, USA
Mirroring the growth and direction of science for nearly a century, the CRC Handbook of Chemistry and Physics, now in its 90th edition, adds several new tables that will be among the most accessed in the world. These include Structure and Functions of Common Drugs, Solubility Parameters of Polymers, Major World Earthquakes, and Equilibrium Constants of Selected Enzyme Reactions. It adds major updates to several more, including Threshold Limits for Airborne Contaminants, Mass Spectral Peaks of Common Organic Solvents, and Properties of the Solar System. Also included is a table of the Handbook’s greatest fans: Nobel Laureates in Chemistry and Physics.
Caspases (cysteine aspartyl proteases) represent one of the most specific protease families described to date. As caspase family members are involved in pro-inflammatory responses, inhibition of caspase activity represents a novel yet core approach to disease treatment. Design of Caspase Inhibitors as Potential Clinical Agents discusses the role of caspases in inducing cell death. It reviews recent efforts to develop small molecule inhibitors that are capable of modulating caspase activity. The text also examines the difficulties encountered in transitioning small molecule inhibitors from the lab to clinical use, and discusses how these challenges can best be overcome to allow continued progress.
Catalog no. 90844, ISBN: 978-1-4200-9084-0 June 2009, 8-1/2 x 11, 2700 pp. Suggested Price: $149.95 / £89.00 Also available as a CD and in a web version
Cyclic Nucleotide Phosphodiesterases in Health and Disease Edited by
Joseph A. Beavo
University of Washington, Seattle, USA
Sharron H. Francis
Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Enzyme Inhibitors Series
Catalog no. 45407, ISBN: 978-1-4200-4540-6 January 2009, 6-1/8 x 9-1/4, 312 pp. Suggested Price: $169.95 / £94.00
Dictionary of Carbohydrates with CD-ROM
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Second Edition Edited by
Miles D. Houslay
Peter M. Collins
University of Glasgow, Scotland
Birkbeck College, London, UK
Presenting a modern, comprehensive reference book on cyclic nucleotide phosophodiesterases (PDE), this text appeals to scientists in academia, the pharmaceutical industry, and related clinical disciplines. In the last 15 years, information relating to PDE genetics, physiological functions, roles in disease states, regulation, structure and interaction with pharmacologically active agents has burgeoned. This book covers the current information and its potential for future development. It describes the fundamental biochemical features of each of the known PDE families and the advances being made in developing selective inhibitors for these various enzymes.
The new edition of this authoritative reference includes 3000 new compounds, bringing the total to 26,000. All existing entries have been carefully reviewed and updated where necessary. The data included in each entry includes chemical names and synonyms, including CAS and IUPAC names, trade names, and trivial names; full and clear description of equilibrium studies, cyclic forms, and their derivatives; extensive occurrence and use data; structure diagrams showing stereochemistry and configuration; and physical properties including melting point, optical rotation, and mutarotation data. This edition also features a structure-searchable CD-ROM providing quick, convenient access.
Catalog no. DK9668, ISBN: 978-0-8493-9668-7 2007, 7 x 10, 728 pp. Suggested Price: $209.95 / £117.00
Biochemistry
David R. Lide
Catalog no. 3829, ISBN: 978-0-8493-3829-8 2006, 8-1/2 x 11, 1304 pp. Suggested Price: $519.00 / £288.00
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