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Fig. 3.3 p53 as transcription section: tumor suppressor activity

More than 50% of human cancer contain mutation or deletion of p53 (Neoplasia 1999, p. 290). Relation between p53 and oral squmous cell carcinoma: According to the result of the study performed by Jang-Jaer et al. (2005, p.471) activation of P53 play a role of in the process of malignant changes of oral mucosal pre malignant lesions. They also stated that the gradually increasing expression of P53 in normal epithelium , hyperplasia , dysplasia and carcinoma supports the values of this protein as an indicator of OSCC. The suppressor gene frequently alterd in carcinomas of the upper aerodigestive tract is the p 53 gene. P 53 mutation or over expression has been demonetrated in 43 % to 93 % of cases of oral cells than in any human cancer (Sunitha et al. 2004). The highly direct correlation between p53 expression and neoangiogenesis suggested that p53 is important in regulation of angiogenesis and both factors may play a critical role in oral carcinogenesis (Abbas et al. 2003, p.197).

Thesis on oral cancer and bangladesh  

The term oral cancer encompasses all malignancies that originate in the oral tissues. Squamous cell carcinoma of the oral cavity comprises 9...

Thesis on oral cancer and bangladesh  

The term oral cancer encompasses all malignancies that originate in the oral tissues. Squamous cell carcinoma of the oral cavity comprises 9...