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Hypothesis Immunohistochemical analysis of Oral Squamous Cell Carcinoma (OSCC) shows over expression of p53 protein.

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OBJECTIVES & AIMS General Objectives: To analyze the expression of p53 protein in Oral Squamous Cell Carcinoma by immunohistochemical method. Specific Objectives: a) To assess the p53 protein expression in Oral Squamous Cell Carcinoma. b) To evaluate the expression pattern (intensity and distribution) of the p53 protein in different grades of Oral Squamous Cell Carcinoma. c) To correlate the expression of p53 protein with specific risk factors associated with development of Oral Squamous Cell Carcinoma.

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LITERATURE REVIEW What is p53 ? p 53 is a tumor protein which acts as a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor. P 53 has been described as, ‘the guardian of the genome’. Referring to its role in conserving stability by preventing the genome mutation. It is located on Chromosome 17 p.13.1 (Neoplasia 1999, p.290).

Thesis on oral cancer and bangladesh  

The term oral cancer encompasses all malignancies that originate in the oral tissues. Squamous cell carcinoma of the oral cavity comprises 9...

Thesis on oral cancer and bangladesh  

The term oral cancer encompasses all malignancies that originate in the oral tissues. Squamous cell carcinoma of the oral cavity comprises 9...