reviews REPORTS T-cells latch onto these MHC Class I antigens of the splenocyte and are directed against attacking the beta-cells of the pancreas. This has the potential to reverse diabetes by inducing the reappearance of insulin-secreting islets in the pancreas. Of the 12 non-obese diabetic mice injected with live splenocytes, 11 remained normogylcemic for more than 26 weeks after the onset of diabetes, while 11 of 13 mice that received irradiated splenocytes also remained normoglycemic for greater than 27 weeks. The diabetic mice treated with the irradiated splenocytes demonstrated restoration of normal glucose levels and even islet regeneration, however at a slower rate than that of the live splenocytes control. Overall, both instances of splenocytes were able to yield newly functional islet cells, an amazing feat nevertheless . Next time you pop a seemingly innocuous piece of candy or lollipop into your mouth, remember that such a luxury eludes 8.3% of the population. Yet hope has been shed on this suffering contingency with the advent of modern medical techniques. While regular diet, daily exercise and insulin supplementation have until now been the best way for regulating diabetes, it is the audacity of medical research that promises to produce longterm solutions and the hope of a tomorrow free of lancing.
References 1. 3.”Diabetes Overview.” National Diabetes Information Clearinghouse. Web. 17 Apr. 2011. <http://diabetes.niddk.nih. gov/dm/pubs/overview/>. 2. Razavi R, Chan Y, Afifiyan FN et al. 2006. TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes. Cell. 127(6):1123-35. 3. “What Are iPS Cells?” University of Wisconsin System. Web. 18 Apr. 2011. <stemcells.wisc.edu/pdf/What_Are_IPS_Cells. pdf>. 4. Alipio Z, Liao W, Roemer EJ, et al. 2010. Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells. Proc Natl Acad Sci U S A. 107(30):13426-31 5. Kodama, Shohta. 2003. “Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice.” Science Magazine 302 Cytostem. Web. 18 Apr. 2011. 6. Bour-Jordan, Helene, and Jeffrey Bluestone. 2006. Sensory Neurons Link the Nervous System and Autoimmune Diabetes. Cell. 127(6):1097-9. 7. “Diabetes - PubMed Health.” National Center for Biotechnology Information. Web. 17 Apr. 2011. <http://www.ncbi.nlm. nih.gov/pubmedhealth/PMH0002194/>. 8. “Diagnosis of Diabetes.” Cleveland Clinic. Web. 17 Apr. 2011.<http://my.clevelandclinic.org/disorders/Diabetes_Mellitus/hic_Diagnosis_of_Diabetes.aspx
The Stony Brook Young Investigators Review, Fall 2011
Fall Fall2011 2011